Research Topics
Genomes and GenesSpecies | Daniel A ArberSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Expression of CD163 (hemoglobin scavenger receptor) in normal tissues, lymphomas, carcinomas, and sarcomas is largely restricted to the monocyte/macrophage lineageTuDung T Nguyen
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5243, USA
Am J Surg Pathol 29:617-24. 2005....
Bone marrow biopsy involvement by non-Hodgkin's lymphoma: frequency of lymphoma types, patterns, blood involvement, and discordance with other sites in 450 specimensDaniel A Arber
Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
Am J Surg Pathol 29:1549-57. 2005....
The frequency of dual TCR-PCR clonality in granulomatous disordersSalma Dabiri
Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
J Cutan Pathol 38:704-9. 2011..The frequency of T-cell clonality in association with granulomatous dermatitides has not yet been established...
BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic featuresReetesh K Pai
Departments of Pathology, Stanford University, CA 94305, USA
Am J Surg Pathol 36:744-52. 2012....
PD-1 expression in T-cell lymphomas and reactive lymphoid entities: potential overlap in staining patterns between lymphoma and viral lymphadenitisChandra Krishnan
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
Am J Surg Pathol 34:178-89. 2010....
DNA methylation analysis of ALOX12 and GSTM1 in acute myeloid leukaemia identifies prognostically significant groupsRobert S Ohgami
Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
Br J Haematol 159:182-90. 2012....
Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic featuresDaniel T Chang
Department of Radiation Oncology, Stanford University, Stanford, CA, USA
Mod Pathol 25:1128-39. 2012....
Detection of isolated tumor cells in neuroblastoma by immunohistochemical analysis in bone marrow biopsy specimens: improved detection with use of beta-cateninChandra Krishnan
Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
Am J Clin Pathol 131:49-57. 2009..We also identified beta-catenin as a sensitive immunohistochemical marker of primary and metastatic neuroblastoma...
Evaluation of B-cell clonality using the BIOMED-2 PCR method effectively distinguishes cutaneous B-cell lymphoma from benign lymphoid infiltratesAnjali V Morales
Department of Dermatology, Stanford University Medical Center, Stanford, CA 94305, USA
Am J Dermatopathol 30:425-30. 2008..This study forms the basis for further investigating the role of Ig clonality in distinguishing CBCL from benign lymphoid infiltrates that may pose a challenge in morphologic diagnosis...
Combined use of PCR-based TCRG and TCRB clonality tests on paraffin-embedded skin tissue in the differential diagnosis of mycosis fungoides and inflammatory dermatosesBing Zhang
Department of Pathology, L235, Stanford University Medical Center, Stanford, CA 94305, USA
J Mol Diagn 12:320-7. 2010..Combined use of the two tests in patients with intermediate pretest probabilities as proposed in the algorithm could improve test utility...
Microtubule-associated protein-2 is a sensitive marker of primary and metastatic neuroblastomaChandra Krishnan
Department of Pathology, Stanford University, Stanford, CA 94205, USA
Am J Surg Pathol 33:1695-704. 2009..We examined the diagnostic utility of MAP-2 as a marker of neuroblastoma and attempted to characterize the expression of this protein in other tumors in the morphologic differential diagnosis of neuroblastoma...
Low stage follicular lymphoma: biologic and clinical characterization according to nodal or extranodal primary originOlga K Weinberg
Department of Pathology, Stanford University Medical Center, Stanford Comprehensive Cancer Center, Stanford, CA 94305, USA
Am J Surg Pathol 33:591-8. 2009..019) and disease-specific survival (P=0.006) in comparison with the t(14;18)-negative group. In low stage FL, the status of t(14;18) seems to be more predictive of outcome than origin from an extranodal versus nodal site...
Histologic and molecular analyses of colonic perineurial-like proliferations in serrated polyps: perineurial-like stromal proliferations are seen in sessile serrated adenomasReetesh K Pai
Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
Am J Surg Pathol 35:1373-80. 2011....
