Research Topics
| Thomas AndriacchiSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
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Detail Information
Publications
Rotational changes at the knee after ACL injury cause cartilage thinningThomas P Andriacchi
Biomechanical Engineering, Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA
Clin Orthop Relat Res 442:39-44. 2006....
Gait mechanics influence healthy cartilage morphology and osteoarthritis of the kneeThomas P Andriacchi
Department of Mechanical Engineering, Stanford University, 496 Lomita Mall, Stanford, CA 94305 4038, USA
J Bone Joint Surg Am 91:95-101. 2009....- Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4Dong Hyun Sohn
GRECC, VA Palo Alto Health Care System, 3801 Miranda Ave, Palo Alto, CA 94304, USA
Arthritis Res Ther 14:R7. 2012..We therefore surveyed the proteins present in OA synovial fluid and assessed their immunostimulatory properties... - Interactions between kinematics and loading during walking for the normal and ACL deficient kneeThomas P Andriacchi
Department of Mechanical Engineering, Division of Biomechanical Engineering, Stanford University, Stanford, CA 94305 4038, USA
J Biomech 38:293-8. 2005..The altered rotational position would cause changes in tibiofemoral contact during walking that could cause the type of degenerative changes reported in the meniscus and the articular cartilage following ACL injury... - A framework for the in vivo pathomechanics of osteoarthritis at the kneeThomas P Andriacchi
Department of Mechanical Engineering, Stanford University, Division of Biomechanical Engineering, Stanford, CA 94305 4038, USA
Ann Biomed Eng 32:447-57. 2004..The integrated in vivo framework presented here will be helpful for the interpretation of laboratory experiments as well as for the development of new methods for the evaluation of OA at the knee... - The role of ambulatory mechanics in the initiation and progression of knee osteoarthritisThomas P Andriacchi
Department of Mechanical Engineering, Biomechanical Engineering, Stanford University, Stanford, CA 94305, USA
Curr Opin Rheumatol 18:514-8. 2006..This review examines recent in-vivo studies of ambulation and discusses the fundamental role of mechanics of ambulation in the initiation and progression of osteoarthritis at the knee... - In healthy subjects without knee osteoarthritis, the peak knee adduction moment influences the acute effect of shoe interventions designed to reduce medial compartment knee loadDavid S Fisher
Department of Mechanical Engineering, Stanford University, 496 Lomita Mall BME, Durand Building 061, Stanford, California 94305 4038, USA
J Orthop Res 25:540-6. 2007.... 
Change in serum COMP concentration due to ambulatory load is not related to knee OA statusAnnegret Mundermann
Department of Mechanical Engineering, Stanford University, Stanford, California, USA
J Orthop Res 27:1408-13. 2009..These results, taken together with a previous study of a younger healthy population, suggest the possibility that the influence of ambulatory loads on cartilage turnover is dependent on age...- In vivo knee loading characteristics during activities of daily living as measured by an instrumented total knee replacementAnnegret Mundermann
Department of Mechanical Engineering, Durand Building 205, 496 Lomita Mall, Stanford University, Stanford, California 94305 4038, USA
J Orthop Res 26:1167-72. 2008.... - Gender differences exist in the hip joint moments of healthy older walkersKatherine A Boyer
VA Palo Alto Health Care System, Bone and Joint Rehabilitation R and D Center of Excellence, Palo Alto, CA 94304, USA
J Biomech 41:3360-5. 2008..This is in favor of a hypothesis that the increased joint contact stress in a female population could contribute to a greater joint degeneration at the hip in females as compared with males... - Adaptive patterns of movement during stair climbing in patients with knee osteoarthritisJessica L Asay
Department of Mechanical Engineering, Stanford University, Durand Building 227, Stanford, California 94305 4038, USA
J Orthop Res 27:325-9. 2009..Assessing forward trunk lean during stair climbing may be a useful functional marker for evaluating osteoarthritis status and quadriceps function that appears to be a more sensitive indicator of disease severity than perceived pain... - Posturographic analysis through markerless motion capture without ground reaction forces measurementStefano Corazza
Stanford University, Stanford, CA, USA
J Biomech 42:370-4. 2009..This new method requires only kinematic data through MMC method and without the need of a force plate can identify the influence of individual body segments to motion of the COM... - A variable-stiffness shoe lowers the knee adduction moment in subjects with symptoms of medial compartment knee osteoarthritisJennifer C Erhart
Bone and Joint Center, Palo Alto VA, Palo Alto, CA, USA
J Biomech 41:2720-5. 2008.... - The knee joint center of rotation is predominantly on the lateral side during normal walkingSeungbum Koo
