Robert G Webster

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc Efficacy of zanamivir against avian influenza A viruses that possess genes encoding H5N1 internal proteins and are pathogenic in mammals
    I A Leneva
    Department of Virology and Molecular Biology, Memphis, Tennessee 38105, USA
    Antimicrob Agents Chemother 45:1216-24. 2001
  2. pmc The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04
    Rachelle Salomon
    Department of Infectious Diseases, St Jude Children s Research Hospital, and Department of Pathology, University of Tennessee, Memphis, TN 38105, USA
    J Exp Med 203:689-97. 2006
  3. pmc Influenza (H5N1) viruses in poultry, Russian Federation, 2005-2006
    Aleksandr S Lipatov
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Emerg Infect Dis 13:539-46. 2007
  4. pmc Human-like receptor specificity does not affect the neuraminidase-inhibitor susceptibility of H5N1 influenza viruses
    Natalia A Ilyushina
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 4:e1000043. 2008
  5. pmc Extensive mammalian ancestry of pandemic (H1N1) 2009 virus
    Natalia A Ilyushina
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Emerg Infect Dis 16:314-7. 2010
  6. pmc Role of terrestrial wild birds in ecology of influenza A virus (H5N1)
    Adrianus C M Boon
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Emerg Infect Dis 13:1720-4. 2007
  7. pmc Domestic ducks and H5N1 influenza epidemic, Thailand
    Thaweesak Songserm
    Kaselsart University, Nakorn Pathom, Thailand
    Emerg Infect Dis 12:575-81. 2006
  8. pmc H5N1 influenza viruses in Lao People's Democratic Republic
    David A Boltz
    St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Emerg Infect Dis 12:1593-5. 2006
  9. pmc The potential of avian H1N1 influenza A viruses to replicate and cause disease in mammalian models
    Zeynep A Koçer
    Department of Infectious Diseases, Division of Virology, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS ONE 7:e41609. 2012
  10. pmc Live bird markets of Bangladesh: H9N2 viruses and the near absence of highly pathogenic H5N1 influenza
    Nicholas J Negovetich
    St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS ONE 6:e19311. 2011

Research Grants

  1. COMBINATION CHEMOTHERAPY FOR PANDEMIC INFLUENZA
    Robert Webster; Fiscal Year: 2005

Detail Information

Publications155 found, 100 shown here

  1. pmc Efficacy of zanamivir against avian influenza A viruses that possess genes encoding H5N1 internal proteins and are pathogenic in mammals
    I A Leneva
    Department of Virology and Molecular Biology, Memphis, Tennessee 38105, USA
    Antimicrob Agents Chemother 45:1216-24. 2001
    ..Thus, zanamivir is efficacious in treating avian influenza viruses that can be transmitted to mammals...
  2. pmc The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04
    Rachelle Salomon
    Department of Infectious Diseases, St Jude Children s Research Hospital, and Department of Pathology, University of Tennessee, Memphis, TN 38105, USA
    J Exp Med 203:689-97. 2006
    ..Thus, novel antivirals targeting polymerase proteins should be developed...
  3. pmc Influenza (H5N1) viruses in poultry, Russian Federation, 2005-2006
    Aleksandr S Lipatov
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Emerg Infect Dis 13:539-46. 2007
    ..Pathogenicity in mammalian models was generally correlated with Lys at residue 627 of polymerase basic protein 2...
  4. pmc Human-like receptor specificity does not affect the neuraminidase-inhibitor susceptibility of H5N1 influenza viruses
    Natalia A Ilyushina
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 4:e1000043. 2008
    ..Sequence analysis of the NA gene alone, rather than analysis of both the NA and HA genes, and phenotypic assays in NHBE cells are likely to adequately identify drug-resistant H5N1 variants isolated from humans during an outbreak...
  5. pmc Extensive mammalian ancestry of pandemic (H1N1) 2009 virus
    Natalia A Ilyushina
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Emerg Infect Dis 16:314-7. 2010
    ..The biological properties of these viruses are consistent with those of their phylogenetic progenitors, indicating longstanding adaptation to mammals...
  6. pmc Role of terrestrial wild birds in ecology of influenza A virus (H5N1)
    Adrianus C M Boon
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Emerg Infect Dis 13:1720-4. 2007
    ..In summary, recent influenza (H5N1) viruses are pathogenic for small terrestrial bird species but the rate of intraspecies transmission in these hosts is very low...
