Ranjana H Advani
Affiliation: Stanford University
- Angioimmunoblastic T cell lymphoma: treatment experience with cyclosporineRanjana Advani
Stanford University Medical Center, Stanford, CA 94305 5821, USA
Leuk Lymphoma 48:521-5. 2007..By interrupting T-cell activation, CsA may alter the immune dysregulation that characterizes AILT. The efficacy of CsA is being explored in patients with recurrent AILT in a prospective trial (ECOG 2402)...
- Lymphoma cell VEGFR2 expression detected by immunohistochemistry predicts poor overall survival in diffuse large B cell lymphoma treated with immunochemotherapy (R-CHOP)Dita Gratzinger
Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
Br J Haematol 148:235-44. 2010..In contrast to our prior results with chemotherapy alone, microvessel density was not prognostic of PFS or OS with R-CHOP-like therapy...
- A phase II study of dacetuzumab (SGN-40) in patients with relapsed diffuse large B-cell lymphoma (DLBCL) and correlative analyses of patient-specific factorsSven de Vos
David Geffen School of Medicine at UCLA, University of California Los Angeles, 650 Charles E, Young Drive 11 934 Factor Bldg, Los Angeles, CA 90095 1678, USA
J Hematol Oncol 7:44. 2014..Dacetuzumab (SGN-40), a non-blocking, partial agonist, humanized IgG1, anti-CD40 monoclonal antibody, has previously demonstrated anti-lymphoma activity in a phase I study...
- Retreatment with brentuximab vedotin in patients with CD30-positive hematologic malignanciesNancy L Bartlett
Washington University Medical School, St Louis, MO, USA
J Hematol Oncol 7:24. 2014..gov NCT00947856)...
- Efficacy of abbreviated Stanford V chemotherapy and involved-field radiotherapy in early-stage Hodgkin lymphoma: mature results of the G4 trialR H Advani
Departments of Medicine Oncology, Stanford University Medical Center, 875 Blake Wilbur Drive, CC 2338, Stanford, CA 94305, USA
Ann Oncol 24:1044-8. 2013..Stanford V chemotherapy was administered for 8 weeks followed by radiation therapy (RT) 30 Gy to involved fields (IF). Freedom from progression (FFP), disease-specific survival (DSS) and overall survival (OS) were estimated...
- Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignanciesRanjana H Advani
Stanford University Medical Center, Stanford, CA 94305 5821, USA
J Clin Oncol 31:88-94. 2013..We evaluated ibrutinib (PCI-32765), a small-molecule irreversible inhibitor of BTK, in patients with B-cell malignancies...
- Interim-treatment quantitative PET parameters predict progression and death among patients with Hodgkin's diseaseDiane Tseng
Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Dr, Stanford, CA 94305, USA
Radiat Oncol 7:5. 2012..We hypothesized that quantitative PET parameters may have predictive value beyond that of traditional clinical factors such as the International Prognostic Score (IPS) among Hodgkin's disease (HD) patients...
- Stage I-IIA non-bulky Hodgkin's lymphoma. Is further distinction based on prognostic factors useful? The Stanford experienceRanjana H Advani
Department of Medicine, Division of Medical Oncology, Stanford University Medical Center, Stanford, California 94305, USA
Int J Radiat Oncol Biol Phys 81:1374-9. 2011..We sought to determine the prognostic significance of these factors in patients with early-stage disease treated at Stanford University Medical Center...
- Impact of positive positron emission tomography on prediction of freedom from progression after Stanford V chemotherapy in Hodgkin's diseaseRanjana Advani
Stanford University Comprehensive Cancer Center, Stanford, CA 94305, USA
J Clin Oncol 25:3902-7. 2007..To correlate [(18)F]fluorodeoxyglucose positron emission tomography ([(18)F]FDG-PET) status after chemotherapy, but before radiation, with outcome in patients treated with the Stanford V regimen...
- A phase I trial of aprinocarsen (ISIS 3521/LY900003), an antisense inhibitor of protein kinase C-alpha administered as a 24-hour weekly infusion schedule in patients with advanced cancerRanjana Advani
Oncology Division, Stanford University School of Medicine, Stanford, CA 94305 5151, USA
Invest New Drugs 23:467-77. 2005..A phase I study was performed to determine the maximum tolerated dose (MTD), safety profile and pharmacology of aprinocarsen (ISIS 3521), an antisense oligonucleotide to protein kinase C-alpha, in patients with refractory solid tumors...
