F Z Stanczyk

Summary

Country: USA

Publications

  1. ncbi Effect of oral versus transdermal steroidal contraceptives on androgenic markers
    Terry White
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of South California Keck School of Medicine, Los Angeles, USA
    Am J Obstet Gynecol 192:2055-9. 2005
  2. ncbi Gestodene: a review of its pharmacology, potency and tolerability in combined contraceptive preparations
    Frank Z Stanczyk
    University of Southern California Keck School of Medicine, Los Angeles, CA, USA Electronic address
    Contraception 89:242-52. 2014
  3. doi Effect of finasteride on serum levels of androstenedione, testosterone and their 5α-reduced metabolites in men at risk for prostate cancer
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, United States Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, United States Electronic address
    J Steroid Biochem Mol Biol 138:10-6. 2013
  4. doi Dexamethasone suppressibility and adrenal and ovarian venous effluents of 5α-reduced C19 conjugates in hyperandrogenic women
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, CA, United States Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, United States Electronic address
    J Steroid Biochem Mol Biol 139:73-7. 2014
  5. doi Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment
    Frank Z Stanczyk
    Departments of Obstetrics and Gynecology and Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Contraception 87:706-27. 2013
  6. doi Therapeutically equivalent pharmacokinetic profile across three application sites for AG200-15, a novel low-estrogen dose contraceptive patch
    Frank Z Stanczyk
    University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    Contraception 87:744-9. 2013
  7. pmc Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Livingston Research Building, 1321 North Mission Road, Room 201, Los Angeles, California 90033, USA
    Endocr Rev 34:171-208. 2013
  8. pmc Prospective case-control study of premenopausal serum estradiol and testosterone levels and breast cancer risk
    Joanne F Dorgan
    Fox Chase Cancer Center, hiladelphia, PA 19111, USA
    Breast Cancer Res 12:R98. 2010
  9. ncbi Measurement of androgens in women
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Semin Reprod Med 24:78-85. 2006
  10. doi Limitations of direct immunoassays for measuring circulating estradiol levels in postmenopausal women and men in epidemiologic studies
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Epidemiol Biomarkers Prev 19:903-6. 2010

Detail Information

Publications113 found, 100 shown here

  1. ncbi Effect of oral versus transdermal steroidal contraceptives on androgenic markers
    Terry White
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of South California Keck School of Medicine, Los Angeles, USA
    Am J Obstet Gynecol 192:2055-9. 2005
    ..The purpose of this study was to compare biochemical androgen profiles in women treated with the contraceptive patch versus an oral contraceptive (OC)...
  2. ncbi Gestodene: a review of its pharmacology, potency and tolerability in combined contraceptive preparations
    Frank Z Stanczyk
    University of Southern California Keck School of Medicine, Los Angeles, CA, USA Electronic address
    Contraception 89:242-52. 2014
    ..In this review we present an overview of the pharmacology, potency and tolerability of gestodene...
  3. doi Effect of finasteride on serum levels of androstenedione, testosterone and their 5α-reduced metabolites in men at risk for prostate cancer
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, United States Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, United States Electronic address
    J Steroid Biochem Mol Biol 138:10-6. 2013
    ..3%). The present data suggest that either 3α-diol G or DHT S may serve as a potential diagnostic marker of intraprostatic 5α-reductase activity during treatment of patients with 5α-reductase inhibitors. ..
  4. doi Dexamethasone suppressibility and adrenal and ovarian venous effluents of 5α-reduced C19 conjugates in hyperandrogenic women
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, CA, United States Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, United States Electronic address
    J Steroid Biochem Mol Biol 139:73-7. 2014
    ..However, since no adrenal or ovarian vein gradient exists, these markers of the manifestations of androgen excess largely reflect peripheral androgen metabolism. ..
  5. doi Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment
    Frank Z Stanczyk
    Departments of Obstetrics and Gynecology and Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Contraception 87:706-27. 2013
    ..This review provides a brief summary of the pharmacology of EE and E₂, including metabolism, pharmacokinetics and pharmacodynamics, as well as adverse effects of these estrogens...
  6. doi Therapeutically equivalent pharmacokinetic profile across three application sites for AG200-15, a novel low-estrogen dose contraceptive patch
    Frank Z Stanczyk
    University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    Contraception 87:744-9. 2013
    ..This study determined whether application of the AP to three different anatomical sites (lower abdomen, buttock and upper torso) influences the pharmacokinetic profile of EE and levonorgestrel (LNG)...