Clinical characterization of acute myeloid leukemia with myelodysplasia-related changes as defined by the 2008 WHO classification systemOlga K Weinberg
Department of Pathology, Center for Clinical Investigation, Stanford University Medical Center, CA 94305, USA
Blood 113:1906-8. 2009..001). These data support the clinical, morphologic, and cytogenetic criteria for this 2008 WHO AML category...
Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutationJason Gotlib
Department of Medicine, Division of Hematology, Stanford University, Stanford Cancer Center, 875 Blake Wilbur Dr, Rm 2327B, Stanford, CA 94305 5821, USA
Blood 106:2865-70. 2005..This case indicates that KIT tyrosine kinase inhibition is a feasible approach in SM, but single-agent clinical efficacy may be limited by clonal evolution in the advanced leukemic phase of this disease...
Epstein-Barr virus-associated peripheral T-cell lymphoma and hemophagocytic syndrome arising after liver transplantation: case report and review of the literatureTracy I George
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
Pediatr Blood Cancer 44:270-6. 2005..He presented with hemophagocytic syndrome (HPS) and active EBV infection, with positive serum titers and polymerase chain reaction (PCR) for EBV in blood, colon, and antral samples...
Fluorescence in situ hybridization investigation of cutaneous lesions in acute promyelocytic leukemiaJoanna E Wrede
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5627, USA
Mod Pathol 18:1569-76. 2005..Fluorescence in situ hybridization appears to be a robust technique to detect cutaneous manifestations of acute promyelocytic leukemia in formalin-fixed paraffin-embedded skin biopsies...
Pathology of the myeloproliferative diseasesTracy I George
Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive, Room H1501B, Stanford, CA 94305 5627, USA
Hematol Oncol Clin North Am 17:1101-27. 2003..Given the overlap in morphology among these diseases, correlation with clinical, hematologic, and cytogenetic/molecular genetic findings is imperative for precise classification...
''Minor'' BCL2 breakpoints in follicular lymphoma: frequency and correlation with grade and disease presentation in 236 casesOlga K Weinberg
Stanford University, Department of Pathology, 300 Pasteur Dr, Room L235, Stanford, CA 94305, USA
J Mol Diagn 9:530-7. 2007..Correlation of breakpoints with survival did not reveal significant differences. Diagnostic laboratories should consider expanding their PCR methods to include other BCL2 breakpoints and correlating with FISH methods when appropriate...
The frequency of B- and T-cell gene rearrangements and epstein-barr virus in T-cell lymphomas: a comparison between angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified with and without associated B-cell proliferationsBrenton T Tan
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Dr, Room L235, Stanford, CA 94305 5324, USA
J Mol Diagn 8:466-75; quiz 527. 2006..Our findings demonstrate that B-cell clonality is a common finding in AILT and PTCL-NOS, and its presence should not negate the diagnosis established by morphologic, immunophenotypic, and clinical findings...
Low-grade B-Cell lymphomas with plasmacytic differentiation lack PAX5 gene rearrangementsTracy I George
Department of Pathology, Stanford University Medical Center, 300 Pasteur Dr, Room H1501B, MC 5627, Stanford, CA 94305 5627, USA
J Mol Diagn 7:346-51. 2005..This study also confirms recent reports that found an absence of PAX5 rearrangements in LPL, suggesting the reassessment of PAX5 rearrangements in LPL...
Chromosomal aberrations in a case of synchronous extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type and bronchogenic adenocarcinomaJohn S Cupp
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, UAS
Appl Immunohistochem Mol Morphol 16:296-300. 2008..The presence of differing genetic compositions suggests a biclonal environment composed of 2 distinct neoplastic processes...