  7. pmc Domestic ducks and H5N1 influenza epidemic, Thailand
    Thaweesak Songserm
    Kaselsart University, Nakorn Pathom, Thailand
    Emerg Infect Dis 12:575-81. 2006
    ..However, H5N1 influenza virus was prevalent among ducks raised in "open" houses, free-ranging (grazing) ducks, and backyard ducks...
  8. pmc H5N1 influenza viruses in Lao People's Democratic Republic
    David A Boltz
    St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Emerg Infect Dis 12:1593-5. 2006
    ..We report isolation of H5N1 virus genetically distinct from H5N1 circulating in 2004, which indicates reintroduction of H5N1 into Lao PDR after its disappearance (i.e., no virologic or serologic evidence) for 2 years...
  9. pmc The potential of avian H1N1 influenza A viruses to replicate and cause disease in mammalian models
    Zeynep A Koçer
    Department of Infectious Diseases, Division of Virology, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS ONE 7:e41609. 2012
    ..These findings suggest that avian H1N1 influenza viruses are unique among influenza A viruses in their potential to infect mammals...
  10. pmc Live bird markets of Bangladesh: H9N2 viruses and the near absence of highly pathogenic H5N1 influenza
    Nicholas J Negovetich
    St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS ONE 6:e19311. 2011
    ..e., reassortment and attenuation of host morbidity, highlight the importance of active surveillance of the poultry markets...
  11. pmc Spread of influenza virus A (H5N1) clade 2.3.2.1 to Bulgaria in common buzzards
    Atanaska Marinova-Petkova
    Regional Diagnostic Laboratory on Avian Infl uenza and Newcastle Disease in Birds, Varna, Bulgaria
    Emerg Infect Dis 18:1596-602. 2012
    ..The establishment of clade 2.3.2.1 highly pathogenic avian influenza viruses of the H5N1 subtype in wild birds in Europe would increase the likelihood of health threats to humans and poultry in the region...
  12. pmc Genetic analysis of influenza B viruses isolated in Uganda during the 2009-2010 seasons
    Denis K Byarugaba
    College of Veterinary Medicine, Makerere University, P, O, Box 7062, Kampala, Uganda
    Virol J 10:11. 2013
    ..Complete genome analysis of one influenza B virus and several gene segments of other influenza B viruses isolated from Uganda from May 2009 through December 2010 was therefore undertaken in this study...
  13. pmc Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade
    Henju Marjuki
    Division of Virology, Department of Infectious Diseases, St, Jude Children s Research Hospital, Memphis, TN 38105, USA
    Virol J 4:134. 2007
    ....
  14. pmc A model to control the epidemic of H5N1 influenza at the source
    Y Guan
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    BMC Infect Dis 7:132. 2007
    ..Systematic surveillance in southern China showed that ducks and geese are the primary reservoirs which transmit the virus to chickens, minor poultry and even migratory birds...
  15. pmc Influenza: an emerging disease
    R G Webster
    St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Emerg Infect Dis 4:436-41. 1998
    ..Moreover, if pigs are the mixing vessel for influenza viruses, surveillance in this population may also provide an early warning system for humans...
  16. pmc CK2beta gene silencing increases cell susceptibility to influenza A virus infection resulting in accelerated virus entry and higher viral protein content
    Henju Marjuki
    Division of Virology, Department of Infectious Diseases, St, Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Mol Signal 3:13. 2008
    ..We studied the role of CK2beta in IVA-infected A549 human epithelial lung cells...
  17. ncbi request reprint The importance of animal influenza for human disease
    Robert G Webster
    Department of Infectious Disease, Division of Virology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Vaccine 20:S16-20. 2002
    ..The separation of aquatic birds from other "land based" domestic poultry in Hong Kong after the H5N1 bird flu incident indicates that animal husbandry practices could influence the interspecies transmission of influenza viruses...
  18. ncbi request reprint Wet markets--a continuing source of severe acute respiratory syndrome and influenza?
    Robert G Webster
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet 363:234-6. 2004
    ..Wet markets are widespread in Asian countries and in countries where Asian people have migrated. Live-poultry markets were the source of the H5N1 bird-influenza virus that transmitted to and killed six of 18 people in Hong Kong...
  19. pmc Characterization of H5N1 influenza viruses that continue to circulate in geese in southeastern China
    Robert G Webster
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 76:118-26. 2002
    ....
