Ash A Alizadeh

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Evaluation and management of angioimmunoblastic T-cell lymphoma: a review of current approaches and future strategies
    Ash A Alizadeh
    Division of Hematology and Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Clin Adv Hematol Oncol 6:899-909. 2008
  2. pmc Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment
    Ash A Alizadeh
    Department of Medicine, Division of Oncology, Stanford University, Stanford, CA, USA
    Blood 118:1350-8. 2011
  3. ncbi request reprint Surprise! HSC are aberrant in chronic lymphocytic leukemia
    Ash A Alizadeh
    Institute for Stem Cell Biology and Regenerative Medicine, Cancer Institute, and Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cancer Cell 20:135-6. 2011
  4. ncbi request reprint Distinct IL-4-induced gene expression, proliferation, and intracellular signaling in germinal center B-cell-like and activated B-cell-like diffuse large-cell lymphomas
    XiaoQing Lu
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, University of Miami, 1475 NW 12th Ave D8 4, Miami, FL 33136, USA
    Blood 105:2924-32. 2005
  5. pmc The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
    Stephen B Willingham
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:6662-7. 2012
  6. pmc B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression
    Jonathan M Irish
    Department of Medicine, Oncology Division, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:12747-54. 2010
  7. pmc Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia
    Mark P Chao
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, and Ludwig Center at Stanford, Palo Alto, California, USA
    Cancer Res 71:1374-84. 2011
  8. pmc T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression
    Jeroen P Roose
    Department of Medicine, University of California, San Francisco, USA
    PLoS Biol 1:E53. 2003
  9. ncbi request reprint Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes
    Izidore S Lossos
    Division of Oncology, Department of Medicine, Stanford University Medical Center, Stanford, Calif, USA
    N Engl J Med 350:1828-37. 2004
  10. pmc Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker
    Max Jan
    Program in Cancer Biology, Cancer Center, Institute for Stem Cell Biology and Regenerative Medicine, Department of Internal Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Proc Natl Acad Sci U S A 108:5009-14. 2011

Detail Information

Publications41

  1. ncbi request reprint Evaluation and management of angioimmunoblastic T-cell lymphoma: a review of current approaches and future strategies
    Ash A Alizadeh
    Division of Hematology and Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Clin Adv Hematol Oncol 6:899-909. 2008
    ..Finally, we discuss recent clinical trials and novel treatment approaches in the management of patients with AITL...
  2. pmc Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment
    Ash A Alizadeh
    Department of Medicine, Division of Oncology, Stanford University, Stanford, CA, USA
    Blood 118:1350-8. 2011
    ..We conclude that the measurement of a single gene expressed by tumor cells (LMO2) and a single gene expressed by the immune microenvironment (TNFRSF9) powerfully predicts overall survival in patients with DLBCL...
  3. ncbi request reprint Surprise! HSC are aberrant in chronic lymphocytic leukemia
    Ash A Alizadeh
    Institute for Stem Cell Biology and Regenerative Medicine, Cancer Institute, and Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cancer Cell 20:135-6. 2011
    ....
  4. ncbi request reprint Distinct IL-4-induced gene expression, proliferation, and intracellular signaling in germinal center B-cell-like and activated B-cell-like diffuse large-cell lymphomas
    XiaoQing Lu
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, University of Miami, 1475 NW 12th Ave D8 4, Miami, FL 33136, USA
    Blood 105:2924-32. 2005
    ..These differences in tyrosine phosphatase expression might underlie distinct expression profiles of some of the IL-4 target genes and could contribute to a different clinical outcome of patients with GCB-like and ABC-like DLBCLs...
  5. pmc The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
    Stephen B Willingham
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:6662-7. 2012
    ..CD47 is therefore a validated target for cancer therapies...
  6. pmc B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression
    Jonathan M Irish
    Department of Medicine, Oncology Division, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:12747-54. 2010
    ..Both the existence of these LNP cells and their aberrant signaling profiles provide targets for new therapies for follicular lymphoma...
