T Takimoto

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi Molecular cloning and expression of human parainfluenza virus type 1 L gene
    T Takimoto
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Virus Res 70:45-53. 2000
  2. ncbi Role of matrix and fusion proteins in budding of Sendai virus
    T Takimoto
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 75:11384-91. 2001
  3. ncbi Role of the hemagglutinin-neuraminidase protein in the mechanism of paramyxovirus-cell membrane fusion
    Toru Takimoto
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    J Virol 76:13028-33. 2002
  4. ncbi Nucleocapsid incorporation into parainfluenza virus is regulated by specific interaction with matrix protein
    E C Coronel
    Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 75:1117-23. 2001
  5. ncbi Two regions of the P protein are required to be active with the L protein for human parainfluenza virus type 1 RNA polymerase activity
    T Bousse
    Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, 332 N. Lauderdale St, Memphis, Tennessee 38105-2794, USA
    Virology 283:306-14. 2001
  6. ncbi Receptor specificities of human respiroviruses
    T Suzuki
    Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105
    J Virol 75:4604-13. 2001
  7. ncbi The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae
    Irina V Alymova
    Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794, USA
    Antimicrob Agents Chemother 49:398-405. 2005
  8. ncbi A recombinant Sendai virus is controlled by CD4+ effector T cells responding to a secreted human immunodeficiency virus type 1 envelope glycoprotein
    Scott A Brown
    Department of Immunology, Memphis, TN 38105, USA
    J Virol 81:12535-42. 2007
  9. ncbi Respiratory syncytial virus (RSV) fusion protein expressed by recombinant Sendai virus elicits B-cell and T-cell responses in cotton rats and confers protection against RSV subtypes A and B
    Xiaoyan Zhan
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332N Lauderdale, Memphis, TN 38105, United States
    Vaccine 25:8782-93. 2007
  10. ncbi Biological significance of the second receptor binding site of Newcastle disease virus hemagglutinin-neuraminidase protein
    Tatiana L Bousse
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Virol 78:13351-5. 2004

