Erin Schuetz

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. doi Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s
    Amarjit S Chaudhry
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Drug Metab Dispos 41:1538-47. 2013
  2. pmc Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier
    Kazuto Yasuda
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105
    Drug Metab Dispos 41:923-31. 2013
  3. pmc Tandem machine learning for the identification of genes regulated by transcription factors
    Deendayal Dinakarpandian
    School of Computing and Engineering, University of Missouri Kansas City, Kansas City, Missouri, USA
    BMC Bioinformatics 6:204. 2005
  4. pmc Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element
    E G Schuetz
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Pharmacol 54:1113-7. 1998
  5. ncbi Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents
    Erin Schuetz
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Pharmacol 62:439-45. 2002
  6. ncbi Induction of cytochromes P450
    E G Schuetz
    St Jude Children s Research Hospital, Dept Pharmaceutical Sciences, Memphis, TN 38105, USA
    Curr Drug Metab 2:139-47. 2001
  7. ncbi Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes
    E G Schuetz
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Mol Pharmacol 57:188-97. 2000
  8. ncbi Lessons from the CYP3A4 promoter
    Erin G Schuetz
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Pharmacol 65:279-81. 2004
  9. ncbi MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype
    Jatinder Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Clin Pharmacol Ther 79:325-38. 2006
  10. doi A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine
    Kazuto Yasuda
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Drug Metab Dispos 36:1689-97. 2008