  7. pmc Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia
    Mark P Chao
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, and Ludwig Center at Stanford, Palo Alto, California, USA
    Cancer Res 71:1374-84. 2011
    ..These data provide preclinical support for the development of an anti-CD47 antibody therapy for treatment of human ALL...
  8. pmc T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression
    Jeroen P Roose
    Department of Medicine, University of California, San Francisco, USA
    PLoS Biol 1:E53. 2003
    ..Our data suggest that physiologic gene expression programs depend upon tonic activity of signaling pathways independent of receptor ligation...
  9. ncbi request reprint Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes
    Izidore S Lossos
    Division of Oncology, Department of Medicine, Stanford University Medical Center, Stanford, Calif, USA
    N Engl J Med 350:1828-37. 2004
    ..Several gene-expression signatures can be used to predict the prognosis in diffuse large-B-cell lymphoma, but the lack of practical tests for a genome-scale analysis has restricted the use of this method...
  10. pmc Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker
    Max Jan
    Program in Cancer Biology, Cancer Center, Institute for Stem Cell Biology and Regenerative Medicine, Department of Internal Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Proc Natl Acad Sci U S A 108:5009-14. 2011
    ..Significantly, differential TIM3 expression enabled the prospective separation of HSC from LSC in the majority of AML specimens with detectable residual HSC function...
  11. pmc Treatment advances have not improved the early death rate in acute promyelocytic leukemia
    James Scott McClellan
    Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305 5821, USA
    Haematologica 97:133-6. 2012
    ..Our findings show that early death is now the greatest contributor to treatment failure in this otherwise highly curable form of leukemia...
  12. doi request reprint Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia
    Andrew J Gentles
    Department of Radiology, Lucas Center for MR Spectroscopy and Imaging, School of Medicine, Stanford University, Palo Alto, CA 94305, USA
    JAMA 304:2706-15. 2010
    ..This model has significant implications for the development of novel therapies, but its clinical relevance has yet to be determined...
  13. pmc Individuality and variation in gene expression patterns in human blood
    Adeline R Whitney
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:1896-901. 2003
    ..These data help to define human individuality and provide a database with which disease-associated gene expression patterns can be compared...
  14. pmc Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma
    Michael R Green
    Division of Oncology, Department of Medicine, Stanford University, Stanford, CA 94305, USA
    Blood 121:1604-11. 2013
    ..These observations provide insight into which of the genetic lesions represent suitable candidates for targeted therapies...
  15. pmc Self-antigen recognition by follicular lymphoma B-cell receptors
    Kacey L Sachen
    Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 120:4182-90. 2012
    ..These results suggest that antigen stimulation may provide survival signals to tumor cells and that there is a selective pressure to preserve antigen recognition as the tumor evolves...
  16. pmc High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells
    June H Myklebust
    Department of Medicine, Oncology Division, Stanford University, Stanford, CA, USA
    Blood 121:1367-76. 2013
    ..Because FL TILs in vivo probably receive suppressive signals through PD-1, this provides a rationale for testing PD-1 Ab in combination with immunotherapy in patients with FL...
  17. pmc CD137 is expressed in follicular dendritic cell tumors and in classical Hodgkin and T-cell lymphomas: diagnostic and therapeutic implications
    Matthew W Anderson
    Department of Pathology, Stanford University School of Medicine, California, USA
    Am J Pathol 181:795-803. 2012
    ..CD137 is a novel diagnostic marker of these tumors and suggests a possible target for tumor-directed antibody therapy...
  18. pmc Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion
    Roch Houot
    Department of Medicine, Division of Oncology, Stanford University, CA, USA
    Blood 114:3431-8. 2009
    ..Moreover, the antitumor activity of anti-CD137 mAb could be further enhanced by depletion of regulatory T cell (T(regs)). These results support the evaluation of anti-CD137 therapy in clinical trials for patients with lymphoma...
