Winfred C Wang

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)
    Winfred C Wang
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet 377:1663-72. 2011
  2. ncbi request reprint The pathophysiology, prevention, and treatment of stroke in sickle cell disease
    Winfred C Wang
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Curr Opin Hematol 14:191-7. 2007
  3. doi request reprint The effects of hydroxycarbamide and magnesium on haemoglobin SC disease: results of the multi-centre CHAMPS trial
    Winfred Wang
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Br J Haematol 152:771-6. 2011
  4. ncbi request reprint The pharmacotherapy of sickle cell disease
    Winfred C Wang
    St Jude Children s Research Hospital, Department of Hematology, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Expert Opin Pharmacother 9:3069-82. 2008
  5. ncbi request reprint Central nervous system complications of sickle cell disease in children: an overview
    Winfred C Wang
    Department of Hematology Oncology, St Jude Children s Research Hospital Memphis, TN38105, USA
    Child Neuropsychol 13:103-19. 2007
  6. ncbi request reprint Effect of long-term transfusion on growth in children with sickle cell anemia: results of the STOP trial
    Winfred C Wang
    St Jude Children s Research Hospital, Memphis, Tenn 38105, USA
    J Pediatr 147:244-7. 2005
  7. ncbi request reprint Brain imaging findings in pediatric patients with sickle cell disease
    R Grant Steen
    Department of Diagnostic Imaging, St Jude Children s Research Hosp, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Radiology 228:216-25. 2003
  8. pmc Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study
    Jane S Hankins
    St Jude Comprehensive Sickle Cell Center, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 106:2269-75. 2005
  9. doi request reprint Abdominal ultrasound with scintigraphic and clinical correlates in infants with sickle cell anemia: baseline data from the BABY HUG trial
    M Beth McCarville
    Department of Radiological Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Mail Stop 210, Memphis, TN 38105, USA
    AJR Am J Roentgenol 196:1399-404. 2011
  10. ncbi request reprint Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia
    Jane S Hankins
    Comprehensive Sickle Cell Center, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Br J Haematol 140:80-5. 2008

