Ranjana H Advani

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Angioimmunoblastic T cell lymphoma: treatment experience with cyclosporine
    Ranjana Advani
    Stanford University Medical Center, Stanford, CA 94305 5821, USA
    Leuk Lymphoma 48:521-5. 2007
  2. pmc Lymphoma cell VEGFR2 expression detected by immunohistochemistry predicts poor overall survival in diffuse large B cell lymphoma treated with immunochemotherapy (R-CHOP)
    Dita Gratzinger
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    Br J Haematol 148:235-44. 2010
  3. pmc Efficacy of abbreviated Stanford V chemotherapy and involved-field radiotherapy in early-stage Hodgkin lymphoma: mature results of the G4 trial
    R H Advani
    Departments of Medicine Oncology, Stanford University Medical Center, 875 Blake Wilbur Drive, CC 2338, Stanford, CA 94305, USA
    Ann Oncol 24:1044-8. 2013
  4. doi request reprint Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies
    Ranjana H Advani
    Stanford University Medical Center, Stanford, CA 94305 5821, USA
    J Clin Oncol 31:88-94. 2013
  5. pmc Interim-treatment quantitative PET parameters predict progression and death among patients with Hodgkin's disease
    Diane Tseng
    Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Dr, Stanford, CA 94305, USA
    Radiat Oncol 7:5. 2012
  6. pmc Stage I-IIA non-bulky Hodgkin's lymphoma. Is further distinction based on prognostic factors useful? The Stanford experience
    Ranjana H Advani
    Department of Medicine, Division of Medical Oncology, Stanford University Medical Center, Stanford, California 94305, USA
    Int J Radiat Oncol Biol Phys 81:1374-9. 2011
  7. ncbi request reprint A phase I trial of aprinocarsen (ISIS 3521/LY900003), an antisense inhibitor of protein kinase C-alpha administered as a 24-hour weekly infusion schedule in patients with advanced cancer
    Ranjana Advani
    Oncology Division, Stanford University School of Medicine, Stanford, CA 94305 5151, USA
    Invest New Drugs 23:467-77. 2005
  8. doi request reprint Voreloxin, a first-in-class anticancer quinolone derivative, in relapsed/refractory solid tumors: a report on two dosing schedules
    Ranjana H Advani
    Stanford University Medical Center, Stanford, California, USA
    Clin Cancer Res 16:2167-75. 2010
  9. pmc Comparison of conventional prognostic indices in patients older than 60 years with diffuse large B-cell lymphoma treated with R-CHOP in the US Intergroup Study (ECOG 4494, CALGB 9793): consideration of age greater than 70 years in an elderly prognostic in
    Ranjana H Advani
    Stanford University, Stanford, CA 94305, USA
    Br J Haematol 151:143-51. 2010
  10. doi request reprint Optimal therapy of advanced Hodgkin lymphoma
    Ranjana Advani
    Stanford University Medical Center, Stanford, CA 94305, USA
    Hematology Am Soc Hematol Educ Program 2011:310-6. 2011

Detail Information

Publications45

  1. ncbi request reprint Angioimmunoblastic T cell lymphoma: treatment experience with cyclosporine
    Ranjana Advani
    Stanford University Medical Center, Stanford, CA 94305 5821, USA
    Leuk Lymphoma 48:521-5. 2007
    ..By interrupting T-cell activation, CsA may alter the immune dysregulation that characterizes AILT. The efficacy of CsA is being explored in patients with recurrent AILT in a prospective trial (ECOG 2402)...
  2. pmc Lymphoma cell VEGFR2 expression detected by immunohistochemistry predicts poor overall survival in diffuse large B cell lymphoma treated with immunochemotherapy (R-CHOP)
    Dita Gratzinger
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    Br J Haematol 148:235-44. 2010
    ..In contrast to our prior results with chemotherapy alone, microvessel density was not prognostic of PFS or OS with R-CHOP-like therapy...
  3. pmc Efficacy of abbreviated Stanford V chemotherapy and involved-field radiotherapy in early-stage Hodgkin lymphoma: mature results of the G4 trial
    R H Advani
    Departments of Medicine Oncology, Stanford University Medical Center, 875 Blake Wilbur Drive, CC 2338, Stanford, CA 94305, USA
    Ann Oncol 24:1044-8. 2013
    ..Stanford V chemotherapy was administered for 8 weeks followed by radiation therapy (RT) 30 Gy to involved fields (IF). Freedom from progression (FFP), disease-specific survival (DSS) and overall survival (OS) were estimated...