Collaborators

Detail Information

Publications20

  1. ncbi Molecular cloning and expression of human parainfluenza virus type 1 L gene
    T Takimoto
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Virus Res 70:45-53. 2000
    ..These results indicate that the protein encoded by the cloned hPIV1 L gene was biologically functional and that the hPIV1 polymerase complex recognized SV transcription initiation and termination sequences to produce viral transcripts...
  2. ncbi Role of matrix and fusion proteins in budding of Sendai virus
    T Takimoto
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 75:11384-91. 2001
    ..Our results indicate that both M and F proteins are able to drive the budding of SV and propose the possible role of actin in the budding process...
  3. ncbi Role of the hemagglutinin-neuraminidase protein in the mechanism of paramyxovirus-cell membrane fusion
    Toru Takimoto
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    J Virol 76:13028-33. 2002
    ....
  4. ncbi Nucleocapsid incorporation into parainfluenza virus is regulated by specific interaction with matrix protein
    E C Coronel
    Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 75:1117-23. 2001
    ..Using SV-hPIV1 chimera NP cDNAs, we found that the C-terminal domain of the NP protein (amino acids 420 to 466) is responsible for the interaction with M...
  5. ncbi Two regions of the P protein are required to be active with the L protein for human parainfluenza virus type 1 RNA polymerase activity
    T Bousse
    Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, 332 N. Lauderdale St, Memphis, Tennessee 38105-2794, USA
    Virology 283:306-14. 2001
    ..Our results indicate that in addition to a P--L binding domain, hPIV1 L requires a specific region on P protein to be biologically functional as a polymerase...
  6. ncbi Receptor specificities of human respiroviruses
    T Suzuki
    Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105
    J Virol 75:4604-13. 2001
    ..These findings provide important information that can be used to develop inhibitors that prevent human parainfluenza virus infection...
  7. ncbi The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae
    Irina V Alymova
    Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794, USA
    Antimicrob Agents Chemother 49:398-405. 2005
    ..Prophylaxis of parainfluenza virus infections with antivirals might be an effective strategy for prevention of secondary bacterial complications in humans...
  8. ncbi A recombinant Sendai virus is controlled by CD4+ effector T cells responding to a secreted human immunodeficiency virus type 1 envelope glycoprotein
    Scott A Brown
    Department of Immunology, Memphis, TN 38105, USA
    J Virol 81:12535-42. 2007
    ....
  9. ncbi Respiratory syncytial virus (RSV) fusion protein expressed by recombinant Sendai virus elicits B-cell and T-cell responses in cotton rats and confers protection against RSV subtypes A and B
    Xiaoyan Zhan
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332N Lauderdale, Memphis, TN 38105, United States
    Vaccine 25:8782-93. 2007
    ..Together, experimental results encourage promotion of this recombinant SV construct as a vaccine candidate for the prevention of RSV in humans...
  10. ncbi Biological significance of the second receptor binding site of Newcastle disease virus hemagglutinin-neuraminidase protein
    Tatiana L Bousse
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Virol 78:13351-5. 2004
    ..Furthermore, the mutations at Arg516 slowed the growth rate of virus in tissue culture cells. These results suggest that the second binding site facilitates virus infection and growth by enhancing the fusion promotion activity of the HN...
  11. ncbi Sendai virus recombinant vaccine expressing hPIV-3 HN or F elicits protective immunity and combines with a second recombinant to prevent hPIV-1, hPIV-3 and RSV infections
    Xiaoyan Zhan
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, United States
    Vaccine 26:3480-8. 2008
    ..Results encourage the continued development of the candidate recombinant SeV vaccines to combat serious respiratory infections of children...
  12. ncbi Efficacy of novel hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 against human parainfluenza viruses in vitro and in vivo
    Irina V Alymova
    Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA
    Antimicrob Agents Chemother 48:1495-502. 2004
    ..Together, our results indicate that BCX 2798 and BCX 2855 are effective inhibitors of parainfluenza virus HN and may limit parainfluenza virus infections in humans...
  13. ncbi Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion
    Viatcheslav Zaitsev
    Centre for Biomolecular Sciences, University of St. Andrews, St. Andrews, Fife KY16 9ST, United Kingdom
    J Virol 78:3733-41. 2004
    ..Three different crystal forms of NDV HN now reveal identical tetrameric arrangements of HN monomers, perhaps indicative of the tetramer association found on the viral surface...
  14. ncbi Probing the sialic acid binding site of the hemagglutinin-neuraminidase of Newcastle disease virus: identification of key amino acids involved in cell binding, catalysis, and fusion
    Helen Connaris
    Centre for Biomolecular Sciences, University of St. Andrews, St. Andrews, Fife KY16 9ST, Scotland
    J Virol 76:1816-24. 2002
    ..These results further support the single-site model and suggest certain residues to be important for the triggering of fusion...
  15. ncbi Recombinant Sendai virus as a novel vaccine candidate for respiratory syncytial virus
    Toru Takimoto
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    Viral Immunol 18:255-66. 2005
    ..Sendai virus may prove an enormously valuable vaccine platform, permitting the delivery of recombinants targeting important pediatric respiratory pathogens, RSV chief among them...
  16. ncbi Human parainfluenza virus type 1 but not Sendai virus replicates in human respiratory cells despite IFN treatment
    Tatiana Bousse
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, NY 14642, USA
    Virus Res 121:23-32. 2006
    ..These results suggest that SeV is less effective than hPIV1 in overcoming antiviral activity in human cells, which could be one of the factors that restrict the host range of SeV...
  17. ncbi Differentially regulated interferon response determines the outcome of Newcastle disease virus infection in normal and tumor cell lines
    Sateesh Krishnamurthy
    Department of Infectious Diseases, Mail Stop 330, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794, USA
    J Virol 80:5145-55. 2006
    ..The rapid spread of NDV in HT-1080 cells appears to be caused by their deficient expression of anti-NDV proteins upon exposure to IFN-beta...
  18. ncbi Mutation at residue 523 creates a second receptor binding site on human parainfluenza virus type 1 hemagglutinin-neuraminidase protein
    Tatiana Bousse
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Virol 80:9009-16. 2006
    ..Our study indicates that the presence and requirement of a second binding site vary among paramyxoviruses...
  19. ncbi The long noncoding region of the human parainfluenza virus type 1 f gene contributes to the read-through transcription at the m-f gene junction
    Tatiana Bousse
    Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 76:8244-51. 2002
    ..These phenotypes seem to be responsible for the extended survival of mice infected with rSVhMFjCG...
  20. ncbi Recombinant Sendai virus expressing the G glycoprotein of respiratory syncytial virus (RSV) elicits immune protection against RSV
    Toru Takimoto
    St. Jude Children's Research Hospital, 332 N. Lauderdale St, Memphis, TN 38105, USA
    J Virol 78:6043-7. 2004
    ..RSV G-recombinant SV is thus a promising live virus vaccine candidate for RSV...