Yong Mei Zhang

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc Thematic review series: Glycerolipids. Acyltransferases in bacterial glycerophospholipid synthesis
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Lipid Res 49:1867-74. 2008
  2. pmc PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 283:28788-94. 2008
  3. doi request reprint Membrane lipid homeostasis in bacteria
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, Tennessee 38105, USA
    Nat Rev Microbiol 6:222-33. 2008
  4. ncbi request reprint Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites
    Yong Mei Zhang
    Protein Science Division, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 279:50969-75. 2004
  5. ncbi request reprint The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Lipid Res 44:1-10. 2003
  6. pmc Structural basis for the transcriptional regulation of membrane lipid homeostasis
    Darcie J Miller
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Struct Mol Biol 17:971-5. 2010
  7. ncbi request reprint The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites
    Robert A Ivey
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 279:35622-9. 2004
  8. ncbi request reprint Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 280:32594-601. 2005
  9. pmc Transcriptional regulation of membrane lipid homeostasis in Escherichia coli
    Kun Zhu
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 284:34880-8. 2009
  10. ncbi request reprint The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli
    Yong Mei Zhang
    Department of Infectious Diseases, Protein Science Division, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 277:15558-65. 2002

Collaborators

Detail Information

Publications50

  1. pmc Thematic review series: Glycerolipids. Acyltransferases in bacterial glycerophospholipid synthesis
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Lipid Res 49:1867-74. 2008
    ..This unique activated fatty acid is formed from the acyl-ACP end products of the fatty acid biosynthetic pathway by PlsX, an acyl-ACP:phosphate transacylase...
  2. pmc PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 283:28788-94. 2008
    ..DHQ was produced by Escherichia coli coexpressing PqsA and PqsD, illustrating that these two proteins are the only factors necessary for DHQ synthesis. Thus, PqsD is responsible for the production of DHQ in P. aeruginosa...
  3. doi request reprint Membrane lipid homeostasis in bacteria
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, Tennessee 38105, USA
    Nat Rev Microbiol 6:222-33. 2008
    ..Here, the principal genetic and biochemical processes that are responsible for membrane lipid homeostasis in bacteria are reviewed...
  4. ncbi request reprint Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites
    Yong Mei Zhang
    Protein Science Division, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 279:50969-75. 2004
    ..Thus, the pantothenamides are pro-antibiotics that inhibit fatty acid synthesis and bacterial growth because of the covalent modification of ACP...
  5. ncbi request reprint The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Lipid Res 44:1-10. 2003
    ....
  6. pmc Structural basis for the transcriptional regulation of membrane lipid homeostasis
    Darcie J Miller
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Struct Mol Biol 17:971-5. 2010
    ..The regulation of DesT by the unsaturated:saturated ratio of acyl chains rather than the concentration of a single ligand is a paradigm for understanding transcriptional regulation of membrane lipid homeostasis...
  7. ncbi request reprint The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites
    Robert A Ivey
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 279:35622-9. 2004
    ....
  8. ncbi request reprint Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 280:32594-601. 2005
    ....
  9. pmc Transcriptional regulation of membrane lipid homeostasis in Escherichia coli
    Kun Zhu
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 284:34880-8. 2009
    ..This mechanism ensures that a balanced composition of fatty acids is available for incorporation into the membrane via the PlsB/PlsC acyltransferases...
  10. ncbi request reprint The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli
    Yong Mei Zhang
    Department of Infectious Diseases, Protein Science Division, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 277:15558-65. 2002
    ..Thus, FabR functions as a repressor that potently controls the expression of the fabB gene, which in turn, modulates the physical properties of the membrane by altering the level of unsaturated fatty acid production...
  11. ncbi request reprint Crystal structures of the Dab homology domains of mouse disabled 1 and 2
    Mikyung Yun
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 278:36572-81. 2003
    ..These findings suggest that simultaneous interaction of the rigid DH domain with the NPXY sequence and PtdIns-4,5-P2 plays a role in the attachment of Dab proteins to the APP/lipoprotein receptors and phosphoinositide-rich membranes...
