Richard C Allsopp
Affiliation: Stanford University
- Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role?Richard C Allsopp
Department of Pathology, Stanford University School of Medicine, Stanford, California, CA 94305, USA
Oncogene 21:3270-3. 2002....
- Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantationRichard C Allsopp
Beckman Center, Department of Pathology, Stanford University School of Medicine, CA, USA
Blood 102:517-20. 2003....
- Telomerase activation and rejuvenation of telomere length in stimulated T cells derived from serially transplanted hematopoietic stem cellsRichard C Allsopp
Beckman Center, Pathology Department, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA
J Exp Med 196:1427-33. 2002..Together, these results imply that one role for telomerase in T cells may be to renew or extend replicative potential via the rejuvenation of telomere length...
- Changes in integrin expression are associated with altered homing properties of Lin(-/lo)Thy1.1(lo)Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factorAmy J Wagers
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Exp Hematol 30:176-85. 2002....
- Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cellsRichard C Allsopp
Nat Med 9:369-71. 2003
- SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activitySwami R Narala
Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada
Mol Biol Cell 19:1210-9. 2008..Our findings challenge certain models and connect nutrient sensing enzymes to the immortalization process. Furthermore, they show that in certain cell lineages, SIRT1 can act as a growth suppressor gene...