Stephen X Skapek

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. doi request reprint Pediatric nonrhabdomyosarcoma soft tissue sarcomas
    Sheri L Spunt
    Department of Oncology, St Jude Children s Research Hospital, Department of Oncology, 332 N Lauderdale Street, ALSAC 6032, Memphis, TN 38105 2794, USA
    Oncologist 13:668-78. 2008
  2. ncbi request reprint Cytogenetics and the biologic basis of sarcomas
    S X Skapek
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Curr Opin Oncol 12:315-22. 2000
  3. ncbi request reprint Persistent expression of cyclin D1 disrupts normal photoreceptor differentiation and retina development
    S X Skapek
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Oncogene 20:6742-51. 2001
  4. ncbi request reprint Vinblastine and methotrexate for desmoid fibromatosis in children: results of a Pediatric Oncology Group Phase II Trial
    Stephen X Skapek
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:501-6. 2007
  5. ncbi request reprint Regulation of cell lineage specification by the retinoblastoma tumor suppressor
    S X Skapek
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Oncogene 25:5268-76. 2006
  6. ncbi request reprint Persistent hyperplastic primary vitreous due to somatic mosaic deletion of the arf tumor suppressor
    J Derek Thornton
    Department of Oncology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Invest Ophthalmol Vis Sci 48:491-9. 2007
  7. ncbi request reprint The Arf tumor suppressor regulates platelet-derived growth factor receptor beta signaling: a new view through the eyes of Arf(-/-) mice
    J Derek Thornton
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell Cycle 4:1316-9. 2005
  8. pmc Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development
    Natalie E Freeman-Anderson
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Development 136:2081-9. 2009
  9. pmc Arf-dependent regulation of Pdgf signaling in perivascular cells in the developing mouse eye
    Ricardo L A Silva
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    EMBO J 24:2803-14. 2005
  10. ncbi request reprint MRI and biologic behavior of desmoid tumors in children
    M Beth McCarville
    Division of Diagnostic Imaging, Department of Radiological Sciences, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    AJR Am J Roentgenol 189:633-40. 2007