  19. pmc Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma
    Mark P Chao
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, and Ludwig Center at Stanford, Stanford University, Palo Alto, CA 94304, USA
    Cell 142:699-713. 2010
    ..These antibodies synergized through a mechanism combining Fc receptor (FcR)-dependent and FcR-independent stimulation of phagocytosis that might be applicable to many other cancers...
  20. pmc Cell-type specific gene expression profiles of leukocytes in human peripheral blood
    Chana Palmer
    Department of Genetics, Stanford University School of Medicine, Stanford, USA
    BMC Genomics 7:115. 2006
    ..We did this by comparing the global gene expression profiles of purified B-cells, CD4+ T-cells, CD8+ T-cells, granulocytes, and lymphocytes using cDNA microarrays...
  21. pmc Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds
    Howard Y Chang
    Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 2:E7. 2004
    ..Thus, the transcriptional signature of the response of fibroblasts to serum provides a possible link between cancer progression and wound healing, as well as a powerful predictor of the clinical course in several common carcinomas...
  22. ncbi request reprint HGAL is a novel interleukin-4-inducible gene that strongly predicts survival in diffuse large B-cell lymphoma
    Izidore S Lossos
    Division of Oncology, Department of Medicine and the Department of Health Research and Policy, Stanford University School of Medicine, CA, USA
    Blood 101:433-40. 2003
    ..This association was independent of the clinical international prognostic index. High HGAL mRNA expression should be used as a prognostic factor in DLBCL...
  23. pmc Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation
    Maximilian Diehn
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:11796-801. 2002
    ....
  24. pmc SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data
    Maximilian Diehn
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Nucleic Acids Res 31:219-23. 2003
    ..SOURCE is available at http://source.stanford.edu...
  25. pmc CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies
    Holbrook E Kohrt
    Department of Medicine, Division of Oncology, Stanford University Medical Center, Stanford, CA 94305, USA
    Blood 117:2423-32. 2011
    ..These results support a novel, sequential antibody approach against B-cell malignancies by targeting first the tumor and then the host immune system...
  26. doi request reprint Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47
    Mark P Chao
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, and Ludwig Center at Stanford, Stanford, CA 94305, USA
    Sci Transl Med 2:63ra94. 2010
    ....
  27. pmc A pluripotency signature predicts histologic transformation and influences survival in follicular lymphoma patients
    Andrew J Gentles
    Department of Radiology, Stanford University School of Medicine, Lucas Center for MR Spectroscopy and Imaging, Stanford, CA 94305, USA
    Blood 114:3158-66. 2009
    ..Together, these findings suggest a central role for an ESC-like signature in the mechanism of HT and provide new clues for potential therapeutic targets...
  28. doi request reprint Second-line mitoxantrone, etoposide, and cytarabine for acute myeloid leukemia: a single-center experience
    Holbrook E Kohrt
    Department of Medicine, Division of Hematology, Stanford University, Stanford, CA 94305, USA
    Am J Hematol 85:877-81. 2010
    ..3 and 7.6 months, P = 0.36). Despite risk stratification by the European Prognostic Index, our series demonstrates inferior rates of response and survival, illustrating the limited activity of this regimen in our cohort...
  29. doi request reprint Immunophenotypic features of acute myeloid leukemia with inv(3)(q21q26.2)/t(3;3)(q21;q26.2)
    Bruno C Medeiros
    Department of Medicine, Division of Hematology, Stanford University, Stanford, CA, USA
    Leuk Res 34:594-7. 2010
    ..2). Differential karyotype and expression of certain antigens were noted in patients with de novo AML with inv(3)(q21q26.2) vs. those with inv(3)(q21q26.2)-containing blasts...
  30. doi request reprint Expression profiles of adult T-cell leukemia-lymphoma and associations with clinical responses to zidovudine and interferon alpha
    Ash A Alizadeh
    Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Leuk Lymphoma 51:1200-16. 2010
    ..Demonstration of specific gene expression signatures associated with response to AZT-IFNalpha therapy may provide novel insights into the mechanisms of action in ATLL...
