Sheng Zhou

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint Hematopoietic cells from mice that are deficient in both Bcrp1/Abcg2 and Mdr1a/1b develop normally but are sensitized to mitoxantrone
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Biotechniques 35:1248-52. 2003
  2. ncbi request reprint Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    Blood 105:2571-6. 2005
  3. pmc Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 99:12339-44. 2002
  4. pmc A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA
    Blood 116:900-8. 2010
  5. pmc Identification of a novel, tissue-specific ABCG2 promoter expressed in pediatric acute megakaryoblastic leukemia
    Patrick K Campbell
    Division of Leukemia Lymphoma, St Jude Children s Research Hospital, Memphis, TN, USA
    Leuk Res 35:1321-9. 2011
  6. doi request reprint Abcg2 expression marks tissue-specific stem cells in multiple organs in a mouse progeny tracking model
    Soghra Fatima
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Stem Cells 30:210-21. 2012
  7. pmc Mouse transplant models for evaluating the oncogenic risk of a self-inactivating XSCID lentiviral vector
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS ONE 8:e62333. 2013
  8. ncbi request reprint Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo
    Markos Leggas
    Departments of Pharmaceutical Sciences, Hematology Oncology, and Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 66:4802-7. 2006
  9. ncbi request reprint The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
    Partha Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 279:24218-25. 2004
  10. pmc Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential
    Louise M Treanor
    Department of Hematology and 2 Department of Pathology, Division of Experimental Hematology, St Jude Children s Research Hospital, Memphis, TN 38105
    J Exp Med 211:701-13. 2014

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Hematopoietic cells from mice that are deficient in both Bcrp1/Abcg2 and Mdr1a/1b develop normally but are sensitized to mitoxantrone
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Biotechniques 35:1248-52. 2003
    ....
  2. ncbi request reprint Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    Blood 105:2571-6. 2005
    ..Taken together, our results demonstrate that ABCG2 plays a role in regulating PPIX levels during erythroid differentiation and suggest a potential role for ABCG2 as a genetic determinant in erythropoietic protoporphyria...
  3. pmc Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 99:12339-44. 2002
    ..These results show that Bcrp1 gene expression alone defines the SP stem cell phenotype, and suggest that the physiological function of Bcrp1 expression in HSCs is to provide protection from cytotoxic substrates...
  4. pmc A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA
    Blood 116:900-8. 2010
    ..We conclude that the CL20i4-EF1alpha-hgamma(c)OPT vector may be suitable for testing in a clinical trial based on these preclinical demonstrations of efficacy and safety...
  5. pmc Identification of a novel, tissue-specific ABCG2 promoter expressed in pediatric acute megakaryoblastic leukemia
    Patrick K Campbell
    Division of Leukemia Lymphoma, St Jude Children s Research Hospital, Memphis, TN, USA
    Leuk Res 35:1321-9. 2011
    ..We also show a relatively high incidence of ABCG2 mRNA expression in non-Down associated M7 AML, which may contribute to the relatively poor prognosis of the M7 AML subtype...
  6. doi request reprint Abcg2 expression marks tissue-specific stem cells in multiple organs in a mouse progeny tracking model
    Soghra Fatima
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Stem Cells 30:210-21. 2012
    ....
  7. pmc Mouse transplant models for evaluating the oncogenic risk of a self-inactivating XSCID lentiviral vector
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS ONE 8:e62333. 2013
    ..Overall, this comprehensive study of mouse transplant safety assays demonstrate the relative safety of the XSCID lentiviral vector but also highlight the limitations of these assays...
  8. ncbi request reprint Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo
    Markos Leggas
    Departments of Pharmaceutical Sciences, Hematology Oncology, and Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 66:4802-7. 2006
    ..4-AQ molecules may offer a means to increase the low and variable oral drug absorption of transporter substrates while decreasing interpatient variability and reversing tumor drug resistance...