Department of Mechanical Engineering, Durand Building, Room 205, Stanford University, Stanford, CA 94305 4038, USA
J Biomech 41:1269-73. 2008..These results also demonstrate the importance of describing knee kinematics in the context of a specific activity or the constraints of the test conditions... - Predicting changes in knee adduction moment due to load-altering interventions from pressure distribution at the foot in healthy subjectsJennifer C Erhart
Bone and Joint Center, Palo Alto VA, Palo Alto, CA, USA
J Biomech 41:2989-94. 2008.... - Automatic generation of a subject-specific model for accurate markerless motion capture and biomechanical applicationsStefano Corazza
Biomotion Laboratory, Mechanical Engineering Department, Stanford University, Stanford, CA 94305, USA
IEEE Trans Biomed Eng 57:806-12. 2010..Experimental training error and cross-validation errors were 19 and 25 mm, respectively, on average over the joints of the ten subjects analyzed in the study... - The effect of kinematic and kinetic changes on meniscal strains during gaitNathan A Netravali
Department of Mechanical Engineering, Stanford University, Stanford, CA 94305 4038, USA
J Biomech Eng 133:011006. 2011.... - Changes in in vivo knee loading with a variable-stiffness intervention shoe correlate with changes in the knee adduction momentJennifer C Erhart
Department of Mechanical Engineering, Stanford University, Stanford, California, USA
J Orthop Res 28:1548-53. 2010..The reductions in the external knee adduction moment are indicative of reductions in in vivo medial compressive force with this intervention... - Partial medial meniscectomy and rotational differences at the knee during walkingNathan A Netravali
Bone and Joint Center, Palo Alto VA, Palo Alto, CA, USA
J Biomech 43:2948-53. 2010..The altered rotational position found likely results in changes of tibio-femoral contact during walking and could cause the type of degenerative changes found in the articular cartilage following meniscal injury... - Gait modification via verbal instruction and an active feedback system to reduce peak knee adduction momentAriel V Dowling
Department of Mechanical Engineering, Stanford University, Durand Building 061, 496 Lomita Mall, Stanford, CA 94305 4308, USA
J Biomech Eng 132:071007. 2010.... - An automated image-based method of 3D subject-specific body segment parameter estimation for kinetic analyses of rapid movementsAlison L Sheets
Department of Mechanical Engineering, Biomotion Laboratory, Stanford University, Stanford, CA 94305, USA
J Biomech Eng 132:011004. 2010..BSP differences have the largest effect on kinetic analyses of motions with large limb accelerations, for joints farther along the kinematic chain from the known forces and moments, and for subjects with larger limb masses or BMIs... - Differences in tibial rotation during walking in ACL reconstructed and healthy contralateral kneesSean F Scanlan
Biomechanical Engineering, Department of Mechanical Engineering, Stanford University, Stanford, CA, USA
J Biomech 43:1817-22. 2010.... - Changes in knee adduction moment, pain, and functionality with a variable-stiffness walking shoe after 6 monthsJennifer C Erhart
Bone and Joint Center, Palo Alto VA, Palo Alto, California, USA
J Orthop Res 28:873-9. 2010..The lower adduction moment associated with wearing this shoe may slow the rate of progression of osteoarthritis after long-term use... - Changes in running kinematics and kinetics in response to a rockered shoe interventionKatherine A Boyer
Mechanical Engineering, Stanford University, Stanford, CA 94305 4038, USA
Clin Biomech (Bristol, Avon) 24:872-6. 2009.... - Graft orientation influences the knee flexion moment during walking in patients with anterior cruciate ligament reconstructionSean F Scanlan
Biomechanical Engineering, Department of Mechanical Engineering, Stanford University, Stanford, CA 94305 4038, USA
Am J Sports Med 37:2173-8. 2009.... - Implications of increased medio-lateral trunk sway for ambulatory mechanicsAnnegret Mundermann
Department of Mechanical Engineering, Stanford University, Durand Building 205, Stanford, CA 94305 4038, USA
J Biomech 41:165-70. 2008..This result supports the potential of using gait retraining for walking with increased medio-lateral trunk sway as treatment for patients with degenerative joint disease such as medial compartment knee osteoarthritis... - Shoe-surface friction influences movement strategies during a sidestep cutting task: implications for anterior cruciate ligament injury riskAriel V Dowling
Department of Mechanical Engineering, Stanford University, Durand Building 061, Stanford, CA 94305 4308, USA
Am J Sports Med 38:478-85. 2010..Previous studies indicate that specific biomechanical measures during landing are associated with an increased risk for ACL injury... - A comparison of the influence of global functional loads vs. local contact anatomy on articular cartilage thickness at the kneeSeungbum Koo
Department of Mechanical Engineering, Stanford University, Stanford, CA, USA