  4. doi request reprint Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies
    Ranjana H Advani
    Stanford University Medical Center, Stanford, CA 94305 5821, USA
    J Clin Oncol 31:88-94. 2013
    ..We evaluated ibrutinib (PCI-32765), a small-molecule irreversible inhibitor of BTK, in patients with B-cell malignancies...
  5. pmc Interim-treatment quantitative PET parameters predict progression and death among patients with Hodgkin's disease
    Diane Tseng
    Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Dr, Stanford, CA 94305, USA
    Radiat Oncol 7:5. 2012
    ..We hypothesized that quantitative PET parameters may have predictive value beyond that of traditional clinical factors such as the International Prognostic Score (IPS) among Hodgkin's disease (HD) patients...
  6. pmc Stage I-IIA non-bulky Hodgkin's lymphoma. Is further distinction based on prognostic factors useful? The Stanford experience
    Ranjana H Advani
    Department of Medicine, Division of Medical Oncology, Stanford University Medical Center, Stanford, California 94305, USA
    Int J Radiat Oncol Biol Phys 81:1374-9. 2011
    ..We sought to determine the prognostic significance of these factors in patients with early-stage disease treated at Stanford University Medical Center...
  7. ncbi request reprint A phase I trial of aprinocarsen (ISIS 3521/LY900003), an antisense inhibitor of protein kinase C-alpha administered as a 24-hour weekly infusion schedule in patients with advanced cancer
    Ranjana Advani
    Oncology Division, Stanford University School of Medicine, Stanford, CA 94305 5151, USA
    Invest New Drugs 23:467-77. 2005
    ..A phase I study was performed to determine the maximum tolerated dose (MTD), safety profile and pharmacology of aprinocarsen (ISIS 3521), an antisense oligonucleotide to protein kinase C-alpha, in patients with refractory solid tumors...
  8. doi request reprint Voreloxin, a first-in-class anticancer quinolone derivative, in relapsed/refractory solid tumors: a report on two dosing schedules
    Ranjana H Advani
    Stanford University Medical Center, Stanford, California, USA
    Clin Cancer Res 16:2167-75. 2010
    ..We report the phase 1 experience of voreloxin in patients with relapsed/refractory solid tumors, including dose-limiting toxicity (DLT), maximum-tolerated dose (MTD), pharmacokinetics, and clinical activity...
  9. pmc Comparison of conventional prognostic indices in patients older than 60 years with diffuse large B-cell lymphoma treated with R-CHOP in the US Intergroup Study (ECOG 4494, CALGB 9793): consideration of age greater than 70 years in an elderly prognostic in
    Ranjana H Advani
    Stanford University, Stanford, CA 94305, USA
    Br J Haematol 151:143-51. 2010
    ..The prognostic discrimination provided by the E-IPI for low and low-intermediate elderly DLBCL patients needs validation by other datasets...
  10. doi request reprint Optimal therapy of advanced Hodgkin lymphoma
    Ranjana Advani
    Stanford University Medical Center, Stanford, CA 94305, USA
    Hematology Am Soc Hematol Educ Program 2011:310-6. 2011
    ..Lastly, the expanding population of survivors cured of HL outnumbers patients with the disease and needs to be monitored for therapy-related late effects...
  11. ncbi request reprint Management of advanced stage Hodgkin lymphoma
    Ranjana Advani
    Stanford University Medical Center, Stanford, California 94305, USA
    J Natl Compr Canc Netw 4:241-7. 2006
    ....
  12. doi request reprint Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma
    Ranjana Advani
    Division of Oncology, Stanford University Medical Center, 875 Blake Wilbur Dr, Stanford, CA 94305, USA
    J Clin Oncol 27:4371-7. 2009
    ..To evaluate the safety, maximum-tolerated dose (MTD), pharmacokinetics, and antitumor activity of dacetuzumab in patients with refractory or recurrent B-cell non-Hodgkin's lymphoma (NHL)...
  13. ncbi request reprint Stage I and II follicular non-Hodgkin's lymphoma: long-term follow-up of no initial therapy
    Ranjana Advani
    Division of Oncology, Department of Medicine, Stanford University Medical Center, 875 Blake Wilber Drive, Stanford, CA 94305, USA
    J Clin Oncol 22:1454-9. 2004
    ....
