Research Topics
Genomes and Genes | Sheng ZhouSummaryAffiliation: St. Jude Children's Research Hospital Country: USA Publications
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Detail Information
Publications
Hematopoietic cells from mice that are deficient in both Bcrp1/Abcg2 and Mdr1a/1b develop normally but are sensitized to mitoxantroneSheng Zhou
Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
Biotechniques 35:1248-52. 2003....- Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levelsSheng Zhou
Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
Blood 105:2571-6. 2005..Taken together, our results demonstrate that ABCG2 plays a role in regulating PPIX levels during erythroid differentiation and suggest a potential role for ABCG2 as a genetic determinant in erythropoietic protoporphyria... 
Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivoSheng Zhou
Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Proc Natl Acad Sci U S A 99:12339-44. 2002..These results show that Bcrp1 gene expression alone defines the SP stem cell phenotype, and suggest that the physiological function of Bcrp1 expression in HSCs is to provide protection from cytotoxic substrates...- A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cellsSheng Zhou
Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA
Blood 116:900-8. 2010..We conclude that the CL20i4-EF1alpha-hgamma(c)OPT vector may be suitable for testing in a clinical trial based on these preclinical demonstrations of efficacy and safety... - Identification of a novel, tissue-specific ABCG2 promoter expressed in pediatric acute megakaryoblastic leukemiaPatrick K Campbell
Division of Leukemia Lymphoma, St Jude Children s Research Hospital, Memphis, TN, USA
Leuk Res 35:1321-9. 2011..We also show a relatively high incidence of ABCG2 mRNA expression in non-Down associated M7 AML, which may contribute to the relatively poor prognosis of the M7 AML subtype... 
Abcg2 expression marks tissue-specific stem cells in multiple organs in a mouse progeny tracking modelSoghra Fatima
Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Stem Cells 30:210-21. 2012....- Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivoMarkos Leggas
Departments of Pharmaceutical Sciences, Hematology Oncology, and Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer Res 66:4802-7. 2006..4-AQ molecules may offer a means to increase the low and variable oral drug absorption of transporter substrates while decreasing interpatient variability and reversing tumor drug resistance... - The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with hemePartha Krishnamurthy
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
J Biol Chem 279:24218-25. 2004..Our findings have implications for the survival of stem cells and tumor cells in hypoxic environments... - Prospective isolation of murine hematopoietic stem cells by expression of an Abcg2/GFP alleleMehrdad Tadjali
Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Stem Cells 24:1556-63. 2006..There was no HSC activity detected in Lin(-)/GFP(+) cells. Altogether, these results show that Abcg2 is expressed on essentially all murine BM HSCs and can be used as a prospective marker for HSC enrichment... - Expression of mouse Abcg2 mRNA during hematopoiesis is regulated by alternative use of multiple leader exons and promotersYang Zong
Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
J Biol Chem 281:29625-32. 2006..In summary, our data show that the expression of Abcg2 during hematopoiesis is transcriptionally regulated by alternative use of multiple leader exons and promoters in a developmental stage-specific manner... - Hemgn is a direct transcriptional target of HOXB4 and induces expansion of murine myeloid progenitor cellsJie Jiang
Experimental Hematology Division, Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
Blood 116:711-9. 2010..Our results identify a functionally relevant, direct transcriptional target of HOXB4 and identify other target genes that may also participate in the HOXB4 genetic network... - Efficient construction of producer cell lines for a SIN lentiviral vector for SCID-X1 gene therapy by concatemeric array transfectionRobert E Throm
Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Blood 113:5104-10. 2009.... - Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignanciesLouise M Treanor
Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
Blood 117:5453-62. 2011..Notch mutation and Arf inactivation appear to independently cooperate in no requisite order with Lmo2 overexpression in inducing T-ALL, and all 3 events remained insufficient to guarantee immediate tumor development... - alpha-Fetoprotein shields hepatocellular carcinoma cells from apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligandMengsen Li
Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China
Cancer Lett 249:227-34. 2007..This study suggests the possibility a therapeutic strategy for improving clinical treatment of liver tumor with TRAIL could be effected through antagonizing the shelter effect of AFP... - Eukaryotic initiation factor 4E (eIF4E) and angiogenesis: prognostic markers for breast cancerSheng Zhou
Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
BMC Cancer 6:231. 2006..This study investigates the relationship between eIF4E and angiogenesis, as well as their prognostic impact in patients with human breast cancer... - Effects of alpha fetoprotein on escape of Bel 7402 cells from attack of lymphocytesMengsen Li
Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China
BMC Cancer 5:96. 2005..However, the molecular events of immune escape mechanisms are still unknown. The major observations reported here relate to a possible mechanism by which heptoloma Bel 7402 cells escape immune surveillance in vitro... - [Study on the expression of DNA excision repair biomarkers in cispatin-treated lung cancer cell line]Zhi-Yong Wang
Institute of Environmental Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Zhonghua Yu Fang Yi Xue Za Zhi 37:109-11. 2003..Cisplatin was a positive regulation of ERCC2, UDG, PCNA expression levels, which causes the increase of mRNA, and protein. The positive regulation only works in a short time and returns normal after 24 h of cisplatin treatment...