Bing Yan

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi Advances in HPLC detection--towards universal detection
    Bin Zhang
    School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China
    Anal Bioanal Chem 390:299-301. 2008
  2. ncbi A kinetic study of product cleavage reactions from the solid phase by a biocompatible and removable cleaving reagent, HCl
    Bing Yan
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Comb Chem 9:684-9. 2007
  3. pmc Exploring the immunotoxicity of carbon nanotubes
    Yanmei Yu
    School of Pharmaceutical Sciences, Shandong University, Jinan, China
    Nanoscale Res Lett 3:271-7. 2008
  4. pmc The adsorption of biomolecules to multi-walled carbon nanotubes is influenced by both pulmonary surfactant lipids and surface chemistry
    Michael Gasser
    Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Materials Biology Interactions, St, Gallen, Switzerland
    J Nanobiotechnology 8:31. 2010
  5. doi Leading neuroblastoma cells to die by multiple premeditated attacks from a multifunctionalized nanoconstruct
    Peifu Jiao
    School of Pharmaceutical Sciences, Shandong University, Jinan, China
    J Am Chem Soc 133:13918-21. 2011
  6. doi Anti-tumor selectivity of a novel tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models
    Qiu Zhang
    School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
    Biochem Pharmacol 86:351-60. 2013
  7. pmc Steering carbon nanotubes to scavenger receptor recognition by nanotube surface chemistry modification partially alleviates NFκB activation and reduces its immunotoxicity
    Ningning Gao
    School of Pharmaceutical Sciences, Shandong University, Jinan 250100, China
    ACS Nano 5:4581-91. 2011
  8. doi Permission to enter cell by shape: nanodisk vs nanosphere
    Yi Zhang
    School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
    ACS Appl Mater Interfaces 4:4099-105. 2012
  9. doi Accelerating the multifunctionalization of therapeutic nanoparticles by using a multicomponent reaction
    Hongyu Zhou
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Chemistry 18:5501-5. 2012
  10. doi Size-dependent cell uptake of protein-coated graphene oxide nanosheets
    Qingxin Mu
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, United States
    ACS Appl Mater Interfaces 4:2259-66. 2012

Collaborators

  • Bin Zhang
  • Yi Zhang
  • Qiu Zhang
  • Lei Yang
  • Wei Zhang
  • Guangbo Qu
  • Xi Li
  • Ying Sun
  • Xiaojun Liu
  • Yang Li
  • Wei Feng
  • Naoaki Fujii
  • Raviraj Vankayala
  • Gang Liu
  • Lingxin Chen
  • Richard E Lee
  • Mario Otto
  • Fei Wang
  • Anjaparavanda P Naren
  • Taosheng Chen
  • Hongyu Zhou
  • Qingxin Mu
  • Liwen Li
  • Shumei Zhai
  • Aifeng Liu
  • Guibin Jiang
  • Yin Liu
  • Gaoxing Su
  • Ruinan Zhang
  • Peifu Jiao
  • Ying Tu
  • Yuhong Bai
  • Andrew Lemoff
  • Xifeng Ma
  • Chengke Zhang
  • M Jason Hatfield
  • Elizabeth R Butch
  • Scott E Snyder
  • Ningning Gao
  • Ling Wu
  • Jianling Sun
  • Philip M Potter
  • Carol C Edwards
  • Janice L Hyatt
  • Cynthia Jeffries
  • Elizabeth I Parkinson
  • Julian G Hurdle
  • Yanyan Liu
  • Michael Gasser
  • Neeraj Mahindroo
  • Zhaochun Wu
  • Yanmei Yu
  • Minghua Qi
  • Jingfu Liu
  • Hao Zhu
  • Lin Zhang
  • ChangLong Li
  • Xiaohong Pan
  • Xuehui Cui
  • Fei Li
  • Lyudmila G Tsurkan
  • Zhiping Wang
  • Ben O Gilbertson
  • Lam H Yu
  • Amy E Heathcott
  • Tremaine B Powell
  • Lyudmila Tsurkan
  • Latorya D Hicks
  • Kip Guy
  • Hong Ruan
  • Michele C Connelly
  • Peter Wick
  • Peter Gehr
  • Larry Walker
  • Q Ping Dou
  • Barbara Rothen-Rutishauser
  • Troy Smillie
  • Chandanamali Punchihewa
  • Kuo Chu Hwang
  • Kristin M Brown
  • David Smithson
  • Jingping Zhang
  • John P Hester
  • Harald F Krug
  • Jincai Zhao
  • Ikhlas A Khan
