K Akashi

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Multiple autoimmune haemopoietic disorders and insidious clonal proliferation of large granular lymphocytes
    K Akashi
    First Department of Internal Medicine, Kyushu University, Fukuoka, Japan
    Br J Haematol 107:670-3. 1999
  2. ncbi request reprint Lymphoid precursors
    K Akashi
    Departments of Pathology and Developmental Biology, Beckman Center B 261, Stanford University School of Medicine, Stanford, CA 94305, USA
    Curr Opin Immunol 12:144-50. 2000
  3. ncbi request reprint A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Nature 404:193-7. 2000
  4. ncbi request reprint Aclarubicin induces differentiation of leukemic progenitors in myelodysplastic syndrome cooperating with granulocyte colony-stimulating factor
    K Akashi
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Leuk Res 24:243-8. 2000
  5. ncbi request reprint Dendritic cell potentials of early lymphoid and myeloid progenitors
    M G Manz
    Department of Pathology, Stanford University School of Medicine, 279 Campus Dr, Stanford, CA 94305 5428, USA
    Blood 97:3333-41. 2001
  6. pmc Two distinct pathways of positive selection for thymocytes
    K Akashi
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 95:2486-91. 1998
  7. ncbi request reprint Dendritic cell development from common myeloid progenitors
    M G Manz
    Department of Pathology and Developmental Biology, B261 Beckman Center, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305 5428, USA
    Ann N Y Acad Sci 938:167-73; discussion 173-4. 2001
  8. ncbi request reprint Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets
    D Traver
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 98:627-35. 2001
  9. ncbi request reprint Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines
    M Kondo
    Department of Pathology, Stanford University School of Medicine, California 94305 5324, USA
    Nature 407:383-6. 2000
  10. pmc Characteristics of splenic CD8+ T cell exhaustion in patients with hepatitis C
    K Sumida
    Department of Medicine and Biosystemic Science, Kyushu University, Fukuoka, Japan
    Clin Exp Immunol 174:172-8. 2013

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Multiple autoimmune haemopoietic disorders and insidious clonal proliferation of large granular lymphocytes
    K Akashi
    First Department of Internal Medicine, Kyushu University, Fukuoka, Japan
    Br J Haematol 107:670-3. 1999
    ..Accordingly, an undetectable level of proliferation of a clonal LGL population could cause various autoimmune haemopoietic disorders...
  2. ncbi request reprint Lymphoid precursors
    K Akashi
    Departments of Pathology and Developmental Biology, Beckman Center B 261, Stanford University School of Medicine, Stanford, CA 94305, USA
    Curr Opin Immunol 12:144-50. 2000
    ..These studies may ultimately provide candidate genes involved in lineage commitment, cell death or survival, self-renewal and migratory capacities of progenitors...
  3. ncbi request reprint A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Nature 404:193-7. 2000
    ....
  4. ncbi request reprint Aclarubicin induces differentiation of leukemic progenitors in myelodysplastic syndrome cooperating with granulocyte colony-stimulating factor
    K Akashi
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Leuk Res 24:243-8. 2000
    ....
  5. ncbi request reprint Dendritic cell potentials of early lymphoid and myeloid progenitors
    M G Manz
    Department of Pathology, Stanford University School of Medicine, 279 Campus Dr, Stanford, CA 94305 5428, USA
    Blood 97:3333-41. 2001
    ..Blood. 2001;97:3333-3341)..
  6. pmc Two distinct pathways of positive selection for thymocytes
    K Akashi
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 95:2486-91. 1998
    ..In this view, positive selection on the c-Kit- path results from a salvage of cells that failed positive selection on the c-Kit+ path...
  7. ncbi request reprint Dendritic cell development from common myeloid progenitors
    M G Manz
    Department of Pathology and Developmental Biology, B261 Beckman Center, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305 5428, USA
    Ann N Y Acad Sci 938:167-73; discussion 173-4. 2001
    ..On the basis of transplantation studies, it seems likely that most of the DCs in secondary lymphoid organs and a substantial fraction of thymic DCs are myeloid-derived...
  8. ncbi request reprint Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets
    D Traver
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 98:627-35. 2001
    ..Blood. 2001;98:627-635)..
  9. ncbi request reprint Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines
    M Kondo
    Department of Pathology, Stanford University School of Medicine, California 94305 5324, USA
    Nature 407:383-6. 2000
    ..We conclude that cytokine signalling can regulate cell-fate decisions and propose that a critical step in lymphoid commitment is downregulation of cytokine receptors that drive myeloid cell development...
