Robert G Webster
Affiliation: St. Jude Children's Research Hospital
el Shesheny R, Franks J, Marathe B, Hasan M, Feeroz M, Krauss S, et al
. Genetic characterization and pathogenic potential of H10 avian influenza viruses isolated from live poultry markets in Bangladesh. Sci Rep. 2018;8:10693 pubmed publisher
..Moreover, H10N6 and H10N1 AIVs caused high mortality with systemic dissemination. These results indicate that H10 AIVs pose a potential threat to human health and the mechanisms of their transmissibility should be elucidated. ..
Barman S, Franks J, Turner J, Yoon S, Webster R, Webby R. Egg-adaptive mutations in H3N2v vaccine virus enhance egg-based production without loss of antigenicity or immunogenicity. Vaccine. 2015;33:3186-92 pubmed publisher
..This combination of egg-adaptive mutations appears to most effectively generate high egg-based yields of influenza A/Indiana/08/2011-like CVVs. ..
el Shesheny R, Feeroz M, Krauss S, Vogel P, McKenzie P, Webby R, et al
. Replication and pathogenic potential of influenza A virus subtypes H3, H7, and H15 from free-range ducks in Bangladesh in mammals. Emerg Microbes Infect. 2018;7:70 pubmed publisher
..Our study highlights the role of free-range ducks in the spread of influenza viruses to other species in live poultry markets and the potential for these viruses to infect and cause disease in mammals. ..
Webster R, Webby R, Hoffmann E, Rodenberg J, Kumar M, Chu H, et al
. The immunogenicity and efficacy against H5N1 challenge of reverse genetics-derived H5N3 influenza vaccine in ducks and chickens. Virology. 2006;351:303-11 pubmed
..015 to 1.2 microg of HA protein provide highly efficacious protection against lethal H5N1 challenge in ducks; only the two dose regimen has so far been tested in chickens with high protective efficacy. ..
Smith J, Smith N, Yu L, Paton I, Gutowska M, Forrest H, et al
. A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance. BMC Genomics. 2015;16:574 pubmed publisher
Krauss S, Stallknecht D, Slemons R, Bowman A, Poulson R, Nolting J, et al
. The enigma of the apparent disappearance of Eurasian highly pathogenic H5 clade 126.96.36.199 influenza A viruses in North American waterfowl. Proc Natl Acad Sci U S A. 2016;113:9033-8 pubmed publisher
Zanin M, Koçer Z, Poulson R, Gabbard J, Howerth E, Jones C, et al
. Potential for Low-Pathogenic Avian H7 Influenza A Viruses To Replicate and Cause Disease in a Mammalian Model. J Virol. 2017;91: pubmed publisher
..Therefore, the disease-causing potential of LP avian H7 influenza A viruses in mammals may be underestimated, and these viruses therefore pose a potential public health risk. ..
Barman S, Krylov P, Turner J, Franks J, Webster R, Husain M, et al
. Manipulation of neuraminidase packaging signals and hemagglutinin residues improves the growth of A/Anhui/1/2013 (H7N9) influenza vaccine virus yield in eggs. Vaccine. 2017;35:1424-1430 pubmed publisher
..The HA-G218E substitution and a chimeric NA, thus, combine to provide an Anhui/1 CVV with properties more favorable for vaccine manufacture. ..
Zanin M, Wong S, Barman S, Kaewborisuth C, Vogel P, Rubrum A, et al
. Molecular basis of mammalian transmissibility of avian H1N1 influenza viruses and their pandemic potential. Proc Natl Acad Sci U S A. 2017;114:11217-11222 pubmed publisher
..The transmissibility of these viruses further highlights the pandemic potential of AIVs in the wild bird reservoir and the need to maintain surveillance. ..