  12. pmc Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain
    Roberta Leonardi
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Chem Biol 17:892-902. 2010
    ..The flexible allosteric acetyl-CoA regulatory domain of PanK3 also binds the substrates, pantothenate and pantetheine, and small molecule inhibitors and activators to modulate PanK3 activity...
  13. ncbi request reprint The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes
    Charles O Rock
    Protein Science Division, Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
    Gene 291:35-43. 2002
    ..Differential expression of the PanK1 alpha and PanK1 beta transcripts would alter the amount of CoA produced in cells as a function of the ratio of free CoA to acetyl-CoA, a reflection of the metabolic status of the tissue...
  14. ncbi request reprint A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A
    Roberta Leonardi
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 280:3314-22. 2005
    ..aureus, which lacks glutathione and relies on the CoA/CoA disulfide reductase redox system for protection from oxidative damage...
  15. ncbi request reprint The structural biology of type II fatty acid biosynthesis
    Stephen W White
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Biochem 74:791-831. 2005
    ..These structures are also a valuable resource to guide antibacterial drug discovery...
  16. pmc Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism
    Matthew Garcia
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS ONE 7:e40871. 2012
    ..The data indicate that PanK1 and PanK2 can compensate for each other to supply tissue CoA, but PanK1 is more important to CoA levels in liver whereas PanK2 contributes more to CoA synthesis in the brain...
  17. ncbi request reprint Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors
    Kristopher G Virga
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, 38163, USA
    Bioorg Med Chem 14:1007-20. 2006
    ..coli enzyme showed greater selectivity. The overall activity data from these analogues suggest a complex and non-enzyme specific SAR for pantothenamide substrate/inhibitors of the different PanK enzymes...
  18. pmc Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria
    Kimberly D Grimes
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 847 Monroe Ave, Memphis, TN 38163, USA
    ChemMedChem 3:1936-45. 2008
    ..anthracis...
  19. ncbi request reprint Two aerobic pathways for the formation of unsaturated fatty acids in Pseudomonas aeruginosa
    Kun Zhu
    Department of Infectious Diseases, Protein Science Division, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Microbiol 60:260-73. 2006
    ....
  20. ncbi request reprint Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG
    Allen C Price
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, TN 38105 USA
    Structure 12:417-28. 2004
    ..Biochemical data confirm that FabG[Y151F] is defective in NADPH binding. Finally, structural changes consistent with the observed negative cooperativity of FabG are described...
  21. ncbi request reprint Key residues responsible for acyl carrier protein and beta-ketoacyl-acyl carrier protein reductase (FabG) interaction
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 278:52935-43. 2003
    ..The specific FabG-ACP interactions involve the most conserved ACP residues, which accounts for the ability of ACPs and the type II proteins from different species to function interchangeably...
  22. ncbi request reprint Structure and mechanism of CTP:phosphocholine cytidylyltransferase (LicC) from Streptococcus pneumoniae
    Bo Yeon Kwak
    Department of Structural Biology and the Protein Science Division, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 277:4343-50. 2002
    ..These results provide a structural basis for assigning a specific role for magnesium in the catalytic mechanism of pneumococcal LicC...
  23. pmc A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli
    Suzanne Jackowski
    Protein Science Division, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Antimicrob Agents Chemother 46:1246-52. 2002
    ..These data illustrate that missense mutations that introduce valine at position 390 confer TLM resistance while maintaining the vital catalytic properties of FabB...
  24. ncbi request reprint Coenzyme A: back in action
    Roberta Leonardi
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Prog Lipid Res 44:125-53. 2005
    ..The purpose of this review is to integrate previous knowledge with the most recent findings in the genetics, enzymology and regulation of CoA biosynthesis in bacteria, plants and mammals...
  25. ncbi request reprint A Pseudomonas aeruginosa transcription factor that senses fatty acid structure
    Yong Mei Zhang
    Protein Science Division, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Microbiol 66:622-32. 2007
    ..This unique ligand selectivity allows DesT to sense the physical properties of the cellular acyl-CoA pool and modulate the expression of the acyl-CoA Delta9-desaturase system to adjust fatty acid desaturation activity accordingly...
