DARIO AA VIGNALI

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo
    Creg J Workman
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 172:5450-5. 2004
  2. pmc How regulatory T cells work
    Dario A A Vignali
    Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105 2794, USA
    Nat Rev Immunol 8:523-32. 2008
  3. ncbi request reprint Profound enhancement of T cell activation mediated by the interaction between the TCR and the D3 domain of CD4
    D A Vignali
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38101, USA
    J Immunol 162:1431-9. 1999
  4. doi request reprint How many mechanisms do regulatory T cells need?
    Dario Vignali
    Department of Immunology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Eur J Immunol 38:908-11. 2008
  5. ncbi request reprint Multiplexed particle-based flow cytometric assays
    D A Vignali
    Department of Immunology, St Jude Children s Research Hospital, 332 N Lauderdale, 38105, Memphis, TN, USA
    J Immunol Methods 243:243-55. 2000
  6. pmc Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells
    Amanda R Burton
    Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    J Immunol 184:4863-70. 2010
  7. pmc Regulatory T cells and inhibitory cytokines in autoimmunity
    Maria Bettini
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Curr Opin Immunol 21:612-8. 2009
  8. pmc T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event
    Greig P Lennon
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 31:643-53. 2009
  9. pmc The development and function of regulatory T cells
    Creg J Workman
    Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Cell Mol Life Sci 66:2603-22. 2009
  10. pmc Cutting edge: regulatory T cells do not require stimulation through their TCR to suppress
    Andrea L Szymczak-Workman
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 182:5188-92. 2009

Research Grants

Collaborators

  • DAVID L contact WOODLAND
  • David Artis
  • P Santamaria
  • Peter Murray
  • JOHN J O'SHEA
  • D V Serreze
  • Creg J Workman
  • Amanda R Burton
  • Lauren W Collison
  • Maria Bettini
  • Andrea L Szymczak-Workman
  • Linda S Cauley
  • Greig P Lennon
  • Rodolfo José Chaparro
  • Roland Tisch
  • Jerold E Rehg
  • Paul R Giacomin
  • Abigail L Henderson
  • David Finkelstein
  • Michael L Jones
  • Hsiao Tzu Ni
  • Jaishree Bankoti
  • Scott A Brown
  • Zachary Baquet
  • George S Eisenbarth
  • Cliff Guy
  • Richard Smeyne
  • Vandana Chaturvedi
  • Karen Forbes
  • Mary Jo Turk
  • Yao Wang
  • Paula Y Arnold
  • Meenu R Pillai
  • Karim C El Kasmi
  • Drew M Pardoll
  • Erica Vincent
  • Charles G Drake
  • Teresa P DiLorenzo
  • Marcia A Blackman
  • In Jeong Kim
  • Timothy B Miller
  • Pamela S Adams
  • Kate M Vignali
  • Tres Cookenham

