John T Sandlund

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc Results of treatment of advanced-stage lymphoblastic lymphoma at St Jude Children's Research Hospital from 1962 to 2002
    J T Sandlund
    Department of Oncology, St Jude Children s Research Hospital, TN 38105 3678, USA
    Ann Oncol 24:2425-9. 2013
  2. doi request reprint Frequent mutations in SH2D1A (XLP) in males presenting with high-grade mature B-cell neoplasms
    J T Sandlund
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 60:E85-7. 2013
  3. pmc Burkitt lymphoma: staging and response evaluation
    John T Sandlund
    Department of Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Br J Haematol 156:761-5. 2012
  4. pmc Effective treatment of advanced-stage childhood lymphoblastic lymphoma without prophylactic cranial irradiation: results of St Jude NHL13 study
    J T Sandlund
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 23:1127-30. 2009
  5. ncbi request reprint Persistence of lymphoblasts in bone marrow on day 15 and days 22 to 25 of remission induction predicts a dismal treatment outcome in children with acute lymphoblastic leukemia
    John T Sandlund
    Department of Hematology Oncology, St Jude Children s Research Hospital, and the University of Tennessee, College of Medicine, Memphis, TN 38105, USA
    Blood 100:43-7. 2002
  6. pmc Efficacy of high-dose methotrexate, ifosfamide, etoposide and dexamethasone salvage therapy for recurrent or refractory childhood malignant lymphoma
    J T Sandlund
    Department of Oncology, St Jude Children s Research Hospital, University of Tennessee, Memphis, TN, USA
    Ann Oncol 22:468-71. 2011
  7. pmc Combination of dexamethasone, high-dose cytarabine, and carboplatin is effective for advanced large-cell non-Hodgkin lymphoma of childhood
    John T Sandlund
    Department of Hematology Oncology, St Jude Children s Research Hospital, the University of Tennessee at Memphis College of Medicine, Memphis, Tennessee 38105, USA
    Cancer 113:782-90. 2008
  8. ncbi request reprint A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia
    John T Sandlund
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer Genet Cytogenet 168:69-72. 2006
  9. ncbi request reprint CNS involvement in children with newly diagnosed non-Hodgkin's lymphoma
    J T Sandlund
    Departments of Hematology Oncology, Radiation Therapy, Pathology and Laboratory Medicine, and Biostatistics, St Jude Children s Research Hospital, and University of Tennessee at Memphis, College of Medicine, Memphis, TN, USA
    J Clin Oncol 18:3018-24. 2000
  10. pmc Treating childhood acute lymphoblastic leukemia without cranial irradiation
    Ching Hon Pui
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    N Engl J Med 360:2730-41. 2009

Detail Information

Publications89

  1. pmc Results of treatment of advanced-stage lymphoblastic lymphoma at St Jude Children's Research Hospital from 1962 to 2002
    J T Sandlund
    Department of Oncology, St Jude Children s Research Hospital, TN 38105 3678, USA
    Ann Oncol 24:2425-9. 2013
    ..We analyzed treatment outcomes and potential risk factors in children and adolescents with advanced-stage LL treated over a 40-year period...
  2. doi request reprint Frequent mutations in SH2D1A (XLP) in males presenting with high-grade mature B-cell neoplasms
    J T Sandlund
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 60:E85-7. 2013
    ..Prospective screening for XLP in males with B-cell lymphoma at the time of initial diagnosis should be considered...
  3. pmc Burkitt lymphoma: staging and response evaluation
    John T Sandlund
    Department of Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Br J Haematol 156:761-5. 2012
    ..An international working group is currently addressing the refinement of both disease staging and response evaluation in children with NHL...
  4. pmc Effective treatment of advanced-stage childhood lymphoblastic lymphoma without prophylactic cranial irradiation: results of St Jude NHL13 study
    J T Sandlund
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 23:1127-30. 2009
    ..The treatment described here produces high cure rates in children with lymphoblastic lymphoma without the use of prophylactic cranial irradiation...