  9. ncbi request reprint The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
    Partha Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 279:24218-25. 2004
    ..Our findings have implications for the survival of stem cells and tumor cells in hypoxic environments...
  10. pmc Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential
    Louise M Treanor
    Department of Hematology and 2 Department of Pathology, Division of Experimental Hematology, St Jude Children s Research Hospital, Memphis, TN 38105
    J Exp Med 211:701-13. 2014
    ..This new murine model recapitulates several important cellular and molecular features of ETP-ALL and should be useful to further define novel therapeutic approaches for this aggressive leukemia. ..
  11. ncbi request reprint Prospective isolation of murine hematopoietic stem cells by expression of an Abcg2/GFP allele
    Mehrdad Tadjali
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Stem Cells 24:1556-63. 2006
    ..There was no HSC activity detected in Lin(-)/GFP(+) cells. Altogether, these results show that Abcg2 is expressed on essentially all murine BM HSCs and can be used as a prospective marker for HSC enrichment...
  12. ncbi request reprint Expression of mouse Abcg2 mRNA during hematopoiesis is regulated by alternative use of multiple leader exons and promoters
    Yang Zong
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 281:29625-32. 2006
    ..In summary, our data show that the expression of Abcg2 during hematopoiesis is transcriptionally regulated by alternative use of multiple leader exons and promoters in a developmental stage-specific manner...
  13. pmc Comparison of insulators and promoters for expression of the Wiskott-Aldrich syndrome protein using lentiviral vectors
    Rachel M Koldej
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Hum Gene Ther Clin Dev 24:77-85. 2013
    ..We propose a clinical trial design in which cytokine-mobilized, autologous, transduced CD34(+) cells are administered after myelosuppression...
  14. pmc Efficient construction of producer cell lines for a SIN lentiviral vector for SCID-X1 gene therapy by concatemeric array transfection
    Robert E Throm
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 113:5104-10. 2009
    ....
  15. pmc Hemgn is a direct transcriptional target of HOXB4 and induces expansion of murine myeloid progenitor cells
    Jie Jiang
    Experimental Hematology Division, Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Blood 116:711-9. 2010
    ..Our results identify a functionally relevant, direct transcriptional target of HOXB4 and identify other target genes that may also participate in the HOXB4 genetic network...
  16. pmc Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies
    Louise M Treanor
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Blood 117:5453-62. 2011
    ..Notch mutation and Arf inactivation appear to independently cooperate in no requisite order with Lmo2 overexpression in inducing T-ALL, and all 3 events remained insufficient to guarantee immediate tumor development...
  17. ncbi request reprint [Study on the expression of DNA excision repair biomarkers in cispatin-treated lung cancer cell line]
    Zhi Yong Wang
    Institute of Environmental Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    Zhonghua Yu Fang Yi Xue Za Zhi 37:109-11. 2003
    ..To study the expression levels of ERCC2, UDG, and PCNA in cisplatin-treated A549 cell line...
  18. pmc Effects of alpha fetoprotein on escape of Bel 7402 cells from attack of lymphocytes
    Mengsen Li
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China
    BMC Cancer 5:96. 2005
    ..However, the molecular events of immune escape mechanisms are still unknown. The major observations reported here relate to a possible mechanism by which heptoloma Bel 7402 cells escape immune surveillance in vitro...
  19. pmc Eukaryotic initiation factor 4E (eIF4E) and angiogenesis: prognostic markers for breast cancer
    Sheng Zhou
    Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    BMC Cancer 6:231. 2006
    ..This study investigates the relationship between eIF4E and angiogenesis, as well as their prognostic impact in patients with human breast cancer...
  20. ncbi request reprint alpha-Fetoprotein shields hepatocellular carcinoma cells from apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand
    Mengsen Li
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China
    Cancer Lett 249:227-34. 2007
    ..This study suggests the possibility a therapeutic strategy for improving clinical treatment of liver tumor with TRAIL could be effected through antagonizing the shelter effect of AFP...