Research Grants

  1. COMPREHENSIVE SICKLE CELL CENTER
    Winfred Wang; Fiscal Year: 2006

Detail Information

Publications43

  1. pmc Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)
    Winfred C Wang
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet 377:1663-72. 2011
    ..We assessed the effect of hydroxycarbamide therapy on organ dysfunction and clinical complications, and examined laboratory findings and toxic effects...
  2. ncbi request reprint The pathophysiology, prevention, and treatment of stroke in sickle cell disease
    Winfred C Wang
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Curr Opin Hematol 14:191-7. 2007
    ..This review focuses on advances reported in the past 2 years...
  3. doi request reprint The effects of hydroxycarbamide and magnesium on haemoglobin SC disease: results of the multi-centre CHAMPS trial
    Winfred Wang
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Br J Haematol 152:771-6. 2011
    ..Mg had no effects. Further investigation of hydroxycarbamide as monotherapy in HbSC disease is warranted...
  4. ncbi request reprint The pharmacotherapy of sickle cell disease
    Winfred C Wang
    St Jude Children s Research Hospital, Department of Hematology, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Expert Opin Pharmacother 9:3069-82. 2008
    ..In the near future we expect to see exploration of the efficacy of drug combinations and an expansion in the use of the proven therapeutic, hydroxycarbamide...
  5. ncbi request reprint Central nervous system complications of sickle cell disease in children: an overview
    Winfred C Wang
    Department of Hematology Oncology, St Jude Children s Research Hospital Memphis, TN38105, USA
    Child Neuropsychol 13:103-19. 2007
    ..However, definitive prophylaxis and treatment for most CNS complications of sickle cell disease have yet to be determined...
  6. ncbi request reprint Effect of long-term transfusion on growth in children with sickle cell anemia: results of the STOP trial
    Winfred C Wang
    St Jude Children s Research Hospital, Memphis, Tenn 38105, USA
    J Pediatr 147:244-7. 2005
    ..To determine whether long-term transfusion improves growth in children with sickle cell anemia...
  7. ncbi request reprint Brain imaging findings in pediatric patients with sickle cell disease
    R Grant Steen
    Department of Diagnostic Imaging, St Jude Children s Research Hosp, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Radiology 228:216-25. 2003
    ..To determine prevalence of imaging abnormalities in the brain of children with sickle cell disease (SCD) and to identify clinical and methodological factors that influence prevalence estimate...
  8. pmc Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study
    Jane S Hankins
    St Jude Comprehensive Sickle Cell Center, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 106:2269-75. 2005
    ..Infants with SCA tolerate prolonged hydroxyurea therapy with sustained hematologic benefits, fewer ACS events, improved growth, and possibly preserved organ function...
  9. doi request reprint Abdominal ultrasound with scintigraphic and clinical correlates in infants with sickle cell anemia: baseline data from the BABY HUG trial
    M Beth McCarville
    Department of Radiological Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Mail Stop 210, Memphis, TN 38105, USA
    AJR Am J Roentgenol 196:1399-404. 2011
    ....
  10. ncbi request reprint Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia
    Jane S Hankins
    Comprehensive Sickle Cell Center, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Br J Haematol 140:80-5. 2008
    ..KCl co-transporter activity declined after 3 months of magnesium pidolate (P = 0.02). A phase II study is needed to investigate the efficacy of this drug combination...
  11. pmc R2* magnetic resonance imaging of the liver in patients with iron overload
    Jane S Hankins
    Departments of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Blood 113:4853-5. 2009
    ..98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038...
  12. doi request reprint The natural history of conditional transcranial Doppler flow velocities in children with sickle cell anaemia
    Jane S Hankins
    Department of Hematology, Comprehensive Sickle Cell Center, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Br J Haematol 142:94-9. 2008
    ..Our data document a high conversion rate to abnormal velocities among untreated children with SCA. Therapy should be considered for the prevention of conversion to abnormal TCD velocities...
  13. doi request reprint Protection from sickle cell retinopathy is associated with elevated HbF levels and hydroxycarbamide use in children
    Jeremie H Estepp
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Haematol 161:402-5. 2013
    ..16%; P = 0.005). We report a protective benefit of elevated HbF regarding retinopathy, and our data suggests induction of HbF with hydroxycarbamide may prevent retinopathy in children...
  14. pmc Hemodynamic responses to visual stimulation in children with sickle cell anemia
    Ping Zou
    Department of Radiological Sciences, St Jude Children s Research Hospital, MS 220, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Brain Imaging Behav 5:295-306. 2011
    ..8, pā€‰ ā‰¤ ā€‰0.05) with Wechsler Abbreviated Scale of Intelligence scores, suggesting that fMRI may help clarify medical, hemodynamic, and neural factors that mediate adverse effects of SCA on neurocognitive function...
  15. doi request reprint Arterial spin-labeled perfusion combined with segmentation techniques to evaluate cerebral blood flow in white and gray matter of children with sickle cell anemia
    Kathleen J Helton
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 52:85-91. 2009
    ..Recent studies have documented elevated gray matter (GM) CBF in untreated children with SCA, but no measurements of white matter (WM) CBF have been reported...
