Research Topics
Species | Martin S AngstSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Aversive and reinforcing opioid effects: a pharmacogenomic twin studyMartin S Angst
Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
Anesthesiology 117:22-37. 2012..Gaining a better understanding of the genetic and environmental mechanisms contributing to an individual's susceptibility to adverse opioid effects is essential to identify patients at risk...- Pain sensitivity and opioid analgesia: a pharmacogenomic twin studyMartin S Angst
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
Pain 153:1397-409. 2012..Such studies will require careful consideration of the studied pain phenotype... 
No evidence for the development of acute tolerance to analgesic, respiratory depressant and sedative opioid effects in humansMartin S Angst
Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Pain 142:17-26. 2009..These results suggest that short-term administration of clinically useful doses of remifentanil is not associated with the development of significant tolerance to analgesic, respiratory depressant, or sedative opioid effects...- Cytokine profile in human skin in response to experimental inflammation, noxious stimulation, and administration of a COX-inhibitor: a microdialysis studyM S Angst
Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5117, USA
Pain 139:15-27. 2008..Explored human bioassay is a promising tool for studying the pathology and pharmacology of inflammatory and chronic pain conditions... - Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritabilityMartin S Angst
Department of Anesthesia, Stanford University School of Medicine, CA, USA
Twin Res Hum Genet 13:412-25. 2010..Methods and first results including heritability estimates for heat and cold pain sensitivity should be of interest to investigators considering similar studies... 
Pharmacology of drugs formulated with DepoFoam: a sustained release drug delivery system for parenteral administration using multivesicular liposome technologyMartin S Angst
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
Clin Pharmacokinet 45:1153-76. 2006....- Opioid-induced hyperalgesia: a qualitative systematic reviewMartin S Angst
Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
Anesthesiology 104:570-87. 2006.... - Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawalMartin S Angst
Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Pain 106:49-57. 2003..This study also points to a differential susceptibility of different pain modalities for the expression of hyperalgesia associated with opioid administration... - Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humansMartin S Angst
Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
Anesthesiology 101:744-52. 2004..However, whether systemic administration of dexmedetomidine in humans produces significant analgesia at doses causing sedation but not unconsciousness remains controversial... - Selective nociceptor activation in volunteers by infrared diode laserAlexander Z Tzabazis
Department of Anesthesia, Friedrich Alexander University, Erlangen, Germany
Mol Pain 7:18. 2011.... - The role of interleukin-1 in wound biology. Part II: In vivo and human translational studiesYajing Hu
Department of Anesthesia, Stanford University, Stanford, USA
Anesth Analg 111:1534-42. 2010..We further investigate the role of IL-1 in incisional wound biology and its effect on wound chemokine production in vivo and whether this mechanism could be active in human subjects... - Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incisionDeYong Liang
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
Mol Pain 4:7. 2008..Most of these proposed mechanisms involve plastic events in the central or peripheral nervous systems. Alterations in the abundance of peripheral mediators of nociception have not previously been explored... - Opioid tolerance and hyperalgesia in chronic pain patients after one month of oral morphine therapy: a preliminary prospective studyLarry F Chu
Department of Anesthesia, Stanford University School of Medicine, CA 94305, USA
J Pain 7:43-8. 2006..This study validates a pharmacologic approach to study these phenomena prospectively in chronic pain patients and suggests that both conditions do occur within 1 month of initiating opioid therapy... - Modulation of remifentanil-induced postinfusion hyperalgesia by the β-blocker propranolol in humansLarry F Chu
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
Pain 153:974-81. 2012..Concomitant infusion of propranolol with remifentanil prevented the expression of RPH. β-adrenergic receptor blockade may be a useful pharmacological strategy for preventing hyperalgesia in patients exposed to opioids... - Continuous subcutaneous instillation of bupivacaine compared to saline reduces interleukin 10 and increases substance P in surgical wounds after cesarean deliveryBrendan Carvalho
Department of Anesthesia, H3580, Stanford University School of Medicine, Stanford, CA 94305, USA
Anesth Analg 111:1452-9. 2010..In this study, we tested the effects of continuous local anesthetic infiltration on the release of inflammatory and nociceptive mediators in skin wounds after cesarean delivery... - Effect of a preemptive femoral nerve block on cytokine release and hyperalgesia in experimentally inflamed skin of human volunteersBrendan Carvalho
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
