Carlos Rodriguez-Galindo

..These studies have shown promising results, and have placed topotecan and irinotecan in the first line treatment for some malignancies. However, studies to better determine the optimal schedules and sequence of combinations are needed...

..The risk for death in patients with retinoblastoma is increased in those who present with metastatic disease, and the role of intensive chemotherapy and autologous hematopoietic stem cell rescue in these patients remains unclear...

..In this report we describe significant single agent activity of clofarabine in disseminated LCH refractory to salvage regimens, including cladribine...

..The individual contributions of each treatment component cannot be analyzed separately; improvements in local and systemic control can influence each other...

..Despite improvements in therapy for osteosarcoma, approximately 4-10% of patients experience a local recurrence and have a poor prognosis...

..The benefit of this approach is unclear and HSCT must therefore be considered investigational. New strategies, such as the use of immunotherapy, biological modifiers and novel classes of chemotherapeutic agents must be explored...

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..Chemotherapy may help to decrease the radiotherapy dose and limit the side effects of local therapies. However, little is known regarding the chemosensitivity of NPC tumors in pediatric patients...

..Combining both agents may increase the amount of camptothecin delivered to the tumor, without additive toxicity...

..Multi-institutional and prospective studies are necessary to further our understanding of the pathogenesis and to improve outcomes...

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..To evaluate the efficacy of chemoreduction using vincristine and carboplatin in preventing or delaying external-beam radiotherapy (EBRT) or enucleation in patients with intraocular retinoblastoma...

..Our current understanding in the biology and treatment of ESFT suggests that a more rational approach to the development of risk-adapted therapy should be undertaken...

..However, because RMS rarely occurs during the neonatal period, little is known about neonatal RMS...

..2-CdA needs to be considered for the treatment of recurrent LCH. However, its incorporation into front-line treatment of patients with multi-system LCH needs further study...

..By identifying new chemotherapeutic strategies, the outcome of these patients can be improved and the toxicity of treatment regimens decreased...

..Despite improved therapies, 30-40% of patients with Ewing tumors (ET) experience recurrence and have a poor prognosis. The authors analyzed factors prognostic of survival in patients with recurrent ET...

..To assess the effect of radiation dose on local tumor control of the Ewing sarcoma family of tumors in 79 patients with localized disease treated at a single institution...

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..The initial study (OS-86) used ifosfamide, cisplatin, doxorubicin, and high-dose methotrexate, and the subsequent study (OS-91) used the same agents at similar doses, but carboplatin was substituted for cisplatin...

..New, effective chemotherapeutic agents are needed for intraocular retinoblastoma...

..We retrospectively assessed the incidence of ototoxicity and its risk factors in children with retinoblastoma who were treated with carboplatin...

..Our objective for this study was to examine the impact of the modern management of intraocular retinoblastoma on the patient and the family...

..Internet meetings are a valuable mechanism for enabling participation from under-resourced countries in the development of cooperative studies...

..The authors evaluated the impact of factors such as age and prior nephrotoxic agents on MTX pharmacokinetics in children and young adults with osteosarcoma and examined whether MTX pharmacokinetic parameters were associated with outcome...

..Our findings identify design and statistical considerations for a future effectiveness study of the EPA intervention in hospitalized pediatric oncology patients...

..To assess the effect of gefitinib on the pharmacokinetics of IV irinotecan and on the bioavailability of a single oral dose of irinotecan...

..To evaluate vincristine and carboplatin with intensive focal treatments in the management of intraocular retinoblastoma...

..The purpose of this study was to document the ocular preservation rate after 36 Gy external beam radiation therapy (EBRT) for retinoblastoma...

..To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS)...

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..In this investigation, we studied the utility of FDG PET/CT in children with NPC...

..Administration of an oral cephalosporin allowed advancement of the dosage of oral irinotecan. This study investigates whether administration of an oral cephalosporin increases the maximum tolerated dose (MTD) of intravenous irinotecan...

..Despite the use of all-trans-retinoic acid during induction for acute promyelocytic leukemia, the incidence of fatal hemorrhage remains unacceptably high...

..As new treatments are developed, a critical review of data from past treatment eras is needed to identify clinically relevant risk groups...