  5. ncbi request reprint Persistence of lymphoblasts in bone marrow on day 15 and days 22 to 25 of remission induction predicts a dismal treatment outcome in children with acute lymphoblastic leukemia
    John T Sandlund
    Department of Hematology Oncology, St Jude Children s Research Hospital, and the University of Tennessee, College of Medicine, Memphis, TN 38105, USA
    Blood 100:43-7. 2002
    ....
  6. pmc Efficacy of high-dose methotrexate, ifosfamide, etoposide and dexamethasone salvage therapy for recurrent or refractory childhood malignant lymphoma
    J T Sandlund
    Department of Oncology, St Jude Children s Research Hospital, University of Tennessee, Memphis, TN, USA
    Ann Oncol 22:468-71. 2011
    ..Children with recurrent or refractory malignant lymphoma generally have a poor prognosis. There is a need for new active drug combinations for this high-risk group of patients...
  7. pmc Combination of dexamethasone, high-dose cytarabine, and carboplatin is effective for advanced large-cell non-Hodgkin lymphoma of childhood
    John T Sandlund
    Department of Hematology Oncology, St Jude Children s Research Hospital, the University of Tennessee at Memphis College of Medicine, Memphis, Tennessee 38105, USA
    Cancer 113:782-90. 2008
    ....
  8. ncbi request reprint A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia
    John T Sandlund
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer Genet Cytogenet 168:69-72. 2006
    ..1) that rearranged BCL6 and placed it adjacent to MYC. We speculate that this genetic lesion occurred as a result of chromosomal instability due to the underlying disease...
  9. ncbi request reprint CNS involvement in children with newly diagnosed non-Hodgkin's lymphoma
    J T Sandlund
    Departments of Hematology Oncology, Radiation Therapy, Pathology and Laboratory Medicine, and Biostatistics, St Jude Children s Research Hospital, and University of Tennessee at Memphis, College of Medicine, Memphis, TN, USA
    J Clin Oncol 18:3018-24. 2000
    ..To determine the frequency of CNS involvement at diagnosis of non-Hodgkin's lymphoma (NHL), to characterize its pattern of presentation, and to determine its prognostic significance...
  10. pmc Treating childhood acute lymphoblastic leukemia without cranial irradiation
    Ching Hon Pui
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    N Engl J Med 360:2730-41. 2009
    ..Prophylactic cranial irradiation has been a standard treatment in children with acute lymphoblastic leukemia (ALL) who are at high risk for central nervous system (CNS) relapse...
  11. ncbi request reprint Bone marrow recurrence after initial intensive treatment for childhood acute lymphoblastic leukemia
    Gaston K Rivera
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer 103:368-76. 2005
    ..The authors studied the clinical outcome of 106 children with acute lymphoblastic leukemia (ALL) who developed a bone marrow recurrence as the first adverse event after contemporary intensified therapy...
  12. pmc Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia
    Nobuko Hijiya
    Department of Oncology, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105 2794, USA
    Blood 108:3997-4002. 2006
    ..Further, the systemic clearance of methotrexate, teniposide, etoposide, and cytarabine did not differ with BMI (P > .3). We conclude that BMI does not affect the outcome or toxicity of chemotherapy in this patient population with ALL...
  13. ncbi request reprint Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital
    Ching Hon Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 104:2690-6. 2004
    ..01% or more at the end of the 6-week remission induction phase. Our results suggest the efficacy of early intensification of intrathecal chemotherapy and provide the basis for studies omitting cranial irradiation altogether...
  14. pmc Improved prognosis for older adolescents with acute lymphoblastic leukemia
    Ching Hon Pui
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 29:386-91. 2011
    ..We reviewed the outcome of older adolescents (age 15 to 18 years) treated in four consecutive Total Therapy studies to determine if recent improved treatment extended to this high-risk group...
  15. ncbi request reprint Use of peripheral blood instead of bone marrow to monitor residual disease in children with acute lymphoblastic leukemia
    Elaine Coustan-Smith
    Departments of Hematology Oncology, Biostatistics, and Pathology, St Jude Children s Research Hospital, and the University of Tennessee, Memphis TN 38105 2794, USA
    Blood 100:2399-402. 2002
    ..007). These results indicate that peripheral blood may be used to monitor MRD in patients with T-lineage ALL and that peripheral blood MRD may provide strong prognostic information in patients with B-lineage ALL...