  14. ncbi request reprint Impact of positive positron emission tomography on prediction of freedom from progression after Stanford V chemotherapy in Hodgkin's disease
    Ranjana Advani
    Stanford University Comprehensive Cancer Center, Stanford, CA 94305, USA
    J Clin Oncol 25:3902-7. 2007
    ..To correlate [(18)F]fluorodeoxyglucose positron emission tomography ([(18)F]FDG-PET) status after chemotherapy, but before radiation, with outcome in patients treated with the Stanford V regimen...
  15. pmc Risk of therapy-related secondary leukemia in Hodgkin lymphoma: the Stanford University experience over three generations of clinical trials
    Michael Zach Koontz
    Stanford University Medical Center, 875 Blake Wilbur Dr, CC 2338, Stanford, CA 94305, USA
    J Clin Oncol 31:592-8. 2013
    ..To assess therapy-related acute myeloid leukemia/myelodysplastic syndrome (t-AML/MDS) risk in patients treated for Hodgkin lymphoma (HL) on successive generations of Stanford clinical trials...
  16. doi request reprint Mature results of a phase II study of rituximab therapy for nodular lymphocyte-predominant Hodgkin lymphoma
    Ranjana H Advani
    Ranjana H Advani, Sandra J Horning, Richard T Hoppe, Sarah Daadi, John Allen, and Yasodha Natkunam, Stanford University Medical Center, Stanford, CA and Nancy L Bartlett, Washington University School of Medicine, St Louis, MO
    J Clin Oncol 32:912-8. 2014
    ..Universal expression of CD20 by malignant cells in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) led us to evaluate rituximab (R) as a therapeutic option...
  17. doi request reprint Phase I trial of oblimersen (Genasense®) and gemcitabine in refractory and advanced malignancies
    Peter S Galatin
    Department of Medicine, Oncology, Stanford University School of Medicine, Stanford, CA, USA
    Invest New Drugs 29:971-7. 2011
    ..The present study was designed to determine the maximum tolerated dose (MTD) of oblimersen (antisense Bcl-2) and gemcitabine when administered to patients with refractory malignancies...
  18. pmc Paraffin-based 6-gene model predicts outcome in diffuse large B-cell lymphoma patients treated with R-CHOP
    Raquel Malumbres
    Department of Medicine, Division of Hematology Oncology and Molecular and Cellular Pharmacology, Sylvester Comprehensive Cancer Center, University of Miami, FL 33136, USA
    Blood 111:5509-14. 2008
    ..008). These findings demonstrate that the prognostic value of the 6-gene model remains significant in the era of R-CHOP treatment and that the model can be applied to routine FFPE tissue from initial diagnostic biopsies...
  19. pmc Improvements in observed and relative survival in follicular grade 1-2 lymphoma during 4 decades: the Stanford University experience
    Daryl Tan
    Department of Medicine, Oncology Division, Stanford University, Stanford, CA 94305, USA
    Blood 122:981-7. 2013
    ..Several factors, including better supportive care and effective therapies for relapsed disease, are likely responsible for this improvement. ..
  20. pmc In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study
    Youn H Kim
    Department of Dermatology, Stanford University School of Medicine, CA, USA
    Blood 119:355-63. 2012
    ..This study is registered at www.clinicaltrials.gov as NCT00226993...
  21. doi request reprint Current concepts and controversies in the management of early stage Hodgkin lymphoma
    Lauren S Maeda
    Department of Medicine Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Leuk Lymphoma 52:962-71. 2011
    ..The collective goal is to further refine current stratification strategies to allow for an individualized, risk-adapted treatment approach that minimizes long-term late effects without compromising high cure rates...
  22. doi request reprint The emerging role for rituximab in the treatment of nodular lymphocyte predominant Hodgkin lymphoma
    Lauren S Maeda
    Department of Medicine Oncology, Stanford University School of Medicine, Stanford, California, USA
    Curr Opin Oncol 21:397-400. 2009
    ..The reliable expression of CD20 has led to the evaluation of the chimeric monoclonal anti-CD20 antibody rituximab in several recent trials...