  26. ncbi request reprint Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens
    Ying Jie Lu
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell 23:765-72. 2006
    ..The PlsX/Y pathway defines the most widely distributed pathway for the initiation of phospholipid formation in bacteria and represents a new target for the development of antibacterial therapeutics...
  27. ncbi request reprint Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type II fatty-acid synthase
    Yong Mei Zhang
    Protein Science Division, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 279:30994-1001. 2004
    ..The ability of the plant secondary metabolites to interfere with the activity of multiple NAD(P)-dependent cellular processes must be taken into account when assessing the specificity of their effects...
  28. ncbi request reprint Inhibiting bacterial fatty acid synthesis
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Biol Chem 281:17541-4. 2006
    ..The role of each enzyme in regulating pathway activity and the diversity in the components of the pathway in the major human pathogens are important considerations in deciding the most suitable targets for future drug development...
  29. ncbi request reprint The reductase steps of the type II fatty acid synthase as antimicrobial targets
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Lipids 39:1055-60. 2004
    ..This review discusses new developments in the discovery of inhibitors that specifically target the two reductase steps of the FAS II system, beta-ketoacyl-acyl carrier potein (ACP) reductase and enoyl-ACP reductase...
  30. ncbi request reprint The solution structure of acyl carrier protein from Mycobacterium tuberculosis
    Hing C Wong
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 277:15874-80. 2002
    ....
  31. pmc Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine
    Roberta Leonardi
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 104:1494-9. 2007
    ..Our results suggest that PanK2 is located in the mitochondria to sense the levels of palmitoylcarnitine and up-regulate CoA biosynthesis in response to an increased mitochondrial demand for the cofactor to support beta-oxidation...
  32. pmc DesT coordinates the expression of anaerobic and aerobic pathways for unsaturated fatty acid biosynthesis in Pseudomonas aeruginosa
    Chitra Subramanian
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis TN 38105 3678, USA
    J Bacteriol 192:280-5. 2010
    ..Thus, DesT senses the overall composition of the acyl-coenzyme A pool to coordinate the expression of the operons for the anaerobic (fabAB) and aerobic (desCB) pathways for unsaturated fatty acid synthesis...
  33. pmc Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Chem Biol 14:291-302. 2007
    ..These results identify the metabolic rearrangements that maintain the CoASH pool which is critical to mitochondrial functions, including gluconeogenesis, fatty acid oxidation, and the tricarboxylic acid and urea cycles...
  34. ncbi request reprint Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae
    Yong Mei Zhang
    Departments of Infectious Diseases and Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 281:17390-9. 2006
    ..Phe396 functions as a gatekeeper that controls the order of substrate addition. These data assign specific roles for each active site residue and lead to a revised general mechanism for this important class of enzymes...
  35. pmc Structural modification of acyl carrier protein by butyryl group
    Bai Nan Wu
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Protein Sci 18:240-6. 2009
    ..This finding supports the more general notion that the attachment of different acyl intermediates alters the ACP structure to facilitate their recognition and turnover by the appropriate target enzymes...
  36. ncbi request reprint Serum opacity factor, a streptococcal virulence factor that binds to apolipoproteins A-I and A-II and disrupts high density lipoprotein structure
    Harry S Courtney
    Veterans Affairs Medical Center and Department of Medicine, University of Tennessee Health Science Center, 1030 Jefferson Avenue, Memphis, TN 38104, USA
    J Biol Chem 281:5515-21. 2006
    ..The disruption of HDL may attenuate its anti-inflammatory functions and contribute to the pathogenesis of group A streptococcal infections...
  37. ncbi request reprint Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 281:107-14. 2006
    ..These data described the unique biochemical features of the PanK2 isoforms and suggested that catalytic defects may not be the sole cause for the neurodegenerative phenotype...
