L D Saravolatz

Summary

Affiliation: St. John Hospital and Medical Center
Country: USA

Publications

  1. pmc In vitro activities of LTX-109, a synthetic antimicrobial peptide, against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus
    Louis D Saravolatz
    St John Hospital and Medical Center, Detroit, Michigan, USA
    Antimicrob Agents Chemother 56:4478-82. 2012
  2. doi request reprint In vitro susceptibilities and molecular analysis of vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus isolates
    Louis D Saravolatz
    St John Hospital and Medical Center, Wayne State University School of Medicine, Detroit, Michigan, USA
    Clin Infect Dis 55:582-6. 2012
  3. pmc Human immunodeficiency virus infection and autoimmune hepatitis during highly active anti-retroviral treatment: a case report and review of the literature
    Hanady Daas
    Department of Internal Medicine, Division of Infectious Diseases, St John Hospital and Medical Center, 19251 Mack Avenue, Suite 340, Grosse Pointe Woods, MI 48236, USA
    J Med Case Reports 5:233. 2011
  4. pmc In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates
    Louis Saravolatz
    St John Hospital and Medical Center, 19251 Mack Ave, Suite 333, Detroit, MI 48236, USA
    Antimicrob Agents Chemother 54:3027-30. 2010
  5. ncbi request reprint Antimicrobial activity and a comparison of published pharmacodynamics of gemifloxacin and eight fluoroquinolones against Streptococcus pneumoniae
    Louis Saravolatz
    Department of Medicine Research Laboratory, St John s Hospital and Medical Center and Wayne State University School of Medicine, 22201 Moross, Suite 80, Detroit, MI 48236, USA
    Int J Antimicrob Agents 26:81-4. 2005
  6. ncbi request reprint Detection of Streptococcus pneumoniae colonisation in respiratory tract secretions of military personnel
    L D Saravolatz
    St John Hospital and Medical Center, Wayne State University School of Medicine, Grosse Pointe Woods, MI 48236, USA
    Clin Microbiol Infect 13:932-6. 2007
  7. doi request reprint In vitro activity of oritavancin against community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), vancomycin-intermediate S. aureus (VISA), vancomycin-resistant S. aureus (VRSA) and daptomycin-non-susceptible S. aureus (DNSSA)
    Louis D Saravolatz
    St John Hospital and Medical Center and Wayne State University School of Medicine, Detroit, MI, USA
    Int J Antimicrob Agents 36:69-72. 2010
  8. ncbi request reprint Comparative activity of telavancin against isolates of community-associated methicillin-resistant Staphylococcus aureus
    Louis D Saravolatz
    Department of Internal Medicine, St John Hospital and Medical Center, Detroit, MI, USA
    J Antimicrob Chemother 60:406-9. 2007
  9. ncbi request reprint Gatifloxacin, gemifloxacin, and moxifloxacin: the role of 3 newer fluoroquinolones
    Louis D Saravolatz
    Department of Medicine, St John Hospital and Medical Center and Wayne State University School of Medicine, Detroit, Michigan 48236, USA
    Clin Infect Dis 37:1210-5. 2003
  10. doi request reprint Ceftaroline: a novel cephalosporin with activity against methicillin-resistant Staphylococcus aureus
    Louis D Saravolatz
    Department of Medicine, St John Hospital and Medical Center, Wayne State University School of Medicine, East Lansing, Michigan, USA
    Clin Infect Dis 52:1156-63. 2011

Collaborators

Detail Information

Publications36

  1. pmc In vitro activities of LTX-109, a synthetic antimicrobial peptide, against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus
    Louis D Saravolatz
    St John Hospital and Medical Center, Detroit, Michigan, USA
    Antimicrob Agents Chemother 56:4478-82. 2012
    ..aureus (VRSA) isolates. LTX-109 demonstrated a MIC range of 2 to 4 μg/ml and dose-dependent rapid bactericidal activity against S. aureus. This activity was not influenced by resistance to other antistaphylococcal agents...