  23. ncbi request reprint Phase II study of gefitinib, fluorouracil, leucovorin, and oxaliplatin therapy in previously treated patients with metastatic colorectal cancer
    Timothy Kuo
    Oncology Division, Department of Medicine, Stanford University School of Medicine, 269 Campus Dr, CCSR 1105, Stanford, CA 94305 5151, USA
    J Clin Oncol 23:5613-9. 2005
    ..To investigate the gefitinib, fluorouracil (FU), leucovorin, and oxaliplatin regimen (IFOX) in previously treated patients with metastatic colorectal cancer...
  24. ncbi request reprint Evaluation and management of angioimmunoblastic T-cell lymphoma: a review of current approaches and future strategies
    Ash A Alizadeh
    Division of Hematology and Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Clin Adv Hematol Oncol 6:899-909. 2008
    ..Finally, we discuss recent clinical trials and novel treatment approaches in the management of patients with AITL...
  25. ncbi request reprint Bevacizumab and cyclosphosphamide, doxorubicin, vincristine and prednisone in combination for patients with peripheral T-cell or natural killer cell neoplasms: an Eastern Cooperative Oncology Group study (E2404)
    Kristen Ganjoo
    Stanford University, Stanford, CA, USA
    Leuk Lymphoma 55:768-72. 2014
    ..Studies of novel therapeutics are needed for this patient population, whose clinical outcome remains poor...
  26. pmc Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment
    Ash A Alizadeh
    Department of Medicine, Division of Oncology, Stanford University, Stanford, CA, USA
    Blood 118:1350-8. 2011
    ..We conclude that the measurement of a single gene expressed by tumor cells (LMO2) and a single gene expressed by the immune microenvironment (TNFRSF9) powerfully predicts overall survival in patients with DLBCL...
  27. ncbi request reprint Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a phase III trial (E2995)
    Peter L Greenberg
    Hematology Division, Stanford University Medical Center, 703 Welch Rd, Suite G 1, Stanford, CA 94305, USA
    J Clin Oncol 22:1078-86. 2004
    ....
  28. doi request reprint Prognostic factors in primary cutaneous anaplastic large cell lymphoma: characterization of clinical subset with worse outcome
    Denise K Woo
    Department of Dermatology, Stanford University, Stanford, CA 94305, USA
    Arch Dermatol 145:667-74. 2009
    ....
  29. ncbi request reprint Non-Hodgkin lymphoma of the breast
    Kristen Ganjoo
    Department of Medical Oncology, Stanford University, Stanford, California, USA
    Cancer 110:25-30. 2007
    ..A retrospective study was done to evaluate the institutional experience in this patient population...
  30. pmc Interim positron emission tomography scans in diffuse large B-cell lymphoma: an independent expert nuclear medicine evaluation of the Eastern Cooperative Oncology Group E3404 study
    Sandra J Horning
    Department of Medicine, Stanford University, CA, USA
    Blood 115:775-7; quiz 918. 2010
    ..This trial was registered at www.clinicaltrials.gov as #NCT00274924 [corrected]...
  31. ncbi request reprint Bruton tyrosine kinase inhibitors: a promising novel targeted treatment for B cell lymphomas
    Amin Aalipour
    Stanford University Medical Center, Stanford, CA, USA
    Br J Haematol 163:436-43. 2013
    ..Recent clinical data suggest significant activity of ibrutinib as a first in class oral inhibitor of BTK. This review provides an overview of ongoing clinical studies of BTK inhibitors...
  32. pmc In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study
    Joshua D Brody
    269 Campus Dr CCSR rm 1105, Stanford, CA 94305, USA
    J Clin Oncol 28:4324-32. 2010
    ..In a preclinical lymphoma model, intratumoral injection of a Toll-like receptor 9 (TLR9) agonist induced systemic antitumor immunity and cured large, disseminated tumors...
  33. ncbi request reprint Beyond the guidelines in the treatment of peripheral T-cell lymphoma: new drug development
    Andy I Chen
    Division of Oncology, Stanford University Medical Center, Stanford, California
    J Natl Compr Canc Netw 6:428-35. 2008
    ..These efforts are ongoing and will hopefully guide new strategies to improve the historically poor outcome of PTCL...
  34. ncbi request reprint Staging accuracy in mycosis fungoides and sezary syndrome using integrated positron emission tomography and computed tomography
    Eunice Y Tsai
    Department of Dermatology, Stanford University School of Medicine, Stanford, Calif, USA
    Arch Dermatol 142:577-84. 2006
    ..To evaluate the usefulness of integrated positron emission tomography and computed tomography (PET/CT) in staging mycosis fungoides (MF) and Sézary syndrome and to correlate PET/CT data with histopathologic diagnosis of lymph nodes (LNs)...