  • Cynthia Nelson
  • Qiuzhi Cindy Cui
  • Mathias Nelle
  • Anang A Shelat

Detail Information

Publications56

  1. ncbi Advances in HPLC detection--towards universal detection
    Bin Zhang
    School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China
    Anal Bioanal Chem 390:299-301. 2008
  2. ncbi A kinetic study of product cleavage reactions from the solid phase by a biocompatible and removable cleaving reagent, HCl
    Bing Yan
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Comb Chem 9:684-9. 2007
    ..Therefore, our kinetic studies establish HCl as a biocompatible, removable, and effective substitute for TFA when final compounds are used for biological screening and drug discovery...
  3. pmc Exploring the immunotoxicity of carbon nanotubes
    Yanmei Yu
    School of Pharmaceutical Sciences, Shandong University, Jinan, China
    Nanoscale Res Lett 3:271-7. 2008
    ..This article reviews some existing studies assessing carbon nanotubes' toxicity to immune system and provides the potential mechanistic explanation...
  4. pmc The adsorption of biomolecules to multi-walled carbon nanotubes is influenced by both pulmonary surfactant lipids and surface chemistry
    Michael Gasser
    Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Materials Biology Interactions, St, Gallen, Switzerland
    J Nanobiotechnology 8:31. 2010
    ..abstract:..
  5. doi Leading neuroblastoma cells to die by multiple premeditated attacks from a multifunctionalized nanoconstruct
    Peifu Jiao
    School of Pharmaceutical Sciences, Shandong University, Jinan, China
    J Am Chem Soc 133:13918-21. 2011
    ..The success of this multipronged attack approach launched by cell-embedded nanoconstructs demonstrates the power and flexibility of nanotechnology in treating cancer, a difficult task for a small molecule...
  6. doi Anti-tumor selectivity of a novel tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models
    Qiu Zhang
    School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
    Biochem Pharmacol 86:351-60. 2013
    ..Furthermore, CDBT effectively inhibits tumor growth by 62.4% relative to the vehicle control after i.p. administration at 30 mg/kg for 11 days while showing no toxicity to normal tissues in NSCLC H460 xenograft mouse model...
  7. pmc Steering carbon nanotubes to scavenger receptor recognition by nanotube surface chemistry modification partially alleviates NFκB activation and reduces its immunotoxicity
    Ningning Gao
    School of Pharmaceutical Sciences, Shandong University, Jinan 250100, China
    ACS Nano 5:4581-91. 2011
    ..The modified MWCNTs change their preferred binding pattern from mannose receptor to scavenger receptor. This switch significantly alleviates NFκB activation and reduces immunotoxicity of MWCNTs...
  8. doi Permission to enter cell by shape: nanodisk vs nanosphere
    Yi Zhang
    School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
    ACS Appl Mater Interfaces 4:4099-105. 2012
    ....
  9. doi Accelerating the multifunctionalization of therapeutic nanoparticles by using a multicomponent reaction
    Hongyu Zhou
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Chemistry 18:5501-5. 2012
    ..The gold nanosystem illustrated in the scheme was built and shown to enhance cancer cell targeting and killing by combining the effects of a therapeutic drug with X-ray radiation...
  10. doi Size-dependent cell uptake of protein-coated graphene oxide nanosheets
    Qingxin Mu
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, United States
    ACS Appl Mater Interfaces 4:2259-66. 2012
    ..These findings will facilitate biomedical and toxicologic studies of graphenes and provide fundamental understanding of interactions at the interface of two-dimensional nanostructures and biological systems...