  7. pmc Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Livingston Research Building, 1321 North Mission Road, Room 201, Los Angeles, California 90033, USA
    Endocr Rev 34:171-208. 2013
    ....
  8. pmc Prospective case-control study of premenopausal serum estradiol and testosterone levels and breast cancer risk
    Joanne F Dorgan
    Fox Chase Cancer Center, hiladelphia, PA 19111, USA
    Breast Cancer Res 12:R98. 2010
    ..The objective of this study was to determine whether estradiol and testosterone levels in serum collected before menopause are associated with subsequent breast cancer risk...
  9. ncbi Measurement of androgens in women
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Semin Reprod Med 24:78-85. 2006
    ..Androgens also can be measured in saliva, but major methodologic problems are associated with the measurements. In addition, there is a misconception that salivary testosterone levels reflect free testosterone levels in serum...
  10. doi Limitations of direct immunoassays for measuring circulating estradiol levels in postmenopausal women and men in epidemiologic studies
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Epidemiol Biomarkers Prev 19:903-6. 2010
    ..Instead, we recommend the use of a well-validated RIA with purification steps to improve sensitivity and specificity and to help achieve the necessary accuracy and reliability needed for epidemiologic studies...
  11. ncbi Diagnosis of hyperandrogenism: biochemical criteria
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Women s and Children s Hospital, Room 1M2, 1240 North Mission Road, Los Angeles, CA 90033, USA
    Best Pract Res Clin Endocrinol Metab 20:177-91. 2006
    ..However, distal metabolites of DHT have been shown to be good markers of clinical manifestations of hirsutism, acne and alopecia. Assays for these peripheral markers need improvement for routine clinical testing...
  12. ncbi Standardization of steroid hormone assays: why, how, and when?
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Women s and Children s Hospital, Room 1M2, 1240 North Mission Road, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 16:1713-9. 2007
    ..These criteria would allow validation of sensitivity, specificity, precision, and accuracy of current steroid hormone assay methodology and provide surrogates until a true gold standard can be developed...
  13. doi Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term oral dehydroepiandrosterone treatment in postmenopausal women
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Menopause 16:272-8. 2009
    ..We investigated the pharmacokinetics of dehydroepiandrosterone and its relevant metabolites after prolonged treatment of postmenopausal women with 25 mg/d of dehydroepiandrosterone...
  14. ncbi Percutaneous administration of progesterone: blood levels and endometrial protection
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Menopause 12:232-7. 2005
    ..In contrast to progesterone creams, progesterone gels are water-soluble and appear to enter the microcirculation rapidly, thus giving rise to elevated serum progesterone levels with progesterone doses comparable to those used in creams...
  15. ncbi Pharmacokinetics and potency of progestins used for hormone replacement therapy and contraception
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, and Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Rev Endocr Metab Disord 3:211-24. 2002
  16. ncbi Comparison of estrogen and androgen levels after oral estrogen replacement therapy
    C C Slater
    Department of Obstetrics and Gynecology, Atherosclerosis Research Unit, Division of Cardiology, Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    J Reprod Med 46:1052-6. 2001
    ....
  17. ncbi Do urinary estrogen metabolites reflect the differences in breast cancer risk between Singapore Chinese and United States African-American and white women?
    G Ursin
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Suite 4407, Los Angeles, CA 90089, USA
    Cancer Res 61:3326-9. 2001
    ....
  18. pmc Altered balance between the 5 alpha-reductase and aromatase pathways of androgen metabolism during controlled ovarian hyperstimulation with human menopausal gonadotropins
    C C Slater
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    J Assist Reprod Genet 18:527-33. 2001
    ..To evaluate androgen production and metabolism during controlled ovarian hyperstimulation...
  19. ncbi Ovarian androgen production in postmenopausal women
    Robin H Fogle
    Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA 90033, USA
    J Clin Endocrinol Metab 92:3040-3. 2007
    ..Several studies previously reported that the postmenopausal ovary produces androgens. However, these findings have recently been questioned in a group of women with adrenal insufficiency...
  20. ncbi Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian-American men
    A H Wu
    Departments of Preventive Medicine, University of Southern California, Los Angeles, California 90089 0251, USA
    Cancer Epidemiol Biomarkers Prev 10:533-8. 2001
    ..This difference may be related to the lower prostate cancer risk in Asian-Americans...