Collaborators

Detail Information

Publications17

  1. doi request reprint Pediatric nonrhabdomyosarcoma soft tissue sarcomas
    Sheri L Spunt
    Department of Oncology, St Jude Children s Research Hospital, Department of Oncology, 332 N Lauderdale Street, ALSAC 6032, Memphis, TN 38105 2794, USA
    Oncologist 13:668-78. 2008
    ..This article summarizes what is known to date about childhood NRSTS, including the epidemiology, pathogenesis, and clinical approach to diagnosis and treatment of these tumors...
  2. ncbi request reprint Cytogenetics and the biologic basis of sarcomas
    S X Skapek
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Curr Opin Oncol 12:315-22. 2000
    ..However, they also highlight some limitations of these approaches as well. Novel experimental approaches may be required to facilitate the continued progress in this field toward the development of better therapeutic strategies...
  3. ncbi request reprint Persistent expression of cyclin D1 disrupts normal photoreceptor differentiation and retina development
    S X Skapek
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Oncogene 20:6742-51. 2001
    ..These findings are distinct from other mouse models in which the retinoblastoma gene pathway is disrupted and suggest that the IRBP-cyclin D1 mouse model may recapitulate an early step in the development of retinoblastoma...
  4. ncbi request reprint Vinblastine and methotrexate for desmoid fibromatosis in children: results of a Pediatric Oncology Group Phase II Trial
    Stephen X Skapek
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:501-6. 2007
    ..To determine the efficacy and safety of using vinblastine (Vbl) and methotrexate (Mtx) in children with desmoid-type fibromatosis that is recurrent or not amenable to treatment with radiation or surgery...
  5. ncbi request reprint Regulation of cell lineage specification by the retinoblastoma tumor suppressor
    S X Skapek
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Oncogene 25:5268-76. 2006
    ..We review recent studies uncovering novel mechanisms by which RB works in several cell lineages and we provide perspectives on how these new findings might relate to RB tumor suppression...
  6. ncbi request reprint Persistent hyperplastic primary vitreous due to somatic mosaic deletion of the arf tumor suppressor
    J Derek Thornton
    Department of Oncology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Invest Ophthalmol Vis Sci 48:491-9. 2007
    ..The current work explores mechanisms by which Arf promotes eye development, and its absence causes a PHPV-like disease...
  7. ncbi request reprint The Arf tumor suppressor regulates platelet-derived growth factor receptor beta signaling: a new view through the eyes of Arf(-/-) mice
    J Derek Thornton
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell Cycle 4:1316-9. 2005
    ..Our findings indicating that p19(Arf) responds to specific developmental cues to disrupt Pdgfrbeta signaling in the developing eye extend existing paradigms for Arf tumor suppressor gene biology...
  8. pmc Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development
    Natalie E Freeman-Anderson
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Development 136:2081-9. 2009
    ..We present the first evidence that p19(Arf) expression can be coupled to extracellular cues in normal cells and suggest a new mechanism for Arf control in tumor cells...
  9. pmc Arf-dependent regulation of Pdgf signaling in perivascular cells in the developing mouse eye
    Ricardo L A Silva
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    EMBO J 24:2803-14. 2005
    ..Instead of solely sensing excessive mitogenic stimuli, developmental cues induce Arf to block Pdgfrbeta-dependent signals and prevent the accumulation of perivascular cells selectively in a vascular bed destined to regress...
  10. ncbi request reprint MRI and biologic behavior of desmoid tumors in children
    M Beth McCarville
    Division of Diagnostic Imaging, Department of Radiological Sciences, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    AJR Am J Roentgenol 189:633-40. 2007
    ..We also aimed to determine how imaging features change during adjuvant treatment and how the imaging features relate to the histologic features...
  11. ncbi request reprint Pharmacologic inhibition of cyclin-dependent kinase 4/6 activity arrests proliferation in myoblasts and rhabdomyosarcoma-derived cells
    Raya Saab
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Mol Cancer Ther 5:1299-308. 2006
    ..Our findings support the concept that pharmacologic inhibition of Cdk4/Cdk6 may represent a useful therapeutic strategy to control cell proliferation and possibly promote myogenic differentiation in rhabdomyosarcoma...
  12. ncbi request reprint Prolactinoma as the first manifestation of Gardner's syndrome
    Geoffrey S Goodin
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 50:409-12. 2008
    ..A germline mutation of the APC (adenomatous polyposis coli) gene was identified. Our case illustrates the association between prolactinoma and FAP, which may represent a rare subtype of Gardner's and BTP syndromes...
  13. pmc Pathogenesis of persistent hyperplastic primary vitreous in mice lacking the arf tumor suppressor gene
    Amy C Martin
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Invest Ophthalmol Vis Sci 45:3387-96. 2004
    ..The present work addressed the pathogenesis of PHPV in a mouse model that replicates many aspects of the human disease...
  14. ncbi request reprint Hematometrocolpos in an adolescent female treated for pelvic Ewing sarcoma
    Pamela Gaillard
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 50:157-60. 2008
    ..We describe the clinical presentation, radiographic features, gross pathology, treatment strategies, outcome, as well as putative predisposing factors and preventative interventions...
  15. ncbi request reprint Continuous delivery of IFN-beta promotes sustained maturation of intratumoral vasculature
    Paxton V Dickson
    Department of Surgery, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Mol Cancer Res 5:531-42. 2007
    ..These results have significant implications for the planning of combination anticancer therapy...
  16. ncbi request reprint Expression and genomic status of EGFR and ErbB-2 in alveolar and embryonal rhabdomyosarcoma
    Ramapriya Ganti
    Department of Pathology and Laboratory Medicine, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mod Pathol 19:1213-20. 2006
    ..Notably, expression of EGFR correlates with the embryonal subtype, which is also more likely to coexpress EGFR and ErbB-2...
  17. pmc The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development
    Robyn N McKeller
    Department of Hematology Oncology, Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 99:3848-53. 2002
    ..The latter finding raises the possibility that Arf may function as a tumor suppressor at least in part by regulating tumor angiogenesis...