  11. pmc Enhancement of cell recognition in vitro by dual-ligand cancer targeting gold nanoparticles
    Xi Li
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Biomaterials 32:2540-5. 2011
    ..Thus DLGNP has the potential to be a cancer-specific nano-theranostic agent...
  12. pmc Proteome interrogation using nanoprobes to identify targets of a cancer-killing molecule
    Liwen Li
    Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
    J Am Chem Soc 133:6886-9. 2011
    ..As an example, target proteins as α-tubulin and HSP 90 have been identified and validated...
  13. ncbi Natural product-inspired synthesis of thiazolidine and thiazolidinone compounds and their anticancer activities
    Qiu Zhang
    School of Chemistry and Chemical Engineering, Shandong University, Jinan, P R China
    Curr Pharm Des 16:1826-42. 2010
    ..The combinatorial library approach has been demonstrated to be effective in lead discovery and optimization in order to improve the potency and toxicity of these compounds...
  14. pmc Biocompatibility of polymer grafted core/shell iron/carbon nanoparticles
    Qingxin Mu
    School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
    Biomaterials 31:5083-90. 2010
    ..Except for the carboxyl modified Fe@CNPs, all other Fe@CNPs present low toxicity and can be used for further functionalization and in a wide range of biomedical applications...
  15. pmc Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen")
    M Jason Hatfield
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Nat Prod 76:36-44. 2013
    ..It is concluded that remedies containing tanshinones should be avoided when individuals are taking esterified agents and that patients should be warned of the potential drug-drug interaction that may occur with this material...
  16. doi Enhancing cell recognition by scrutinizing cell surfaces with a nanoparticle array
    Hongyu Zhou
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, United States
    J Am Chem Soc 133:680-2. 2011
    ..The achieved differentiation provides nanoparticles the ability for potential applications in treatment of patients at a personalized medicine level for drug delivery and radiation therapy with a much better safety profile...
  17. doi Analytical strategies for detecting nanoparticle-protein interactions
    Liwen Li
    School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China
    Analyst 135:1519-30. 2010
    ..Since NP-protein binding is a dynamic event, surface plasmon resonance (SPR) and quartz crystal microbalance (QCM) are methods of choice to study the kinetics of NP-protein binding...
  18. pmc Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells
    Shumei Zhai
    School of Chemistry and Chemical Engineering, Shandong University, Jinan, China
    J Biol Inorg Chem 15:259-69. 2010
    ..In contrast, the non-copper-binding analogs of 8-OHQ or CQ blocked the very first step-copper binding-in this chain of events mediated by 8-OHQ-Cu or CQ-Cu...
  19. pmc A novel dithiocarbamate analogue with potentially decreased ALDH inhibition has copper-dependent proteasome-inhibitory and apoptosis-inducing activity in human breast cancer cells
    Fei Wang
    School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, PR China
    Cancer Lett 300:87-95. 2011
    ....
  20. ncbi Perturbation of physiological systems by nanoparticles
    Yi Zhang
    Key Laboratory for Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
    Chem Soc Rev 43:3762-809. 2014
    ..The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized. ..
  21. ncbi Antitumor activity of (2E,5Z)-5-(2-hydroxybenzylidene)-2-((4-phenoxyphenyl)imino) thiazolidin-4-one, a novel microtubule-depolymerizing agent, in U87MG human glioblastoma cells and corresponding mouse xenograft model
    Qiu Zhang
    School of Chemistry and Chemical Engineering, Shandong University, Jinan, China
    J Pharmacol Sci 122:223-31. 2013
    ..These findings indicate that HBPT has the potential to be developed as a novel agent for the treatment of glioblastoma. [Supplementary Tables: available only at http://dx.doi.org/10.1254/jphs.13064FP]...
