Ruoning Wang

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. doi request reprint Metabolic checkpoints in activated T cells
    Ruoning Wang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 13:907-15. 2012
  2. pmc Metabolic reprogramming and metabolic dependency in T cells
    Ruoning Wang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Immunol Rev 249:14-26. 2012
  3. doi request reprint T cell metabolism and the immune response
    Katherine C Verbist
    St Jude Children s Research Hospital, Department of Immunology, 262 Danny Thomas Place, Memphis, TN 38105, United States
    Semin Immunol 24:399-404. 2012
  4. pmc The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
    Ruoning Wang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 35:871-82. 2011
  5. pmc HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    Lewis Z Shi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Exp Med 208:1367-76. 2011
  6. pmc The relationship between metabolism and the autophagy machinery during the innate immune response
    Jennifer Martinez
    Department of Immunology, St Jude Children s Research Institute, Memphis, TN 38105, USA
    Cell Metab 17:895-900. 2013
  7. pmc Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control
    David C Bedford
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Metab 14:219-30. 2011

Collaborators

  • Hongbo Chi
  • Katherine C Verbist
  • Douglas R Green
  • Jennifer Martinez
  • David C Bedford
  • Lewis Z Shi
  • Gonghua Huang
  • Peter Vogel
  • Geoffrey Neale
  • Yunchao Chang
  • Lawryn H Kasper
  • Paul K Brindle

Detail Information

Publications7

  1. doi request reprint Metabolic checkpoints in activated T cells
    Ruoning Wang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 13:907-15. 2012
    ..Here we define 'metabolic checkpoints' that represent such interconnections and provide examples of how these checkpoints sense metabolic status and transduce signals to affect T lymphocyte responses...
  2. pmc Metabolic reprogramming and metabolic dependency in T cells
    Ruoning Wang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Immunol Rev 249:14-26. 2012
    ..In this review, we illustrate the relevant metabolic pathways revealed by recent metabolic flux analysis and discuss the consequences of metabolic intervention on specific metabolic pathways in T lymphocytes...
  3. doi request reprint T cell metabolism and the immune response
    Katherine C Verbist
    St Jude Children s Research Hospital, Department of Immunology, 262 Danny Thomas Place, Memphis, TN 38105, United States
    Semin Immunol 24:399-404. 2012
    ..Here, we examine the metabolic profiles of T cells during an acute immune response and discuss the signal and transcriptional regulators of these metabolic changes...
  4. pmc The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
    Ruoning Wang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 35:871-82. 2011
    ..Therefore, a Myc-dependent global metabolic transcriptome drives metabolic reprogramming in activated, primary T lymphocytes. This may represent a general mechanism for metabolic reprogramming under patho-physiological conditions...
  5. pmc HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    Lewis Z Shi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Exp Med 208:1367-76. 2011
    ..Our studies demonstrate that HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of T(H)17 and T(reg) cells...
  6. pmc The relationship between metabolism and the autophagy machinery during the innate immune response
    Jennifer Martinez
    Department of Immunology, St Jude Children s Research Institute, Memphis, TN 38105, USA
    Cell Metab 17:895-900. 2013
    ....
  7. pmc Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control
    David C Bedford
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Metab 14:219-30. 2011
    ..CBP(ΔCH1/ΔCH1) mice remain metformin responsive. An intact CH1 domain is thus necessary for normal energy storage, but not for the blood glucose-lowering actions of insulin and metformin...