  31. pmc Three differentiation states risk-stratify bladder cancer into distinct subtypes
    Jens Peter Volkmer
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:2078-83. 2012
    ..We identify here three distinct BC subtypes on the basis of their differentiation states, each harboring a unique tumor-initiating population...
  32. pmc Transformation of follicular lymphoma to diffuse large-cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes
    Izidore S Lossos
    Division of Oncology, Department of Medicine, Stanford Genome Technology Center, and Howard Hughes Medical Institute, Stanford, CA 94305 5306, USA
    Proc Natl Acad Sci U S A 99:8886-91. 2002
    ....
  33. doi request reprint Double trouble in follicular lymphoma: A rare and unusual synergy of oncogenes in the germinal center
    Ash A Alizadeh
    Division of Hematology and Oncology, Department of Medicine, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Leuk Lymphoma 49:377-80. 2008
  34. pmc The chemoattractant chemerin suppresses melanoma by recruiting natural killer cell antitumor defenses
    Russell K Pachynski
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 209:1427-35. 2012
    ....
  35. doi request reprint A retrospective study evaluating the efficacy and safety of bendamustine in the treatment of mantle cell lymphoma
    Sean Warsch
    Department of Medicine, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Leuk Lymphoma 53:1299-305. 2012
    ..There was one case of progressive multifocal leukoencephalopathy 10 months after therapy completion. Bendamustine in combination with rituximab demonstrated a high response rate in this study of patients with predominantly relapsed MCL...
  36. doi request reprint Utility of positron emission tomography scans in mantle cell lymphoma
    Peter J Hosein
    Department of Medicine, Division of Hematology Oncology, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA
    Am J Hematol 86:841-5. 2011
    ..PET scans did not meaningfully contribute to staging or surveillance of MCL patients in this study. There was a trend toward improved survival in patients who had a negative end-of-therapy PET scan...
  37. pmc CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
    Ravindra Majeti
    Department of Internal Medicine, Division of Hematology, Stanford University, Palo Alto, CA 94304, USA
    Cell 138:286-99. 2009
    ..In summary, increased CD47 expression is an independent, poor prognostic factor that can be targeted on human AML stem cells with blocking monoclonal antibodies capable of enabling phagocytosis of LSC...
  38. doi request reprint Identification of gene microarray expression profiles in patients with chronic graft-versus-host disease following allogeneic hematopoietic cell transplantation
    Holbrook E Kohrt
    Department of Medicine Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 USA
    Clin Immunol 148:124-35. 2013
    ..In addition, we identified three genes that were important regulators of extracellular matrix. Validation of this discovery phase study will determine if the identified genes have diagnostic, prognostic or therapeutic implications...
  39. pmc Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies
    Chih Long Liu
    Department of Medicine, Division of Immunology and Rheumatology, Stanford School of Medicine, 269 Campus Drive, Stanford, California 94305, USA
    Arthritis Res Ther 14:R25. 2012
    ..We hypothesized that NETs and their unique histone PTMs might be capable of inducing autoantibodies that target histones...
  40. pmc First isolation of Cryptococcus uzbekistanensis from an immunocompromised patient with Lymphoma
    Michael S Powel
    Department of Pathology, University School of Medicine, Stanford, California, USA
    J Clin Microbiol 50:1125-7. 2012
    ..Here we describe the first case of Cryptococcus uzbekistanensis causing bone marrow infection in an elderly Asian man with undiagnosed T cell lymphoma presenting with fever of unknown origin, pancytopenia, and exposure to chicken manure...
  41. pmc Stereotyped and specific gene expression programs in human innate immune responses to bacteria
    Jennifer C Boldrick
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:972-7. 2002
    ..Modulation of this host-response program by bacterial virulence mechanisms was an important source of variation in the response to different bacteria...