  21. pmc Effect of statins on estrogen and androgen levels in postmenopausal women treated with estradiol
    A Peck
    Departments of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90093, USA
    Climacteric 14:49-53. 2011
    ..We investigated whether long-term administration of statins had an effect on serum estrogen and androgen levels in postmenopausal women receiving and not receiving oral estrogen therapy...
  22. ncbi Markedly elevated levels of estrone sulfate after long-term oral, but not transdermal, administration of estradiol in postmenopausal women
    C C Slater
    Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, USA
    Menopause 8:200-3. 2001
    ..This difference may be attributed to the higher dosage of oral E2 that is required because of the low bioavailability compared with the transdermal dosages...
  23. ncbi Pharmacokinetics of testosterone after percutaneous gel or buccal administration
    C C Slater
    Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    Fertil Steril 76:32-7. 2001
    ..To determine the pharmacokinetics of testosterone following its administration using transdermal gel or buccal lozenges...
  24. ncbi Pregnancy, the postpartum, and steroid hormones: effects on cognition and mood
    J G Buckwalter
    Andrus Gerontology Center, University of Southern California, Los Angeles 90089, USA
    Psychoneuroendocrinology 24:69-84. 1999
    ..Studies beginning earlier in pregnancy and continuing for an extended period of time after delivery are needed to confirm and expand these observations...
  25. ncbi Racial/ethnic differences in postmenopausal endogenous hormones: the multiethnic cohort study
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 15:1849-55. 2006
    ..Many of the differences in endogenous postmenopausal hormonal milieu across these five racial/ethnic groups are consistent with the known differences in breast cancer incidence across these populations...
  26. pmc Ethnic differences in post-menopausal plasma oestrogen levels: high oestrone levels in Japanese-American women despite low weight
    N M Probst Hensch
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90033, USA
    Br J Cancer 82:1867-70. 2000
    ..There was little ethnic difference in E2 levels. In conclusion, post-menopausal plasma oestrogen levels in Japanese-American women are at least as high as those in Whites...
  27. pmc Effects of soy foods on ovarian function in premenopausal women
    A H Wu
    Department of Preventive Medicine, University of Southern California, School of Medicine, Los Angeles, USA
    Br J Cancer 82:1879-86. 2000
    ....
  28. ncbi Is there evidence for preferential delivery of ovarian estradiol to the endometrium?
    D E Tourgeman
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Fertil Steril 75:1156-8. 2001
    ..To determine the direction of delivery of E(2) in the female pelvis by assessing the ratio of endometrial to serum E(2) in women whose ovaries were stimulated to produce E(2) with women who received exogenous E(2)...
  29. pmc Relations between endogenous androgens and estrogens in postmenopausal women with suspected ischemic heart disease
    Glenn D Braunstein
    Department of Medicine, Room 2119, Plaza Level, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 93:4268-75. 2008
    ..If so, then epidemiologic studies that examine the association between androgens and pathological processes should adjust the results for the independent effect of estrogens...
  30. pmc Increases in serum estrone sulfate level are associated with increased mammographic density during menopausal hormone therapy
    Carolyn J Crandall
    David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90024, USA
    Cancer Epidemiol Biomarkers Prev 17:1674-81. 2008
    ..Menopausal hormone therapy increases mammographic density. We determined whether increases in serum estrone sulfate (E(1)S) levels during menopausal hormone therapy predict increased mammographic density...
  31. ncbi Does St. John's wort interfere with the antiandrogenic effect of oral contraceptive pills?
    Robin H Fogle
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Women s and Children s Hospital, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Contraception 74:245-8. 2006
    ..We investigated whether the simultaneous use of SJW with OCPs resulted in elevated serum androgen levels with implications of impaired OCP treatment of hirsutism and acne...
  32. pmc An association between a common variant (G972R) in the IRS-1 gene and sex hormone levels in post-menopausal breast cancer survivors
    Jing Fan
    Integrated Substance Abuse Programs, Neuropsychiatric Institute, University of California, 1640 S Sepulveda Boulevard, Suite 200, Los Angeles, CA 90025, USA
    Breast Cancer Res Treat 99:323-31. 2006
    ..02). No association was present for white patients. Our findings provide suggestive evidence that IRS-1 G972R variant may be associated with circulating levels of sex hormones and SHBG in African American breast cancer survivors...
  33. ncbi Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term daily oral administration to healthy young men
    Brian D Acacio
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Fertil Steril 81:595-604. 2004
    ..To determine the effects of dehydroepiandrosterone (DHEA) supplementation on the pharmacokinetics of DHEA and its metabolites and the reproductive axis of healthy young men...