- Comparison of conventional prognostic indices in patients older than 60 years with diffuse large B-cell lymphoma treated with R-CHOP in the US Intergroup Study (ECOG 4494, CALGB 9793): consideration of age greater than 70 years in an elderly prognostic inRanjana H Advani
Stanford University, Stanford, CA 94305, USA
Br J Haematol 151:143-51. 2010..The prognostic discrimination provided by the E-IPI for low and low-intermediate elderly DLBCL patients needs validation by other datasets...
- Voreloxin, a first-in-class anticancer quinolone derivative, in relapsed/refractory solid tumors: a report on two dosing schedulesRanjana H Advani
Stanford University Medical Center, Stanford, California, USA
Clin Cancer Res 16:2167-75. 2010..We report the phase 1 experience of voreloxin in patients with relapsed/refractory solid tumors, including dose-limiting toxicity (DLT), maximum-tolerated dose (MTD), pharmacokinetics, and clinical activity...
- Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphomaRanjana Advani
Division of Oncology, Stanford University Medical Center, 875 Blake Wilbur Dr, Stanford, CA 94305, USA
J Clin Oncol 27:4371-7. 2009..To evaluate the safety, maximum-tolerated dose (MTD), pharmacokinetics, and antitumor activity of dacetuzumab in patients with refractory or recurrent B-cell non-Hodgkin's lymphoma (NHL)...
- Optimal therapy of advanced Hodgkin lymphomaRanjana Advani
Stanford University Medical Center, Stanford, CA 94305, USA
Hematology Am Soc Hematol Educ Program 2011:310-6. 2011..Lastly, the expanding population of survivors cured of HL outnumbers patients with the disease and needs to be monitored for therapy-related late effects...
- Stage I and II follicular non-Hodgkin's lymphoma: long-term follow-up of no initial therapyRanjana Advani
Division of Oncology, Department of Medicine, Stanford University Medical Center, 875 Blake Wilber Drive, Stanford, CA 94305, USA
J Clin Oncol 22:1454-9. 2004....
- Management of advanced stage Hodgkin lymphomaRanjana Advani
Stanford University Medical Center, Stanford, California 94305, USA
J Natl Compr Canc Netw 4:241-7. 2006....
- Risk of therapy-related secondary leukemia in Hodgkin lymphoma: the Stanford University experience over three generations of clinical trialsMichael Zach Koontz
Stanford University Medical Center, 875 Blake Wilbur Dr, CC 2338, Stanford, CA 94305, USA
J Clin Oncol 31:592-8. 2013..To assess therapy-related acute myeloid leukemia/myelodysplastic syndrome (t-AML/MDS) risk in patients treated for Hodgkin lymphoma (HL) on successive generations of Stanford clinical trials...
- Mature results of a phase II study of rituximab therapy for nodular lymphocyte-predominant Hodgkin lymphomaRanjana H Advani
Ranjana H Advani, Sandra J Horning, Richard T Hoppe, Sarah Daadi, John Allen, and Yasodha Natkunam, Stanford University Medical Center, Stanford, CA and Nancy L Bartlett, Washington University School of Medicine, St Louis, MO
J Clin Oncol 32:912-8. 2014..Universal expression of CD20 by malignant cells in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) led us to evaluate rituximab (R) as a therapeutic option...
- Phase I trial of oblimersen (Genasense®) and gemcitabine in refractory and advanced malignanciesPeter S Galatin
Department of Medicine, Oncology, Stanford University School of Medicine, Stanford, CA, USA
Invest New Drugs 29:971-7. 2011..The present study was designed to determine the maximum tolerated dose (MTD) of oblimersen (antisense Bcl-2) and gemcitabine when administered to patients with refractory malignancies...
- Paraffin-based 6-gene model predicts outcome in diffuse large B-cell lymphoma patients treated with R-CHOPRaquel Malumbres
Department of Medicine, Division of Hematology Oncology and Molecular and Cellular Pharmacology, Sylvester Comprehensive Cancer Center, University of Miami, FL 33136, USA
Blood 111:5509-14. 2008..008). These findings demonstrate that the prognostic value of the 6-gene model remains significant in the era of R-CHOP treatment and that the model can be applied to routine FFPE tissue from initial diagnostic biopsies...
- Improvements in observed and relative survival in follicular grade 1-2 lymphoma during 4 decades: the Stanford University experienceDaryl Tan
Department of Medicine, Oncology Division, Stanford University, Stanford, CA 94305, USA
Blood 122:981-7. 2013..Several factors, including better supportive care and effective therapies for relapsed disease, are likely responsible for this improvement. ..
