Paul G Thomas

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc NFkappaB negatively regulates interferon-induced gene expression and anti-influenza activity
    Lai Wei
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
    J Biol Chem 281:11678-84. 2006
  2. pmc The two faces of heterologous immunity: protection or immunopathology
    Shalini Sharma
    1 MS 351, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA
    J Leukoc Biol 95:405-16. 2014
  3. pmc Constrained evolution drives limited influenza diversity
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    BMC Biol 10:43. 2012
  4. pmc Physiological numbers of CD4+ T cells generate weak recall responses following influenza virus challenge
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 184:1721-7. 2010
  5. pmc Protective memory responses are modulated by priming events prior to challenge
    John A Rutigliano
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Virol 84:1047-56. 2010
  6. ncbi request reprint Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    J Immunol 178:3091-8. 2007
  7. pmc Screening monoclonal antibodies for cross-reactivity in the ferret model of influenza infection
    John A Rutigliano
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, United States
    J Immunol Methods 336:71-7. 2008
  8. pmc TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection
    Jerry R Aldridge
    Division of Virology, Department of Infectious Diseases, and Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 106:5306-11. 2009
  9. pmc Highly pathological influenza A virus infection is associated with augmented expression of PD-1 by functionally compromised virus-specific CD8+ T cells
    John A Rutigliano
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Virol 88:1636-51. 2014
  10. ncbi request reprint Virus-specific CD8+ T cells in the liver: armed and ready to kill
    Rachael Keating
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 178:2737-45. 2007