  20. pmc H5N1 outbreaks and enzootic influenza
    Robert G Webster
    St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Emerg Infect Dis 12:3-8. 2006
    ..In fact, the root cause of the continuing H5N1 pandemic threat may be the way the pathogenicity of H5N1 viruses is masked by co-circulating influenza viruses or bad agricultural vaccines...
  21. ncbi request reprint Potential advantages of DNA immunization for influenza epidemic and pandemic planning
    R G Webster
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38101, USA
    Clin Infect Dis 28:225-9. 1999
    ..The DNA immunization strategy has the potential to rapidly provide a new vaccine in the face of an emerging influenza pandemic...
  22. ncbi request reprint The immunogenicity and efficacy against H5N1 challenge of reverse genetics-derived H5N3 influenza vaccine in ducks and chickens
    Robert G Webster
    St Jude Children s Research Hospital, Department of Infectious Diseases, Division of Virology, 332 N Lauderdale, Memphis, TN 38105, USA
    Virology 351:303-11. 2006
    ..015 to 1.2 microg of HA protein provide highly efficacious protection against lethal H5N1 challenge in ducks; only the two dose regimen has so far been tested in chickens with high protective efficacy...
  23. ncbi request reprint Immunity to influenza in the elderly
    R G Webster
    Virology and Molecular Biology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Vaccine 18:1686-9. 2000
    ..Attempts to increase the immunoresponsiveness of the elderly to influenza vaccines have given mixed results. The most convincing evidence is in rodents where dietary caloric restriction has been shown to enhance viral immunity...
  24. pmc Zoonotic potential of highly pathogenic avian H7N3 influenza viruses from Pakistan
    Uzma B Aamir
    Division of Virology, Department of Infectious Diseases, MS 330, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 2794, USA
    Virology 390:212-20. 2009
    ..We conclude that the H7N3/02 isolates from Pakistan show limited antigenic drift and have evolved slowly during their 8-year circulation in chickens; however, these viruses have the potential to infect mammals...
  25. pmc Antiviral susceptibility of avian and swine influenza virus of the N1 neuraminidase subtype
    Terri D Stoner
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Virol 84:9800-9. 2010
    ..We determined that natural oseltamivir resistance among swine and wild waterbirds is rare. Minor naturally occurring variants in NA can affect antiviral susceptibility...
  26. pmc Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility
    Hui Ling Yen
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Antimicrob Agents Chemother 49:4075-84. 2005
    ..Our results suggest that NAI-resistant influenza virus variants may differ substantially in fitness and transmissibility, depending on different levels of NA functional loss...
  27. ncbi request reprint Contribution of H7 haemagglutinin to amantadine resistance and infectivity of influenza virus
    Natalia A Ilyushina
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Gen Virol 88:1266-74. 2007
    ..Our finding reveals that sequence analysis of the transmembrane domain of M2 protein may not adequately identify all drug-resistant variants...
  28. ncbi request reprint Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses
    Aleksandr S Lipatov
    Department of Infectious Diseases Division of Virology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105 2794, USA
    J Gen Virol 86:1121-30. 2005
    ..This cytokine imbalance is reminiscent of the clinical findings in two humans who died of H5N1/97 infection and may explain the unusual severity of the disease...
  29. pmc Adaptation of pandemic H1N1 influenza viruses in mice
    Natalia A Ilyushina
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    J Virol 84:8607-16. 2010
    ..These modulators of virulence, therefore, may have been the driving components of early evolution, which paved the way for novel 2009 viruses in mammals...
  30. pmc Field assessment of an H5N1 inactivated vaccine in chickens and ducks in Lao PDR
    David A Boltz
    Department of Infectious Diseases, Division of Virology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Arch Virol 154:939-44. 2009
    ..Our results indicate that this inactivated H5N3 vaccine can produce long-lasting antibodies to homologous and heterologous viruses under field conditions...
  31. pmc Competitive fitness of oseltamivir-sensitive and -resistant highly pathogenic H5N1 influenza viruses in a ferret model
    Elena A Govorkova
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Virol 84:8042-50. 2010
    ..Our novel method of assessing viral fitness accounts for both virus-host interactions and virus-virus interactions within the host...