  38. ncbi request reprint Structure of RhlG, an essential beta-ketoacyl reductase in the rhamnolipid biosynthetic pathway of Pseudomonas aeruginosa
    Darcie J Miller
    Department of Structural Biology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    J Biol Chem 281:18025-32. 2006
    ..These structural and biochemical studies establish RhlG as a NADPH-dependent beta-ketoacyl reductase of the SDR protein superfamily and further suggest that the ACP of fatty acid synthesis does not carry the substrates for RhlG...
  39. ncbi request reprint Characterization of a Mn-dependent fructose-1,6-bisphosphate aldolase in Deinococcus radiodurans
    Yong Mei Zhang
    Department of Microbiology and Molecular Cell Sciences, University of Memphis, Memphis, TN 38152, USA
    Biometals 19:31-7. 2006
    ..This active aldolase fraction exhibited masses of about 70 kDa and 35 kDa by gel filtration and by SDS gel electrophoresis, respectively, suggesting that the active aldolase was a dimer...
  40. pmc Transcriptional regulation in bacterial membrane lipid synthesis
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Lipid Res 50:S115-9. 2009
    ....
  41. ncbi request reprint Product diversity and regulation of type II fatty acid synthases
    Ying Jie Lu
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Biochem Cell Biol 82:145-55. 2004
    ....
  42. pmc Disruption of CCTbeta2 expression leads to gonadal dysfunction
    Suzanne Jackowski
    Protein Science Division, Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Mol Cell Biol 24:4720-33. 2004
    ..The results indicate that although CCTbeta2 is expressed at very low levels compared to the alpha-isoform, loss of CCTbeta2 expression causes a breakdown in the gonadal response to hormonal stimulation...
  43. pmc Localization and regulation of mouse pantothenate kinase 2
    Roberta Leonardi
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, United States
    FEBS Lett 581:4639-44. 2007
    ..Differences in expression and subcellular localization should be considered in developing a mouse model for human PanK2 deficiency...
  44. ncbi request reprint Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder
    Bum Soo Hong
    Structural Genomics Consortium and Department of Pharmacology, University of Toronto, Toronto, Ontario M5G 1L5, Canada
    J Biol Chem 282:27984-93. 2007
    ....
  45. ncbi request reprint Lysophospholipid flipping across the Escherichia coli inner membrane catalyzed by a transporter (LplT) belonging to the major facilitator superfamily
    Edgar M Harvat
    Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093 0116, USA
    J Biol Chem 280:12028-34. 2005
    ..Thus, LplT catalyzes the transbilayer movement of lysophospholipids and is the first example of a phospholipid flippase that belongs to the major facilitator superfamily...
  46. ncbi request reprint Role of mitogen-activated protein kinases in the regulation of paraventricular nucleus to gastric ischemia-reperfusion injuries
    Li Li
    Department of Pathophysiology, Xuzhou Medical College, Xuzhou 221002, China
    Chin Med J (Engl) 120:1082-7. 2007
    ..And we elucidated the molecular mechanisms of the protection of PVN from GI-R injuries...
  47. ncbi request reprint Extracellular signal-regulated kinase 1- and 2-mediated gastric mucosal injury and repair in gastric ischemia-reperfusion of rats
    Wei Li Qiao
    Department of Physiology and Neurobiology, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou 221002, Jiangsu, China
    J Gastroenterol 41:1158-68. 2006
    ....
  48. ncbi request reprint Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties
    Bum Soo Hong
    Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L5, Canada
    Structure 14:1251-61. 2006
    ....
  49. pmc Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli
    Pilho Kim
    Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Med Chem 49:159-71. 2006
    ..These results suggest a strict requirement for a conjugated, planar side chain inserting within the condensing enzyme active site...
  50. ncbi request reprint Extracellular signal-regulated kinase pathways may mediate the protective effect of electrical stimulation of the paraventricular nucleus against ischaemia-reperfusion injury of the gastric mucosa
    Yong Mei Zhang
    Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, China
    Clin Exp Pharmacol Physiol 34:742-52. 2007
    ..These results indicate that the PVN protects against GI/RI and that this protection is associated with the inhibition of cellular apoptosis and the promotion of proliferation in the gastric mucosa, probably by activating the ERK pathway...