Lymphoplasmacytic lymphoma arising in the setting of hepatitis C and mixed cryoglobulinemiaChandra Krishnan
Department of Pathology, Stanford University, Palo Alto, CA, USA
J Clin Oncol 25:4312-4. 2007
Immunophenotypic features of acute myeloid leukemia with inv(3)(q21q26.2)/t(3;3)(q21;q26.2)Bruno C Medeiros
Department of Medicine, Division of Hematology, Stanford University, Stanford, CA, USA
Leuk Res 34:594-7. 2010..2). Differential karyotype and expression of certain antigens were noted in patients with de novo AML with inv(3)(q21q26.2) vs. those with inv(3)(q21q26.2)-containing blasts...
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changesJames W Vardiman
Department of Pathology, University of Chicago, IL, USA
Blood 114:937-51. 2009....
The prognostic value of CXCR4 in acute myeloid leukemiaJeong Yeal Ahn
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Appl Immunohistochem Mol Morphol 21:79-84. 2013..CXCR4 expression appears to be an independent prognostic factor for survival in a heterogeneous group of AML patients. To better assess its significance, we analyzed CXCR4 expression in a group of AML patients...
The frequency of immunoglobulin heavy chain gene and T-cell receptor gamma-chain gene rearrangements and Epstein-Barr virus in ALK+ and ALK- anaplastic large cell lymphoma and other peripheral T-cell lymphomasBrent T Tan
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
J Mol Diagn 10:502-12. 2008..These findings suggest that other factors contribute to IGH clonality and demonstrate that, in the absence of an associated B-cell proliferation, IGH clonality occurs infrequently (8%) in specific PTCL subtypes...
Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemiaTuDung T Nguyen
Department of Pathology, Stanford University, Stanford, CA, USA
Genes Chromosomes Cancer 45:918-32. 2006..Future studies would be useful to further characterize these novel fusion protein products...
A comparison of two methods for screening CEBPA mutations in patients with acute myeloid leukemiaJeung Yeal Ahn
Department of Pathology, Stanford University School of Medicine, Stanford, California
J Mol Diagn 11:319-23. 2009..A combination of the two assays may offer some advantages, chiefly in permitting more sensitive detection by fragment length analysis of insertions and deletions...
Prevalence of bone marrow involvement in systemic anaplastic large cell lymphoma: are immunohistochemical studies necessary?Olga K Weinberg
Department of Pathology Stanford University, Stanford, CA 94305, USA
Hum Pathol 39:1331-40. 2008..033). Overall, marrow involvement in anaplastic large cell lymphoma was relatively uncommon, and when present, it was identified on hematoxylin and eosin sections...
Lymphoma in pregnancy initially diagnosed as vaginal intraepithelial neoplasia and lichen planusThuong Thuong Nguyen
Department of Obstetrics and Gynecology Medicine, Division of Oncology and Pathology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
Obstet Gynecol 118:486-9. 2011..Non-Hodgkin's lymphoma presenting as a vaginal mass in pregnancy is uncommon...
High frequency of clonal immunoglobulin receptor gene rearrangements in sporadic histiocytic/dendritic cell sarcomasWei Chen
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Surg Pathol 33:863-73. 2009..The findings suggest that a large subset of H/DC sarcomas have inherited B-cell genotypes, thus providing new insights for the pathogenesis of these rare but aggressive neoplasms...
Nodular lymphocyte-predominant Hodgkin lymphoma presenting as fulminant hepatic failure in a pediatric patient: a case report with pathologic, immunophenotypic, and molecular findingsKirsten M W Woolf
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
Appl Immunohistochem Mol Morphol 16:196-201. 2008..Hodgkin lymphoma as a cause of hepatic failure is rare and has not been previously reported in a pediatric patient...
Bone marrow metastases: a survey of nonhematologic metastases with immunohistochemical study of metastatic carcinomasChandra Krishnan
Department of Pathology, Stanford University, 300 Pasteur Drive, Lane 325, Stanford, CA 94305 5324, USA
Appl Immunohistochem Mol Morphol 15:1-7. 2007..Overall, the immunohistochemical characterization of metastatic carcinomas to the bone marrow show good correlation with the established staining pattern of the primary tumors...