  22. ncbi Tuning cell autophagy by diversifying carbon nanotube surface chemistry
    Ling Wu
    School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China
    ACS Nano 8:2087-99. 2014
    ..Variation of the surface ligand structure of strong autophagy nanoinducers led to the induction of different autophagy-activating signaling pathways, presumably through their different interactions with cell surface receptors. ..
  23. doi Advances in preclinical small molecules for the treatment of NSCLC
    Qiu Zhang
    Shandong University, Chemistry, 27 Shanda Nanlu, Jinan, 250100, China
    Expert Opin Ther Pat 19:731-51. 2009
    ..Advances in the knowledge of molecular events governing oncogenesis have led to a number of novel therapeutic agents targeting specific pathways critical for tumor growth...
  24. pmc Microwave-assisted fluorous synthesis of a 1,4-benzodiazepine-2,5-dione library
    Aifeng Liu
    School of Pharmaceutical Sciences, Shandong University, Jinan, China
    J Comb Chem 11:1083-93. 2009
    ..The fluorous tag facilitated the intermediate purifications using fluorous solid-phase extraction (F-SPE) and had no negative impact on the reactivity of the Ugi reactions and postcondensation reactions...
  25. doi Use of cyclohexylisocyanide and methyl 2-isocyanoacetate as convertible isocyanides for microwave-assisted fluorous synthesis of 1,4-benzodiazepine-2,5-dione library
    Hongyu Zhou
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Comb Chem 12:206-14. 2010
    ..A thirty three-member biaryl-substituted BZD library containing four points of diversity was prepared by microwave-assisted solution-phase fluorous parallel synthesis...
  26. pmc Functionalized carbon nanotubes specifically bind to alpha-chymotrypsin's catalytic site and regulate its enzymatic function
    Bin Zhang
    School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
    Nano Lett 9:2280-4. 2009
    ..By generating surface molecular diversity, we created functionalized CNTs that recognize and bind to the catalytic site of alpha-chymotrypsin and inhibit its enzymatic activity competitively...
  27. doi Kinetics of resin-supported Mitsunobu esterification and etherification reactions
    Xifeng Ma
    School of Pharmaceutical Sciences, Shandong University, Jinan, China
    J Comb Chem 11:438-45. 2009
    ..By studying side reactions and intermediates, we found that the solid-phase reaction mechanism also bears remarkable similarities to that of solution phase Mitsunobu reaction...
  28. ncbi Structural confirmation and quantification of individual ligands from the surface of multi-functionalized gold nanoparticles
    Hongyu Zhou
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Analyst 135:1210-3. 2010
    ..A novel approach to identify structures and quantify the absolute amounts of individual ligands on multi-functionalized gold nanoparticles by an FTIR and HPLC/MS/UV/CLND method has been developed...
  29. pmc Functional regulation of cystic fibrosis transmembrane conductance regulator-containing macromolecular complexes: a small-molecule inhibitor approach
    Weiqiang Zhang
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Biochem J 435:451-62. 2011
    ..The present study might help to identify novel therapeutic targets to treat diseases associated with dysfunctional CFTR Cl- channels...
  30. doi Comparison of cancer cell survival triggered by microtubule damage after turning Dyrk1B kinase on and off
    Liwen Li
    School of Chemistry and Chemical Engineering, Shandong University, Jinan, China 250100
    ACS Chem Biol 9:731-42. 2014
    ..This approach affords a novel drug discovery strategy by targeting both the therapeutic targets and the associated cell survival pathway using a single therapeutic agent. ..
  31. doi Cell rescue by nanosequestration: reduced cytotoxicity of an environmental remediation residue, Mg(OH)2 nanoflake/Cr(VI) adduct
    Ruinan Zhang
    School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
    Environ Sci Technol 48:1984-92. 2014
    ..This cytotoxicity is only a fraction of the cytotoxicity of free Cr(VI) because nano-Mg(OH)2 particles are able to retain more than half of their Cr(VI) anions. ..
