STEPHEN W contact WHITE

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc A statistical framework to evaluate virtual screening
    Wei Zhao
    Department of Biostatistics, St Jude Children s Research Hospital, Memphis, TN, USA
    BMC Bioinformatics 10:225. 2009
  2. ncbi request reprint The high-resolution structure of DNA-binding protein HU from Bacillus stearothermophilus
    S W White
    Department of Structural Biology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Acta Crystallogr D Biol Crystallogr 55:801-9. 1999
  3. ncbi request reprint The structural biology of type II fatty acid biosynthesis
    Stephen W White
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Biochem 74:791-831. 2005
  4. pmc The receptor-binding domain of influenza virus hemagglutinin produced in Escherichia coli folds into its native, immunogenic structure
    Rebecca M DuBois
    Department of Structural Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    J Virol 85:865-72. 2011
  5. ncbi request reprint Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG
    Allen C Price
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, TN 38105 USA
    Structure 12:417-28. 2004
  6. ncbi request reprint The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Lipid Res 44:1-10. 2003
  7. pmc Structural basis for the transcriptional regulation of membrane lipid homeostasis
    Darcie J Miller
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Struct Mol Biol 17:971-5. 2010
  8. pmc A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli
    Suzanne Jackowski
    Protein Science Division, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Antimicrob Agents Chemother 46:1246-52. 2002
  9. pmc Validation of molecular docking programs for virtual screening against dihydropteroate synthase
    Kirk E Hevener
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Chem Inf Model 49:444-60. 2009
  10. pmc Molecular determinants for interfacial binding and conformational change in a soluble diacylglycerol kinase
    Agoston Jerga
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 284:7246-54. 2009

Collaborators

  • C O Rock
  • Wei Zhao
  • Yong Mei Zhang
  • Jie Zheng
  • I Tanaka
  • K S Wilson
  • R J Heath
  • S Jackowski
  • Darcie J Miller
  • Allen C Price
  • Rebecca M DuBois
  • Agoston Jerga
  • Kirk E Hevener
  • Mi Kyung Yun
  • Iain D Kerr
  • Pilho Kim
  • Yuriana Oropeza-Almazán
  • Stacey Schultz-Cherry
  • Charles J Russell
  • Mario Moises Alvarez
  • José Manuel Aguilar-Yañez
  • Gonzalo I Mendoza-Ochoa
  • Chitra Subramanian
  • David M Ball
  • Kerim Babaoglu
  • Richard E Lee
  • Jianjun Qi
  • Zhenmei Li
  • Sivashankar Sivakolundu
  • Jeffrey C Buchsbaum
  • Luke A Knox
  • Richard Kriwacki
  • Amanda Nourse
  • Quynh Anh Nguyen
  • John Lonsdale
  • Cynthia S Dowd
  • Helena I Boshoff
  • Ujjini H Manjunatha
  • Ken Duncan
  • Clifton E Barry
  • Michael B Goodwin
  • Gautham Shenoy