J Biomech 40:2961-6. 2007..43,P<0.01) and tibia (R(2)=0.32,P<0.01). The results of this study suggest that the dynamics of walking is an important factor to describe individual differences in cartilage thickness for normal subjects... - Quantitative analysis of the relative effectiveness of 3 iliotibial band stretchesMichael Fredericson
Department of Functional Restoration, Division of Physical Medicine and Rehabilitation, Stanford University, Stanford, CA 94305 5336, USA
Arch Phys Med Rehabil 83:589-92. 2002..To compare the relative effectiveness of 3 common standing stretches for the iliotibial band (ITB): arms at side (stretch A), arms extending overhead (stretch B), and arms reaching diagonally downward (stretch C)... - Potential strategies to reduce medial compartment loading in patients with knee osteoarthritis of varying severity: reduced walking speedAnne Mündermann
Stanford University, Stanford, California 94305 3030, USA
Arthritis Rheum 50:1172-8. 2004..To determine whether reducing walking speed is a strategy used by patients with knee osteoarthritis (OA) of varying disease severity to reduce the maximum knee adduction moment... - Secondary motions of the knee during weight bearing and non-weight bearing activitiesChris O Dyrby
Department of Mechanical Engineering, Biomechanical Engineering, Stanford University, 061 Durand Building, Stanford, CA 94305 4038, USA
J Orthop Res 22:794-800. 2004..The weight bearing secondary motion AP and IE rotation seen during a walking activity demonstrated an envelope of dynamic laxity that could potentially be used to evaluate functional instabilities at the knee... - Functional evaluation of the Scandinavian Total Ankle ReplacementChris Dyrby
Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA
Foot Ankle Int 25:377-81. 2004..The moment in arthroplasty patients was increased, indicating improved function of the ankle joint... - Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy adultsAnnegret Mundermann
Department of Mechanical Engineering, Stanford University, Stanford, CA, USA
Osteoarthritis Cartilage 13:34-8. 2005..To test the hypothesis that physiological cyclic loading during a 30-min walking exercise causes an increase in serum cartilage oligomeric matrix protein (COMP) concentration in a healthy population... - Secondary gait changes in patients with medial compartment knee osteoarthritis: increased load at the ankle, knee, and hip during walkingAnnegret Mundermann
Stanford University Medical Center, Stanford, California 94305 4038, USA
Arthritis Rheum 52:2835-44. 2005..This study tested the hypothesis that gait changes related to knee osteoarthritis (OA) of varied severity are associated with increased loads at the ankle, knee, and hip... - The mechanical consequences of dynamic frontal plane limb alignment for non-contact ACL injuryAjit M Chaudhari
Department of Mechanical Engineering, Stanford University, Division of Biomechanical Engineering, Durand Bldg, Room 201, Stanford, CA 94305 4038, USA
J Biomech 39:330-8. 2006.... - Sport-dependent variations in arm position during single-limb landing influence knee loading: implications for anterior cruciate ligament injuryAjit M Chaudhari
Stanford Biomotion Laboratory, Department of Mechanical Engineering, Stanford University, Stanford, California 94305 4038, USA
Am J Sports Med 33:824-30. 2005..Arm position variation may affect risk of injury by altering valgus knee loading... - The influence of deceleration forces on ACL strain during single-leg landing: a simulation studyChoongsoo S Shin
Department of Mechanical Engineering, Division of Biomechanical Engineering, Stanford University, 496 Lomita Mall, Durand Building Room 224, Stanford, CA 94305 4038, USA
J Biomech 40:1145-52. 2007.... - The patella ligament insertion angle influences quadriceps usage during walking of anterior cruciate ligament deficient patientsChoongsoo S Shin
Biomechanical Engineering Group, Department of Mechanical Engineering, Stanford University, Stanford, California, USA
J Orthop Res 25:1643-50. 2007..In the future, individually tailored treatment and rehabilitation considering individuals' specific extensor anatomy may improve clinical outcomes... - Risk factors for progressive cartilage loss in the knee: a longitudinal magnetic resonance imaging study in forty-three patientsSandip Biswal
Stanford University Medical Center, Stanford, California, USA
Arthritis Rheum 46:2884-92. 2002..The findings in this study suggest that patients entering clinical trials investigating antiarthritis regimens may need to be randomized based on location of the lesion... - A comparison of measuring mechanical axis alignment using three-dimensional position capture with skin markers and radiographic measurements in patients with bilateral medial compartment knee osteoarthritisAnnegret Mundermann
Department of Mechanical Engineering, Stanford University, Stanford, CA, USA Bone and Joint Center, Palo Alto VA, Palo Alto, CA, USA School of Physiotherapy, University of Otago, Dunedin, New Zealand
Knee 15:480-5. 2008.... - The effect of isolated valgus moments on ACL strain during single-leg landing: a simulation studyChoongsoo S Shin