Collaborators

Detail Information

Publications52

  1. doi Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s
    Amarjit S Chaudhry
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Drug Metab Dispos 41:1538-47. 2013
    ..In conclusion, we provide the first experimental evidence supporting a role for AKR1D1 as a key genetic regulator of the P450 network. ..
  2. pmc Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier
    Kazuto Yasuda
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105
    Drug Metab Dispos 41:923-31. 2013
    ..Thus, like blood-brain barrier cells and choroid plexus cells, AB cells highly express drug transport proteins and likely contribute to the blood-CSF drug permeation barrier...
  3. pmc Tandem machine learning for the identification of genes regulated by transcription factors
    Deendayal Dinakarpandian
    School of Computing and Engineering, University of Missouri Kansas City, Kansas City, Missouri, USA
    BMC Bioinformatics 6:204. 2005
    ....
  4. pmc Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element
    E G Schuetz
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Pharmacol 54:1113-7. 1998
    ..Moreover, PXR-mediated PCB activation of the (CYP3A23)2-tk-CAT may serve as a rapid assay for effects of nonplanar PCBs...
  5. ncbi Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents
    Erin Schuetz
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Pharmacol 62:439-45. 2002
    ..The utility of the method is demonstrated in the discovery that topotecan and etoposide are ligands of pregnane X receptor that induce CYP3A4 transcription...
  6. ncbi Induction of cytochromes P450
    E G Schuetz
    St Jude Children s Research Hospital, Dept Pharmaceutical Sciences, Memphis, TN 38105, USA
    Curr Drug Metab 2:139-47. 2001
    ..Metabolism by Phase I enzymes, particularly the heme containing monooxygenases cytochromes P450 is frequently the first line of defense against such xenobiotics...
  7. ncbi Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes
    E G Schuetz
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Mol Pharmacol 57:188-97. 2000
    ....
  8. ncbi Lessons from the CYP3A4 promoter
    Erin G Schuetz
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Pharmacol 65:279-81. 2004
  9. ncbi MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype
    Jatinder Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Clin Pharmacol Ther 79:325-38. 2006
    ..This study investigated whether common single-nucleotide polymorphisms (SNPs) in multidrug resistance 1 (MDR1), encoding P-glycoprotein, or the pregnane X receptor (PXR) were associated with basal or inducible CYP3A4 expression...
  10. doi A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine
    Kazuto Yasuda
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Drug Metab Dispos 36:1689-97. 2008
    ..In summary, nafcillin, dicloxacillin, cephradine, tetracycline, sulfixoxazole, erythromycin, clindamycin, and griseofulvin exhibit a clear propensity to induce CYP3A4 and warrant further clinical investigation...
  11. ncbi Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression
    Jatinder Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Drug Metab Dispos 36:169-81. 2008
    ....
  12. ncbi G2677T and C3435T genotype and haplotype are associated with hepatic ABCB1 (MDR1) expression
    Pengfei Song
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA
    J Clin Pharmacol 46:373-9. 2006
  13. doi Association of breast cancer resistance protein/ABCG2 phenotypes and novel promoter and intron 1 single nucleotide polymorphisms
    Balasubramanian Poonkuzhali
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Drug Metab Dispos 36:780-95. 2008
    ..BCRP used multiple promoters, and livers differentially using alternative exon 1b had lower BCRP. In conclusion, BCRP expression in lymphoblasts, liver, and intestine is associated with novel promoter and intron 1 SNPs...
  14. ncbi Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics
    Jatinder Lamba
    Department of Pharmaceutical Sciences, Mail Stop 313, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Curr Drug Metab 6:369-83. 2005
    ..Identification of PXR and CAR genetic variants and alternatively spliced mRNAs may ultimately allow predictions of interindividual differences in target gene induction and drug-drug interactions...
  15. ncbi Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants
    Jatinder K Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105, USA
    J Pharmacol Exp Ther 323:935-45. 2007
    ..These results suggest that genetic variation in DCK influences its activity and expression and may predict the variability observed in intracellular levels of the ara-C active metabolite ara-CTP...
  16. ncbi Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences
    Jatinder K Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    J Pharmacol Exp Ther 311:811-21. 2004
    ..The expression of CAR in additional human cell types increases the range of tissue specific transcriptional responses regulated by this receptor, suggesting additional biological roles for CAR and CAR-SV proteins in these tissues...
  17. ncbi Common allelic variants of cytochrome P4503A4 and their prevalence in different populations
    Jatinder K Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pharmacogenetics 12:121-32. 2002
    ..None of the 28 CYP3A4 SNPs identified in CYP3A4 phenotyped persons (most individuals being heterozygous for any CYP3A4 variant) was associated with low hepatic CYP3A4 protein expression or low CYP3A4 activity in vivo...
  18. ncbi Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia
    Shinji Kishi
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, University of Tennessee, Memphis, TN 38105, USA
    Blood 103:67-72. 2004
    ..Prednisone strongly induces etoposide clearance, genetic polymorphisms may predict the constitutive and induced clearance of etoposide, and the relationship between genotype and phenotype differs by race...
  19. ncbi Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression
    Vishal Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    J Pharmacol Exp Ther 307:906-22. 2003