  16. ncbi request reprint Preservation of spleen and brain function in children with sickle cell anemia treated with hydroxyurea
    Jane S Hankins
    Department of Hematology, Comprehensive Sickle Cell Center, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 50:293-7. 2008
    ..Chronic organ damage is an insidious process in patients with sickle cell anemia (SCA). Although hydroxyurea prevents acute vaso-occlusive events, its effects on the preservation of organ function remain undefined...
  17. doi request reprint Renal function in infants with sickle cell anemia: baseline data from the BABY HUG trial
    Russell E Ware
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr 156:66-70.e1. 2010
    ..To examine the feasibility and accuracy of glomerular filtration rate (GFR) measurements in infants with sickle cell anemia (SCA)...
  18. ncbi request reprint The effect of hydroxyurea on vasculopathy in a child with sickle cell disease
    Kathleen J Helton
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    AJNR Am J Neuroradiol 23:1692-6. 2002
    ..Hydroxyurea can be effective in treating vasculopathy, but it might not prevent the progression of parenchymal damage in advanced disease...
  19. doi request reprint Neurocognitive screening with the Brigance preschool screen-II in 3-year-old children with sickle cell disease
    Banu Aygun
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Pediatr Blood Cancer 56:620-4. 2011
    ..However, the age of onset and factors contributing to this problem have not been well studied. We hypothesized that in children with SCD the failure rate with Brigance screening would be higher than in the normal population...
  20. ncbi request reprint Natural history of moderate aplastic anemia in children
    Scott C Howard
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 43:545-51. 2004
    ..We evaluated the rate of progression to SAA...
  21. doi request reprint Heparin induced thrombocytopenia and re-thrombosis associated with warfarin and fondaparinux in a child
    Scott H Maurer
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 53:468-71. 2009
    ..The argatroban/warfarin transition was monitored with chromogenic factor X levels. This case highlights several difficult problems in pediatric thrombosis...
  22. ncbi request reprint Pseudotumor cerebri in two adolescents with acquired aplastic anemia
    Michael R Jeng
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Pediatr Hematol Oncol 24:765-8. 2002
    ....
  23. pmc Hydroxyurea use and hospitalization trends in a comprehensive pediatric sickle cell program
    Kerri A Nottage
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS ONE 8:e72077. 2013
    ..This analysis evaluates the impact of increasing usage of HU on trends in hospitalizations and blood transfusions within a large SCD treatment program...
  24. ncbi request reprint Prospective brain imaging evaluation of children with sickle cell trait: initial observations
    R Grant Steen
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Radiology 228:208-15. 2003
    ..To determine whether sickle cell trait (hemoglobin AS) is associated with abnormalities in the brain of asymptomatic children...
  25. doi request reprint MRI abnormalities of the brain in one-year-old children with sickle cell anemia
    Winfred C Wang
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 51:643-6. 2008
    ..We performed MRI examinations of the brain in infants with SCA, who were evaluated as part of the multicenter randomized double-blinded Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG)...
  26. ncbi request reprint Effect of hydroxyurea on growth in children with sickle cell anemia: results of the HUG-KIDS Study
    Winfred C Wang
    Hematology Division, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr 140:225-9. 2002
    ..We report the growth characteristics of patients in the Phase I-II pediatric hydroxyurea trial (HUG-KIDS) before and during treatment at the maximum tolerated dose for one year...
  27. ncbi request reprint Resolution of chronic hepatic sequestration in a patient with homozygous sickle cell disease receiving hydroxyurea
    Michael R Jeng
    Departments of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr Hematol Oncol 25:257-60. 2003
    ..The findings in this case suggest that hydroxyurea may benefit patients who have unusual complications of sickle cell disease, such as chronic erythrocyte sickling in the liver...
  28. doi request reprint Dietary water and sodium intake of children and adolescents with sickle cell anemia
    Katherine T Fowler
    Department of Health and Sport Sciences, University of Memphis, Memphis, TN, USA
    J Pediatr Hematol Oncol 32:350-3. 2010
    ..Sociodemographic factors were not associated with dietary water or sodium intake. Our results suggest that children and adolescents with SCA would benefit from education regarding increasing fluid intake and limiting high sodium foods...
  29. ncbi request reprint Kindergarten readiness skills in children with sickle cell disease: evidence of early neurocognitive damage?
    R Grant Steen
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Child Neurol 17:111-6. 2002
    ..01), and there was a trend (P < .10) toward lower patient scores in language. Deficits cannot be attributed to school absence and may predict academic problems for patients with sickle cell disease...
  30. ncbi request reprint Pyogenic hepatic abscess after percutaneous liver biopsy in a patient with sickle cell disease
    Marta B Garcia-Arias
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr Hematol Oncol 27:103-5. 2005
    ..The presence of a hepatic abscess should be considered in the differential diagnosis of atypical abdominal pain in patients with SCD...
  31. ncbi request reprint A case of hemoglobin SC disease with cold agglutinin-induced hemolysis
