K Akashi

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi Role of interleukin-7 in T-cell development from hematopoietic stem cells
    K Akashi
    Department of Pathology, Standford University School of Medicine 94305, USA
    Immunol Rev 165:13-28. 1998
  2. ncbi Lymphoid development from hematopoietic stem cells
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Int J Hematol 69:217-26. 1999
  3. pmc Two distinct pathways of positive selection for thymocytes
    K Akashi
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 95:2486-91. 1998
  4. ncbi A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Nature 404:193-7. 2000
  5. ncbi Dendritic cell potentials of early lymphoid and myeloid progenitors
    M G Manz
    Department of Pathology, Stanford University School of Medicine, 279 Campus Dr, Stanford, CA 94305 5428, USA
    Blood 97:3333-41. 2001
  6. ncbi Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines
    M Kondo
    Department of Pathology, Stanford University School of Medicine, California 94305 5324, USA
    Nature 407:383-6. 2000
  7. ncbi Lymphoid precursors
    K Akashi
    Departments of Pathology and Developmental Biology, Beckman Center B 261, Stanford University School of Medicine, Stanford, CA 94305, USA
    Curr Opin Immunol 12:144-50. 2000
  8. ncbi Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Cell 89:1033-41. 1997
  9. ncbi Dendritic cell development from common myeloid progenitors
    M G Manz
    Department of Pathology and Developmental Biology, B261 Beckman Center, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305 5428, USA
    Ann N Y Acad Sci 938:167-73; discussion 173-4. 2001
  10. ncbi B lymphopoiesis in the thymus
    K Akashi
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    J Immunol 164:5221-6. 2000

Collaborators

  • E Lagasse
  • M Kondo
  • J Domen
  • F Ishikawa
  • T Miyamoto
  • Leonard D Shultz
  • Kazusato Ohshima
  • Kazushi Tanimoto
  • M Merad
  • I L Weissman
  • D Traver
  • H Iwasaki
  • M G Manz
  • N Kawano
  • Y Yuan
  • J Shiraishi
  • Y Li
  • S K Ye
  • K Hahm
  • H Gondo
  • E Baba
  • K Nagafuji
  • M Harada
  • K Shimoda
  • T Tanaka
  • T Otsuka
  • M Yasukawa
  • S Yamasaki
  • S Yamanaka
  • S Fushiki
  • H S Radomska
  • H Fliss
  • Y Okuno
  • D G Tenen
  • J Asayama
  • N Keira
  • T Tatsumi
  • D E Zhang
  • P Zhang
  • S Matoba
  • R A Maki
  • J Iwasaki-Arai
  • S R McKercher
  • N Harakawa
  • M Nakagawa
  • M J Klemsz
  • S A Burel
  • C J Hetherington
  • A Mano
  • T Yaoi
  • L Zhou
  • H Chen
  • E G Engleman
  • J Christensen
  • K Maki
  • K Ikuta
  • S Sunaga
  • T Kitamura
  • T Honjo
  • A S McCarty
  • B S Cobb
  • A G Fisher
  • R Lee
  • C A Klug
  • K E Brown
  • S T Smale

