R V Srinivas

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc Antiviral activities of 9-R-2-phosphonomethoxypropyl adenine (PMPA) and bis(isopropyloxymethylcarbonyl)PMPA against various drug-resistant human immunodeficiency virus strains
    R V Srinivas
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, USA
    Antimicrob Agents Chemother 42:1484-7. 1998
  2. pmc Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters
    R V Srinivas
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Antimicrob Agents Chemother 42:3157-62. 1998
  3. ncbi request reprint MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
    J D Schuetz
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Med 5:1048-51. 1999
  4. ncbi request reprint A 585-bp deletion found in the spleen focus-forming virus (SFFV) env gene is responsible for the defective intracellular transport of SFFV gp52
    R V Srinivas
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38101
    Virology 188:181-92. 1992
  5. ncbi request reprint Subcutaneous administration of a recombinant vaccinia virus vaccine expressing multiple envelopes of HIV-1
    K S Slobod
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Eur J Clin Microbiol Infect Dis 23:106-10. 2004
  6. ncbi request reprint Cytosolic domain of the human immunodeficiency virus envelope glycoproteins binds to calmodulin and inhibits calmodulin-regulated proteins
    S K Srinivas
    Department of Medicine, University of Alabama at Birmingham 35294
    J Biol Chem 268:22895-9. 1993
  7. ncbi request reprint Enhanced susceptibility to human immunodeficiency virus infection in CD4+ T lymphocytes genetically deficient in CD43
    R V Srinivas
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    AIDS Res Hum Retroviruses 11:1015-21. 1995
  8. ncbi request reprint Inhibition of human immunodeficiency virus type 1 replication by a cellular transcriptional factor MBP-1
    R B Ray
    Department of Internal Medicine, St Louis University, Missouri 63110 0250, USA
    J Cell Biochem 64:565-72. 1997

Collaborators

Detail Information

Publications8

  1. pmc Antiviral activities of 9-R-2-phosphonomethoxypropyl adenine (PMPA) and bis(isopropyloxymethylcarbonyl)PMPA against various drug-resistant human immunodeficiency virus strains
    R V Srinivas
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, USA
    Antimicrob Agents Chemother 42:1484-7. 1998
    ....
  2. pmc Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters
    R V Srinivas
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Antimicrob Agents Chemother 42:3157-62. 1998
    ..Therefore, overexpression of MDR1 or MRP1 by T lymphocytes is not likely to limit the antiviral efficacy of HIV PI therapy...
  3. ncbi request reprint MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
    J D Schuetz
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Med 5:1048-51. 1999
    ..MRP4 is the first transporter, to our knowledge, directly linked to the efflux of nucleoside monophosphate analogs from mammalian cells...
  4. ncbi request reprint A 585-bp deletion found in the spleen focus-forming virus (SFFV) env gene is responsible for the defective intracellular transport of SFFV gp52
    R V Srinivas
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38101
    Virology 188:181-92. 1992
    ..The results indicate that the 585-bp deletion, although essential, is not the sole determinant of SFFV-induced disease in adult mice...
  5. ncbi request reprint Subcutaneous administration of a recombinant vaccinia virus vaccine expressing multiple envelopes of HIV-1
    K S Slobod
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Eur J Clin Microbiol Infect Dis 23:106-10. 2004
    ..These findings have global implications because they support the consideration of recombinant vaccinia virus as a valuable HIV vaccine vector system...
  6. ncbi request reprint Cytosolic domain of the human immunodeficiency virus envelope glycoproteins binds to calmodulin and inhibits calmodulin-regulated proteins
    S K Srinivas
    Department of Medicine, University of Alabama at Birmingham 35294
    J Biol Chem 268:22895-9. 1993
    ..We postulate that CaM binding by HIV envelope proteins is likely to exert diverse modulatory effects, and the mechanism for HIV-induced cytotoxicity may involve, in part, inhibition of CaM-regulated cellular functions...
  7. ncbi request reprint Enhanced susceptibility to human immunodeficiency virus infection in CD4+ T lymphocytes genetically deficient in CD43
    R V Srinivas
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    AIDS Res Hum Retroviruses 11:1015-21. 1995
    ..These data suggest that factors that diminish CD43 expression on T lymphocytes may enhance their susceptibility to HIV-1 infection...
  8. ncbi request reprint Inhibition of human immunodeficiency virus type 1 replication by a cellular transcriptional factor MBP-1
    R B Ray
    Department of Internal Medicine, St Louis University, Missouri 63110 0250, USA
    J Cell Biochem 64:565-72. 1997
    ..These results suggest that exogenous expression of MBP-1 plays an important role in the regulation of HIV-1 replication in infected cells...