- In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 studyYoun H Kim
Department of Dermatology, Stanford University School of Medicine, CA, USA
Blood 119:355-63. 2012..This study is registered at www.clinicaltrials.gov as NCT00226993...
- Current concepts and controversies in the management of early stage Hodgkin lymphomaLauren S Maeda
Department of Medicine Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Leuk Lymphoma 52:962-71. 2011..The collective goal is to further refine current stratification strategies to allow for an individualized, risk-adapted treatment approach that minimizes long-term late effects without compromising high cure rates...
- The emerging role for rituximab in the treatment of nodular lymphocyte predominant Hodgkin lymphomaLauren S Maeda
Department of Medicine Oncology, Stanford University School of Medicine, Stanford, California, USA
Curr Opin Oncol 21:397-400. 2009..The reliable expression of CD20 has led to the evaluation of the chimeric monoclonal anti-CD20 antibody rituximab in several recent trials...
- Evaluation and management of angioimmunoblastic T-cell lymphoma: a review of current approaches and future strategiesAsh A Alizadeh
Division of Hematology and Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Clin Adv Hematol Oncol 6:899-909. 2008..Finally, we discuss recent clinical trials and novel treatment approaches in the management of patients with AITL...
- Phase II study of gefitinib, fluorouracil, leucovorin, and oxaliplatin therapy in previously treated patients with metastatic colorectal cancerTimothy Kuo
Oncology Division, Department of Medicine, Stanford University School of Medicine, 269 Campus Dr, CCSR 1105, Stanford, CA 94305 5151, USA
J Clin Oncol 23:5613-9. 2005..To investigate the gefitinib, fluorouracil (FU), leucovorin, and oxaliplatin regimen (IFOX) in previously treated patients with metastatic colorectal cancer...
- Bevacizumab and cyclosphosphamide, doxorubicin, vincristine and prednisone in combination for patients with peripheral T-cell or natural killer cell neoplasms: an Eastern Cooperative Oncology Group study (E2404)Kristen Ganjoo
Stanford University, Stanford, CA, USA
Leuk Lymphoma 55:768-72. 2014..Studies of novel therapeutics are needed for this patient population, whose clinical outcome remains poor...
- Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironmentAsh A Alizadeh
Department of Medicine, Division of Oncology, Stanford University, Stanford, CA, USA
Blood 118:1350-8. 2011..We conclude that the measurement of a single gene expressed by tumor cells (LMO2) and a single gene expressed by the immune microenvironment (TNFRSF9) powerfully predicts overall survival in patients with DLBCL...
- Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a phase III trial (E2995)Peter L Greenberg
Hematology Division, Stanford University Medical Center, 703 Welch Rd, Suite G 1, Stanford, CA 94305, USA
J Clin Oncol 22:1078-86. 2004....
- Non-Hodgkin lymphoma of the breastKristen Ganjoo
Department of Medical Oncology, Stanford University, Stanford, California, USA
Cancer 110:25-30. 2007..A retrospective study was done to evaluate the institutional experience in this patient population...
- Interim positron emission tomography scans in diffuse large B-cell lymphoma: an independent expert nuclear medicine evaluation of the Eastern Cooperative Oncology Group E3404 studySandra J Horning
Department of Medicine, Stanford University, CA, USA
Blood 115:775-7; quiz 918. 2010..This trial was registered at www.clinicaltrials.gov as #NCT00274924 [corrected]...
- Prognostic factors in primary cutaneous anaplastic large cell lymphoma: characterization of clinical subset with worse outcomeDenise K Woo
Department of Dermatology, Stanford University, Stanford, CA 94305, USA
Arch Dermatol 145:667-74. 2009....
- Bruton tyrosine kinase inhibitors: a promising novel targeted treatment for B cell lymphomasAmin Aalipour
Stanford University Medical Center, Stanford, CA, USA
Br J Haematol 163:436-43. 2013..Recent clinical data suggest significant activity of ibrutinib as a first in class oral inhibitor of BTK. This review provides an overview of ongoing clinical studies of BTK inhibitors...
- In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II studyJoshua D Brody
269 Campus Dr CCSR rm 1105, Stanford, CA 94305, USA
J Clin Oncol 28:4324-32. 2010..In a preclinical lymphoma model, intratumoral injection of a Toll-like receptor 9 (TLR9) agonist induced systemic antitumor immunity and cured large, disseminated tumors...