Detail Information

Publications15

  1. pmc A statistical framework to evaluate virtual screening
    Wei Zhao
    Department of Biostatistics, St Jude Children s Research Hospital, Memphis, TN, USA
    BMC Bioinformatics 10:225. 2009
    ..Also no comparisons have been made between these metrics under a statistical framework to better understand their performances...
  2. ncbi request reprint The high-resolution structure of DNA-binding protein HU from Bacillus stearothermophilus
    S W White
    Department of Structural Biology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Acta Crystallogr D Biol Crystallogr 55:801-9. 1999
    ..Most notably, the surfaces of the molecule which appear to mediate protein-DNA and protein-protein interactions have the ideal shapes and physicochemical properties to perform these functions...
  3. ncbi request reprint The structural biology of type II fatty acid biosynthesis
    Stephen W White
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Biochem 74:791-831. 2005
    ..These structures are also a valuable resource to guide antibacterial drug discovery...
  4. pmc The receptor-binding domain of influenza virus hemagglutinin produced in Escherichia coli folds into its native, immunogenic structure
    Rebecca M DuBois
    Department of Structural Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    J Virol 85:865-72. 2011
    ..The insertion of independently folding domains into fusogenic stalk domains may be a common feature of class I viral fusion proteins...
  5. ncbi request reprint Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG
    Allen C Price
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, TN 38105 USA
    Structure 12:417-28. 2004
    ..Biochemical data confirm that FabG[Y151F] is defective in NADPH binding. Finally, structural changes consistent with the observed negative cooperativity of FabG are described...
  6. ncbi request reprint The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Lipid Res 44:1-10. 2003
    ....
  7. pmc Structural basis for the transcriptional regulation of membrane lipid homeostasis
    Darcie J Miller
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Struct Mol Biol 17:971-5. 2010
    ..The regulation of DesT by the unsaturated:saturated ratio of acyl chains rather than the concentration of a single ligand is a paradigm for understanding transcriptional regulation of membrane lipid homeostasis...
  8. pmc A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli
    Suzanne Jackowski
    Protein Science Division, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Antimicrob Agents Chemother 46:1246-52. 2002
    ..These data illustrate that missense mutations that introduce valine at position 390 confer TLM resistance while maintaining the vital catalytic properties of FabB...
  9. pmc Validation of molecular docking programs for virtual screening against dihydropteroate synthase
    Kirk E Hevener
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Chem Inf Model 49:444-60. 2009
    ..Postdocking ligand relaxation and consensus scoring did not improve overall enrichment...
  10. pmc Molecular determinants for interfacial binding and conformational change in a soluble diacylglycerol kinase
    Agoston Jerga
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 284:7246-54. 2009
    ..This sequence conservation suggests that the mammalian enzymes also require a structural divalent cation and surface positively charged residues to bind phospholipid bilayers and trigger conformational changes that accelerate catalysis...
  11. ncbi request reprint Crystallographic and NMR analyses of UvsW and UvsW.1 from bacteriophage T4
    Iain D Kerr
    Department of Structural Biology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    J Biol Chem 282:34392-400. 2007
    ..The NMR solution structure of UvsW.1 reveals a dynamic four-helix bundle with homology to the structure-specific nucleic acid binding module of RecQ helicases...
  12. pmc Crystal structure and allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase I
    Mi Kyung Yun
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Mol Biol 369:794-811. 2007
    ..These data define the structural basis for the cooperative regulation of the intracellular asparaginase that is required for proper functioning within the cell...
  13. ncbi request reprint Structure of RhlG, an essential beta-ketoacyl reductase in the rhamnolipid biosynthetic pathway of Pseudomonas aeruginosa
    Darcie J Miller
    Department of Structural Biology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    J Biol Chem 281:18025-32. 2006
    ..These structural and biochemical studies establish RhlG as a NADPH-dependent beta-ketoacyl reductase of the SDR protein superfamily and further suggest that the ACP of fatty acid synthesis does not carry the substrates for RhlG...
  14. ncbi request reprint Inhibiting bacterial fatty acid synthesis
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Biol Chem 281:17541-4. 2006
    ..The role of each enzyme in regulating pathway activity and the diversity in the components of the pathway in the major human pathogens are important considerations in deciding the most suitable targets for future drug development...
  15. pmc Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli
    Pilho Kim
    Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Med Chem 49:159-71. 2006
    ..These results suggest a strict requirement for a conjugated, planar side chain inserting within the condensing enzyme active site...

Research Grants18

  1. Novel Inhibitors to DHPS to Probe Catalytic Mechanism & Therapeutic Potential
    Stephen W White; Fiscal Year: 2010
    ..However, we are also focused on developing specific therapies for the category A biowarfare agents B. anthracis, Y. pestis and F. tularensis, as well as for pathogenic protozoa and fungi. ..
  2. Recombination and fork progression in bacteriophage T4
    Stephen White; Fiscal Year: 2007
    ..The P.I. will direct the structural studies, and the co-P.I. will direct the in vivo studies. The in vitro analyses will be performed in both laboratories as appropriate. ..
  3. Novel Inhibitors to DHPS to Probe Catalytic Mechanism & Therapeutic Potential
    Stephen White; Fiscal Year: 2007
    ..However, we are also focused on developing specific therapies for the category A biowarfare agents B. anthracis, Y. pestis and F. tularensis, as well as for pathogenic protozoa and fungi. ..
  4. Development of DHPS as a Bioterrorism Therapeutic Target
    Stephen White; Fiscal Year: 2005
    ..The institutions have complementary programs in infectious diseases with a strong emphasis on studying bioterrorism. ..
  5. STRUCTURAL STUDIES ON RIBOSOMAL COMPONENTS
    Stephen White; Fiscal Year: 2002
    ..Future work will improve this image to accurately orient the IF3 molecule, and additional factors will be added to build up the complete initiation complex. ..
  6. Recombination and fork progression in bacteriophage T4
    STEPHEN W contact WHITE; Fiscal Year: 2010
    ..The project encompasses structural, genetics and biochemical techniques working in tandem to study these important biological questions. ..