Low CD27 expression in plasma cell dyscrasias correlates with high-risk disease: an immunohistochemical analysisTerry K Morgan
Department of Pathology, Stanford University Medical Center, Stanford, USA
Am J Clin Pathol 126:545-51. 2006..05). Our results support the hypothesis that low CD27 expression correlates with high-risk disease, including primary PCL and decreased progression-free survival in solitary plasmacytoma...
Acute myeloid leukemiaAmy Heerema-McKenney
Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
Hematol Oncol Clin North Am 23:633-54. 2009..In this article, the authors discuss the different types of AML and their diagnoses...
Recurrent B-cell neoplasms after Rituximab therapy: an immunophenotypic and genotypic studyPeiguo G Chu
Department of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
Leuk Lymphoma 43:2335-41. 2002..Seven of ten pairs of recurrent CD20-negative cases showed identical Ig heavy chain and Igkappa gene rearrangements by PCR assay, strongly suggesting that the pre- and post-Rituxan treated B cell neoplasms are clonally-related...
Metastasizing splenic littoral cell hemangioendotheliomaSusan Fernandez
Department of Pathology, Stanford University, Stanford, CA 94305, USA
Am J Surg Pathol 30:1036-40. 2006..This case suggests that the presence of solid areas of clear cells in a littoral cell angioma may be a marker of low-grade malignant potential in these tumors...
Durable clinical, cytogenetic, and molecular remissions after allogeneic hematopoietic cell transplantation for refractory Sezary syndrome and mycosis fungoidesArturo Molina
City of Hope Comprehensive Cancer Center, Division of Hematology and Hematopoietic Cell Transplantation, 1500 E Duarte Rd, Duarte, CA 94305, USA
J Clin Oncol 23:6163-71. 2005..We conducted a retrospective study to evaluate the outcome of allogeneic hematopoietic stem-cell transplantation (HSCT) in this patient population...
Expression of SHP-1 phosphatase indicates post-germinal center cell derivation of B-cell posttransplant lymphoproliferative disordersMichele Paessler
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Lab Invest 82:1599-606. 2002..By being expressed earlier, SHP-1 is a more sensitive marker of post-germinal center B cells than CD138, which is seen on the terminally differentiated immunoblasts and plasma cells...
Immunoglobulin heavy chain gene analysis in lymphomas: a multi-center study demonstrating the heterogeneity of performance of polymerase chain reaction assaysAdam Bagg
Department of Pathology and Laboratory Medicine, 7 103 Founders Pavilion, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
J Mol Diagn 4:81-9. 2002..Importantly, there is a need for greater standardization to reduce the unacceptably high false negative rate of this crucial diagnostic assay...
Diagnostic utility of bilateral bone marrow examination: significance of morphologic and ancillary technique study in malignancyJun Wang
Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
Cancer 94:1522-31. 2002..The role of bilateral molecular analysis needs to be defined further, but pooled samples for molecular studies may be adequate...
Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma cloneAndrew L Feldman
Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 1500, USA
Blood 111:5433-9. 2008..1 was seen in all cases tested. These results provide evidence for a common clonal origin of FL and H/DC neoplasms when occurring in the same patient, and suggest that lineage plasticity may occur in mature lymphoid neoplasms...
Therapy-related acute myeloid leukemia/myelodysplasia with balanced 21q22 translocationsDaniel A Arber
City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Clin Pathol 117:306-13. 2002....
Expression of T/NK-cell and plasma cell antigens in nonhematopoietic epithelioid neoplasms. An immunohistochemical study of 447 casesPeiguo G Chu
Dept of Pathology, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010, USA
Am J Clin Pathol 120:64-70. 2003..Virtually all tumor types studied were CD138+ with a variable positivity rate. The negative staining of CD138 in malignant mesothelioma may be useful for separating mesothelioma from metastatic adenocarcinoma...
