Richard John Webby

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice
    Brendon J Hanson
    Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore 117510
    Respir Res 7:126. 2006
  2. ncbi Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D
    Kevan L Hartshorn
    Department of Medicine, Boston University School of Medicine, Boston MA, USA
    Respir Res 9:65. 2008
  3. ncbi Prospective study of avian influenza transmission to humans in Egypt
    Ghazi Kayali
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    BMC Public Health 10:685. 2010
  4. ncbi Protocol: transmission and prevention of influenza in Hutterites: zoonotic transmission of influenza A: swine & swine workers
    Margaret L Russell
    Department of Community Health Sciences, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    BMC Public Health 9:420. 2009
  5. ncbi Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines
    R J Webby
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet 363:1099-103. 2004
  6. ncbi Influenza vaccines
    A H Ellebedy
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Vaccine 27:D65-8. 2009
  7. ncbi Influenza vaccines
    Richard John Webby
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Front Biosci 13:4912-24. 2008
  8. ncbi Influenza viruses in animal wildlife populations
    R J Webby
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Curr Top Microbiol Immunol 315:67-83. 2007
  9. ncbi Multiple lineages of antigenically and genetically diverse influenza A virus co-circulate in the United States swine population
    R J Webby
    Division of Virology, Department of Infectious Diseases, MS 330, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Virus Res 103:67-73. 2004
  10. ncbi Extent of antigenic cross-reactivity among highly pathogenic H5N1 influenza viruses
    Mariette F Ducatez
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    J Clin Microbiol 49:3531-6. 2011

Research Grants

  1. Therapeutic Monoclonal Antibodies to H5N1 Influenza
    Richard Webby; Fiscal Year: 2007

Collaborators

  • J A Richt
  • Yi Guan
  • Robert G Webster
  • Ghazi Kayali
  • Mariette F Ducatez
  • Glendie Marcelin
  • Jerold Rehg
  • Ali H Ellebedy
  • A H Ellebedy
  • Margaret L Russell
  • Adrianus C M Boon
  • Kevan L Hartshorn
  • Brendon J Hanson
  • Jonathan A McCullers
  • Hazem E Ghoneim
  • Xiu Feng Wan
  • Henju Marjuki
  • Jerry R Aldridge
  • Susu Duan
  • Zhipeng Cai
  • Malik Peiris
  • Zhiping Ye
  • Paul G Thomas
  • Esmat A El-Ghafar
  • Xiaoping Xiong
  • Thomas H Oguin
  • Mohamed A Ali
  • Lobna S Sherif
  • Scott A Brown
  • Thomas P Fabrizio
  • Mark Loeb
  • Kevin Fonseca
  • Pam Singh
  • Julia Keenliside
  • Lorraine Moss
  • Rodney J Moreland
  • Ronald K Scheule
  • Tesfaldet Tecle
  • Erika C Crouch
  • Clark Pan
  • Mitchell R White
  • Susan Boucher
  • Ashley Webb
  • Eng Eong Ooi
  • Angeline P C Lim

Detail Information

Publications12

  1. ncbi Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice
    Brendon J Hanson
    Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore 117510
    Respir Res 7:126. 2006
    ..Humanized monoclonal antibodies (mAbs) that neutralize H5N1 virus could be used as prophylaxis and treatment to aid in the containment of such a pandemic...
  2. ncbi Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D
    Kevan L Hartshorn
    Department of Medicine, Boston University School of Medicine, Boston MA, USA
    Respir Res 9:65. 2008
    ..Surfactant protein D (SP-D) plays an important role in innate defense against influenza A viruses (IAVs) and other pathogens...
  3. ncbi Prospective study of avian influenza transmission to humans in Egypt
    Ghazi Kayali
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    BMC Public Health 10:685. 2010
    ..Our objective for this study is to answer these questions by estimating the prevalence and incidence rates of human cases and determine associated risk and protective factors in areas where H5N1 viruses are endemic...
  4. ncbi Protocol: transmission and prevention of influenza in Hutterites: zoonotic transmission of influenza A: swine & swine workers
    Margaret L Russell
    Department of Community Health Sciences, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    BMC Public Health 9:420. 2009
    ..This project also includes non-Hutterite swine farms that are experiencing swine respiratory illness...
  5. ncbi Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines
    R J Webby
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet 363:1099-103. 2004
    ..Since traditional strategies of vaccine production were not viable, we sought to produce a candidate reference virus using reverse genetics...
  6. ncbi Influenza vaccines
    A H Ellebedy
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Vaccine 27:D65-8. 2009
    ..Within the context of biodefense, the issue will be to reach a balance where some of the diversity of influenza viruses can be encompassed within a vaccine while maintaining an acceptable level of efficacy...
  7. ncbi Influenza vaccines
    Richard John Webby
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Front Biosci 13:4912-24. 2008
    ..In this review current and pending influenza vaccine technologies will be discussed in the context of both epidemic and pandemic influenza...
  8. ncbi Influenza viruses in animal wildlife populations
    R J Webby
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Curr Top Microbiol Immunol 315:67-83. 2007
    ..Even questions as fundamental as which hosts can transmit viruses to humans remain unanswered so far...
  9. ncbi Multiple lineages of antigenically and genetically diverse influenza A virus co-circulate in the United States swine population
    R J Webby
    Division of Virology, Department of Infectious Diseases, MS 330, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Virus Res 103:67-73. 2004
    ....
  10. ncbi Extent of antigenic cross-reactivity among highly pathogenic H5N1 influenza viruses
    Mariette F Ducatez
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    J Clin Microbiol 49:3531-6. 2011
    ..2-specific antisera detected most of the H5N1 antigens), ancestral strain A exhibited the widest reactivity pattern and hence was the best candidate diagnostic reagent for broad detection of H5N1 strains...
  11. ncbi Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice
    Glendie Marcelin
    Department of Infectious Diseases, Division of Virology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Mail Stop 330, Memphis, TN 38105, USA
    J Virol 85:11208-19. 2011
    ..Therefore, immunopathology likely caused by elevated cellular recruitment is an implicated mechanism of severe pH1N1 infection in pregnant mice...
  12. ncbi Contemporary seasonal influenza A (H1N1) virus infection primes for a more robust response to split inactivated pandemic influenza A (H1N1) Virus vaccination in ferrets
    Ali H Ellebedy
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Clin Vaccine Immunol 17:1998-2006. 2010
    ....

Research Grants2

  1. Therapeutic Monoclonal Antibodies to H5N1 Influenza
    Richard Webby; Fiscal Year: 2007
    ..The results of these studies will be the development of an effective, highly cross-reactive anti-influenza therapeutic for prevention and potentially for treatment of H5N1 infections. ..