  16. pmc Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia
    Sima Jeha
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    Blood 108:3302-4. 2006
    ..9% versus 78% +/- 3.1% (P = .08). These data suggest that CD20 expression is not associated with inferior outcome in pediatric patients treated with contemporary regimens...
  17. ncbi request reprint Risk of adverse events after completion of therapy for childhood acute lymphoblastic leukemia
    Ching Hon Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 23:7936-41. 2005
    ..Our goal was to use the information to further refine therapy and advance cure rates...
  18. ncbi request reprint Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia
    Thierry Dervieux
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Clin Pharmacol Ther 73:506-16. 2003
    ..Methotrexate is postulated to enhance mercaptopurine activation to thioguanine (INN, tioguanine) nucleotides, but the interaction has never been studied in vivo in cancer cells...
  19. ncbi request reprint Results of therapy for acute lymphoblastic leukemia in black and white children
    Ching Hon Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    JAMA 290:2001-7. 2003
    ..Treatment results for acute lymphoblastic leukemia (ALL) clearly have improved over the past decade, but black children have not fared as well as white children in large national trials...
  20. ncbi request reprint Pharmacokinetics and pharmacodynamics of oral etoposide in children with relapsed or refractory acute lymphoblastic leukemia
    Mathew J Edick
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, and College of Pharmacy, The University of Tennessee, Memphis 38105, USA
    J Clin Oncol 21:1340-6. 2003
    ..To study the pharmacokinetics and pharmacodynamics of once- versus twice-daily oral etoposide in children with relapsed or refractory acute lymphoblastic leukemia (ALL)...
  21. ncbi request reprint Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphoblastic leukemia
    Nobuko Hijiya
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    JAMA 297:1207-15. 2007
    ..Little is known about the incidence of secondary neoplasms after 15 to 20 years in children and adolescents who were treated for acute lymphoblastic leukemia...
  22. ncbi request reprint Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia
    Ching Hon Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    N Engl J Med 349:640-9. 2003
    ..We determined the long-term survival and the rates of health insurance coverage, marriage, and employment among patients who had attained at least 10 years of event-free survival...
  23. pmc Treatment outcomes in black and white children with cancer: results from the SEER database and St Jude Children's Research Hospital, 1992 through 2007
    Ching Hon Pui
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 30:2005-12. 2012
    ..Treatment outcome for black patients with cancer has been significantly worse than for their white counterparts. We determined whether recent improved treatment had narrowed the gap in outcome between black and white pediatric patients...
  24. pmc High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemia
    Wing Leung
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 118:223-30. 2011
    ..10; P = .01) at the time of transplantation. We concluded that transplantation has improved over time and should be considered for all children with very high-risk leukemia, regardless of matched donor availability...
  25. ncbi request reprint Magnetic resonance imaging detection of avascular necrosis of the bone in children receiving intensive prednisone therapy for acute lymphoblastic leukemia or non-Hodgkin lymphoma
    R C Ribeiro
    Department of Hematology-Oncology, St Jude Children's Research Hospital, 332 N, Lauderdale, Memphis, TN 38105-2794, USA
    Leukemia 15:891-7. 2001
    ..Therefore, the clinical usefulness of MR imaging as a screening tool for AVNB in this set of patients remains uncertain...
  26. pmc Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial
    Torben S Mikkelsen
    St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA
    J Clin Oncol 29:1771-8. 2011
    ....
  27. pmc Prognostic impact of absolute lymphocyte counts at the end of remission induction in childhood acute lymphoblastic leukemia
    Jeffrey E Rubnitz
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer 119:2061-6. 2013
    ..However, the impact of ALC relative to that of other prognostic factors on the outcome of children with acute lymphoblastic leukemia (ALL) treated in recent trials is unknown...
  28. ncbi request reprint De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo
    Thierry Dervieux
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital and University of Tennessee, Memphis, 38105, USA
    Blood 100:1240-7. 2002
    ....
  29. ncbi request reprint Granulocyte colony-stimulating factor and the risk of secondary myeloid malignancy after etoposide treatment
    Mary V Relling
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 101:3862-7. 2003
    ..Even when children receiving irradiation were excluded, the incidence was still higher in those receiving G-CSF (P =.019). In the setting of intensive antileukemic therapy, short-term use of G-CSF may increase the risk of t-ML...