  34. ncbi Does elevated body mass modify the influence of postmenopausal estrogen replacement on atherosclerosis progression: results from the estrogen in the prevention of atherosclerosis trial
    Wendy J Mack
    Department of Preventive Medicine, University of Southern California, Los Angeles, USA
    Atherosclerosis 168:91-8. 2003
    ..To determine whether the estrogen-related reduction in atherosclerosis progression demonstrated in the estrogen in the prevention of atherosclerosis trial (EPAT) is modified by body mass index (BMI)...
  35. ncbi Limitations of direct estradiol and testosterone immunoassay kits
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, Women s and Children s Hospital, 1240 N Mission Road, Room 1M2, Los Angeles, CA 90033, USA
    Steroids 68:1173-8. 2003
    ....
  36. ncbi All progestins are not created equal
    Frank Z Stanczyk
    Departments of Obstetrics and Gynecology, and Preventive Medicine, University of Southern California Keck School of Medicine, Women s and Children s Hospital, 1240 N Mission Road, Los Angeles, CA 90033, USA
    Steroids 68:879-90. 2003
    ..Progestins differ widely in their chemical structures, structure-function relationships, metabolism, pharmacokinetics, and potencies; they are not created equal...
  37. ncbi Biologic effects of 17 alpha-dihydroequilin sulfate
    J G Wilcox
    University of Southern California School of Medicine, Los Angeles, USA
    Fertil Steril 66:748-52. 1996
    ..To determine the independent biologic effects of 17 alpha-dihydroequilin sulfate...
  38. ncbi Androgens modulate beta-amyloid levels in male rat brain
    M Ramsden
    Andrus Gerontology Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 0191, USA
    J Neurochem 87:1052-5. 2003
    ..These findings suggest that age-related androgen depletion may result in accumulation of Abeta in the male brain and thereby act as a risk factor for the development of AD...
  39. ncbi Plasma progesterone, dehydroepiandrosterone sulfate and estriol levels during labor induction with a sustained-release prostaglandin E2 vaginal insert
    N Goharkhay
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, USA
    J Matern Fetal Med 10:197-202. 2001
    ..Additional studies are needed to substantiate the decrease in progesterone levels observed in this study and the importance of this phenomenon for the mechanism of labor induction with prostaglandin E2...
  40. ncbi The effect of transdermal and vaginal estrogen therapy on markers of postmenopausal estrogen status
    Pratima Gupta
    Departments of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Menopause 15:94-7. 2008
    ..5 microg of E2 per day...
  41. pmc Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women
    Roksana Karim
    Department of Pediatrics and Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Menopause 17:785-90. 2010
    ..It is not known how sex hormone concentrations relate to the markers of inflammation in postmenopausal women taking or not taking hormone therapy...
  42. pmc Relationship between serum levels of sex hormones and progression of subclinical atherosclerosis in postmenopausal women
    Roksana Karim
    Department of Pediatrics, Keck School of Medicine, University of Southern California, 1540 Alcazar Street, CHP Suite 222R, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 93:131-8. 2008
    ..Postmenopausal hormone therapy has been examined extensively in relation to cardiovascular disease. However, research relating serum levels of sex hormones to cardiovascular disease is sparse, and the results are inconclusive...
  43. pmc Pharmacokinetics of a combined oral contraceptive in obese and normal-weight women
    Carolyn L Westhoff
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10032, USA
    Contraception 81:474-80. 2010
    ..This study was conducted to compare oral contraceptive (OC) pharmacokinetics (PK) in normal-weight [body mass index (BMI) 19.0-24.9] and obese (BMI 30.0-39.9) women...
  44. doi Follicular development in a 7-day versus 4-day hormone-free interval with an oral contraceptive containing 20 mcg ethinyl estradiol and 1 mg norethindrone acetate
    Radhika D Rible
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Contraception 79:182-8. 2009
    ..This study evaluates differences in follicular development during a 7-day versus 4-day hormone-free interval in a COC regimen with 20 mcg EE and 1 mg norethindrone acetate...
  45. ncbi Dietary fiber intake and endogenous serum hormone levels in naturally postmenopausal Mexican American women: the Multiethnic Cohort Study
    Kristine R Monroe
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Nutr Cancer 58:127-35. 2007
    ..The suggestive findings relating increased estrogen levels to avocado and grapefruit intakes need confirmation...
