Charles J Russell
Affiliation: St. Jude Children's Research Hospital
Russier M, Yang G, Rehg J, Wong S, Mostafa H, Fabrizio T, et al
. Molecular requirements for a pandemic influenza virus: An acid-stable hemagglutinin protein. Proc Natl Acad Sci U S A. 2016;113:1636-41 pubmed publisher
..Overall, these studies reveal that a stable HA (activation pH â‰¤ 5.5) is necessary for pH1N1 influenza virus pathogenicity and airborne transmissibility in ferrets and is associated with pandemic potential in humans. ..
Cai H, Liu M, Russell C. Directed evolution of an influenza reporter virus to restore replication and virulence and enhance non-invasive bioluminescence imaging in mice. J Virol. 2018;: pubmed publisher
..The adapted virus can be used to study influenza infection, immunology, and disease in living mice. The strategy can also be used to adapt other viruses. ..
Russell C, Luque L. The structural basis of paramyxovirus invasion. Trends Microbiol. 2006;14:243-6 pubmed
..Conformational changes in key regions of the F protein suggest the mechanism by which the F protein is activated and refolds. ..
Burke C, Li M, Hurwitz J, Vogel P, Russell C. Relationships among dissemination of primary parainfluenza virus infection in the respiratory tract, mucosal and peripheral immune responses, and protection from reinfection: a noninvasive bioluminescence-imaging study. J Virol. 2015;89:3568-83 pubmed publisher
Russell C, Hu M, Okda F. Influenza Hemagglutinin Protein Stability, Activation, and Pandemic Risk. Trends Microbiol. 2018;26:841-853 pubmed publisher
..Most importantly, HA stabilization appears to be necessary for adapting emerging influenza viruses to humans. ..