Research Grants

Collaborators

Detail Information

Publications34

  1. pmc NFkappaB negatively regulates interferon-induced gene expression and anti-influenza activity
    Lai Wei
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
    J Biol Chem 281:11678-84. 2006
    ....
  2. pmc The two faces of heterologous immunity: protection or immunopathology
    Shalini Sharma
    1 MS 351, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA
    J Leukoc Biol 95:405-16. 2014
    ..Despite these limitations, epidemiological analyses in humans and the data from mouse models of coinfection can be applied toward advancing the design of therapeutics and vaccination strategies. ..
  3. pmc Constrained evolution drives limited influenza diversity
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    BMC Biol 10:43. 2012
    ....
  4. pmc Physiological numbers of CD4+ T cells generate weak recall responses following influenza virus challenge
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 184:1721-7. 2010
    ..Taken together, significant expansion was not a feature of these secondary influenza-specific CD4 T cell responses and the recall of memory did not enhance recovery...
  5. pmc Protective memory responses are modulated by priming events prior to challenge
    John A Rutigliano
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Virol 84:1047-56. 2010
    ....
  6. ncbi request reprint Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    J Immunol 178:3091-8. 2007
    ..Overall, these findings suggest that vaccine approaches using virus vectors to deliver an Ag may be optimized by disrupting key peptides in the normal CD8+ T cell response associated with common HLA types...
  7. pmc Screening monoclonal antibodies for cross-reactivity in the ferret model of influenza infection
    John A Rutigliano
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, United States
    J Immunol Methods 336:71-7. 2008
    ....
  8. pmc TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection
    Jerry R Aldridge
    Division of Virology, Department of Infectious Diseases, and Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 106:5306-11. 2009
    ..Targeting the tipDCs in this way thus offers possibilities for therapeutic intervention in the face of a catastrophic pandemic...
  9. pmc Highly pathological influenza A virus infection is associated with augmented expression of PD-1 by functionally compromised virus-specific CD8+ T cells
    John A Rutigliano
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Virol 88:1636-51. 2014
    ..Treatment with an antibody that blocks PD-1 improves T cell functionality and increases virus clearance...
  10. ncbi request reprint Virus-specific CD8+ T cells in the liver: armed and ready to kill
    Rachael Keating
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 178:2737-45. 2007
    ..Together, these results show clearly that the liver is not a "graveyard" for influenza virus-specific CD8+ T cells...
  11. pmc The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus
    Rachael Keating
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 14:1266-76. 2013
    ..Our findings have implications for the design of a vaccine against influenza virus. ..
  12. pmc Non-random lymphocyte distribution among virus-infected cells of the respiratory tract
    Rajeev Rudraraju
    1 Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee
    Viral Immunol 26:378-84. 2013
    ....
  13. pmc Compromised respiratory function in lethal influenza infection is characterized by the depletion of type I alveolar epithelial cells beyond threshold levels
    Catherine J Sanders
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Am J Physiol Lung Cell Mol Physiol 304:L481-8. 2013
    ..A threshold for maintenance of proper respiratory function appears to be crossed once 10% of alveolar type I cells are lost. These data indicate that lethality in influenza virus infection is a matter of degree rather than quality...
  14. pmc An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 103:2764-9. 2006
    ..These findings suggest intriguing possibilities for vaccination and, at the same time, emphasize that engineered modifications in viruses may have unintended immunological consequences...
  15. pmc Contemporary seasonal influenza A (H1N1) virus infection primes for a more robust response to split inactivated pandemic influenza A (H1N1) Virus vaccination in ferrets
    Ali H Ellebedy
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Clin Vaccine Immunol 17:1998-2006. 2010
    ....
  16. pmc Paired analysis of TCRα and TCRβ chains at the single-cell level in mice
    Pradyot Dash
    St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    J Clin Invest 121:288-95. 2011
    ..This technique may have broad applications in mouse models of human disease...
  17. pmc Enhanced susceptibility of Ago1/3 double-null mice to influenza A virus infection
    Melanie Van Stry
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Virol 86:4151-7. 2012
    ....
  18. pmc A multi-valent vaccine approach that elicits broad immunity within an influenza subtype
    Victor C Huber
    Department of Infectious Disease, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Vaccine 27:1192-200. 2009
    ....
  19. pmc The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 30:566-75. 2009
    ..These findings reveal a function of the cryopyrin inflammasome in healing responses. Thus, cryopyrin and caspase-1 are central to both innate immunity and to moderating lung pathology in influenza pneumonia...
  20. pmc Ecological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populations
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 110:1839-44. 2013
    ....
  21. pmc Respiratory tract epithelial cells express retinaldehyde dehydrogenase ALDH1A and enhance IgA production by stimulated B cells in the presence of vitamin A
    Rajeev Rudraraju
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS ONE 9:e86554. 2014
    ....
  22. pmc Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection
    Christopher Lupfer
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 14:480-8. 2013
    ..These results demonstrate a role for NOD2-RIPK2 signaling in protection against virally triggered immunopathology by negatively regulating activation of the NLRP3 inflammasome and production of IL-18 via ULK1-dependent mitophagy...
  23. pmc Consequences of immunodominant epitope deletion for minor influenza virus-specific CD8+-T-cell responses
    Samita S Andreansky
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Virol 79:4329-39. 2005
    ..A possible explanation is that novel, as yet undetected epitopes emerge following primary exposure to the -NP-PA deletion viruses. These findings have implications for both natural infections and vaccines...
  24. pmc Cell-mediated protection in influenza infection
    Paul G Thomas
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Emerg Infect Dis 12:48-54. 2006
    ..We discuss the advantages of developing a vaccine based on cell-mediated immune responses toward highly pathogenic influenza virus and potential problems arising from immune pressure...
  25. doi request reprint Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections
    Hazem E Ghoneim
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 191:1250-9. 2013
    ..This novel mechanism will inform development of novel therapeutic approaches to restore lung innate immunity against bacterial superinfections...
  26. pmc Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence
    Jason S Rawlings
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN, USA
    EMBO J 30:263-76. 2011
    ..This mechanism ensures that cytokine driven proliferation can only occur in the context of TCR stimulation...
  27. pmc Detection of antibodies against Turkey astrovirus in humans
    Victoria A Meliopoulos
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS ONE 9:e96934. 2014
    ..These studies suggest that people with contact to turkeys can develop serological responses to turkey astrovirus. Further work is needed to determine if these exposures result in virus replication and/or clinical disease. ..
  28. doi request reprint Respiratory epithelial cells in innate immunity to influenza virus infection
    Catherine J Sanders
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, USA
    Cell Tissue Res 343:13-21. 2011
    ..This review details immune events during influenza infection from the viewpoint of the epithelial cells, secretory host defense mechanisms, cell death, and recovery...
  29. pmc Clonally related CD8+ T cells responsible for rapid population of both diffuse nasal-associated lymphoid tissue and lung after respiratory virus infection
    Sherri L Surman
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 187:835-41. 2011
    ....
  30. doi request reprint Rules to 'prime' by
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Immunol 10:14-6. 2009
    ..A systems biology approach provides correlates of successful vaccination, which allows a new method for measuring early vaccine efficiency and suggests hypotheses for the mechanisms that underlie immunogenicity...
  31. ncbi request reprint Nucleotide Oligomerization and Binding Domain 2-Dependent Dendritic Cell Activation Is Necessary for Innate Immunity and Optimal CD8+ T Cell Responses to Influenza A Virus Infection
    Christopher Lupfer
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Virol 88:8946-55. 2014
    ..Thus, Nod2(-/-) DCs are unable to efficiently prime CD8(+) T cells. These findings demonstrate that Nod2 is critical for the generation of both innate and adaptive immune responses necessary for controlling IAV infection...
  32. pmc Membrane association of the CD3ε signaling domain is required for optimal T cell development and function
    Matthew L Bettini
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, 38105
    J Immunol 193:258-67. 2014
    ..Collectively, these results indicate that membrane association of the CD3ε signaling domain is required for optimal thymocyte development and peripheral T cell function...
  33. ncbi request reprint Intranasal influenza infection of mice and methods to evaluate progression and outcome
    Catherine J Sanders
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, USA
    Methods Mol Biol 1031:177-88. 2013
    ..Here, we describe the technique of intranasal inoculation of mice and methods for assessing the severity of disease and humane endpoints, and discuss data acquired from infection of female C57BL/6J mice. ..
  34. pmc The human side of influenza
    Christine M Oshansky
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, USA
    J Leukoc Biol 92:83-96. 2012
    ..Here, we examine and review the current literature on immunity in humans infected with influenza virus, noting evidence offered by select murine studies and suggesting directions in which future research is most warranted...

Research Grants1

  1. Antigen-specific CD4+ T cell responses to influenza
    Paul Thomas; Fiscal Year: 2007
    ..Finally, the effects of antigen-specific vs. unrelated antigen priming by influenza on allergic responses on different genetic backgrounds will be examined. ..