Martin S Angst

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Aversive and reinforcing opioid effects: a pharmacogenomic twin study
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Anesthesiology 117:22-37. 2012
  2. pmc Pain sensitivity and opioid analgesia: a pharmacogenomic twin study
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Pain 153:1397-409. 2012
  3. doi request reprint Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritability
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, CA, USA
    Twin Res Hum Genet 13:412-25. 2010
  4. doi request reprint No evidence for the development of acute tolerance to analgesic, respiratory depressant and sedative opioid effects in humans
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Pain 142:17-26. 2009
  5. doi request reprint Cytokine profile in human skin in response to experimental inflammation, noxious stimulation, and administration of a COX-inhibitor: a microdialysis study
    M S Angst
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5117, USA
    Pain 139:15-27. 2008
  6. ncbi request reprint Pharmacology of drugs formulated with DepoFoam: a sustained release drug delivery system for parenteral administration using multivesicular liposome technology
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Clin Pharmacokinet 45:1153-76. 2006
  7. ncbi request reprint Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Pain 106:49-57. 2003
  8. ncbi request reprint Opioid-induced hyperalgesia: a qualitative systematic review
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Anesthesiology 104:570-87. 2006
  9. ncbi request reprint Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Anesthesiology 101:744-52. 2004
  10. pmc Selective nociceptor activation in volunteers by infrared diode laser
    Alexander Z Tzabazis
    Department of Anesthesia, Friedrich Alexander University, Erlangen, Germany
    Mol Pain 7:18. 2011