    Hiroto Inaba
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Am J Hematol 78:37-40. 2005
    ..Careful evaluation of CBCs and peripheral blood smears is required in cases of worsening anemia among sickle cell patients and consideration should be given to cold hemagglutinin disease as an etiology...
  32. ncbi request reprint Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease
    Charles H Pegelow
    Department of Pediatrics, University of Miami, Miami, FL 33101, USA
    Blood 99:3014-8. 2002
    ..Until safe and effective preventive strategies against infarct recurrence are discovered, MRI studies are best reserved for children with neurologic symptoms, neuropsychometric deficits, or elevated cerebral artery velocities...
  33. ncbi request reprint Hydroxyurea therapy associated with declining serum levels of magnesium in children with sickle cell anemia
    Rachel A Altura
    Division of Hematology Oncology, Columbus Children s Hospital and Ohio State University, 43205, USA
    J Pediatr 140:565-9. 2002
    ..To obtain quantitative serum levels of total and ionized magnesium (Mg(2+)) in children with homozygous sickle cell anemia (SCA) undergoing therapy with hydroxyurea...
  34. ncbi request reprint Equation to estimate resting energy expenditure in adolescents with sickle cell anemia
    Maciej S Buchowski
    Center for Nutrition and Department of Family and Community Medicine, Meharry Medical College, Nashville, TN 37208, USA
    Am J Clin Nutr 76:1335-44. 2002
    ..Basal energy requirements are higher in adolescents with sickle cell anemia (SCA) than in healthy control subjects. However, no equation is available to accurately predict their energy needs...
  35. ncbi request reprint Predictors of fetal hemoglobin response in children with sickle cell anemia receiving hydroxyurea therapy
    Russell E Ware
    Duke University Medical Center, Durham, NC 27710, USA
    Blood 99:10-4. 2002
    ..The HbF response to hydroxyurea is variable and complex, however, and even children with low baseline %HbF values can develop substantial increases in %HbF at MTD...
  36. ncbi request reprint Pain at home in sickle cell disease: an underrecognized problem
    Winfred C Wang
    J Pediatr Hematol Oncol 24:610-2. 2002
  37. ncbi request reprint A prospective study of the relationship over time of behavior problems, intellectual functioning, and family functioning in children with sickle cell disease: a report from the Cooperative Study of Sickle Cell Disease
    Robert J Thompson
    Duke University, 114 Allen Building, Box 90042, Durham, NC 27708 0042, USA
    J Pediatr Psychol 28:59-65. 2003
    ..To longitudinally assess the relationship of behavioral problems, intellectual functioning, and family functioning in children with sickle cell disease (SCD)...
  38. ncbi request reprint Invasive pneumococcal infections in children with sickle cell disease in the era of penicillin prophylaxis, antibiotic resistance, and 23-valent pneumococcal polysaccharide vaccination
    Thomas V Adamkiewicz
    Centers for Disease Control and Prevention, and Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Drive NE, Atlanta, GA 30333, USA
    J Pediatr 143:438-44. 2003
    ..The pneumococcal-polysaccharide vaccine was 80.4% effective within 3 years after vaccination (95% CI, 39.7, 93.6). Children with sickle cell disease of all ages may benefit from PVC boosted with polysaccharide vaccination...
  39. ncbi request reprint Medical care utilization and mortality in sickle cell disease: a population-based study
    Sadhna M Shankar
    Division of Pediatric Hematology Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6310, USA
    Am J Hematol 80:262-70. 2005
    ..001). The death rate in adolescents and young adults with SCD continues to be much higher than population-specific rates. Interventions to prevent morbidity and mortality related to SCD are urgently needed...
  40. ncbi request reprint Hemoglobinopathies mimicking Hb S/beta-thalassemia: Hb S/S with alpha-thalassemia and Hb S/Volga
    Hong Yuan Luo
    Hemoglobin Diagnostic Reference Laboratory, Boston Medical Center, Boston, Massachusetts 02118, USA
    Am J Hematol 81:361-5. 2006
    ..These studies underscore the importance to correlate clinical course with laboratory diagnosis and to make DNA-based diagnostics more widely available for patients with unusual or complicated hemoglobin disorders...
  41. ncbi request reprint Pseudoscore-based estimation from biased observations
    X Joan Hu
    Department of Statistics and Actuarial Science, Simon Fraser University, Vancouver, BC V5A 1S6, Canada
    Stat Med 26:2836-52. 2007
    ..The methodology is illustrated by an example involving kindergarten readiness skills in children with sickle cell disease...
  42. ncbi request reprint Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine
    Natasha B Halasa
    Department of Pediatrics, Vanderbilt University School of Medicine, USA
    Clin Infect Dis 44:1428-33. 2007
    ..We sought to determine the incidence of invasive pneumococcal disease (IPD) among individuals with sickle cell disease (SCD) before and after the introduction of the pneumococcal conjugate vaccine (PCV)...
  43. ncbi request reprint Impact of proximity to comprehensive sickle cell center on utilization of healthcare services among children with sickle cell disease
    Sadhna M Shankar
    Department of Pediatrics, Division of Pediatric Hematology Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Pediatr Blood Cancer 50:66-71. 2008
    ..We compared the medical care utilization and mortality in children less than 20 years of age with SCD in four regions in the state of Tennessee with and without a comprehensive sickle cell center (CSCC)...

Research Grants2

  1. COMPREHENSIVE SICKLE CELL CENTER
    Winfred Wang; Fiscal Year: 2006
    ..abstract_text> ..