  32. pmc Increased acid stability of the hemagglutinin protein enhances H5N1 influenza virus growth in the upper respiratory tract but is insufficient for transmission in ferrets
    Hassan Zaraket
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Virol 87:9911-22. 2013
    ....
  33. pmc Intramuscularly administered neuraminidase inhibitor peramivir is effective against lethal H5N1 influenza virus in mice
    David A Boltz
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Antiviral Res 80:150-7. 2008
    ..Overall, our results demonstrate that IM administration of peramivir is effective in promoting the survival of mice infected with systemically replicating H5N1 virus...
  34. ncbi request reprint Influenza A viruses of migrating wild aquatic birds in North America
    Scott Krauss
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Vector Borne Zoonotic Dis 4:177-89. 2004
    ..The viruses reported in this study are available for genomic study to determine whether prediction of host range or pandemic potential is possible...
  35. pmc Role of quail in the interspecies transmission of H9 influenza A viruses: molecular changes on HA that correspond to adaptation from ducks to chickens
    Daniel R Perez
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Virol 77:3148-56. 2003
    ..Our findings suggest that quail provide an environment in which the adaptation of influenza viruses from ducks generates novel variants that can cross the species barrier...
  36. ncbi request reprint Preparation of a standardized, efficacious agricultural H5N3 vaccine by reverse genetics
    Ming Liu
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Virology 314:580-90. 2003
    ..3/02 (H5N1) but did not provide sterilizing immunity. Thus, reverse genetics allows the inexpensive preparation of standardized, efficacious H5N3 poultry vaccines that may also reduce the reemergence of H5N1 genotypes...
  37. pmc Neuraminidase inhibitor-resistant recombinant A/Vietnam/1203/04 (H5N1) influenza viruses retain their replication efficiency and pathogenicity in vitro and in vivo
    Hui Ling Yen
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Virol 81:12418-26. 2007
    ..Patients receiving NA inhibitors for H5N1 influenza virus infection should be closely monitored for the emergence of resistant variants...
  38. doi request reprint Influenza virus isolation
    Scott Krauss
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, USA
    Methods Mol Biol 865:11-24. 2012
    ..Successful isolation of influenza virus depends on the quality of the sample and matching the appropriate culture method to the sample type...
  39. pmc Emergence of influenza A virus variants after prolonged shedding from pheasants
    Jennifer Humberd
    Department of Infectious Diseases, Division of Virology, St Jude Children s Research Hospital, and Department of Biology, University of Memphis, TN 38152, USA
    J Virol 81:4044-51. 2007
    ..This study provided evidence that drift variants can occur naturally in pheasants after prolonged shedding of virus, thus strengthening our argument for the removal of pheasants from live-bird retail markets...
  40. pmc Emergence of H5N1 avian influenza viruses with reduced sensitivity to neuraminidase inhibitors and novel reassortants in Lao People's Democratic Republic
    David A Boltz
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Gen Virol 91:949-59. 2010
    ..These changes may contribute to the emergence of a pandemic influenza strain and are critical in devising surveillance strategies...
  41. pmc Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferrets
    Natalia A Ilyushina
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 6:e1000933. 2010
    ..There is a need for novel anti-influenza drugs that target different virus/host factors and can limit the emergence of resistance...
  42. pmc Feasibility of reconstructed ancestral H5N1 influenza viruses for cross-clade protective vaccine development
    Mariette F Ducatez
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Proc Natl Acad Sci U S A 108:349-54. 2011
    ..Such technologies should be explored to enhance the cross reactivity and availability of H5N1 influenza vaccines...
  43. pmc Inefficient transmission of H5N1 influenza viruses in a ferret contact model
    Hui Ling Yen
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    J Virol 81:6890-8. 2007
    ..Our results suggest that despite their receptor binding affinity, circulating H5N1 viruses retain molecular determinants that restrict their spread among mammalian species...
  44. pmc Pathogenicity and vaccine efficacy of different clades of Asian H5N1 avian influenza A viruses in domestic ducks
    Jeong Ki Kim
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    J Virol 82:11374-82. 2008
    ..The mechanism of complete protection in the absence of detectable antibody responses remains an open question...
  45. pmc Neurovirulence in mice of H5N1 influenza virus genotypes isolated from Hong Kong poultry in 2001
    Aleksandr S Lipatov
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, University of Tennessee, Memphis, Tennessee 38105, USA
    J Virol 77:3816-23. 2003
    ..We conclude that the original H5N1/01 isolates of genotypes A, C, D, and E were heterogeneous and that highly pathogenic neurotropic variants can be rapidly selected in mice...