  32. doi Functionalized carbon nanotubes for potential medicinal applications
    Yi Zhang
    School of Pharmaceutical Sciences, Shandong University, Jinan, 250100, China
    Drug Discov Today 15:428-35. 2010
    ..These potential applications are particularly encouraged by their ability to penetrate biological membranes and relatively low toxicity...
  33. pmc Regulation of enzyme activity through interactions with nanoparticles
    Zhaochun Wu
    Shandong University, Jinan, China
    Int J Mol Sci 10:4198-209. 2009
    ..Recent representative studies on the NP-enzyme interactions and the regulation of enzyme activity by NPs with different size, composition and surface modification are reviewed...
  34. ncbi Toward a better understanding of pharmacokinetics of nanomaterials
    Chengke Zhang
    School of Pharmaceutical Sciences and School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
    Curr Pharm Des 19:6667-80. 2013
    ..In this review, we highlight some recent advances in the pharmacokinetic studies of representative nanomaterials. We focus on the relationships between the physicochemical properties of nanomaterials and physiological consequences. ..
  35. ncbi Characterizing the surface chemistry of nanoparticles: an analogy to solid-phase synthesis samples
    Yin Liu
    School of Chemistry and Chemical Engineering, Shandong University, Jinan, China
    Comb Chem High Throughput Screen 14:191-7. 2011
    ..FTIR, NMR, MS and other analytical methods have been used as effective methods to analyze surface bound molecules and monitor organic reactions directly, or indirectly, on a solid phase of a resin or a NPs...
  36. doi Feasibility of a self-calibrated LC/MS/UV method to determine the absolute amount of compounds in their storage and screening lifecycle
    Minghua Qi
    School of Pharmaceutical Sciences, Shandong University, Jinan, China
    J Comb Chem 10:162-5. 2008
  37. doi A nano-combinatorial library strategy for the discovery of nanotubes with reduced protein-binding, cytotoxicity, and immune response
    Hongyu Zhou
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nano Lett 8:859-65. 2008
    ..Our results demonstrated the general utility of the nanocombinatorial library approach in nanomedicine and nanotoxicity research...
  38. ncbi Suppression of human bone morphogenetic protein signaling by carboxylated single-walled carbon nanotubes
    Qingxin Mu
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    ACS Nano 3:1139-44. 2009
    ..This finding may have potential therapeutic applications to treat human diseases related to Id proteins or BMP signaling such as breast cancer and bone diseases...
  39. pmc Analytical strategies for characterizing the surface chemistry of nanoparticles
    Bin Zhang
    School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China
    Anal Bioanal Chem 396:973-82. 2010
    ....
  40. doi Dual detection approach to a more accurate measure of relative purity in high-throughput characterization of compound collections
    Andrew Lemoff
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Comb Chem 10:746-51. 2008
    ..This technique was applied to 959 compounds from our compound collection to more accurately determine their relative purity...
  41. doi Real-time monitoring of cellular responses to carbon nanotubes
    Qingxin Mu
    School of Chemistry and Chemical Engineering, Shandong University, Jinan, P R China
    Methods Mol Biol 625:85-94. 2010
    ..The label-free, real-time, and high-throughput assay overcomes many drawbacks in current optical based cytotoxicity assays in carbon nanotubes research, and enables dynamic monitoring of cellular responses to carbon nanotubes...
  42. doi Nanoparticle-based strategies for detection and remediation of environmental pollutants
    Yanyan Liu
    School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China
    Analyst 136:872-7. 2011
    ....
  43. doi High-throughput fractionation of natural products for drug discovery
    Ying Tu
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, TN, USA
    Methods Mol Biol 918:117-26. 2012
    ..5-10 mg scale for creation of libraries that could be used for the screening of multiple targets to identify hits for various applications including drug discovery...
  44. doi Cell cycle regulation by carboxylated multiwalled carbon nanotubes through p53-independent induction of p21 under the control of the BMP signaling pathway
    Yi Zhang
    School of Pharmaceutical Sciences, Shandong University, Jinan 250100, China
    Chem Res Toxicol 25:1212-21. 2012
    ..Hypophosphorylation of Rb prevents the release of E2F factors and causes cell cycle arrest. These findings provide valuable insight into a mechanistic understanding of carbon nanotubes' effects on cellular functions...