    ..In conclusion, we found several common SNPs that are associated with polymorphic CYP2B6 expression...
  20. pmc Transporter-mediated protection against thiopurine-induced hematopoietic toxicity
    Partha Krishnamurthy
    Department of Pharmaceutical Sciences and Animal Resource Center, St Jude Children s Research Hospital, Memphis, Tenessee 38105, USA
    Cancer Res 68:4983-9. 2008
    ..This SNP is common (>18%) in the Japanese population and indicates that the increased sensitivity of some Japanese patients to thiopurines may reflect the greater frequency of this MRP4 SNP...
  21. ncbi Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans
    Jatinder K Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pharmacogenet Genomics 16:415-27. 2006
    ..Tumors with increased CYP3A copy number (via amplification or increased chromosome 7q) would be expected to show reduced cytotoxicity to some chemotherapeutic drugs and potentially an increase in the outgrowth of drug resistant tumors...
  22. ncbi PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators
    Vishal Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Toxicol Appl Pharmacol 199:251-65. 2004
    ..Moreover, the identification of PXR in many human tissues, such as brain, and activation by tissue specific ligands (such as neurosteroids) suggests additional biological roles for this receptor in these tissues...
  23. ncbi Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine
    Charis P Zamber
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, and Department of Pharmaceutical Sciences, University of Washington, Seattle, WA, USA
    Pharmacogenetics 13:19-28. 2003
    ..Thus, common natural allelic variants of BCRP have been identified, and did not influence interindividual variation in expression of BCRP mRNA in human intestine, but remain to be tested for their effect on BCRP function...
  24. ncbi Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice
    Mahfoud Assem
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 279:22250-7. 2004
    ....
  25. pmc CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose
    Amarjit S Chaudhry
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pharmacol Exp Ther 332:599-611. 2010
    ..These findings may also be relevant to the clinical use of other PXR, CAR, and Nrf2 activators...
  26. pmc Genetic predictors of interindividual variability in hepatic CYP3A4 expression
    Vishal Lamba
    Department of Pharmaceutical Sciences, 262 Danny Thomas Place, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pharmacol Exp Ther 332:1088-99. 2010
    ..This approach identified sex and polymorphisms in FoxA2, HNF4alpha, FoxA3, PXR, ABCB1, and the CYP3A4 promoter that together explained as much as 24.6% of the variation in hepatic CYP3A4 expression...
  27. pmc A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor
    Satyanarayana R Pondugula
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, 262 Danny Thomas Place, Mail Stop 1000, Memphis, TN 38105, USA
    Drug Metab Dispos 37:719-30. 2009
    ....
  28. ncbi The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4
    Rommel G Tirona
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Med 9:220-4. 2003
    ..These data identify HNF4alpha as an important regulator of coordinate nuclear-receptor-mediated response to xenobiotics...
  29. ncbi Interaction of cytochrome P450 3A inhibitors with P-glycoprotein
    Kazuto Yasuda
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pharmacol Exp Ther 303:323-32. 2002
    ..Simultaneous inhibition of Pgp by many CYP3A inhibitors contributes to human variation in the extent of drug-drug interactions...
  30. ncbi Genetic contribution to variable human CYP3A-mediated metabolism
    Jatinder K Lamba
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Adv Drug Deliv Rev 54:1271-94. 2002
    ....
  31. ncbi Polarized cell cultures for integrated studies of drug metabolism and transport
    Cynthia Brimer-Cline
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Methods Enzymol 357:321-9. 2002
  32. pmc Functional characterization of the promoter of human carbonyl reductase 1 (CBR1). Role of XRE elements in mediating the induction of CBR1 by ligands of the aryl hydrocarbon receptor
    Sukhwinder S Lakhman
    Department of Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, New York 14260 1200, USA
    Mol Pharmacol 72:734-43. 2007
    ..These studies provide the first insights on the functional characteristics of the human CBR1 gene promoter. Our data indicate that the AHR pathway contributes to the transcriptional regulation of CBR1...
  33. ncbi CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults
    Raymond C Givens
    General Clinical Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA
    J Appl Physiol 95:1297-300. 2003
    ..3 mmHg. We speculate whether a high CYP3A5 expressor allele frequency among African-Americans may contribute to a high prevalence of sodium-sensitive hypertension in this population...
  34. ncbi CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes
    Jacqueline Ramirez
    University of Chicago, Department of Medicine, Section of Hematology Oncology, 5841 S Maryland Avenue, MC2115, Chicago, IL 60637, USA
    Drug Metab Dispos 32:930-6. 2004
    ..We conclude that normeperidine formation in human liver microsomes is mainly catalyzed by CYP2B6 and CYP3A4, with a minor contribution from CYP2C19...
  35. ncbi Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5
    St├ęphane J Mouly
    General Clinical Research Center, School of Pharmacy, and Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    Clin Pharmacol Ther 78:605-18. 2005
    ..The polymorphic CYP3A5 has also been shown to influence the saquinavir metabolite/parent urinary ratio, suggesting a role for CYP3A5...
  36. ncbi A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression
    Catia Marzolini
    Division of Clinical Pharmacology, Department of Medicine, The University of Western Ontario, London Health Sciences Centre, University Hospital, London, Ontario, Canada N6A 5A5
    Mol Endocrinol 21:1769-80. 2007
    ..These findings are the first to identify the presence of a common genetic variant in FXR with functional consequences that could contribute to disease risk or therapeutic outcomes...