  46. pmc Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread
    Hui Ling Yen
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 106:286-91. 2009
    ..These results show that VN1203 HA glycoprotein confers pathogenicity by facilitating systemic spread in mice; they also suggest that a minor change in receptor binding domain may modulate the virulence of H5N1 viruses...
  47. pmc Decreased neuraminidase activity is important for the adaptation of H5N1 influenza virus to human airway epithelium
    Natalia A Ilyushina
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Virol 86:4724-33. 2012
    ..This ability of decreased NA activity to promote H5N1 infection underlines the necessity to optimize management strategies for a plausible H5N1 pandemic...
  48. pmc Susceptibility of avian influenza viruses of the N6 subtype to the neuraminidase inhibitor oseltamivir
    Terri D Stoner
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, United States
    Antiviral Res 93:322-9. 2012
    ..This study showed that oseltamivir-resistant N6 NA avian influenza viruses are rare, and must be tested both phenotypically and genotypically to confirm resistance...
  49. pmc Novel genotyping and quantitative analysis of neuraminidase inhibitor resistance-associated mutations in influenza a viruses by single-nucleotide polymorphism analysis
    Susu Duan
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Antimicrob Agents Chemother 55:4718-27. 2011
    ....
  50. pmc The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity and transmissibility in ducks
    Mark L Reed
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    J Virol 84:1527-35. 2010
    ..The data also demonstrate that H5N1 neuraminidase activity increases the pH of activation of the HA protein in vitro...
  51. ncbi request reprint Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 influenza virus in mice
    Hui Ling Yen
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 192:665-72. 2005
    ..CONCLUSIONS. Oseltamivir prophylaxis is efficacious against lethal challenge with VN1203/04 virus in mice. Viral virulence may affect the antiviral treatment schedule...
  52. pmc Single- and multiple-clade influenza A H5N1 vaccines induce cross protection in ferrets
    Heather L Forrest
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Vaccine 27:4187-95. 2009
    ..Importantly, all vaccines protected against lethal challenge with A/Vietnam/1203/04 virus and provided cross-clade protection...
  53. pmc Influenza in migratory birds and evidence of limited intercontinental virus exchange
    Scott Krauss
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 3:e167. 2007
    ..Overall, the available evidence does not support the perpetuation of HP H5N1 influenza in migratory birds and suggests that the introduction of HP Asian H5N1 to the Americas by migratory birds is likely to be a rare event...
  54. pmc Cross-reactive neutralizing antibodies directed against pandemic H1N1 2009 virus are protective in a highly sensitive DBA/2 mouse influenza model
    Adrianus C M Boon
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 84:7662-7. 2010
    ..Passive transfer of these antibodies prior to infection protected mice from H1N1pdm-induced pathogenicity, demonstrating the effectiveness of these cross-reactive neutralizing antibodies in vivo...
  55. pmc Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice
    Natalia A Ilyushina
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Antimicrob Agents Chemother 52:3889-97. 2008
    ..Our preliminary results suggest that oseltamivir-ribavirin combinations can have a greater or lesser antiviral effect than monotherapy, depending on the H5N1 virus and the concentrations used...
  56. pmc Three amino acid changes in PB1-F2 of highly pathogenic H5N1 avian influenza virus affect pathogenicity in mallard ducks
    Henju Marjuki
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Arch Virol 155:925-34. 2010
    ..In cultured cells, repairing three mutations in PB1-F2 increased viral polymerase activity and expression levels of viral RNA...
  57. pmc Reemerging H5N1 influenza viruses in Hong Kong in 2002 are highly pathogenic to ducks
    Katharine M Sturm-Ramirez
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Virol 78:4892-901. 2004
    ..This is the first reported case of lethal influenza virus infection in wild aquatic birds since 1961...
  58. pmc Assessment of the efficacy of the neuraminidase inhibitor oseltamivir against 2009 pandemic H1N1 influenza virus in ferrets
    Elena A Govorkova
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Antiviral Res 91:81-8. 2011
    ..Overall, oseltamivir treatment decreases the signs of infection and reduced the spread of H1N1pdm influenza virus in the lungs of ferrets and therefore impeded the development of viral pneumonia...