- Beyond the guidelines in the treatment of peripheral T-cell lymphoma: new drug developmentAndy I Chen
Division of Oncology, Stanford University Medical Center, Stanford, California
J Natl Compr Canc Netw 6:428-35. 2008..These efforts are ongoing and will hopefully guide new strategies to improve the historically poor outcome of PTCL...
- Staging accuracy in mycosis fungoides and sezary syndrome using integrated positron emission tomography and computed tomographyEunice Y Tsai
Department of Dermatology, Stanford University School of Medicine, Stanford, Calif, USA
Arch Dermatol 142:577-84. 2006..To evaluate the usefulness of integrated positron emission tomography and computed tomography (PET/CT) in staging mycosis fungoides (MF) and Sézary syndrome and to correlate PET/CT data with histopathologic diagnosis of lymph nodes (LNs)...
- A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C alpha, administered as a 21-day infusion to patients with advanced ovarian carcinomaRanjana Advani
Oncology Division, Stanford University Medical Center, 269 Campus Drive, Stanford, CA 94305 5151, USA
Cancer 100:321-6. 2004..In a previous Phase I trial, the authors demonstrated the safety and some evidence of activity in ovarian carcinoma of aprinocarsen administered as a 21-day, continuous, intravenous infusion...
- Extranodal natural killer/T-cell lymphoma: current concepts in biology and treatmentHolbrook Kohrt
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Leuk Lymphoma 50:1773-84. 2009..International and multicenter clinical trials are needed for this rare and aggressive disease...
- Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell linesAshley A Powell
Department of Surgery, Stanford University School of Medicine, Stanford, California, USA
PLoS ONE 7:e33788. 2012..Here we demonstrate feasibility of performing high dimensional single CTC profiling, providing early insight into CTC heterogeneity and allowing comparisons to breast cancer cell lines widely used for drug discovery...
- Targeting CD40 in Waldenström's macroglobulinemiaMark Lee
Oncology Division, Stanford University Medical Center, Stanford, CA 94305, USA
Clin Lymphoma Myeloma 9:87-9. 2009..These observations support the testing of CD40-targeted agents in WM...
- Indolent primary cutaneous B-cell lymphoma: experience using systemic rituximabAnjali V Morales
Multidisciplinary Cutaneous Lymphoma Program, Stanford Comprehensive Cancer Center, Stanford, California 94305, USA
J Am Acad Dermatol 59:953-7. 2008..Rituximab is a chimeric monoclonal IgG1 antibody directed against the CD20 antigen of B cells. Clinical efficacy of systemic rituximab in CBCL has yet to be established...
- Treatment of mantle cell lymphoma: current approach and future directionsJoshua Brody
Department of Medicine, Division of Oncology, Stanford University Medical Center, Clinical Cancer Center, 875 Blake Wilbur Drive, Stanford, CA 94305, USA
Crit Rev Oncol Hematol 58:257-65. 2006....
- Phase I and pharmacokinetic study of BMS-188797, a new taxane analog, administered on a weekly schedule in patients with advanced malignanciesRanjana Advani
Oncology Division, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Clin Cancer Res 9:5187-94. 2003..The purpose of this study was to establish the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), and preliminary activity of BMS-188797 administered weekly...
- Cutaneous involvement by angioimmunoblastic T-cell lymphoma: a unique histologic presentation, mimicking an infectious etiologyAnu G Jayaraman
Department of Pathology, Stanford University Medical Center, Stanford, California 94305 5324, USA
J Cutan Pathol 33:6-11. 2006....
- Dynamic CD8 T-cell responses to tumor-associated Epstein-Barr virus antigens in patients with Epstein-Barr virus-negative Hodgkin's diseaseHolbrook Kohrt
Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA
Oncol Res 18:287-92. 2009..Our observation challenges prior belief that patients with HD remain immunodeficient following therapy and argues that the clinical significance of the EBV-specific immune response in EBV-negative HD should be further investigated...
- Multicenter clinical trial of bortezomib in relapsed/refractory Waldenstrom's macroglobulinemia: results of WMCTG Trial 03-248Steven P Treon
Bing Center for Waldenstrom s Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Clin Cancer Res 13:3320-5. 2007..Waldenstrom's macroglobulinemia (WM) is a B-cell disorder. Despite advances in the therapy, WM remains incurable. As such, novel therapeutic agents are needed for the treatment of WM...
- Splenic diffuse large B-cell lymphoma in a patient with type 1 Gaucher disease: Diagnostic and therapeutic challengesJoshua D Brody
Ann Hematol 85:817-20. 2006