Telomerase activity and proliferation index in aggressive mature B-cell lymphoma: comparison to germinal center phenotypic markersKatharine C Chiu
Division of Pathology, City of Hope National Medical Center, Duarte, CA, USA
Hum Pathol 34:1259-64. 2003..With the exception of FLC, the tumors exhibited poor correlation between telomerase activity and Ki-67 proliferation index. These tests did show some correlation with expression of GC cell phenotypic markers, however...
CD117 expression in mesotheliomaDaniel A Arber
Mod Pathol 17:1021. 2004
21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshopMarilyn L Slovak
Department of Cytogenetics, City of Hope National Medical Center, Duarte, California 91010, USA
Genes Chromosomes Cancer 33:379-94. 2002..In general, patients could be divided into two prognostic risk groups, those with t(8;21) (median OS, 19 mo) and those without t(8;21) (median OS, 7 mo) leukemia (log-rank, P = 0.0007)...
Effect of prolonged formalin fixation on the immunohistochemical reactivity of breast markersDaniel A Arber
Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
Appl Immunohistochem Mol Morphol 10:183-6. 2002..The loss of antigen preservation is not accompanied by a loss of vimentin immunoreactivity, making vimentin a suboptimal marker for ER, PR, or c-erb-B2 preservation...
Epstein-Barr virus nuclear antigen (EBNA)-1 carboxy-terminal and EBNA-4 sequence polymorphisms in nasal natural killer/T-cell lymphoma in the United StatesKarl Gaal
Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
Lab Invest 82:957-62. 2002..S.-reactive and non-U.S.-NL cases. Although the significance of this difference is not known for certain, it may be related to geographic and/or site-specific variations, rather than oncogenicity per se...
Targeting multiple genetic aberrations in isolated tumor cells by spectral fluorescence in situ hybridizationMarilyn L Slovak
Department of Cytogenetics, City of Hope National Medical Center, Duarte, CA 91010, USA
Cancer Detect Prev 26:171-9. 2002..Simultaneous detection of more than three chromosomal or gene targets should increase the overall power of molecular cytogenetics by permitting detection of multiple genetic aberrations at the single cell level...
Primary effusion lymphoma with subsequent development of a small bowel mass in an HIV-seropositive patient: a case report and literature reviewQin Huang
Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
Am J Surg Pathol 26:1363-7. 2002....
Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasiaDaniel A Arber
Division of Pathology, City of Hope National Medical Center, Duarte, CA, USA
Hum Pathol 34:809-13. 2003..These findings suggest that an NPM/MLF1 fusion is the primary molecular abnormality in t(3;5) MDS and AML with multilineage dysplasia, and also that cases with NPM/MLF1 may be clinically distinct from other MDS-associated disease...
Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatmentRavi Bhatia
Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
Blood 101:4701-7. 2003..Patients in CCR with imatinib mesylate treatment need to be followed carefully to assess for risk of relapse...
Value of combined morphologic, cytochemical, and immunophenotypic features in predicting recurrent cytogenetic abnormalities in acute myeloid leukemiaDaniel A Arber
Divisions of pathology and Biostatistics, City of Hope National Medical Center, Duatre, CA 94305-5627, USA
Hum Pathol 34:479-83. 2003..Cytogenetic studies are still needed on all cases to identify the small proportion of cases that will be missed by these methods and to identify other significant cytogenetic abnormalities in AML...
Prognostic impact of acute myeloid leukemia classification. Importance of detection of recurring cytogenetic abnormalities and multilineage dysplasia on survivalDaniel A Arber
Division of Pathology, City of Hope National Medical Center, Duarte, CA, USA
Am J Clin Pathol 119:672-80. 2003..These findings suggest that the detection of recurring cytogenetic abnormalities and multilineage dysplasia are the most significant features of current AML classification...