Detail Information

Publications24

  1. ncbi Role of interleukin-7 in T-cell development from hematopoietic stem cells
    K Akashi
    Department of Pathology, Standford University School of Medicine 94305, USA
    Immunol Rev 165:13-28. 1998
    ..Detailed analysis of the signaling cascades activated by the IL-7R may help to reveal the differential roles of IL-7 signaling in T and B-cell development...
  2. ncbi Lymphoid development from hematopoietic stem cells
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Int J Hematol 69:217-26. 1999
    ..Thus, common lymphoid progenitors exist in early hematopoiesis, and expression of the IL-7R is a critical step in the initiation of lymphoid development from HSC...
  3. pmc Two distinct pathways of positive selection for thymocytes
    K Akashi
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 95:2486-91. 1998
    ..In this view, positive selection on the c-Kit- path results from a salvage of cells that failed positive selection on the c-Kit+ path...
  4. ncbi A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Nature 404:193-7. 2000
    ....
  5. ncbi Dendritic cell potentials of early lymphoid and myeloid progenitors
    M G Manz
    Department of Pathology, Stanford University School of Medicine, 279 Campus Dr, Stanford, CA 94305 5428, USA
    Blood 97:3333-41. 2001
    ..Blood. 2001;97:3333-3341)..
  6. ncbi Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines
    M Kondo
    Department of Pathology, Stanford University School of Medicine, California 94305 5324, USA
    Nature 407:383-6. 2000
    ..We conclude that cytokine signalling can regulate cell-fate decisions and propose that a critical step in lymphoid commitment is downregulation of cytokine receptors that drive myeloid cell development...
  7. ncbi Lymphoid precursors
    K Akashi
    Departments of Pathology and Developmental Biology, Beckman Center B 261, Stanford University School of Medicine, Stanford, CA 94305, USA
    Curr Opin Immunol 12:144-50. 2000
    ..These studies may ultimately provide candidate genes involved in lineage commitment, cell death or survival, self-renewal and migratory capacities of progenitors...
  8. ncbi Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Cell 89:1033-41. 1997
    ..We propose cell survival signals to be the principal function of IL-7R engagement in thymic and T cell development...
  9. ncbi Dendritic cell development from common myeloid progenitors
    M G Manz
    Department of Pathology and Developmental Biology, B261 Beckman Center, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305 5428, USA
    Ann N Y Acad Sci 938:167-73; discussion 173-4. 2001
    ..On the basis of transplantation studies, it seems likely that most of the DCs in secondary lymphoid organs and a substantial fraction of thymic DCs are myeloid-derived...
  10. ncbi B lymphopoiesis in the thymus
    K Akashi
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    J Immunol 164:5221-6. 2000
    ..Thus, the thymus contributes to the formation of peripheral pools of B cells as well as of alphabeta and gammadelta T cells...
  11. ncbi Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets
    D Traver
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 98:627-35. 2001
    ..Blood. 2001;98:627-635)..
  12. ncbi Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia
    D Traver
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 9:47-57. 1998
    ..Taken together, these data suggest that Fas has a novel role in the regulation of myelopoiesis and that Fas may act as a tumor suppressor to control leukemogenic transformation in myeloid progenitor cells...
  13. ncbi Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice
    M Kondo
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:155-62. 1997
    ..Therefore, the development of T, B, and NK cells may be influenced by distinct intracytoplasmic signaling cascades that are activated by coupling of gamma(c)-related receptors...
  14. ncbi Identification of clonogenic common lymphoid progenitors in mouse bone marrow
    M Kondo
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Cell 91:661-72. 1997
    ..A single Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) cell could generate at least both T and B cells. These data provide direct evidence for the existence of common lymphoid progenitors in sites of early hematopoiesis...
  15. ncbi The c-kit+ maturation pathway in mouse thymic T cell development: lineages and selection
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 5:147-61. 1996
    ..Some DPhi c-kit blast cells can be salvaged to produce mature single-positive (SP) cells. DPint c-kit+ maturation to SP cells can occur in <12 hr in vitro on thymic stromal monolayers...
  16. pmc AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation
    T Miyamoto
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 97:7521-6. 2000
    ....
  17. ncbi Epstein-Barr virus-infected natural killer cell leukemia
    K Akashi
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    Leuk Lymphoma 40:57-66. 2000
    ....
  18. pmc AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations
    Y Yuan
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:10398-403. 2001
    ..The hMRP8-AML1-ETO-transgenic mice provide an excellent model that can be used to isolate additional genetic events and to further understand the molecular pathogenesis of AML1-ETO-related leukemia...
  19. ncbi Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor
    S K Ye
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    Immunity 11:213-23. 1999
    ..Therefore, this study reveals a potential role of Stat5 in T cell development and also implies that IL-7R may control the accessibility of the TCRgamma locus through Stat5-induced germline transcription...
  20. pmc Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin
    K Hahm
    Howard Hughes Medical Institute, Molecular Biology Institute, and Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California 90095 1662, USA
    Genes Dev 12:782-96. 1998
    ..These results establish immunoaffinity chromatography as a useful method for identifying Ikaros partners and suggest that Helios is a limiting regulatory subunit for Ikaros within centromeric heterochromatin...
  21. ncbi Important role of energy-dependent mitochondrial pathways in cultured rat cardiac myocyte apoptosis
    J Shiraishi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
    Am J Physiol Heart Circ Physiol 281:H1637-47. 2001
    ..Our data therefore suggest that staurosporine induces cell demise through a mitochondrial death signaling pathway and that the presence of intracellular ATP favors a shift from necrosis to apoptosis through caspase activation...
  22. ncbi Regulation of the PU.1 gene by distal elements
    Y Li
    Harvard Institutes of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Blood 98:2958-65. 2001
    ..1. Further analysis of this myeloid-specific regulatory element will provide insight into the regulation of this key transcriptional regulator and may be useful as a tool for targeting expression to the myeloid lineage...
  23. ncbi Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/beta2-microglobulin(null) mice
    N Kawano
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan
    Leukemia 19:1384-90. 2005
    ..Taken together, the NOD/SCID/beta2m(null) newborn system is useful to understand kinetics, metastasis, and disease progression of ATL in vivo...
  24. ncbi Hematopoietic developmental pathways: on cellular basis
    H Iwasaki
    Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
    Oncogene 26:6687-96. 2007
    ..Here, we summarize the phenotype and functional properties and their differences of hematopoietic stem and progenitor cell populations between mouse and human...