  30. ncbi request reprint A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia
    John Carl Panetta
    St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105 2794, USA
    Cancer Chemother Pharmacol 50:419-28. 2002
    ..These differences provide mechanistic and treatment insights for lineage and ploidy differences in MTXPG accumulation in human leukemia cells in vivo...
  31. ncbi request reprint Typhlitis in childhood cancer
    M Beth McCarville
    Division of Diagnostic Imaging, Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA jude org
    Cancer 104:380-7. 2005
    ..The authors investigated the demographic, clinical, and imaging (ultrasonography and computed tomography [CT] scans) variables related to the diagnosis, risk, and outcome of typhlitis...
  32. pmc Initial response to salvage therapy determines prognosis in relapsed pediatric Hodgkin lymphoma patients
    Monika L Metzger
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 116:4376-84. 2010
    ..Pediatric Hodgkin lymphoma (HL) is a highly curable disease; however, prognostic factors for the survival of patients who develop recurrent disease have not been clearly defined...
  33. pmc Between-course targeting of methotrexate exposure using pharmacokinetically guided dosage adjustments
    Jennifer L Pauley
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Cancer Chemother Pharmacol 72:369-78. 2013
    ..It is advantageous to individualize high-dose methotrexate (HDMTX) to maintain adequate exposure while minimizing toxicities. Previously, we accomplished this through within-course dose adjustments...
  34. ncbi request reprint Utility of automated counting to determine absolute neutrophil counts and absolute phagocyte counts for pediatric cancer treatment protocols
    Nobuko Hijiya
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer 101:2681-6. 2004
    ..By analyzing blood samples from children undergoing cancer treatment, the authors determined whether ANCs and APCs obtained by automated methods correlated positively with ANCs and APCs obtained manually...
  35. ncbi request reprint Clinical implications and surgical management of intussusception in pediatric patients with Burkitt lymphoma
    Himesh Gupta
    Department of Surgery, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr Surg 42:998-1001; discussion 1001. 2007
    ..We determined the incidence, presentation, stage, and outcome of children with Burkitt lymphoma presenting with intussusception...
  36. doi request reprint Successful treatment of pediatric plasmacytoid dendritic cell tumors with a contemporary regimen for acute lymphoblastic leukemia
    Karen D Wright
    Department of Oncology, St Jude Children s Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 60:E38-41. 2013
    ..Cases of DCL among pediatric patients have been reported to respond to therapeutic regimens for acute lymphoblastic leukemia, but details regarding the specifics of therapy are lacking...
  37. pmc Neuropathic pain during treatment for childhood acute lymphoblastic leukemia
    Doralina L Anghelescu
    Division of Anesthesia and Pain Management Service, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Pediatr Blood Cancer 57:1147-53. 2011
    ..Neuropathic pain (NP) is an unpleasant side effect of chemotherapeutic agents for leukemia, especially vincristine...
  38. pmc Detectable minimal residual disease before hematopoietic cell transplantation is prognostic but does not preclude cure for children with very-high-risk leukemia
    Wing Leung
    Department of Bone Marrow Transplantation and Cellular Therapy, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105 2794, USA
    Blood 120:468-72. 2012
    ..Although MRD before HCT is a strong prognostic factor, its impact has diminished and should not be regarded as a contraindication for HCT...
  39. ncbi request reprint Pharmacogenetic risk factors for osteonecrosis of the hip among children with leukemia
    Mary V Relling
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Clin Oncol 22:3930-6. 2004
    ..Putative risk factors for osteonecrosis have included being female, white race, and older age. Our goal was to define possible genetic risk factors for osteonecrosis among children treated for newly diagnosed ALL...
  40. ncbi request reprint ALK-positive anaplastic large cell lymphoma with leukemic peripheral blood involvement is a clinicopathologic entity with an unfavorable prognosis. Report of three cases and review of the literature
    Mihaela Onciu
    Dept of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    Am J Clin Pathol 120:617-25. 2003
    ....