  35. doi request reprint Extranodal natural killer/T-cell lymphoma: current concepts in biology and treatment
    Holbrook Kohrt
    Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Leuk Lymphoma 50:1773-84. 2009
    ..International and multicenter clinical trials are needed for this rare and aggressive disease...
  36. ncbi request reprint A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C alpha, administered as a 21-day infusion to patients with advanced ovarian carcinoma
    Ranjana Advani
    Oncology Division, Stanford University Medical Center, 269 Campus Drive, Stanford, CA 94305 5151, USA
    Cancer 100:321-6. 2004
    ..In a previous Phase I trial, the authors demonstrated the safety and some evidence of activity in ovarian carcinoma of aprinocarsen administered as a 21-day, continuous, intravenous infusion...
  37. pmc Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines
    Ashley A Powell
    Department of Surgery, Stanford University School of Medicine, Stanford, California, USA
    PLoS ONE 7:e33788. 2012
    ..Here we demonstrate feasibility of performing high dimensional single CTC profiling, providing early insight into CTC heterogeneity and allowing comparisons to breast cancer cell lines widely used for drug discovery...
  38. doi request reprint Targeting CD40 in Waldenström's macroglobulinemia
    Mark Lee
    Oncology Division, Stanford University Medical Center, Stanford, CA 94305, USA
    Clin Lymphoma Myeloma 9:87-9. 2009
    ..These observations support the testing of CD40-targeted agents in WM...
  39. doi request reprint Indolent primary cutaneous B-cell lymphoma: experience using systemic rituximab
    Anjali V Morales
    Multidisciplinary Cutaneous Lymphoma Program, Stanford Comprehensive Cancer Center, Stanford, California 94305, USA
    J Am Acad Dermatol 59:953-7. 2008
    ..Rituximab is a chimeric monoclonal IgG1 antibody directed against the CD20 antigen of B cells. Clinical efficacy of systemic rituximab in CBCL has yet to be established...
  40. ncbi request reprint Cutaneous involvement by angioimmunoblastic T-cell lymphoma: a unique histologic presentation, mimicking an infectious etiology
    Anu G Jayaraman
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305 5324, USA
    J Cutan Pathol 33:6-11. 2006
    ....
  41. ncbi request reprint Phase I and pharmacokinetic study of BMS-188797, a new taxane analog, administered on a weekly schedule in patients with advanced malignancies
    Ranjana Advani
    Oncology Division, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Clin Cancer Res 9:5187-94. 2003
    ..The purpose of this study was to establish the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), and preliminary activity of BMS-188797 administered weekly...
  42. ncbi request reprint Dynamic CD8 T-cell responses to tumor-associated Epstein-Barr virus antigens in patients with Epstein-Barr virus-negative Hodgkin's disease
    Holbrook Kohrt
    Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA
    Oncol Res 18:287-92. 2009
    ..Our observation challenges prior belief that patients with HD remain immunodeficient following therapy and argues that the clinical significance of the EBV-specific immune response in EBV-negative HD should be further investigated...
  43. ncbi request reprint Treatment of mantle cell lymphoma: current approach and future directions
    Joshua Brody
    Department of Medicine, Division of Oncology, Stanford University Medical Center, Clinical Cancer Center, 875 Blake Wilbur Drive, Stanford, CA 94305, USA
    Crit Rev Oncol Hematol 58:257-65. 2006
    ....
  44. ncbi request reprint Multicenter clinical trial of bortezomib in relapsed/refractory Waldenstrom's macroglobulinemia: results of WMCTG Trial 03-248
    Steven P Treon
    Bing Center for Waldenstrom s Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Clin Cancer Res 13:3320-5. 2007
    ..Waldenstrom's macroglobulinemia (WM) is a B-cell disorder. Despite advances in the therapy, WM remains incurable. As such, novel therapeutic agents are needed for the treatment of WM...
  45. ncbi request reprint Splenic diffuse large B-cell lymphoma in a patient with type 1 Gaucher disease: Diagnostic and therapeutic challenges
    Joshua D Brody
    Ann Hematol 85:817-20. 2006