  37. ncbi Expression of the pregnane X receptor in mice antagonizes the cholic acid-mediated changes in plasma lipoprotein profile
    David Masson
    INSERM U498, Faculte de Medecine, Dijon, France
    Arterioscler Thromb Vasc Biol 25:2164-9. 2005
    ..The aim of the present study was to determine the relative contribution of the pregnane X receptor (PXR), another bile acid-activated nuclear receptor to changes in plasma lipoprotein profile...
  38. pmc Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia
    Changcheng Zhou
    Department of Pharmaceutics, University of Washington, Seattle, Washington 98195 7610, USA
    J Clin Invest 116:1703-12. 2006
    ....
  39. ncbi Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes
    Jacqueline Ramirez
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Pharmacogenet Genomics 16:79-86. 2006
    ..The indel at -53 affects the basal phenotype and appears to limit the hepatocyte capability of maximal induction after phenobarbital. However, variants at -53, -3156 and -3279 are not associated with variability in UGT1A1 inducibility...
  40. ncbi Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity
    Kristina K Wolf
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Drug Metab Dispos 33:1827-36. 2005
    ....
  41. ncbi Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: I. Expression and role of cytochromes P450
    Piyush M Vyas
    Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, USA
    J Pharmacol Exp Ther 319:488-96. 2006
    ....
  42. ncbi Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo
    Jennifer A Lowry
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA
    Clin Pharmacol Ther 73:209-22. 2003
    ..Cisapride was compared with midazolam in vivo to determine its potential applicability as a cytochrome P450 (CYP) 3A4 "probe." As well, we evaluated whether cisapride was transported by P-glycoprotein...
  43. ncbi Structural determinants of P-glycoprotein-mediated transport of glucocorticoids
    Charles R Yates
    Department of Pharmaceutical Sciences, The University of Tennessee, Memphis, TN 38163, USA
    Pharm Res 20:1794-803. 2003
    ..The aim of this study was to determine requisite structural features for P-glycoprotein-mediated transport of a series of structurally related glucocorticoids (GCs)...
  44. ncbi A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta
    Sean Ekins
    Concurrent Pharmaceuticals Inc, Fort Washington, Pennsylvania 19034, USA
    Pharm Res 19:1788-800. 2002
    ..Simultaneously, we might learn which came first: the transporter, the enzyme, or the nuclear hormone receptor?..
  45. ncbi Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia
    Yang Xu
    Department of Pharmaceutics, Box 357610, University of Washington, Seattle, WA 98195 7610, USA
    Mol Pharmacol 69:56-65. 2006
    ..These and other data suggest that induction of CYP3A4-dependent 1,25(OH)(2)D(3) metabolism by antiepileptic drugs and other PXR ligands may diminish intestinal effects of the hormone and contribute to osteomalacia...
  46. pmc Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts
    Matthew D Krasowski
    University of Pittsburgh, Department of Pathology, 200 Lothrop, Pittsburgh, PA 15213, USA
    Mol Endocrinol 19:1720-39. 2005
    ..PXR specificity for bile salts has thus paralleled the increasing complexity of the bile salt synthetic pathway during vertebrate evolution, an unusual example of ligand-receptor coevolution in the nuclear hormone receptor superfamily...
  47. pmc The influence of CYP3A5 genotype on dexamethasone induction of CYP3A activity in African Americans
    Patrick J Roberts
    Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina, Chapel Hill, NC, USA
    Drug Metab Dispos 36:1465-9. 2008
    ....
  48. ncbi Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein
    Sean Ekins
    Lilly Research Laboratories, Eli Lilly and Co, Lilly Corporate Center, Indianapolis, Indiana, USA
    Mol Pharmacol 61:964-73. 2002
    ..Utilization of such models may prove to be of value for prediction of molecules that may modulate one or more P-gp binding sites...
  49. ncbi The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluation
    Nina Isoherranen
    Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA
    Drug Metab Dispos 36:146-54. 2008
    ..In conclusion, the effect of CYP3A5 on hepatic CYP3A-mediated inhibitory drug-drug interactions is substrate-dependent, and HLM, rather than rCYP3A, are the preferred in vitro system for predicting these interactions in vivo...
  50. ncbi Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism
    Yvonne S Lin
    Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA
    Mol Pharmacol 62:162-72. 2002
    ..93) as were wt-CYP3A5 and CYP3A4 mRNA (r = 0.76). These findings suggest that CYP3A4 and CYP3A5 genes share a common regulatory pathway for constitutive expression, possibly involving conserved elements in the 5'-flanking region...
  51. ncbi Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons
    Jatinder Kaur Lamba
    St Jude Children s Research Hospital, Department of Pharmaceutical Sciences, Memphis, TN, USA
    Hum Mol Genet 12:99-109. 2003
    ..These are the first studies to indicate that the highly conserved PTC exons of the ABCC4 gene may dictate its expression...
  52. ncbi Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates
    Sean Ekins
    Lilly Research Laboratories, Eli Lilly and Co, Lilly Corporate Center, Indianapolis, Indiana, USA
    Mol Pharmacol 61:974-81. 2002
    ..These 3D-QSAR models will be useful for future prediction of likely substrates and inhibitors of P-gp...

Research Grants15

  1. Pregnane X Receptor: Regulation and Pharmacogenomics
    Erin Schuetz; Fiscal Year: 2007
    ..In total this proposal describes a comprehensive set of experiments to determine how PXR is regulated. ..
  2. DNA SEQUENCE DIVERSITY IN THE HUMAN PREGNANE X RECEPTOR
    Erin Schuetz; Fiscal Year: 2003
    ..abstract_text> ..
  3. INTERACTIONS OF P GLYCOPROTEIN WITH CYTOCHROME P4503A
    Erin Schuetz; Fiscal Year: 2001
    ....
  4. Genetic Predictors of Human Liver CYP Expression & Activity
    Erin G Schuetz; Fiscal Year: 2010
    ....