  45. doi The potential health risk of titania nanoparticles
    Ruinan Zhang
    School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
    J Hazard Mater 211:404-13. 2012
    ..This review summarizes relevant reports to support the development of better predictive toxicological models and the safe future application of TNPs...
  46. pmc Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones
    Elizabeth I Parkinson
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 2794, USA
    Bioorg Med Chem 19:4635-43. 2011
    ..We conclude from these studies that that the inhibitory power of these 1,2-dione derivatives depends primarily upon the hydrophobicity of the R group, but also on the electrophilicity of the carbonyl group...
  47. pmc Endosomal leakage and nuclear translocation of multiwalled carbon nanotubes: developing a model for cell uptake
    Qingxin Mu
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nano Lett 9:4370-5. 2009
    ..Our data is consistent with a working model for MWCNTs' cell uptake and cellular translocations...
  48. pmc Nanotoxicity overview: nano-threat to susceptible populations
    Yang Li
    School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
    Int J Mol Sci 15:3671-97. 2014
    ..This review will help minimize adverse effects of nanoparticles to susceptible population in future nanotechnology applications. ..
  49. pmc Effects of nanotoxicity on female reproductivity and fetal development in animal models
    Jianling Sun
    School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
    Int J Mol Sci 14:9319-37. 2013
    ..Limited studies on the mechanisms of nanotoxicity are also documented and reviewed herein...
  50. doi Design, synthesis, cytoselective toxicity, structure-activity relationships, and pharmacophore of thiazolidinone derivatives targeting drug-resistant lung cancer cells
    Hongyu Zhou
    Department of Chemical Biology and Therapeutics, St Jude Research Hospital, Memphis, Tennessee 38105, USA
    J Med Chem 51:1242-51. 2008
    ..Activities against P-gp-overexpressing and paclitaxel-resistant cell line H460 taxR and modeling using a previously validated P-gp substrate pharmacophore suggested that active compounds were not likely P-gp substrates...
  51. doi Microwave-assisted fluorous synthesis of 2-aryl-substituted 4-thiazolidinone and 4-thiazinanone libraries
    Hongyu Zhou
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Comb Chem 10:303-12. 2008
    ....
  52. pmc Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations
    Julian G Hurdle
    Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Antimicrob Chemother 66:1773-6. 2011
    ..The aim of this study was to explore whether probiotic-derived reutericyclin and related synthetic analogues could kill stationary phase C. difficile at concentrations achievable in the gastrointestinal tract...
  53. ncbi Structure-dependent response of a chemiluminescence nitrogen detector for organic compounds with adjacent nitrogen atoms connected by a single bond
    Bing Yan
    School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China Bristol Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA
    Anal Chem 79:718-26. 2007
    ..5/nitrogen atom for compounds with adjacent nitrogen atoms connected by a single bond should be abandoned. Compounds with similar structures should be used to generate calibration curves for quantification of this class of compounds...
  54. pmc Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility
    Yuhong Bai
    School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
    Nat Nanotechnol 5:683-9. 2010
    ..The fertility of treated male mice was unaffected; the pregnancy rate and delivery success of female mice that mated with the treated male mice did not differ from those that mated with untreated male mice...
  55. pmc Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway
    Neeraj Mahindroo
    Departments of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Bioorg Med Chem 18:4801-11. 2010
    ..6 μM and 1.6 μM of IC₅₀, respectively, and in Rh30 cells that endogenously overexpress Gli1, and were selective to Gli1 over Gli2...
  56. pmc Automated high-throughput system to fractionate plant natural products for drug discovery
    Ying Tu
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Nat Prod 73:751-4. 2010
    ..This procedure modernizes the traditional natural product fractionation paradigm by seamlessly integrating automation, informatics, and multimodal analytical interrogation capabilities...