  10. pmc Characteristics of splenic CD8+ T cell exhaustion in patients with hepatitis C
    K Sumida
    Department of Medicine and Biosystemic Science, Kyushu University, Fukuoka, Japan
    Clin Exp Immunol 174:172-8. 2013
    ..Counteracting this process may contribute to inducing an effective immune response to HCV...
  11. ncbi request reprint Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor
    S K Ye
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    Immunity 11:213-23. 1999
    ..Therefore, this study reveals a potential role of Stat5 in T cell development and also implies that IL-7R may control the accessibility of the TCRgamma locus through Stat5-induced germline transcription...
  12. ncbi request reprint B lymphopoiesis in the thymus
    K Akashi
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    J Immunol 164:5221-6. 2000
    ..Thus, the thymus contributes to the formation of peripheral pools of B cells as well as of alphabeta and gammadelta T cells...
  13. ncbi request reprint Role of interleukin-7 in T-cell development from hematopoietic stem cells
    K Akashi
    Department of Pathology, Standford University School of Medicine 94305, USA
    Immunol Rev 165:13-28. 1998
    ..Detailed analysis of the signaling cascades activated by the IL-7R may help to reveal the differential roles of IL-7 signaling in T and B-cell development...
  14. doi request reprint Validation of pretransplantation assessment of mortality risk score in the outcome of hematopoietic SCT in non-Caucasians
    Y Mori
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Fukuoka, Japan
    Bone Marrow Transplant 47:1075-81. 2012
    ..The PAM score developed in Caucasian populations is thus useful in non-Caucasian populations...
  15. doi request reprint A novel filtration method for cord blood processing using a polyester fabric filter
    T Shima
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan
    Int J Lab Hematol 35:436-46. 2013
    ..CB processing requires costly machinery or a clean room that hampers wider application of CBT particularly in the developing countries...
  16. ncbi request reprint Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia
    D Traver
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 9:47-57. 1998
    ..Taken together, these data suggest that Fas has a novel role in the regulation of myelopoiesis and that Fas may act as a tumor suppressor to control leukemogenic transformation in myeloid progenitor cells...
  17. doi request reprint Role of autotransplantation in the treatment of acute promyelocytic leukemia patients in remission: Fukuoka BMT Group observations and a literature review
    T Kamimura
    Department of Hematology, Harasanshin Hospital, Fukuoka, Japan
    Bone Marrow Transplant 46:820-6. 2011
    ..We review previous reports and discuss the role of autotransplantation in the treatment of APL patients in CR...
  18. ncbi request reprint Evaluating the association between histological manifestations of cord colitis syndrome with GVHD
    S Shimoji
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan
    Bone Marrow Transplant 48:1249-52. 2013
    ..These results demonstrate that chronic active colitis with granuloma and Paneth cell metaplasia is not only a specific feature of CCS but also is present in GVHD and CMV colitis, irrespective of stem cell source. ..
  19. ncbi request reprint Lymphoid development from hematopoietic stem cells
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Int J Hematol 69:217-26. 1999
    ..Thus, common lymphoid progenitors exist in early hematopoiesis, and expression of the IL-7R is a critical step in the initiation of lymphoid development from HSC...
  20. ncbi request reprint Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Cell 89:1033-41. 1997
    ..We propose cell survival signals to be the principal function of IL-7R engagement in thymic and T cell development...
  21. ncbi request reprint Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice
    M Kondo
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:155-62. 1997
    ..Therefore, the development of T, B, and NK cells may be influenced by distinct intracytoplasmic signaling cascades that are activated by coupling of gamma(c)-related receptors...
  22. ncbi request reprint Identification of clonogenic common lymphoid progenitors in mouse bone marrow
    M Kondo
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Cell 91:661-72. 1997
    ..A single Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) cell could generate at least both T and B cells. These data provide direct evidence for the existence of common lymphoid progenitors in sites of early hematopoiesis...
  23. doi request reprint Long-term outcomes of autologous PBSCT for peripheral T-cell lymphoma: retrospective analysis of the experience of the Fukuoka BMT group
    A Numata
    Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
    Bone Marrow Transplant 45:311-6. 2010
    ..4% vs 27.3%, P=0.046). HDCT supported by auto-SCT may therefore be effective as consolidation in CR for PTCL treatment...
  24. doi request reprint Disseminated tuberculosis following second unrelated cord blood transplantation for acute myelogenous leukemia
    T Shima
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Transpl Infect Dis 11:75-7. 2009
    ..Despite anti-tuberculous treatment, she died on day 85. TB should always be considered as a possible diagnosis when treating febrile immunocompromised patients...
  25. pmc AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation
    T Miyamoto
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 97:7521-6. 2000
    ....
