Steven Artandi

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Telomere shortening and cell fates in mouse models of neoplasia
    Steven E Artandi
    Dept of Hematology, Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94304, USA
    Trends Mol Med 8:44-7. 2002
  2. pmc Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
    Elaine J Middleman
    Department of Medicine, Division of Hematology, Stanford University, 269 Campus Drive, Stanford, CA 94305 5156, USA
    Mol Cell Biol 26:2146-59. 2006
  3. pmc Telomeres and telomerase in cancer
    Steven E Artandi
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Carcinogenesis 31:9-18. 2010
  4. doi request reprint Reverse transcribing the code for chromosome stability
    Steven E Artandi
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell 36:715-9. 2009
  5. pmc Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene
    Steven E Artandi
    Department of Medicine, Division of Hematology, and Cancer Biology Program, Stanford School of Medicine, Stanford, CA 94305, USA
    J Exp Med 203:1143-5. 2006
  6. ncbi request reprint Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer
    Steven E Artandi
    Department of Medicine, Division of Hematology and Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biochem Biophys Res Commun 331:881-90. 2005
  7. pmc Complex roles for telomeres and telomerase in breast carcinogenesis
    Steven E Artandi
    Department of Medicine Hematology, Cancer Biology Program, Stanford University School of Medicine, Stanford, California, USA
    Breast Cancer Res 5:37-41. 2003
  8. ncbi request reprint Telomeres, telomerase, and human disease
    Steven E Artandi
    Stanford University School of Medicine, Stanford, CA, USA
    N Engl J Med 355:1195-7. 2006
  9. pmc Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo
    Sripriya Rajaraman
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:17747-52. 2007
  10. doi request reprint Stem cell aging and aberrant differentiation within the niche
    Jinkuk Choi
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stem Cell 5:6-8. 2009