  41. doi request reprint Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia
    Deepa Bhojwani
    All authors St Jude Children s Research Hospital and Deepa Bhojwani, Jun J Yang, Hiroto Inaba, Jeffrey E Rubnitz, Monika L Metzger, Scott C Howard, Raul C Ribeiro, Sima Jeha, John T Sandlund, and Ching Hon Pui, University of Tennessee Health Sciences Center, College of Medicine, Memphis, TN
    J Clin Oncol 32:949-59. 2014
    ....
  42. ncbi request reprint Premedication with acetaminophen or diphenhydramine for transfusion with leucoreduced blood products in children
    Robert P Sanders
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Haematol 130:781-7. 2005
    ..Febrile and allergic transfusion reactions were rare in paediatric patients transfused with leucoreduced, irradiated blood products, whether premedication was used or not...
  43. ncbi request reprint Death during induction therapy and first remission of acute leukemia in childhood: the St. Jude experience
    Jeffrey E Rubnitz
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 101:1677-84. 2004
    ..Despite improvements in supportive care, death due to treatment toxicity remains a significant problem for children treated for acute leukemia...
  44. ncbi request reprint Reassessment of the prognostic significance of hypodiploidy in pediatric patients with acute lymphoblastic leukemia
    Susana C Raimondi
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 98:2715-22. 2003
    ..In addition, the authors determined whether subdivision of the hypodiploid category served a prognostic purpose for these patients...
  45. ncbi request reprint Clinical and diagnostic imaging findings predict anesthetic complications in children presenting with malignant mediastinal masses
    Doralina L Anghelescu
    Division of Anesthesiology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Paediatr Anaesth 17:1090-8. 2007
    ..The presence of a mediastinal mass in a child poses significant anesthesia-related risks including death. To optimize outcome clinicians must be able to predict which patients are at highest risk of anesthetic complications...
  46. pmc Lessons from the past: opportunities to improve childhood cancer survivor care through outcomes investigations of historical therapeutic approaches for pediatric hematological malignancies
    Melissa M Hudson
    Department of Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Pediatr Blood Cancer 58:334-43. 2012
    ....
  47. ncbi request reprint Abdominal compartment syndrome in a newly diagnosed patient with Burkitt lymphoma
    Jennifer M Hendrick
    Department of Radiological Sciences, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Pediatr Radiol 36:254-7. 2006
    ..We present the radiological and clinical aspects of a patient with advanced-stage Burkitt lymphoma who presented with an acute abdomen complicated by abdominal compartment syndrome...
  48. ncbi request reprint Secondary chromosomal abnormalities predict outcome in pediatric and adult high-stage Burkitt lymphoma
    Mihaela Onciu
    Department of Pathology, St Jude Children s Hospital, Memphis, Tennessee 38105, USA
    Cancer 107:1084-92. 2006
    ..However, to the authors' knowledge, very limited studies have focused on the secondary chromosomal abnormalities in pediatric BL as compared with those of adult BL and on their prognostic impact...
  49. pmc Spinal epidural lipomatosis in children with hematologic malignancies
    Rachel C Brennan
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Ann Hematol 90:1067-74. 2011
    ..Investigation for SEL in leukemia or lymphoma patients with difficult lumbar punctures is warranted. Placement of an Ommaya reservoir may facilitate safe CNS-directed therapy in severely affected patients...
  50. ncbi request reprint Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia
    Elaine Coustan-Smith
    Department of Hematology Oncology, St Jude Children s Research Hospital and the University of Tennessee, Memphis, TN 38105, USA
    Blood 100:52-8. 2002
    ..Thus, approximately half of the children with ALL achieve profound clearance of leukemic cells after 2 to 3 weeks of remission-induction chemotherapy, and these patients have an excellent treatment outcome...
  51. pmc Genetic mediators of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia
    Kevin R Krull
    Department of Epidemiology and Cancer Control, St Jude Children s Research Hospital, 262 Danny Thomas Place, MS 735, Memphis, TN 38105 3678, USA
    J Clin Oncol 31:2182-8. 2013
    ..This study examined genetic polymorphisms associated with variability in neurocognitive outcome...