  46. ncbi Accelerated endometrial maturation in the luteal phase of cycles utilizing controlled ovarian hyperstimulation: impact of gonadotropin-releasing hormone agonists versus antagonists
    Peyman Saadat
    Keck School of Medicine of the University of Southern California, Los Angeles, and Good Samaritan Hospital, Los Angeles, California 90033, USA
    Fertil Steril 82:167-71. 2004
    ....
  47. ncbi Effects of transdermal and oral contraceptives on estrogen-sensitive hepatic proteins
    Terry White
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Contraception 74:293-6. 2006
    ..The purpose of this study was to evaluate the effects of the contraceptive patch and an oral contraceptive (OC) on serum concentrations of estrogen-sensitive hepatic proteins, ethinyl estradiol (EE) and levonorgestrel (LNG)...
  48. pmc DHEA-S levels and cardiovascular disease mortality in postmenopausal women: results from the National Institutes of Health--National Heart, Lung, and Blood Institute (NHLBI)-sponsored Women's Ischemia Syndrome Evaluation (WISE)
    Chrisandra Shufelt
    Heart Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 95:4985-92. 2010
    ..Low levels have been associated with increased cardiovascular disease (CVD) risk and all-cause mortality, although these results have not been consistently replicated, particularly in women...
  49. doi Age-related changes in serum and brain levels of androgens in male Brown Norway rats
    Emily R Rosario
    Neuroscience Graduate Program, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Neuroreport 20:1534-7. 2009
    ..Collectively, these findings highlight differences in brain and circulating levels of androgens during aging, and identify an inverse correlation with beta-amyloid levels that may be relevant to Alzheimer's disease risk...
  50. doi Advantages and challenges of mass spectrometry assays for steroid hormones
    Frank Z Stanczyk
    Departments of Obstetrics and Gynecology, and Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    J Steroid Biochem Mol Biol 121:491-5. 2010
    ..The present review discusses the advantages of MS assays over conventional RIAs and direct immunoassays in steroid hormone measurements, and points out some of the important challenges facing the rapid increase in usage of MS assays...
  51. pmc Influence of age and obesity on serum estradiol, estrone, and sex hormone binding globulin concentrations following oral estrogen administration in postmenopausal women
    Roksana Karim
    Department of Pediatrics, University of Southern California, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 94:4136-43. 2009
    ..Risk of venous thrombosis and stroke is higher in older, overweight, and obese women using HT. However, the impact of age and obesity on estrogen concentrations among HT users is not well defined...
  52. pmc Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells
    Li Jia
    Department of Urology, Norris Cancer Center, USC Keck School of Medicine, Los Angeles, California, USA
    Mol Cell Biol 26:7331-41. 2006
    ..These features contribute to the androgen-independent phenotype of these cells...
  53. ncbi Soy intake and other lifestyle determinants of serum estrogen levels among postmenopausal Chinese women in Singapore
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
    Cancer Epidemiol Biomarkers Prev 11:844-51. 2002
    ..Current smokers showed significantly higher E(2) levels (28%) than nonsmokers (P = 0.04). These findings are discussed in relation to the recent doubling of breast cancer incidence among Chinese women in Singapore...
  54. ncbi Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling
    Qing Ji
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Cancer Res 64:7610-7. 2004
    ..We speculate that loss of AKR1C1 and AKR1C2 in breast cancer results in decreased progesterone catabolism, which, in combination with increased PR expression, may augment progesterone signaling by its nuclear receptors...
  55. ncbi Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice
    Jenna C Carroll
    Neuroscience Graduate Program, Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 27:13357-65. 2007
    ..These results demonstrate that estrogen and progesterone independently and interactively regulate AD-like neuropathology and suggest that an optimized hormone therapy may be useful in reducing the risk of AD in postmenopausal women...
  56. ncbi Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism
    Qing Ji
    Division of Gastrointestinal and Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Prostate 54:275-89. 2003
    ..Functional activity and regulation of AKR1C2, a 3 alpha-hydroxysteroid dehydrogenase (HSD) type III, was also assessed in prostate cancer cell lines...
  57. ncbi Increased insulin-like growth factor-1 after oophorectomy in postmenopausal women
    Robin H Fogle
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Fertil Steril 90:1236-9. 2008
    ..This finding raises concerns, given the association between increased IGF-1 and elevated colon cancer risk, and adds to the literature suggesting a potential benefit from ovarian preservation...