Collaborators

Detail Information

Publications31

  1. pmc Aversive and reinforcing opioid effects: a pharmacogenomic twin study
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Anesthesiology 117:22-37. 2012
    ..Gaining a better understanding of the genetic and environmental mechanisms contributing to an individual's susceptibility to adverse opioid effects is essential to identify patients at risk...
  2. pmc Pain sensitivity and opioid analgesia: a pharmacogenomic twin study
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Pain 153:1397-409. 2012
    ..Such studies will require careful consideration of the studied pain phenotype...
  3. doi request reprint Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritability
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, CA, USA
    Twin Res Hum Genet 13:412-25. 2010
    ..Methods and first results including heritability estimates for heat and cold pain sensitivity should be of interest to investigators considering similar studies...
  4. doi request reprint No evidence for the development of acute tolerance to analgesic, respiratory depressant and sedative opioid effects in humans
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Pain 142:17-26. 2009
    ..These results suggest that short-term administration of clinically useful doses of remifentanil is not associated with the development of significant tolerance to analgesic, respiratory depressant, or sedative opioid effects...
  5. doi request reprint Cytokine profile in human skin in response to experimental inflammation, noxious stimulation, and administration of a COX-inhibitor: a microdialysis study
    M S Angst
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5117, USA
    Pain 139:15-27. 2008
    ..Explored human bioassay is a promising tool for studying the pathology and pharmacology of inflammatory and chronic pain conditions...
  6. ncbi request reprint Pharmacology of drugs formulated with DepoFoam: a sustained release drug delivery system for parenteral administration using multivesicular liposome technology
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Clin Pharmacokinet 45:1153-76. 2006
    ....
  7. ncbi request reprint Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Pain 106:49-57. 2003
    ..This study also points to a differential susceptibility of different pain modalities for the expression of hyperalgesia associated with opioid administration...
  8. ncbi request reprint Opioid-induced hyperalgesia: a qualitative systematic review
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Anesthesiology 104:570-87. 2006
    ....
  9. ncbi request reprint Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Anesthesiology 101:744-52. 2004
    ..However, whether systemic administration of dexmedetomidine in humans produces significant analgesia at doses causing sedation but not unconsciousness remains controversial...
  10. pmc Selective nociceptor activation in volunteers by infrared diode laser
    Alexander Z Tzabazis
    Department of Anesthesia, Friedrich Alexander University, Erlangen, Germany
    Mol Pain 7:18. 2011
    ....
  11. doi request reprint The role of interleukin-1 in wound biology. Part II: In vivo and human translational studies
    Yajing Hu
    Department of Anesthesia, Stanford University, Stanford, USA
    Anesth Analg 111:1534-42. 2010
    ..We further investigate the role of IL-1 in incisional wound biology and its effect on wound chemokine production in vivo and whether this mechanism could be active in human subjects...
  12. pmc Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incision
    DeYong Liang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Mol Pain 4:7. 2008
    ..Most of these proposed mechanisms involve plastic events in the central or peripheral nervous systems. Alterations in the abundance of peripheral mediators of nociception have not previously been explored...
  13. ncbi request reprint Opioid tolerance and hyperalgesia in chronic pain patients after one month of oral morphine therapy: a preliminary prospective study
    Larry F Chu
    Department of Anesthesia, Stanford University School of Medicine, CA 94305, USA
    J Pain 7:43-8. 2006
    ..This study also validated methodology for prospectively studying these phenomena in larger populations of pain patients...
  14. doi request reprint Modulation of remifentanil-induced postinfusion hyperalgesia by the β-blocker propranolol in humans
    Larry F Chu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Pain 153:974-81. 2012
    ..Concomitant infusion of propranolol with remifentanil prevented the expression of RPH. β-adrenergic receptor blockade may be a useful pharmacological strategy for preventing hyperalgesia in patients exposed to opioids...
  15. doi request reprint Local and systemic release of cytokines, nerve growth factor, prostaglandin E2, and substance P in incisional wounds and serum following cesarean delivery
    Brendan Carvalho
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    J Pain 9:650-7. 2008
    ..The lack of significant correlations between wound and serum levels emphasizes the importance of determining site-specific release if localized pathologies are to be studied...
  16. doi request reprint Effect of a preemptive femoral nerve block on cytokine release and hyperalgesia in experimentally inflamed skin of human volunteers
    Brendan Carvalho
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Reg Anesth Pain Med 35:514-9. 2010
    ..The aim of this study was to determine whether a peripheral nerve block at the time of tissue injury could modify the development of wound hyperalgesia and the local release of inflammatory and nociceptive mediators...
  17. doi request reprint Continuous subcutaneous instillation of bupivacaine compared to saline reduces interleukin 10 and increases substance P in surgical wounds after cesarean delivery
    Brendan Carvalho
    Department of Anesthesia, H3580, Stanford University School of Medicine, Stanford, CA 94305, USA
    Anesth Analg 111:1452-9. 2010
    ..In this study, we tested the effects of continuous local anesthetic infiltration on the release of inflammatory and nociceptive mediators in skin wounds after cesarean delivery...
  18. pmc Morphine reduces local cytokine expression and neutrophil infiltration after incision
    J David Clark
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Mol Pain 3:28. 2007
    ..Our studies were directed towards determining if opioids alter cytokine production near incisions and to identify cell populations responsible for producing these cytokines...
  19. doi request reprint The role of interleukin-1 in wound biology. Part I: Murine in silico and in vitro experimental analysis
    Yajing Hu
    Department of Anesthesia, Stanford University, Stanford, USA
    Anesth Analg 111:1525-33. 2010
    ..Conflicting results have been obtained when conventional methods have been used to study wound biology. Therefore, we analyzed the wound response in a mouse genetic model...
  20. ncbi request reprint The site of action of epidural fentanyl in humans: the difference between infusion and bolus administration
    Yehuda Ginosar
    Department of Anesthesia, Stanford University, Stanford, California, USA
    Anesth Analg 97:1428-38. 2003
    ..These findings support our hypothesis and might explain the apparent conflict in the literature regarding the site of action of epidural fentanyl...
  21. doi request reprint The endogenous opioid system is not involved in modulation of opioid-induced hyperalgesia
    Larry F Chu
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    J Pain 12:108-15. 2011
    ..These results suggested that the endogenous opioid system did not appear to modulate OIH...
  22. doi request reprint Postoperative subcutaneous instillation of low-dose ketorolac but not hydromorphone reduces wound exudate concentrations of interleukin-6 and interleukin-10 and improves analgesia following cesarean delivery
    Brendan Carvalho
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    J Pain 14:48-56. 2013
    ....
  23. doi request reprint Analgesic tolerance without demonstrable opioid-induced hyperalgesia: a double-blinded, randomized, placebo-controlled trial of sustained-release morphine for treatment of chronic nonradicular low-back pain
    Larry F Chu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5640, USA
    Pain 153:1583-92. 2012
    ..After 1 month of oral morphine therapy, patients with chronic low-back pain developed tolerance but not opioid-induced hyperalgesia. Improvements in pain and functional ability were observed...
  24. pmc Integrative approach to pain genetics identifies pain sensitivity loci across diseases
    David Ruau
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Comput Biol 8:e1002538. 2012
    ..This data-derived list of pain gene candidates enables additional focused and efficient biological studies validating additional candidates...
  25. doi request reprint Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations
    Larry F Chu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5640, USA
    Clin J Pain 24:479-96. 2008
    ....
  26. ncbi request reprint Input characteristics and bioavailability after administration of immediate and a new extended-release formulation of hydromorphone in healthy volunteers
    David R Drover
    Department of Anesthesia, Stanford University School of Medicine, California 94305 5940, USA
    Anesthesiology 97:827-36. 2002
    ..To compare the pharmacokinetics of intravenous, oral immediate-release (IR), and oral extended-release (OROS ) formulations of hydromorphone...
  27. ncbi request reprint Experimental heat pain for detecting pregnancy-induced analgesia in humans
    Brendan Carvalho
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Anesth Analg 103:1283-7. 2006
    ..These effects persist during the first 24-48 h after delivery. Experimental heat pain is a suitable modality for further characterizing the phenomenon of pregnancy-induced analgesia in humans...
  28. ncbi request reprint Blockade of the complement C5a receptor reduces incisional allodynia, edema, and cytokine expression
    J David Clark
    Department of Anesthesia, Stanford University School of Medicine, California 94304, USA
    Anesthesiology 104:1274-82. 2006
    ..Complement-mediated enhancement of the inflammation surrounding surgical incisions may increase pain...
  29. pmc Sex differences in reported pain across 11,000 patients captured in electronic medical records
    David Ruau
    Division of Systems Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
    J Pain 13:228-34. 2012
    ..Our results are consistent with previous studies reporting pain differences between sexes and also suggest that clinicians should pay increased attention to this idea...
  30. doi request reprint Identification of a complex between fibronectin and aggrecan G3 domain in synovial fluid of patients with painful meniscal pathology
    Gaetano J Scuderi
    Stanford University, Stanford, CA, USA
    Clin Biochem 43:808-14. 2010
    ..Validation studies using other immunologic techniques confirmed the presence of IL-6, MCP-1 and MIP-1beta, but not IFN-gamma. Therefore we sought the identity of the IFN-gamma signal in synovial fluid...
  31. pmc Changes resembling complex regional pain syndrome following surgery and immobilization
    Alison Pepper
    Department of Anesthesia, Stanford University, Palo Alto, California
    J Pain 14:516-24. 2013
    ..Further studies using this population may be useful in refining our understanding of CRPS mechanisms and treatments for this condition...