  52. pmc Minimal disseminated disease in childhood T-cell lymphoblastic lymphoma: a report from the children's oncology group
    Elaine Coustan-Smith
    Department of Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis TN 38105, USA
    J Clin Oncol 27:3533-9. 2009
    ..Measurements of disease dissemination at diagnosis might provide useful prognostic information, which can be further refined by monitoring response to therapy through blood testing...
  53. ncbi request reprint Risk factors for traumatic and bloody lumbar puncture in children with acute lymphoblastic leukemia
    Scott C Howard
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    JAMA 288:2001-7. 2002
    ..Traumatic or bloody lumbar puncture (LP) reduces the diagnostic value of the procedure and may worsen the outcome of patients with acute lymphoblastic leukemia (ALL). Little is known about the risk factors for traumatic and bloody LP...
  54. ncbi request reprint Impact of treatment on the outcome of acute myeloid leukemia with inversion 16: a single institution's experience
    B I Razzouk
    Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
    Leukemia 15:1326-30. 2001
    ..They also suggest that dose intensification of etoposide and addition of 2-CDA may also offer an advantage. This study underscores the dependence of the prognostic impact of cytogenetic features on the efficacy of treatment...
  55. pmc Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1
    S Jeha
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 23:1406-9. 2009
    ..These data suggest that with contemporary treatment, patients with the t(1;19) and TCF3/PBX1 fusion have a favorable overall outcome but increased risk of CNS relapse...
  56. ncbi request reprint Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia
    Shinji Kishi
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    J Clin Oncol 21:3084-91. 2003
    ....
  57. ncbi request reprint ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases
    Mihaela Onciu
    Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    Blood 102:2642-4. 2003
    ..Both were positive for NPM-ALK by reverse transcriptase-polymerase chain reaction. Thus, ALK-positive plasmablastic B-cell lymphomas are more heterogeneous at the molecular level than previously recognized...
  58. ncbi request reprint Manifestations of fungal cellulitis of the orbit in children with neutropenia and fever
    Melanie L McCarty
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Ophthal Plast Reconstr Surg 20:217-23. 2004
    ..To delineate clinical manifestations of fungal orbital cellulitis in immunocompromized patients...
  59. ncbi request reprint Reappraisal of the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia
    C H Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 16:3768-73. 1998
    ..To reassess the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia (ALL)...
  60. ncbi request reprint Second malignancy after treatment of childhood acute myeloid leukemia
    W Leung
    Department of Hematology-Oncology, St Jude Children's Research Hospital, and University of Tennessee, College of Medicine, Memphis, USA
    Leukemia 15:41-5. 2001
    ..Future studies should focus on improving treatments for primary AML while preventing second malignancies...
  61. pmc Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia
    C H Pui
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 24:371-82. 2010
    ..The next main challenge is to further increase cure rates while improving quality of life for all patients...
  62. ncbi request reprint Second malignancy after treatment of childhood non-Hodgkin lymphoma
    W Leung
    St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Cancer 92:1959-66. 2001
    ....
  63. ncbi request reprint Low-dose oral etoposide-based induction regimen for children with acute lymphoblastic leukemia in first bone marrow relapse
    N Hijiya
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Leukemia 18:1581-6. 2004
    ..0+/-9.6% for those with late relapse and 20.0+/-8.0% for those with early relapse. We conclude that low-dose etoposide administered orally has a cytoreductive effect in relapsed ALL...
  64. ncbi request reprint Oral cefixime is similar to continued intravenous antibiotics in the empirical treatment of febrile neutropenic children with cancer
    J L Shenep
    Department of Infectious Diseases, St Jude Children s Research Hospital, University of Tennessee Health Sciences Center, Memphis, TN 38105, USA
    Clin Infect Dis 32:36-43. 2001
    ..0). Results support the safety of oral cefixime therapy for low-risk febrile neutropenic children, a therapeutic approach that would facilitate earlier outpatient management and decrease the costs of treatment...
  65. ncbi request reprint Traumatic lumbar puncture at diagnosis adversely affects outcome in childhood acute lymphoblastic leukemia
    A Gajjar
    Departments of Hematology Oncology, Biostatistics and Epidemiology, Pharmaceutical Sciences, and Pathology, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 96:3381-4. 2000
    ..These data indicate that contamination of CSF with circulating leukemic blast cells during diagnostic lumbar puncture can adversely affect the treatment outcome of children with ALL and is an indication to intensify intrathecal therapy...