  58. pmc Impact of obesity on oral contraceptive pharmacokinetics and hypothalamic-pituitary-ovarian activity
    Alison B Edelman
    Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA
    Contraception 80:119-27. 2009
    ..This study was conducted to determine whether increased body mass index (BMI) affects oral contraceptive (OC) pharmacokinetics and suppression of hypothalamic-pituitary-ovarian (HPO) axis activity...
  59. pmc Androgens, growth factors, and risk of prostate cancer: the Multiethnic Cohort
    Jasmeet K Gill
    Department of Health Science, California State University, Fullerton, CA, USA
    Prostate 70:906-15. 2010
    ..Androgens and growth factors are thought to be associated with prostate cancer risk, although past research has produced mixed results...
  60. pmc 3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism
    Anne Z Steiner
    Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Endocrinol Metab 93:1298-303. 2008
    ..3alpha-HSD may play a role in the pathogenesis of hirsutism...
  61. ncbi Ovarian suppression in normal-weight and obese women during oral contraceptive use: a randomized controlled trial
    Carolyn L Westhoff
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York, USA
    Obstet Gynecol 116:275-83. 2010
    ..To assess ovarian suppression during oral contraceptive pill (OCP) use among normal-weight and obese women using two OCP doses...
  62. pmc Sleep duration, melatonin and breast cancer among Chinese women in Singapore
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Carcinogenesis 29:1244-8. 2008
    ..However, data are inconclusive from the three studies conducted in Western populations on sleep duration and breast cancer risk...
  63. doi Dietary patterns and breast cancer risk in Asian American women
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
    Am J Clin Nutr 89:1145-54. 2009
    ..The role of diet as a cause of breast cancer in Asian Americans has not been adequately studied...
  64. pmc Antimullerian hormone and obesity: insights in oral contraceptive users
    Anne Z Steiner
    Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC 27599, USA
    Contraception 81:245-8. 2010
    ..The study was conducted to examine the impact of oral contraceptives (OCs) on serum antimullerian hormone (AMH) levels by obesity status in reproductive-age women...
  65. ncbi The insulin resistant subphenotype of polycystic ovary syndrome: clinical parameters and pathogenesis
    Eliran Mor
    University of Southern California Keck School of Medicine, Los Angeles, USA
    Am J Obstet Gynecol 190:1654-60. 2004
    ..This study was undertaken to compare clinical and biochemical characteristics of the insulin resistant (IR) and non-IR subphenotypes of polycystic ovary syndrome (PCOS)...
  66. pmc Postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: results from the National Institutes of Health--National Heart, Lung, and Blood Institute sponsored W
    Leslee J Shaw
    Division of Cardiology, Department of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 93:1276-84. 2008
    ..Women with polycystic ovary syndrome (PCOS) have a greater clustering of cardiac risk factors. However, the link between PCOS and cardiovascular (CV) disease is incompletely described...
  67. doi Oral contraceptives and individual variability of circulating levels of ethinyl estradiol and progestins
    Joseph W Goldzieher
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 78212, USA
    Contraception 78:4-9. 2008
  68. pmc Changes in the mouse estrus cycle in response to BRCA1 inactivation suggest a potential link between risk factors for familial and sporadic ovarian cancer
    Hao Hong
    Department of Pathology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Res 70:221-8. 2010
    ....
  69. ncbi Diabetes and risk of breast cancer in Asian-American women
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
    Carcinogenesis 28:1561-6. 2007
    ..08) than women without such a history after adjusting for BMI and WHR. Our results support the hypothesis that diabetes may have a role in the development of breast cancer, influencing risk via both sex hormone and insulin pathways...
  70. ncbi Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signaling
    Qing Ji
    Department of Medicine, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1361-9. 2007
    ..We speculate that selective loss of AKR1C2 in prostate cancer promotes clonal expansion of tumor cells by enhancement of androgen-dependent cellular proliferation by reducing DHT metabolism...
  71. ncbi Tea and circulating estrogen levels in postmenopausal Chinese women in Singapore
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9175, USA
    Carcinogenesis 26:976-80. 2005
    ..Larger studies are needed to confirm results from this cross-sectional study and to better understand the potentially differing effect of black and green tea on circulating estrogen levels and ultimately on the risk of breast cancer...
  72. ncbi A controlled 2-mo dietary fat reduction and soy food supplementation study in postmenopausal women
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90089 9175, USA
    Am J Clin Nutr 81:1133-41. 2005
    ..Low intake of dietary fat and high intake of soy foods have been suggested to partly explain the lower breast cancer rates in Asia, perhaps because of lower endogenous estrogens...