Biomechanical Engineering Group, Department of Mechanical Engineering, Stanford University, Stanford, CA 94305 4038, USA
J Biomech 42:280-5. 2009..Training that reduces the external valgus moment, however, can reduce the ACL strain and thus may help athletes reduce their overall ACL injury risk... - Failure and fatigue characteristics of adhesive athletic tapeRichard W Bragg
Stanford University, Department of Mechanical Engineering, Biomechanical Engineering Division, Stanford, CA 94305-4038, USA
Med Sci Sports Exerc 34:403-10. 2002..Ultimately, these improved tapes should reduce ankle injuries among athletes... - Mechanical loads at the knee joint during deep flexionTakeo Nagura
Department of Mechanical Engineering, Stanford University, CA 94305-3030, USA
J Orthop Res 20:881-6. 2002..Thus, it is important to consider the magnitude of the loads at the knee in the treatment of patients that commonly perform deep flexion during activities of daily living... - Knee kinematics, cartilage morphology, and osteoarthritis after ACL injuryAjit M W Chaudhari
Department of Orthopaedics, OSU Sports Medicine Center, Ohio State University, 2050 Kenny Road, Columbus, OH 43221, USA
Med Sci Sports Exerc 40:215-22. 2008.... - A new parametric approach for modeling hip forces during gaitDebra E Hurwitz
Department of Orthopedic Surgery, Rush Medical College, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
J Biomech 36:113-9. 2003..Differences in peak forces between subjects can then be evaluated relative to the uncertainty in not knowing the precise muscle force distributions... - Comparison of clinical and dynamic knee function in patients with anterior cruciate ligament deficiencyRohita R Patel
Department of Orthopedic Surgery, Rush Medical College of Rush University, Rush-Presbyterian-St Luke's Medical Center, Chicago, Illinois 60612, USA
Am J Sports Med 31:68-74. 2003..Patients with greater than normal strength in the anterior cruciate ligament-deficient limb performed low- and high-stress activities in a more normal fashion than those with normal or less-than-normal strength... - Knee and hip loading patterns at different phases in the menstrual cycle: implications for the gender difference in anterior cruciate ligament injury ratesAjit M W Chaudhari
Department of Orthopaedics and Sports Medicine Center, Ohio State University, Columbus, Ohio 43221, USA
Am J Sports Med 35:793-800. 2007..Menstrual cycle phase has been correlated with risk of noncontact anterior cruciate ligament injury in women. The mechanism by which hormonal cycling may affect injury rate is unknown... - Tibiofemoral joint contact force in deep knee flexion and its consideration in knee osteoarthritis and joint replacementTakeo Nagura
Department of Orthopedic Surgery, Keio University, Shinjyuku, Tokyo, Japan
J Appl Biomech 22:305-13. 2006.... - Clinical disability in posterior cruciate ligament deficient patients does not relate to knee laxity, but relates to dynamic knee function during stair descendingShinichiro Iwata
Department of Orthopedic Surgery, Keio University, 35 Shinanomachi Shinjuku, Tokyo, 160 8582, Japan
Knee Surg Sports Traumatol Arthrosc 15:335-42. 2007..This study indicated that the symptom of giving-way during stair descent was related to knee mechanics during stair descent, unlike other quantitative evaluations such as KT-2000 or Biodex... - Comment: effect of fatigue on knee kinetics and kinematics in stop-jump tasksAjit M Chaudhari
Am J Sports Med 34:312; author reply 313-5. 2006 - Comparison of quantitative cartilage measurements acquired on two 3.0T MRI systems from different manufacturersPeter R Kornaat
Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
J Magn Reson Imaging 23:770-3. 2006..0T magnetic resonance imaging (MRI) systems from different manufacturers... - Clinical disability in posterior cruciate ligament deficient patients does not relate to knee laxity, but relates to dynamic knee function during stair descendingShinichiro Iwata
Department of Orthopedic Surgery, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160 8582, Japan
Knee Surg Sports Traumatol Arthrosc 15:258-65. 2007..This study indicated that the symptom of giving-way during stair descent was related to knee mechanics during stair descent, unlike other quantitative evaluations such as KT-2000 or Biodex...
Research Grants
- Anterior Cruciate Ligament Reconstruction and the Initiation of OsteoarthritisThomas P Andriacchi; Fiscal Year: 2010....
- Cartilage Morphology Relative to In Vivo Knee FunctionThomas Andriacchi; Fiscal Year: 2007..Information on the relative importance of loading and motion during walking will provide fundamental new information that can ultimately be applied to prevention and treatment of knee OA. ..
- ANTERIOR CRUCIATE LIGAMENT-FUNCTIONAL BIOMECHANICSThomas Andriacchi; Fiscal Year: 2004..This study will also help to identify critical variables that should be considered in a larger prospective clinical outcome study. ..
- Anterior Cruciate Ligament Reconstruction and the Initiation of OsteoarthritisThomas P Andriacchi; Fiscal Year: 2011....