Detail Information

Publications15

  1. ncbi request reprint Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo
    Creg J Workman
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 172:5450-5. 2004
    ..In summary, these data suggest that LAG-3 negatively regulates T cell expansion and controls the size of the memory T cell pool...
  2. pmc How regulatory T cells work
    Dario A A Vignali
    Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105 2794, USA
    Nat Rev Immunol 8:523-32. 2008
    ..In addition, we propose the hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate T(Reg)-cell function...
  3. ncbi request reprint Profound enhancement of T cell activation mediated by the interaction between the TCR and the D3 domain of CD4
    D A Vignali
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38101, USA
    J Immunol 162:1431-9. 1999
    ..These data demonstrate that TCR:CD4.D3 interaction can have a profound effect on T cell activation and obviates the need for receptor oligomerization...
  4. doi request reprint How many mechanisms do regulatory T cells need?
    Dario Vignali
    Department of Immunology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Eur J Immunol 38:908-11. 2008
    ....
  5. ncbi request reprint Multiplexed particle-based flow cytometric assays
    D A Vignali
    Department of Immunology, St Jude Children s Research Hospital, 332 N Lauderdale, 38105, Memphis, TN, USA
    J Immunol Methods 243:243-55. 2000
    ....
  6. pmc Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells
    Amanda R Burton
    Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    J Immunol 184:4863-70. 2010
    ..These findings suggest that GAD65-reactive CD4(+) T cells alone mediate a lethal encephalomyelitis-like disease that may serve as a useful model to study GAD65-mediated diseases of the CNS...
  7. pmc Regulatory T cells and inhibitory cytokines in autoimmunity
    Maria Bettini
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Curr Opin Immunol 21:612-8. 2009
    ..These recent advances place a large emphasis on the local tissue specific inflammatory environment as it relates to T(reg) function and disease development...
  8. pmc T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event
    Greig P Lennon
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 31:643-53. 2009
    ..Therefore, islet entry and accumulation appears to be a cell-autonomous and tightly regulated event and is governed by islet antigen specificity...
  9. pmc The development and function of regulatory T cells
    Creg J Workman
    Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Cell Mol Life Sci 66:2603-22. 2009
    ..In this review, we will discuss the development of natural and induced Tregs as well as the role of Tregs in a variety of disease settings and the mechanisms they utilize for suppression...
  10. pmc Cutting edge: regulatory T cells do not require stimulation through their TCR to suppress
    Andrea L Szymczak-Workman
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 182:5188-92. 2009
    ..These data suggest that Tregs may possess constitutive regulatory activity that can be mediated in the absence of cognate peptide:MHC-TCR stimulation...
  11. pmc LAG-3 regulates plasmacytoid dendritic cell homeostasis
    Creg J Workman
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Immunol 182:1885-91. 2009
    ..Collectively, our data suggests that LAG-3 plays an important but selective cell intrinsic and cell extrinsic role in pDC biology, and may serve as a key functional marker for their study...
  12. ncbi request reprint Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223)
    Creg J Workman
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 174:688-95. 2005
    ..Lastly, regulatory T cells were dependent on LAG-3 for their optimal control of T cell homeostasis. Our data suggest that LAG-3 negatively regulates T cell homeostasis by regulatory T cell-dependent and independent mechanisms...
  13. pmc IL-35-mediated induction of a potent regulatory T cell population
    Lauren W Collison
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 11:1093-101. 2010
    ..Thus, iT(R)35 cells constitute a key mediator of infectious tolerance and contribute to T(reg) cell-mediated tumor progression. Furthermore, iT(R)35 cells generated ex vivo might have therapeutic utility...
  14. pmc Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells
    Rodolfo José Chaparro
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol Methods 335:106-15. 2008
    ..Our method is the first to combine the speed of Rg technology with an optimized in vitro Rg T cell expansion protocol to enable the rapid discovery of T cell antigens...
  15. ncbi request reprint Cutting edge: virus-specific CD4+ memory T cells in nonlymphoid tissues express a highly activated phenotype
    Linda S Cauley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 169:6655-8. 2002
    ..Differences in CD25 and CD11a expression indicate that the CD4(+) cells from the lung airways and parenchyma are distinct memory populations...

Research Grants18

  1. Mechanism and function of the regulatory protein LAG-3
    DARIO AA VIGNALI; Fiscal Year: 2010
    ..Appropriate regulation of the immune system is imperative. LAG-3 has emerged as a key negative regulatory molecule and its clear requirement for optimal regulatory T cell function warrants further study. ..
  2. Mechanism and function of the regulatory protein LAG-3
    Dario Vignali; Fiscal Year: 2009
    ....
  3. Mechanism and function of the regulatory protein LAG-3
    Dario Vignali; Fiscal Year: 2009
    ..Appropriate regulation of the immune system is imperative. LAG-3 has emerged as a key negative regulatory molecule and its clear requirement for optimal regulatory T cell function warrants further study. ..
  4. Mechanism and function of the regulatory protein LAG-3
    Dario Vignali; Fiscal Year: 2007
    ..Appropriate regulation of the immune system is imperative. LAG-3 has emerged as a key negative regulatory molecule and its clear requirement for optimal regulatory T cell function warrants further study. ..
  5. Molecular Control of TCR Signaling and Function
    Dario Vignali; Fiscal Year: 2007
    ..Biochemical analysis will be performed to assess TCR stability and surface expression. The effect of these mutations on T cell development and function will be assessed as outlined in Aim 2. ..
  6. MULTIMOLECULAR INTERACTIONS DURING TCR RECOGNITION
    Dario Vignali; Fiscal Year: 2005
    ..Our preliminary data suggest that LAG-3 may contribute to this important process. This project will define the physiological role of LAG-3 and how it exerts its function. ..
  7. Tolerance Induction by Targeted Expression of GAD
    Dario Vignali; Fiscal Year: 2003
    ..The incidence of insulitis and diabetes will be monitored to determine the extent of tolerance induction and prevention of disease. ..
  8. A Regulatory Triad: IL35, Tregs and iTr35
    DARIO AA VIGNALI; Fiscal Year: 2011
    ..Furthermore, this will also lead to the development of improved vaccination strategies for chronic infections and new therapies for cancer. ..