  73. ncbi Comparison of vaginal and oral administration of emergency contraception
    Eliran Mor
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Fertil Steril 84:40-5. 2005
    ..To compare the physiologic effects of vaginally and orally administered emergency contraception...
  74. ncbi Correlation of adrenocorticotropin steroid levels between women with polycystic ovary syndrome and their sisters
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Obstet Gynecol 196:398.e1-5; discussion 398.e5-6. 2007
    ..The purpose of this study was to assess the sibling correlation of adrenocorticotropic hormone-stimulated steroid hormone levels between probands with polycystic ovary syndrome and their sisters...
  75. pmc Treatment-associated serum FSH levels in very poor responders to ovarian stimulation
    Peyman Saadat
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    J Assist Reprod Genet 20:395-9. 2003
    ....
  76. ncbi Acute effects of metformin therapy include improvement of insulin resistance and ovarian morphology
    Aykut Bayrak
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Fertil Steril 87:870-5. 2007
    ..To evaluate the acute effects of metformin therapy on biochemical markers and polycystic ovarian morphology among insulin-resistant (IR) and noninsulin-resistant (NIR) patients with polycystic ovary syndrome (PCOS)...
  77. ncbi 17beta-estradiol reduces plasma Abeta40 for HRT-naïve postmenopausal women with Alzheimer disease: a preliminary study
    Laura D Baker
    Geriatric Research, Education, and Clinical Center, the VA Puget Sound Health Care System, Seattle Tacoma, WA, USA
    Am J Geriatr Psychiatry 11:239-44. 2003
    ..The authors evaluated the effects of estrogen administration on plasma concentration of one by-product of APP processing, Abeta40, for postmenopausal women with AD...
  78. ncbi Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women
    Giske Ursin
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles 90089, USA
    Breast Cancer Res Treat 72:139-43. 2002
    ..Our data suggest that among premenopausal women, family history is not associated with higher urinary estrogen levels or a lower ratio of urinary 2-OHE1/16alpha-OHE1...
  79. ncbi Extraction/chromatographic testosterone RIA can be used as the "gold standard" for determining the reliability of direct testosterone immunoassay measurements
    Frank Z Stanczyk
    Clin Chem 50:2219-20; author reply 2220-1. 2004
  80. pmc UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R488-98. 2004
    ....
  81. ncbi Measurement of serum estradiol levels in postmenopausal women
    Frank Z Stanczyk
    JAMA 288:450-1; author reply 451. 2002
  82. ncbi Associations between reproductive and menstrual factors and postmenopausal sex hormone concentrations
    Jessica Chubak
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 13:1296-301. 2004
    ....
  83. ncbi Specimen allocation in longitudinal biomarker studies: controlling subject-specific effects by design
    Shelley S Tworoger
    Channing Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 13:1257-60. 2004
    ..These results suggest that bias can be artificially introduced into intervention effect estimates of longitudinal studies if samples from a subject are not assayed in the same batch...
  84. ncbi Estrogen increases endothelial nitric oxide synthase via estrogen receptors in rat cerebral blood vessels: effect preserved after concurrent treatment with medroxyprogesterone acetate or progesterone
    Anne Marie McNeill
    Department of Pharmacology, College of Medicine, University of California at Irvine, CA 92697 4625, USA
    Stroke 33:1685-91. 2002
    ....
  85. ncbi Effect of exercise on serum androgens in postmenopausal women: a 12-month randomized clinical trial
    Anne McTiernan
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA
    Cancer Epidemiol Biomarkers Prev 13:1099-105. 2004
    ..The association between exercise and breast cancer risk may be partly explained by the effects of exercise on these hormones...
  86. pmc Prevention of coronary hyperreactivity in preatherogenic menopausal rhesus monkeys by transdermal progesterone
    R Kent Hermsmeyer
    Dimera Incorporated, Portland, Ore 97210, USA
    Arterioscler Thromb Vasc Biol 24:955-61. 2004
    ..To test if transdermal progesterone (P) confers coronary vascular protection in surgically menopausal preatherosclerotic rhesus monkeys...
  87. ncbi Growth effects of raloxifene, estradiol, medroxy-progesterone acetate, and progesterone on human endometrial adenocarcinoma cells
    Robert Boostanfar
    Fertil Steril 79:223-5. 2003
  88. ncbi Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:94-101. 2004
    ..This study provides further evidence that genetic variation may appreciably alter sex hormone concentrations in postmenopausal women not taking hormone therapy...