  59. pmc The neuraminidase inhibitor oseltamivir is effective against A/Anhui/1/2013 (H7N9) influenza virus in a mouse model of acute respiratory distress syndrome
    Tatiana Baranovich
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee
    J Infect Dis 209:1343-53. 2014
    ..High mortality and uncertainty about the effectiveness of neuraminidase inhibitors (NAIs) in humans infected with influenza A(H7N9) viruses are public health concerns...
  60. pmc Risk assessment of H2N2 influenza viruses from the avian reservoir
    Jeremy C Jones
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Virol 88:1175-88. 2014
    ..Nonetheless, the sustained pathogenicity of avian H2N2 viruses in multiple mammalian models elevates their risk potential for human infections and stresses the need for continual surveillance as a component of prepandemic planning. ..
  61. pmc Different incubation temperatures affect viral polymerase activity and yields of low-pathogenic avian influenza viruses in embryonated chicken eggs
    Victoria Lang
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Arch Virol 156:987-94. 2011
    ..Our findings revealed that the optimal activity of the viral polymerase complex, resulting in the highest yield of LPAIV field isolates, could be obtained by incubation for two days in ECE at 37°C and 39°C...
  62. pmc TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection
    Jerry R Aldridge
    Division of Virology, Department of Infectious Diseases, and Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 106:5306-11. 2009
    ..Targeting the tipDCs in this way thus offers possibilities for therapeutic intervention in the face of a catastrophic pandemic...
  63. pmc Role of specific hemagglutinin amino acids in the immunogenicity and protection of H5N1 influenza virus vaccines
    Erich Hoffmann
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Proc Natl Acad Sci U S A 102:12915-20. 2005
    ..Our results suggest that inclusion of the N223 residue in the HA glycoproteins of diagnostic reference viruses may facilitate the evaluation of vaccine efficacy in humans...
  64. pmc Influenza: emergence and control
    Aleksandr S Lipatov
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 78:8951-9. 2004
  65. pmc Importance of neuraminidase active-site residues to the neuraminidase inhibitor resistance of influenza viruses
    Hui Ling Yen
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Virol 80:8787-95. 2006
    ..The results of our study may help to optimize the design of NAIs...
  66. pmc Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004
    Elena A Govorkova
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Virol 79:2191-8. 2005
    ....
  67. pmc Antiviral resistance among highly pathogenic influenza A (H5N1) viruses isolated worldwide in 2002-2012 shows need for continued monitoring
    Elena A Govorkova
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Antiviral Res 98:297-304. 2013
    ..Continued antiviral susceptibility monitoring of H5N1 viruses is needed to maintain therapeutic approaches for control of disease...
  68. pmc Persistent host markers in pandemic and H5N1 influenza viruses
    David B Finkelstein
    Hartwell Center for Bioinformatics and Biotechnology, St Jude Children s Research Hospital, and Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38105 2794, USA
    J Virol 81:10292-9. 2007
    ..The markers reported here should be useful in monitoring potential pandemic influenza viruses...
  69. pmc Comparison of the replication of influenza A viruses in Chinese ring-necked pheasants and chukar partridges
    Jennifer Humberd
    Department of Infectious Diseases, Division of Virology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Virol 80:2151-61. 2006
    ..Their continued presence in live markets contributes to the perpetuation and genetic interaction of influenza viruses there. On the basis of our findings, it does not make good sense to ban quail but not pheasants from the live markets...
  70. pmc Modulation of the severity of highly pathogenic H5N1 influenza in chickens previously inoculated with Israeli H9N2 influenza viruses
    Alexey Khalenkov
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Virology 383:32-8. 2009
    ..The modulation of survivability was time-dependent; the effect was maximal 5 days after H9N2 inoculation. These findings suggest that co-circulation of H9N2 viruses can contribute to the spread of lethal H5N1 viruses...
  71. ncbi request reprint Efficacy of H5 influenza vaccines produced by reverse genetics in a lethal mouse model
    Aleksandr S Lipatov
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 191:1216-20. 2005
    ..Protection was achieved despite antigenic differences and incomplete matching of the vaccine strain and the challenge virus. Therefore, high levels of cross-protection are predicted in the mouse model...
  72. pmc Oseltamivir-resistant pandemic H1N1/2009 influenza virus possesses lower transmissibility and fitness in ferrets
    Susu Duan
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    PLoS Pathog 6:e1001022. 2010
    ....