  2. doi request reprint In vitro susceptibilities and molecular analysis of vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus isolates
    Louis D Saravolatz
    St John Hospital and Medical Center, Wayne State University School of Medicine, Detroit, Michigan, USA
    Clin Infect Dis 55:582-6. 2012
    ..There are limited reports evaluating susceptibility patterns and molecular characteristics of these strains...
  3. pmc Human immunodeficiency virus infection and autoimmune hepatitis during highly active anti-retroviral treatment: a case report and review of the literature
    Hanady Daas
    Department of Internal Medicine, Division of Infectious Diseases, St John Hospital and Medical Center, 19251 Mack Avenue, Suite 340, Grosse Pointe Woods, MI 48236, USA
    J Med Case Reports 5:233. 2011
    ..abstract:..
  4. pmc In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates
    Louis Saravolatz
    St John Hospital and Medical Center, 19251 Mack Ave, Suite 333, Detroit, MI 48236, USA
    Antimicrob Agents Chemother 54:3027-30. 2010
    ..aureus (VRSA), heteroresistant VISA (hVISA), and daptomycin-nonsusceptible S. aureus (DNSSA) isolates. Ceftaroline may represent a bactericidal treatment option for infections caused by these pathogens...
  5. ncbi request reprint Antimicrobial activity and a comparison of published pharmacodynamics of gemifloxacin and eight fluoroquinolones against Streptococcus pneumoniae
    Louis Saravolatz
    Department of Medicine Research Laboratory, St John s Hospital and Medical Center and Wayne State University School of Medicine, 22201 Moross, Suite 80, Detroit, MI 48236, USA
    Int J Antimicrob Agents 26:81-4. 2005
    ..Compared with the other eight fluoroquinolones tested, gemifloxacin demonstrated the best in vitro activity and Cmax/MIC90...
  6. ncbi request reprint Detection of Streptococcus pneumoniae colonisation in respiratory tract secretions of military personnel
    L D Saravolatz
    St John Hospital and Medical Center, Wayne State University School of Medicine, Grosse Pointe Woods, MI 48236, USA
    Clin Microbiol Infect 13:932-6. 2007
    ..pneumoniae can be identified rapidly and reliably by PCR assays. The use of this technique may greatly enhance the ability to identify a microbial aetiology for pneumonia when compared with conventional culture methods...
  7. doi request reprint In vitro activity of oritavancin against community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), vancomycin-intermediate S. aureus (VISA), vancomycin-resistant S. aureus (VRSA) and daptomycin-non-susceptible S. aureus (DNSSA)
    Louis D Saravolatz
    St John Hospital and Medical Center and Wayne State University School of Medicine, Detroit, MI, USA
    Int J Antimicrob Agents 36:69-72. 2010
    ..Oritavancin was more bactericidal than any of the other comparators against CA-MRSA and demonstrated excellent activity against VRSA and VISA...
  8. ncbi request reprint Comparative activity of telavancin against isolates of community-associated methicillin-resistant Staphylococcus aureus
    Louis D Saravolatz
    Department of Internal Medicine, St John Hospital and Medical Center, Detroit, MI, USA
    J Antimicrob Chemother 60:406-9. 2007
    ....
  9. ncbi request reprint Gatifloxacin, gemifloxacin, and moxifloxacin: the role of 3 newer fluoroquinolones
    Louis D Saravolatz
    Department of Medicine, St John Hospital and Medical Center and Wayne State University School of Medicine, Detroit, Michigan 48236, USA
    Clin Infect Dis 37:1210-5. 2003
    ....
  10. doi request reprint Ceftaroline: a novel cephalosporin with activity against methicillin-resistant Staphylococcus aureus
    Louis D Saravolatz
    Department of Medicine, St John Hospital and Medical Center, Wayne State University School of Medicine, East Lansing, Michigan, USA
    Clin Infect Dis 52:1156-63. 2011
    ..Ceftaroline demonstrated a safety profile similar to that of comparator drugs in clinical trials...