Research Grants

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Telomere shortening and cell fates in mouse models of neoplasia
    Steven E Artandi
    Dept of Hematology, Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94304, USA
    Trends Mol Med 8:44-7. 2002
    ..These alternate fates depend on the integrity of the p53 pathway and on cell type...
  2. pmc Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
    Elaine J Middleman
    Department of Medicine, Division of Hematology, Stanford University, 269 Campus Drive, Stanford, CA 94305 5156, USA
    Mol Cell Biol 26:2146-59. 2006
    ..Thus, the TERT carboxy terminus contains sequences that regulate TERT protein levels and determinants that are required for productive action on telomere ends...
  3. pmc Telomeres and telomerase in cancer
    Steven E Artandi
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Carcinogenesis 31:9-18. 2010
    ..This review covers the role of telomeres and telomerase in the biology of normal tissue stem/progenitor cells and in the development of cancer...
  4. doi request reprint Reverse transcribing the code for chromosome stability
    Steven E Artandi
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell 36:715-9. 2009
    ..This year's Nobel Prize in Physiology or Medicine recognized groundbreaking studies establishing the telomere field as a crucial area of biomedical research...
  5. pmc Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene
    Steven E Artandi
    Department of Medicine, Division of Hematology, and Cancer Biology Program, Stanford School of Medicine, Stanford, CA 94305, USA
    J Exp Med 203:1143-5. 2006
    ..These findings highlight the importance of telomerase in cancer and raise new questions regarding the mechanisms by which the telomerase RNA component supports tumorigenesis...
  6. ncbi request reprint Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer
    Steven E Artandi
    Department of Medicine, Division of Hematology and Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biochem Biophys Res Commun 331:881-90. 2005
    ..These fused chromosomes result in cycles of chromosome fusion-bridge-breakage, which can fuel cancer initiation, especially in epithelial tissues, by facilitating changes in gene copy number...
  7. pmc Complex roles for telomeres and telomerase in breast carcinogenesis
    Steven E Artandi
    Department of Medicine Hematology, Cancer Biology Program, Stanford University School of Medicine, Stanford, California, USA
    Breast Cancer Res 5:37-41. 2003
    ..In mature cancers, telomerase probably serves a crucial role in tumor progression and maintenance by stabilizing telomeres and supporting the immortal growth of breast cancer cells...
  8. ncbi request reprint Telomeres, telomerase, and human disease
    Steven E Artandi
    Stanford University School of Medicine, Stanford, CA, USA
    N Engl J Med 355:1195-7. 2006
  9. pmc Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo
    Sripriya Rajaraman
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:17747-52. 2007
    ..These data support a model in which rapidly dividing progenitor cells within a tissue with short telomeres are vulnerable to telomere uncapping during or shortly after telomere replication...
  10. doi request reprint Stem cell aging and aberrant differentiation within the niche
    Jinkuk Choi
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stem Cell 5:6-8. 2009
    ....
  11. doi request reprint Telomere uncapping, chromosomes, and carcinomas
    Luis F Z Batista
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cancer Cell 15:455-7. 2009
    ..In this issue of Cancer Cell, Else et al. demonstrate that telomere uncapping-altering a protein that protects chromosome ends without shortening telomeres-also results in epithelial cancers...
  12. pmc A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis
    Andrew S Venteicher
    Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA
    Science 323:644-8. 2009
    ..Thus, TCAB1 controls telomerase trafficking and is required for telomere synthesis in human cancer cells...
  13. pmc Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly
    Andrew S Venteicher
    Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA
    Cell 132:945-57. 2008
    ..These findings reveal an unanticipated requirement for additional enzymes in telomerase biogenesis and suggest alternative approaches for inhibiting telomerase in cancer...
  14. pmc TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program
    Jinkuk Choi
    Department of Medicine, Stanford School of Medicine, Stanford, California, United States of America
    PLoS Genet 4:e10. 2008
    ..These data show that TERT controls tissue progenitor cells via transcriptional regulation of a developmental program converging on the Myc and Wnt pathways...
  15. ncbi request reprint TCAB1: driving telomerase to Cajal bodies
    Andrew S Venteicher
    Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA
    Cell Cycle 8:1329-31. 2009
    ..These findings provide important new insights into how telomerase functions in cancer and in stem cell biology...
  16. ncbi request reprint Aging, graying and loss of melanocyte stem cells
    Kavita Y Sarin
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Stem Cell Rev 3:212-7. 2007
    ..Furthermore, using the melanocyte lineage as an example, it will discuss common theories of tissue and stem cell aging...
  17. doi request reprint Telomerase modulates Wnt signalling by association with target gene chromatin
    Jae Il Park
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 460:66-72. 2009
    ..These data reveal an unanticipated role for telomerase as a transcriptional modulator of the Wnt/beta-catenin signalling pathway...
  18. pmc Conditional telomerase induction causes proliferation of hair follicle stem cells
    Kavita Y Sarin
    Department of Medicine, Division of Hematology, Stanford School of Medicine, Stanford, California 94305, USA
    Nature 436:1048-52. 2005
    ..These data indicate that, in addition to its established role in extending telomeres, TERT can promote proliferation of resting stem cells through a non-canonical pathway...
  19. ncbi request reprint Telomere dysfunction provokes regional amplification and deletion in cancer genomes
    Rónán C O'Hagan
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Cell 2:149-55. 2002
    ..This model provides a platform for discovery of genes responsible for the major cancers affecting aged humans...
  20. pmc DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse
    Richard S Maser
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell Biol 27:2253-65. 2007
    ....
  21. pmc Constitutive telomerase expression promotes mammary carcinomas in aging mice
    Steven E Artandi
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street M413, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:8191-6. 2002
    ..These data indicate that enforced mTERT expression can promote the development of spontaneous cancers even in the setting of ample telomere reserve...
  22. pmc Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells
    Qing Gao
    Department of Radiation Oncology, University of California, San Francisco, CA 94103, USA
    DNA Repair (Amst) 7:1233-49. 2008
    ....

Research Grants14

  1. TELOMERE DYSFUNCTION, GENOMIC INSTABILITY AND CANCER
    Steven Artandi; Fiscal Year: 2005
    ..Transplantation experiments using this model will reveal if the effect on tumor biology is a cell autonomous one. ..
  2. Regulation of the Telomerase Protein Component In Cancer
    Steven E Artandi; Fiscal Year: 2010
    ....
  3. Defining the telomerase holoenzyme in progenitor cells with aging
    Steven E Artandi; Fiscal Year: 2010
    ..An improved understanding of telomerase is crucial for designing therapies that will delay or reverse certain aspects of aging. ..
  4. Telomeres, Telomerase and Tumor Progression
    Steven Artandi; Fiscal Year: 2009
    ....
  5. Regulation of the Telomerase Protein Component In Cancer
    Steven Artandi; Fiscal Year: 2007
    ....
  6. Novel Functions for Telomerase Enzyme Complex in Vivo
    Steven Artandi; Fiscal Year: 2005
    ..Through analysis of a conditional knockout mouse, we will determine the role of endogenous telomerase in cells in culture and in stern/progenitor compartments in vivo. ..
  7. Telomeres, Telomerase and Tumor Progression
    Steven Artandi; Fiscal Year: 2009
    ....