  73. doi request reprint Respiratory tract versus cloacal sampling of migratory ducks for influenza A viruses: are both ends relevant?
    Scott Krauss
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, USA
    Influenza Other Respir Viruses 7:93-6. 2013
    ..Studies confirmed that some virus subtypes, especially H9 and highly pathogenic H5, are shed primarily through the respiratory tract and may not be detected in cloacal swabs...
  74. pmc Pathogenicity and transmissibility of North American triple reassortant swine influenza A viruses in ferrets
    Subrata Barman
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 8:e1002791. 2012
    ..We conclude that the lineages of HA and NA may play a crucial role in the respiratory droplet transmissibility of these viruses. These findings have important implications for pandemic planning and warrant confirmation...
  75. ncbi request reprint Mx1 gene protects mice against the highly lethal human H5N1 influenza virus
    Rachelle Salomon
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cell Cycle 6:2417-21. 2007
    ..Drugs that mimic this mechanism may be protective in humans...
  76. ncbi request reprint Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice
    Natalia A Ilyushina
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, USA
    Antivir Ther 12:363-70. 2007
    ..The clinical management of H5N1 influenza virus infection in humans remains unclear. Combination chemotherapy with drugs that target different viral proteins might be more effective than monotherapy...
  77. ncbi request reprint Large-scale sequence analysis of avian influenza isolates
    John C Obenauer
    Hartwell Center for Bioinformatics and Biotechnology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Science 311:1576-80. 2006
    ..We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant...
  78. pmc Amino acid residues in the fusion peptide pocket regulate the pH of activation of the H5N1 influenza virus hemagglutinin protein
    Mark L Reed
    Department of Infectious Diseases, MS 330, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    J Virol 83:3568-80. 2009
    ..Overall, the data show that residues comprising the fusion peptide pocket are important in triggering pH-dependent activation of the H5 HA protein...
  79. ncbi request reprint Eight-plasmid system for rapid generation of influenza virus vaccines
    Erich Hoffmann
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
    Vaccine 20:3165-70. 2002
    ..Our findings demonstrate that the eight-plasmid system allows the rapid and reproducible generation of reassortant influenza A viruses for use in the manufacture of vaccines...
  80. pmc Oseltamivir-resistant influenza A and B viruses pre- and postantiviral therapy in children and young adults with cancer
    Silvana Carr
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, USA
    Pediatr Infect Dis J 30:284-8. 2011
    ..Immunocompromised patients are highly susceptible to influenza infection and can have prolonged viral shedding, which is a risk factor for the development of antiviral resistance...
  81. pmc Influenza A virus-induced early activation of ERK and PI3K mediates V-ATPase-dependent intracellular pH change required for fusion
    Henju Marjuki
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Microbiol 13:587-601. 2011
    ..These findings highlight the importance of IAV-induced ERK and PI3K early activation as signalling mediators in V-ATPase-stimulated endosomal acidification required for fusion...
  82. pmc Susceptibility of highly pathogenic H5N1 influenza viruses to the neuraminidase inhibitor oseltamivir differs in vitro and in a mouse model
    Elena A Govorkova
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 2794, USA
    Antimicrob Agents Chemother 53:3088-96. 2009
    ..Multiple viral and host factors modulate the effectiveness of NA inhibitor regimens against such viruses and new, more consistently effective treatment options, including combination therapies, are needed...
  83. pmc Matrix gene of influenza a viruses isolated from wild aquatic birds: ecology and emergence of influenza a viruses
    Linda Widjaja
    Division of Virology, Department of Infectious Diseases, Mail Stop 330, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Virol 78:8771-9. 2004
    ..Overall, these results support the hypothesis that influenza viruses in wild waterfowl contain distinguishable lineages of M genes...
  84. pmc Comparison of efficacies of RWJ-270201, zanamivir, and oseltamivir against H5N1, H9N2, and other avian influenza viruses
    E A Govorkova
    Department of Virology and Molecular Biology, St. Jude's Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA
    Antimicrob Agents Chemother 45:2723-32. 2001
    ....
  85. ncbi request reprint Origin of the pandemic 1957 H2 influenza A virus and the persistence of its possible progenitors in the avian reservoir
    J R Schafer
    St Jude Children s Research Hospital, Department of Virology Molecular Biology, Memphis, Tennessee 38105
    Virology 194:781-8. 1993
    ..We conclude that antigenically conserved counterparts of the human Asian pandemic strain of 1957 continue to circulate in the avian reservoir and are coming into closer proximity to susceptible human populations...