  66. ncbi request reprint Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia after first relapse
    E Coustan-Smith
    Department of Hematology Oncology, Children s Research Hospital, Memphis, TN, USA
    Leukemia 18:499-504. 2004
    ..We conclude that MRD assays should be used to guide the selection of postremission therapy in patients with ALL in first relapse...
  67. ncbi request reprint Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemia
    M V Relling
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet 356:285-90. 2000
    ..Most anticonvulsant drugs induce drug-metabolising enzymes and thereby increase the clearance of anticancer agents. We investigated whether anticonvulsants compromise the efficacy of cancer chemotherapy...
  68. ncbi request reprint Safety of lumbar puncture for children with acute lymphoblastic leukemia and thrombocytopenia
    S C Howard
    Department of Hematology Oncology, ALSAC Bldg, Room C6005, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    JAMA 284:2222-4. 2000
    ..Patients with thrombocytopenia are at risk for spontaneous or procedure-related hemorrhage. Whether such patients can safely undergo lumbar puncture (LP) without prophylactic platelet transfusion is unknown...
  69. ncbi request reprint Molecular evidence of ocular Epstein-Barr virus infection
    K S Slobod
    Departments of Infectious Diseases, St Jude Children s Research Hospital, and Department of Pediatrics, University of Tennessee, Memphis, Tennessee, TN, USA
    Clin Infect Dis 31:184-8. 2000
    ..Recognition of EBV-induced ocular disease as an initial presentation of clinical EBV infection is important to the practitioner because of the ubiquitous nature of this herpesvirus...
  70. ncbi request reprint Late effects of treatment in survivors of childhood acute myeloid leukemia
    W Leung
    After Completion of Therapy Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 18:3273-9. 2000
    ..To investigate the incidence of and risk factors for late sequelae of treatment in patients who survived for more than 10 years after the diagnosis of childhood acute myeloid leukemia (AML)...
  71. ncbi request reprint Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia: lack of therapeutic role of local irradiation
    N Hijiya
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Leukemia 19:1399-403. 2005
    ..In conclusion, the prognostic impact of overt testicular disease has diminished. Irradiation appears to provide no survival advantage to this patient population...
  72. ncbi request reprint Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
    M V Relling
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Natl Cancer Inst 91:2001-8. 1999
    ..We studied the metabolism, dose requirements, and tolerance of 6-mercaptopurine among patients with different TPMT phenotypes...
  73. ncbi request reprint Lactic acidosis: a metabolic complication of hematologic malignancies: case report and review of the literature
    E M Sillos
    Division of Critical Care, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105 2794, USA
    Cancer 92:2237-46. 2001
    ..Lactic acidosis (LA) associated with hematologic malignancies is rare, ominous, and generally occurs in adults. Its pathogenesis is poorly understood...
  74. ncbi request reprint Vincristine-induced vocal cord paralysis in an infant
    Doralina L Anghelescu
    Division of Anesthesia, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Paediatr Anaesth 12:168-70. 2002
    ..Therefore, it should be suspected when stridor is present, and clinicians should consider visualization of the airway to establish the cause of upper airway compromise in infants receiving vincristine...
  75. ncbi request reprint Early complications in children with acute lymphoblastic leukemia presenting with hyperleukocytosis
    Eric J Lowe
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 45:10-5. 2005
    ..The optimal management of childhood acute lymphoblastic leukemia (ALL) with hyperleukocytosis is unclear, largely because the risk of leukostasis-related complications is poorly characterized...
  76. ncbi request reprint Posterior reversible encephalopathy syndrome in children with cancer
    E Brannon Morris
    Division of Neurology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 48:152-9. 2007
    ..To identify predisposing factors, radiologic features, and clinical outcome of posterior reversible leucoencephalopathy (PRES) in children receiving cancer treatment...
  77. ncbi request reprint Significance of appendiceal thickening in association with typhlitis in pediatric oncology patients
    M Beth McCarville
    Department of Radiological Sciences, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105 2794, USA
    Pediatr Radiol 34:245-9. 2004
    ..The management of pediatric oncology patients with imaging evidence of appendiceal thickening is complex because they are generally poor surgical candidates and often have confounding clinical findings...