  89. ncbi Endogenous sex hormones and prostate cancer risk: a case-control study nested within the Carotene and Retinol Efficacy Trial
    Chu Chen
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:1410-6. 2003
    ..The suggestions that intraprostatic androgen activity may increase risk and that serum estrogens may decrease risk, warrant additional study...
  90. pmc Adiposity and sex hormones in postmenopausal breast cancer survivors
    Anne McTiernan
    Cancer Prevention Research Program, MP 900, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Clin Oncol 21:1961-6. 2003
    ..This study examined the association between adiposity and concentrations of estrogens, androgens, and sex hormone-binding globulin (SHBG) in a population-based sample of postmenopausal women with breast cancer...
  91. ncbi Serum sex hormones and breast cancer risk factors in postmenopausal women
    Charisee A Lamar
    Extramural Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 12:380-3. 2003
    ..Although BMI and parity could potentially modify breast cancer risk through hormonal mechanisms, age-related increases in breast cancer incidence do not appear to be mediated through changes in serum levels of the hormones evaluated...
  92. doi Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal women
    Anne McTiernan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Breast Cancer Res Treat 108:217-31. 2008
    ..These results suggest that while age, oophorectomy status, and NSAID use may be associated with selected sex hormone concentrations, few menstrual or reproductive factors affect endogenous sex hormones in the postmenopausal period...
  93. ncbi Bioavailability of the Yuzpe and levonorgestrel regimens of emergency contraception: vaginal vs. oral administration
    Sari Kives
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology Victory 4, Kingston General Hospital, Queen s University, Kingston, Ontario, Canada K7L 2V7
    Contraception 71:197-201. 2005
    ..Our preliminary data suggest that vaginal administration of these emergency contraception regimens appears to require at least three times the standard oral dose to achieve equivalent systemic levonorgestrel concentrations...
  94. ncbi Effectiveness of levonorgestrel emergency contraception given before or after ovulation--a pilot study
    Natalia Novikova
    Department of Obstetrics and Gynaecology, University of Sydney, NSW, 2006, Australia
    Contraception 75:112-8. 2007
    ..There are increasing data to indicate that LNG is particularly effective as an ECP by interrupting follicular development and ovulation. An important outstanding question is whether it has any effect on fertilization or implantation...
  95. ncbi Reproducibility of serum sex steroid assays in men by RIA and mass spectrometry
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 5024, MSC 7234, 6120 Executive Boulevard, Bethesda, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 16:1004-8. 2007
    ....
  96. pmc Associations between the CYP17, CYPIB1, COMT and SHBG polymorphisms and serum sex hormones in post-menopausal breast cancer survivors
    Page E Abrahamson
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA, 98109 1024, USA
    Breast Cancer Res Treat 105:45-54. 2007
    ..These results provide little evidence that the CYP17, CYP1B1, and COMT polymorphisms are associated with different sex hormone levels in post-menopausal breast cancer survivors...
  97. ncbi Relation of BMI and physical activity to sex hormones in postmenopausal women
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Cancer Prevention Research Program, Seattle, WA 98109, USA
    Obesity (Silver Spring) 14:1662-77. 2006
    ..However, the determinants of these hormone concentrations are not established. The purpose of this study was to examine correlates of endogenous sex hormones...
  98. ncbi Alcohol and dietary fibre intakes affect circulating sex hormones among premenopausal women
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Public Health Nutr 9:875-81. 2006
    ..The association of alcohol and fibre intake with breast cancer may be mediated by circulating sex hormone levels, which are predictors of breast cancer risk...
  99. ncbi Parenteral versus oral treatment of postmenopausal women with estrogen
    Frank Z Stanczyk
    Menopause 14:968-70. 2007
  100. ncbi Comparison of methods to measure low serum estradiol levels in postmenopausal women
    Jennifer S Lee
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA
    J Clin Endocrinol Metab 91:3791-7. 2006
    ..Accurate measurement of low serum estradiol (E(2) < 30 pg/ml or < 110 pmol/liter) is needed to study relationships between endogenous E(2) and risks of diseases in older women...
  101. ncbi Effects of a 2-year randomized soy intervention on sex hormone levels in premenopausal women
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 13:1736-44. 2004
    ..The goal of this trial among premenopausal women was to examine the effect of soy foods on menstrual cycle length and circulating sex hormone levels...