  11. ncbi request reprint Broad-range bacterial polymerase chain reaction for early detection of bacterial meningitis
    Louis D Saravolatz
    Department of Medicine, Molecular Biology Research Laboratory, St John Hospital and Medical Center, and Wayne State University School of Medicine, Detroit, MI 48236, USA
    Clin Infect Dis 36:40-5. 2003
    ..4%; and negative predictive value, 100%. Broad-range bacterial PCR may be useful for excluding the diagnosis of meningitis, and the results may influence the decision to initiate or discontinue antimicrobial therapy...
  12. doi request reprint Telavancin: a novel lipoglycopeptide
    Louis D Saravolatz
    St John Hospital and Medical Center, Detroit, Michigan, USA
    Clin Infect Dis 49:1908-14. 2009
    ..Telavancin is associated with higher rates of renal events, altered taste, nausea, and vomiting but lesser rates of pruritus and infusion-related events, compared with vancomycin...
  13. ncbi request reprint Inhibition of Legionella pneumophila multiplication within human macrophages by fleroxacin
    D J Pohlod
    Henry Ford Hospital, Department of Medicine, Detroit, Michigan 48202
    J Antimicrob Chemother 22:49-54. 1988
    ..pneumophila. No intracellular, rifampicin-resistant L. pneumophila emerged. Addition of rifampicin to cefoxotin, erythromycin or fleroxacin provided neither synergy nor antagonism...
  14. doi request reprint Amino acid supplementation differentially modulates STAT1 and STAT3 activation in the myocardium exposed to ischemia/reperfusion injury
    Tiziano M Scarabelli
    Center for Heart and Vessel Preclinical Studies, St John Hospital and Medical Center, Wayne State University School of Medicine, Detroit, Michigan, USA
    Am J Cardiol 101:63E-68E. 2008
    ....
  15. doi request reprint Harvest surgical site infection following coronary artery bypass grafting: risk factors, microbiology, and outcomes
    Mamta Sharma
    Division of Infectious Diseases, Department of Medicine, St John Hospital and Medical Center, Detroit, MI, USA
    Am J Infect Control 37:653-7. 2009
    ....
  16. ncbi request reprint Warm blood cardioplegic arrest induces mitochondrial-mediated cardiomyocyte apoptosis associated with increased urocortin expression in viable cells
    Tiziano M Scarabelli
    Division of Cardiology, St John Hospital and Medical Center, Wayne State University, Detroit, Mich, USA
    J Thorac Cardiovasc Surg 128:364-71. 2004
    ..Here we extend these findings to the human heart exposed to ischemic-reperfusion injury...
  17. ncbi request reprint Nutritional supplementation with mixed essential amino acids enhances myocyte survival, preserving mitochondrial functional capacity during ischemia-reperfusion injury
    Tiziano M Scarabelli
    Division of Cardiology, St John Hospital and Medical Center, Wayne State University, Detroit, Michigan, USA
    Am J Cardiol 93:35A-40A. 2004
    ..01). These results suggest that oral amino acid supplementation attenuates the extent of ischemia-reperfusion injury in the rat heart, through preservation of the mitochondria-generated production of high-energy phosphates...
  18. ncbi request reprint Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO
    Tiziano M Scarabelli
    Division of Cardiology, Detroit, St John Hospital and Medical Center, Detroit, Michigan 48236, USA
    J Am Coll Cardiol 43:865-74. 2004
    ..This study is aimed at investigating the novel use of minocycline for cardiac protection during ischemia/reperfusion (I/R) injury, as well as its mechanism of action...
  19. ncbi request reprint Increase in the rate of sternal surgical site infection after coronary artery bypass graft: a marker of higher severity of illness
    Mohamad G Fakih
    Division of Infectious Diseases, Department of Medicine, St John Hospital and Medical Center, Grosse Pointe Woods, MI 48236, USA
    Infect Control Hosp Epidemiol 28:655-60. 2007
    ..To evaluate factors related to a gradual rise in sternal surgical site infection (SSI) rates...