  78. ncbi request reprint Intensive chemotherapy with hematopoietic stem-cell support for children with recurrent or refractory NHL
    J T Sandlund
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cytotherapy 4:253-8. 2002
    ..Those with chemosensitive disease are usually considered for an intensification phase, with either autologous or allogeneic hematopoietic stem-cell transplantation (HSCT)...
  79. doi request reprint Histiocyte-rich xanthomatous pseudotumor mimicking relapse on positron emission tomography imaging in an adolescent with primary mediastinal diffuse large B-cell lymphoma
    Mario Otto
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    J Pediatr Hematol Oncol 34:232-5. 2012
    ..This case is an important reminder of the limitations of positron emission tomography/computed tomography imaging in patients with lymphoma and stresses the importance of histologic confirmation of suspected treatment failure or relapse...
  80. ncbi request reprint Clinicopathologic analysis of follicular lymphoma occurring in children
    Robert B Lorsbach
    Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Blood 99:1959-64. 2002
    ..However, bcl-2 expression in pediatric follicular lymphoma identifies a subset of patients in whom disease is often disseminated at clinical presentation and is more refractory to combination chemotherapy...
  81. ncbi request reprint Myositis complicating viridans streptococcal sepsis in childhood leukemia
    John T Sandlund
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 44:277-9. 2005
    ..The severity of infectious myositis is highly variable, depending on the etiologic organism and host immunity, making individualized treatment the most effective approach...
  82. ncbi request reprint Burkitt lymphoma in African children: a priority for the global health agenda?
    Raul C Ribeiro
    Department of Oncology, International Outreach Program, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 50:1125-6. 2008
  83. ncbi request reprint Interventional radiology techniques for the diagnosis of lymphoma or leukemia
    Kevin M Garrett
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105 2794, USA
    Pediatr Radiol 32:653-62. 2002
    ..Fluid aspiration, percutaneous biopsy, and catheter drainage are standard minimally invasive methods of diagnosing lymphoma or leukemia in adults...
  84. ncbi request reprint Urolithiasis in pediatric patients with acute lymphoblastic leukemia
    S C Howard
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 17:541-6. 2003
    ..05). Seven patients (35%) had recurrent urolithiasis. Patients with ALL are at risk of developing calcium renal stones during chemotherapy, especially when a glucocorticoid is included...
  85. ncbi request reprint Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia
    C H Pui
    Dept of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Ann Hematol 83:S124-6. 2004
    ....
  86. pmc Clinical consequences of hyperglycemia during remission induction therapy for pediatric acute lymphoblastic leukemia
    J R Roberson
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 23:245-50. 2009
    ..Pediatric patients with or without hyperglycemia during remission induction for ALL have similar clinical outcome. Occurrence of hyperglycemia does not warrant alteration of the antileukemic regimen...
  87. ncbi request reprint Asparaginase pharmacodynamics differ by formulation among children with newly diagnosed acute lymphoblastic leukemia
    L J Hak
    Department of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA
    Leukemia 18:1072-7. 2004
    ..We conclude that asparagine concentrations were less effectively depleted by PEG than by E. coli asparaginase at the doses commonly used. The risk of thrombosis may be affected by the intensity of asparaginase exposure...
  88. pmc Pharmacogenetics of outcome in children with acute lymphoblastic leukemia
    Jose Claudio C Rocha
    Department of Pharmaceutical Sciences, Saint Jude Children s Research Hospital of the University of Tennessee, Memphis 38105 2794, USA
    Blood 105:4752-8. 2005
    ..04). The GSTM1 non-null and TYMS 3/3 genotypes are plausibly linked to drug resistance. Polymorphisms interact to influence antileukemic outcome and represent determinants of response that can be used to optimize therapy...
  89. ncbi request reprint A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiation
    Oussama Abla
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 47:880-5. 2006
    ..To describe the outcome of childhood primary central nervous system lymphoma (PCNSL) treated with chemotherapy alone or with chemotherapy plus cranial radiotherapy (CRT)...