  86. ncbi request reprint Reassortment and interspecies transmission of North American H6N2 influenza viruses
    Richard J Webby
    Division of Virology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Virology 295:44-53. 2002
    ..The presence of multiple H6N2 genotypes suggests that independent transmission and/or reassortment events may have taken place between aquatic bird and chicken influenza viruses...
  87. pmc Neuraminidase inhibitor-rimantadine combinations exert additive and synergistic anti-influenza virus effects in MDCK cells
    Elena A Govorkova
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Antimicrob Agents Chemother 48:4855-63. 2004
    ..These findings provide baseline information for therapeutic testing of the drug combinations in vivo...
  88. ncbi request reprint Are we ready for pandemic influenza?
    Richard J Webby
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Science 302:1519-22. 2003
    ..We conclude by prioritizing the remaining needs and exploring the reasons for our current lack of preparedness for an influenza pandemic...
  89. ncbi request reprint H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificity
    M N Matrosovich
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Virology 281:156-62. 2001
    ..Peculiar features of surface glycoproteins of H9N2 viruses from Hong Kong suggest an enhanced propensity for introduction into humans and emphasize the importance of poultry in the zoonotic transmission of influenza viruses...
  90. ncbi request reprint Microbial adaptation and change: avian influenza
    R G Webster
    Saint Jude Children s Research Hospital, Department of Infectious Diseases, Division of Virology, 332 North Lauderdale, Memphis, TN 38105, USA
    Rev Sci Tech 23:453-65. 2004
    ..More effective co-operation between scientists and veterinary and public health officials is required to achieve these goals...
  91. pmc Emergence of influenza A viruses
    R J Webby
    Department of Virology and Molecular Biology, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Philos Trans R Soc Lond B Biol Sci 356:1817-28. 2001
    ..That these transmission events took place in Hong Kong and China adds further support to the hypothesis that Asia is an epicentre for influenza and stresses the importance of surveillance of pigs and live-bird markets in this area...
  92. ncbi request reprint Avian influenza viruses in Korean live poultry markets and their pathogenic potential
    Young Ki Choi
    Division of Virology, Department of Infectious Diseases, Mail Stop 330, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis TN 38105 2794, USA
    Virology 332:529-37. 2005
    ..The H3N2 viruses replicated in chickens and mice without preadaptation, but the H6N1 virus did not. Our results show an increasingly diverse pool of avian influenza viruses in Korea that are potential pandemic influenza agents...
  93. ncbi request reprint The genesis of a pandemic influenza virus
    Charles J Russell
    Department of Infectious Diseases, St Jude Children s Hospital, Memphis, Tennessee 38105, USA
    Cell 123:368-71. 2005
    ..Meanwhile, Tumpey et al. (2005) reporting in Science show that the reconstructed 1918 Spanish influenza virus kills mice faster than any other influenza virus so far tested...
  94. ncbi request reprint The influenza virus gene pool in a poultry market in South central china
    Ming Liu
    Virology Division, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Virology 305:267-75. 2003
    ..A single H4N6 isolate caused disease and systemic spread in chickens. These findings show that quail are broadly susceptible to different subtypes of influenza A virus...
  95. pmc Cooperation between the hemagglutinin of avian viruses and the matrix protein of human influenza A viruses
    Christoph Scholtissek
    Department of Virology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Virol 76:1781-6. 2002
    ....
  96. pmc Continuing evolution of H9N2 influenza viruses in Southeastern China
    Y K Choi
    Division of Virology, Department of Infectious Diseases, Mail Stop 330, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2694, USA
    J Virol 78:8609-14. 2004
    ..These results show an increasing genetic and biologic diversity of H9N2 viruses in Hong Kong and support their potential role as pandemic influenza agents...
  97. ncbi request reprint Multiple genotypes of nonpathogenic H6N2 influenza viruses isolated from chickens in California
    R J Webby
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Avian Dis 47:905-10. 2003
    ..Analysis of the remaining gene segments of the California viruses revealed that three distinct genotypes of H6N2 viruses were present...

Research Grants1

  1. COMBINATION CHEMOTHERAPY FOR PANDEMIC INFLUENZA
    Robert Webster; Fiscal Year: 2005
    ....