  20. ncbi request reprint In-vitro susceptibility of staphylococci to fleroxacin in comparison with six other quinolones
    D J Pohlod
    Department of Medicine, Henry Ford Hospital, Detroit, Michigan 48202
    J Antimicrob Chemother 22:35-41. 1988
    ..No selection or emergence of resistant organisms was found with fleroxacin, amifloxacin or ofloxacin...
  21. ncbi request reprint A case of fatal ephedra intake associated with lipofuscin accumulation, caspase activation and cleavage of myofibrillary proteins
    Carol Chen-Scarabelli
    Division of Cardiology, VA Medical Center, University of Michigan, Ann Arbor, MI, USA
    Eur J Heart Fail 7:927-30. 2005
    ..Healthcare professionals are therefore urged to warn their patients about the risk of serious adverse effects, which may follow ephedra intake...
  22. doi request reprint Activation of Src protein tyrosine kinase plays an essential role in urocortin-mediated cardioprotection
    Zhaokan Yuan
    Center for Heart and Vessel Preclinical Studies, St John Hospital and Medical Center, USA
    Mol Cell Endocrinol 325:1-7. 2010
    ....
  23. doi request reprint Mechanisms of action and clinical implications of cardiac urocortin: a journey from the heart to the systemic circulation, with a stopover in the mitochondria
    Erlene Kuizon
    Center for Heart and Vessel Preclinical Studies, St John Hospital and Medical Center, Wayne State University Medical School, Detroit, MI, USA
    Int J Cardiol 137:189-94. 2009
    ..Infusion of Ucn may also help reduce the extent of the iatrogenic ischemic/reperfusion injury, associated with cardioplegic arrest...
  24. doi request reprint Oral administration of amino acidic supplements improves protein and energy profiles in skeletal muscle of aged rats: elongation of functional performance and acceleration of mitochondrial recovery in adenosine triphosphate after exhaustive exertion
    Carol Chen Scarabelli
    Center for Heart and Vessel Preclinical Studies, St John Hospital and Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48236, USA
    Am J Cardiol 101:42E-48E. 2008
    ....
  25. ncbi request reprint Differentiating inhalational anthrax from other influenza-like illnesses in the setting of a national or regional anthrax outbreak
    Sandro K Cinti
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Center Ann Arbor VA Medical Center, Ann Arbor 48109 0378, USA
    Arch Intern Med 164:674-6. 2004
    ..The algorithm necessitates stays no longer than 24 hours in the emergency department or hospital...
  26. ncbi request reprint Peripartum cardiomyopathy: a comprehensive review
    John Abboud
    Center for Heart and Vessel Preclinical Studies, Division of Cardiology, St John Hospital and Medical Center, Wayne State University, Detroit, MI 48236, USA
    Int J Cardiol 118:295-303. 2007
    ..About half the patients of PPCM recover without complications. The prognosis is poor in patients with persistent cardiomyopathy. Persistence of disease after 6 months indicates irreversible cardiomyopathy and portends worse survival...
  27. ncbi request reprint Community-associated methicillin-resistant Staphylococcus aureus causing chronic pneumonia
    Iram Enayet
    St John Hospital and Medical Center, Detroit, Michigan, USA
    Clin Infect Dis 42:e57-60. 2006
    ..According to findings of pulsed-field gel electrophoresis, the isolate was identical to USA 300 and carried a type IV Staphylococcus cassette chromosome mec type IV gene and the genes for Panton-Valentine leukocidin...
  28. ncbi request reprint Changing epidemiology of community-onset methicillin-resistant Staphylococcus aureus bacteremia
    Leonard B Johnson
    St John Hospital and Medical Center, Wayne State University, Detroit, Michigan 48236, USA
    Infect Control Hosp Epidemiol 24:431-5. 2003
    ..To review cases of community-onset Staphylococcus aureus bacteremia and to evaluate whether the risk factors and epidemiology of methicillin-resistant S. aureus (MRSA) bacteremia have changed from early reports...