  26. ncbi request reprint Hematopoietic developmental pathways: on cellular basis
    H Iwasaki
    Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
    Oncogene 26:6687-96. 2007
    ..Here, we summarize the phenotype and functional properties and their differences of hematopoietic stem and progenitor cell populations between mouse and human...
  27. ncbi request reprint Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/beta2-microglobulin(null) mice
    N Kawano
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan
    Leukemia 19:1384-90. 2005
    ..Taken together, the NOD/SCID/beta2m(null) newborn system is useful to understand kinetics, metastasis, and disease progression of ATL in vivo...
  28. pmc Modulation of CD4⁺ T cell responses following splenectomy in hepatitis C virus-related liver cirrhosis
    N Hashimoto
    Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Clin Exp Immunol 165:243-50. 2011
    ..Our data suggest that peripheral tolerance is promoted by the spleen in LC via the up-regulated expression of PD-1 ligands...
  29. ncbi request reprint The c-kit+ maturation pathway in mouse thymic T cell development: lineages and selection
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 5:147-61. 1996
    ..Some DPhi c-kit blast cells can be salvaged to produce mature single-positive (SP) cells. DPint c-kit+ maturation to SP cells can occur in <12 hr in vitro on thymic stromal monolayers...
  30. ncbi request reprint Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia
    S Mizuno
    First Department of Internal Medicine, Kyushu University, Fukuoka, Japan
    Blood 97:1172-9. 2001
    ..Up-regulated DNMTs may contribute to the pathogenesis of leukemia by inducing aberrant regional hypermethylation. (Blood. 2001;97:1172-1179)..
  31. pmc The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis
    S Shimoda
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Clin Exp Immunol 168:279-84. 2012
    ..However, the data suggest that adaptive autoimmune effector mechanisms are required for the progression of clinical disease...
  32. doi request reprint Infectious complications in patients receiving autologous CD34-selected hematopoietic stem cell transplantation for severe autoimmune diseases
    K Kohno
    Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Transpl Infect Dis 11:318-23. 2009
    ..Because the risk for infections approaches that seen in allogeneic transplant recipients, infection surveillance, diagnostic workup, and prophylactic strategies similar to those applicable to allogeneic recipients are warranted...
  33. ncbi request reprint Epstein-Barr virus-infected natural killer cell leukemia
    K Akashi
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    Leuk Lymphoma 40:57-66. 2000
    ....
  34. ncbi request reprint Detection of monocyte chemoattractant protein-1 receptor expression in experimental atherosclerotic lesions: an autoradiographic study
    K Ohtsuki
    Division of Nuclear Medicine, Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA
    Circulation 104:203-8. 2001
    ..The uptake of (125)I-MCP-1 correlated with the number of macrophages per unit area (r=0.85, P<0.0001). CONCLUSIONS: Radiolabeled MCP-1 may be a useful tracer for imaging monocyte/macrophage-rich experimental atherosclerotic lesions...
  35. ncbi request reprint Distribution and development of NMDA receptor activities at hippocampal synapses examined using mice lacking the epsilon1 subunit gene
    I Ito
    Department of Biology, Faculty of Science 33, Kyushu University, Fukuoka, Japan
    Neurosci Res 30:119-23. 1998
    ..The LTP at the CA3 stratum oriens synapses was not significantly affected by the mutation at any age...
  36. pmc AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations
    Y Yuan
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:10398-403. 2001
    ..The hMRP8-AML1-ETO-transgenic mice provide an excellent model that can be used to isolate additional genetic events and to further understand the molecular pathogenesis of AML1-ETO-related leukemia...
  37. pmc Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin
    K Hahm
    Howard Hughes Medical Institute, Molecular Biology Institute, and Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California 90095 1662, USA
    Genes Dev 12:782-96. 1998
    ..These results establish immunoaffinity chromatography as a useful method for identifying Ikaros partners and suggest that Helios is a limiting regulatory subunit for Ikaros within centromeric heterochromatin...
  38. ncbi request reprint Important role of energy-dependent mitochondrial pathways in cultured rat cardiac myocyte apoptosis
    J Shiraishi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
    Am J Physiol Heart Circ Physiol 281:H1637-47. 2001
    ..Our data therefore suggest that staurosporine induces cell demise through a mitochondrial death signaling pathway and that the presence of intracellular ATP favors a shift from necrosis to apoptosis through caspase activation...
  39. ncbi request reprint Regulation of the PU.1 gene by distal elements
    Y Li
    Harvard Institutes of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Blood 98:2958-65. 2001
    ..1. Further analysis of this myeloid-specific regulatory element will provide insight into the regulation of this key transcriptional regulator and may be useful as a tool for targeting expression to the myeloid lineage...