Reg Anesth Pain Med 35:514-9. 2010..The aim of this study was to determine whether a peripheral nerve block at the time of tissue injury could modify the development of wound hyperalgesia and the local release of inflammatory and nociceptive mediators... - Local and systemic release of cytokines, nerve growth factor, prostaglandin E2, and substance P in incisional wounds and serum following cesarean deliveryBrendan Carvalho
Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
J Pain 9:650-7. 2008..Our findings confirm the lack of correlation between wound and serum levels of many pro-inflammatory and anti-inflammatory cytokines and nerve growth factor... - Morphine reduces local cytokine expression and neutrophil infiltration after incisionJ David Clark
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
Mol Pain 3:28. 2007..Our studies were directed towards determining if opioids alter cytokine production near incisions and to identify cell populations responsible for producing these cytokines... - The site of action of epidural fentanyl in humans: the difference between infusion and bolus administrationYehuda Ginosar
Department of Anesthesia, Stanford University, Stanford, California, USA
Anesth Analg 97:1428-38. 2003..This finding may help resolve the long-standing controversy surrounding the site of action of epidural fentanyl... - Analgesic tolerance without demonstrable opioid-induced hyperalgesia: a double-blinded, randomized, placebo-controlled trial of sustained-release morphine for treatment of chronic nonradicular low-back painLarry F Chu
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5640, USA
Pain 153:1583-92. 2012..After 1 month of oral morphine therapy, patients with chronic low-back pain developed tolerance but not opioid-induced hyperalgesia. Improvements in pain and functional ability were observed... - Integrative approach to pain genetics identifies pain sensitivity loci across diseasesDavid Ruau
Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America
PLoS Comput Biol 8:e1002538. 2012..This data-derived list of pain gene candidates enables additional focused and efficient biological studies validating additional candidates... - The role of interleukin-1 in wound biology. Part I: Murine in silico and in vitro experimental analysisYajing Hu
Department of Anesthesia, Stanford University, Stanford, USA
Anesth Analg 111:1525-33. 2010..Conflicting results have been obtained when conventional methods have been used to study wound biology. Therefore, we analyzed the wound response in a mouse genetic model... - Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerationsLarry F Chu
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5640, USA
Clin J Pain 24:479-96. 2008.... - The endogenous opioid system is not involved in modulation of opioid-induced hyperalgesiaLarry F Chu
Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
J Pain 12:108-15. 2011..Consequently, this study suggested that alternative mechanisms such as pronociceptive stimulation and neuroplastic changes might be responsible for expression of OIH... - Input characteristics and bioavailability after administration of immediate and a new extended-release formulation of hydromorphone in healthy volunteersDavid R Drover
Department of Anesthesia, Stanford University School of Medicine, California 94305 5940, USA
Anesthesiology 97:827-36. 2002..To compare the pharmacokinetics of intravenous, oral immediate-release (IR), and oral extended-release (OROS ) formulations of hydromorphone... - Experimental heat pain for detecting pregnancy-induced analgesia in humansBrendan Carvalho
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
Anesth Analg 103:1283-7. 2006..These effects persist during the first 24-48 h after delivery. Experimental heat pain is a suitable modality for further characterizing the phenomenon of pregnancy-induced analgesia in humans... - Blockade of the complement C5a receptor reduces incisional allodynia, edema, and cytokine expressionJ David Clark
Department of Anesthesia, Stanford University School of Medicine, California 94304, USA
Anesthesiology 104:1274-82. 2006..Complement-mediated enhancement of the inflammation surrounding surgical incisions may increase pain... - Sex differences in reported pain across 11,000 patients captured in electronic medical recordsDavid Ruau
Division of Systems Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
J Pain 13:228-34. 2012..Our results are consistent with previous studies reporting pain differences between sexes and also suggest that clinicians should pay increased attention to this idea... - Identification of a complex between fibronectin and aggrecan G3 domain in synovial fluid of patients with painful meniscal pathologyGaetano J Scuderi
Stanford University, Stanford, CA, USA
Clin Biochem 43:808-14. 2010..Validation studies using other immunologic techniques confirmed the presence of IL-6, MCP-1 and MIP-1beta, but not IFN-gamma. Therefore we sought the identity of the IFN-gamma signal in synovial fluid... - Postoperative subcutaneous instillation of low-dose ketorolac but not hydromorphone reduces wound exudate concentrations of interleukin-6 and interleukin-10 and improves analgesia following cesarean deliveryBrendan Carvalho
Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
J Pain 14:48-56. 2013..These results suggest that administration of NSAIDs into surgical wounds may be an analgesic alternative to higher systemic dosing of NSAIDs...