  29. ncbi request reprint Do resident physicians use antibiotics appropriately in treating upper respiratory infections? A survey of 11 programs
    Mohamad G Fakih
    Wayne State University School of Medicine, Detroit, Michigan 48236, USA
    Clin Infect Dis 37:853-6. 2003
    ..Although they viewed excess antibiotic use as the most important factor increasing resistance, they had little knowledge regarding antimicrobial resistance and were willing to prescribe antibiotics for common viral illnesses...
  30. ncbi request reprint Epidemiology and clinical outcomes of infective endocarditis in hemodialysis patients
    Desikan Kamalakannan
    St John Hospital and Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48236, USA
    Ann Thorac Surg 83:2081-6. 2007
    ..The aim of our study was to describe the clinical characteristics, outcome, and factors predicting mortality of infective endocarditis in hemodialysis patients...
  31. ncbi request reprint A Web-based course on infection control for physicians in training: an educational intervention
    Mohamad G Fakih
    Department of Medicine, Wayne State University School of Medicine, St John Hospital and Medical Center, Grosse Pointe Woods, MI 48236, USA
    Infect Control Hosp Epidemiol 27:704-8. 2006
    ..To evaluate the effectiveness of a Web-based course on infection control accessed by physicians in training...
  32. doi request reprint Effect of nurse-led multidisciplinary rounds on reducing the unnecessary use of urinary catheterization in hospitalized patients
    Mohamad G Fakih
    Division of Infectious Diseases, Department of Medicine, St John Hospital and Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48236, USA
    Infect Control Hosp Epidemiol 29:815-9. 2008
    ..To determine the effect of nurse-led multidisciplinary rounds on reducing the unnecessary use of urinary catheters (UCs)...
  33. ncbi request reprint Clinical and laboratory features of community-associated methicillin-resistant Staphylococcus aureus: is it really new?
    Leonard B Johnson
    Department of Internal Medicine, St John Hospital and Medical Center, Wayne State University, Detroit, MI, USA
    Infect Control Hosp Epidemiol 27:133-8. 2006
    ..To review the epidemiologic and molecular characteristics of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Detroit, Michigan, to assess the risk factors for infection and the response to therapy...
  34. ncbi request reprint Emergence of community-associated methicillin-resistant Staphylococcus aureus infection among patients with end-stage renal disease
    Leonard B Johnson
    Department of Internal Medicine, St John Hospital and Medical Center, Detroit, MI, USA
    Infect Control Hosp Epidemiol 27:1057-62. 2006
    ..To evaluate the frequency of infections due to community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains among our patients with end-stage renal disease...
  35. ncbi request reprint Monotherapy versus combination therapy
    Shilpa M Patel
    Division of Infectious Diseases, Department of Internal Medicine, St John Hospital and Medical Center, 19251 Mack Avenue, Suite 340, Grosse Pointe Woods, MI 48236, USA
    Med Clin North Am 90:1183-95. 2006
    ..Clinicians also need to consider synergy and local resistance patterns in selecting therapeutic options. In this article, the authors outline monotherapy and combination therapy options for several common infectious diseases...
  36. ncbi request reprint A randomized controlled trial evaluating the efficacy and safety of intermittent 3-, 4-, and 5-day cycles of intravenous recombinant human interleukin-2 combined with antiretroviral therapy (ART) versus ART alone in HIV-seropositive patients with 100-300
    Alberdina W de Boer
    Chiron Corporation, Emeryville, CA 94608 2916, USA
    Clin Immunol 106:188-96. 2003
    ..IL-2 therapy in cycles of 5 days resulted in an optimal increase in CD4(+) T-cell counts and is the preferred cycle length for IL-2 therapy geared toward increasing CD4(+) T-cell numbers...