..Early diagnosis of trilateral retinoblastoma may facilitate the use of less intensive therapeutic approaches and result in excellent outcomes in these patients...

..To determine the impact of chemotherapy or external beam radiotherapy (EBRT) on pediatric anophthalmic sockets...

..The purpose of this study was to report our experience using episcleral plaque brachytherapy (EPBRT) to treat retinoblastoma and to demonstrate its applicability in multimodality treatment...

..Jude Children's Research Hospital (sponsor) and Calvo Mackenna Hospital (CMH, partner), a public pediatric hospital and national center for the treatment of bone tumors in Santiago, Chile...

..The incidence of pediatric nonrhabdomyosarcoma soft tissue sarcomas (NRSTSs) of the groin and axilla is unknown, and the optimal surgical approach to these patients is unclear...

..To use functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) to investigate visual system development in children being treated for retinoblastoma...

..She died within 2 days of admission. CONCLUSION: We believe that this is the first description of a patient with retinoblastoma and Waardenburg syndrome and of an ovarian metastasis from retinoblastoma...

..The impact of chemotherapy, focal therapies, radiation and co-existing ocular morbidities on histology of eyes with retinoblastoma enucleated following chemoreduction is not well known...

..To report the incidence of new tumor formation in hereditary retinoblastoma patients treated with primary systemic chemotherapy...

..To correlate the clinical and histopathological findings of eyes primarily enucleated for advanced intraocular retinoblastoma...

..Furthermore, neurotransmitter receptors, transporters, and biosynthetic enzymes are expressed in human retinoblastoma, and targeted disruption of these pathways reduces retinoblastoma growth in vivo and in vitro...

..Local failure rates for patients who received combined surgery and RT were reviewed to determine outcome and prognostic factors...

..Patients are at risk of second malignancies (SM) after treatment for Ewing sarcoma family of tumours (ESFT)...

..The reduced area under the curve to the active metabolite SN-38 during ifosfamide therapy predicts a compromised efficacy of irinotecan in this combination...

..To compare the expression of multidrug-resistant proteins in retinoblastoma tumors among eyes treated with primary enucleation...

..This prospective study was designed to be the first to evaluate the toxicity of radiofrequency ablation (RFA) in patients with recurrent pediatric solid tumors...

..Carboplatin is the most effective drug in retinoblastoma but systemic clearance is variable in young patients. While most regimens use a flat dose, individualized targeting may provide a more adjusted systemic exposure...

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..The identification of risk factors for ODI may allow modifications of therapy that reduce the incidence and severity of infection, but prevention of all ODIs will require novel strategies...

..Intracranial HPC represents a special subtype with a high proclivity toward recurrence and metastasis...

..Jude Children's Research Hospital, and the University of Tennessee Hamilton Eye Institute...

..To correlate the histologic and magnetic resonance imaging results of the optic nerve in eyes primarily enucleated for retinoblastoma...

..ESFT arising as a second cancer was reviewed and characterized at our childhood cancer center...

..Instead, rosette formation reflects extensive cell-cell contacts between retinoblastoma cells in both early-stage (differentiated) and late-stage (dedifferentiated) tumors...

..In addition, they support the idea that MDMX is a specific chemotherapeutic target for treating retinoblastoma...

..Therefore, not all hotspot mutants are functionally equivalent and the biochemical nature of the mutant may significantly influence clinical outcome. The implications of these results for genetic counseling are discussed...

..The authors studied the survival and long-term morbidities of children with nasopharyngeal carcinoma (NPC)...

..The authors describe three patients with RDD who had exclusive extranodal disease in the head and neck area, in whom the clinical presentation mimicked other more common conditions...

..The authors studied a series of patients with Langerhans cell histiocytosis in an attempt to better define the incidence and significance of orbital involvement within the vast spectrum of the disease...

..We evaluated the rate of progression to SAA...

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..We conclude that PET-CT information is clinically useful to evaluate disease activity and response to therapy and provides information that cannot be obtained from technetium 99m methylene diphosphonate bone scans or radiographs...

..Furthermore, our initial experience has demonstrated to us the potential power of expanded cooperation and collaboration at a global level...

..This study evaluated the outcome of retinoblastoma patients, when employing a telemedicine-based twinning program in Jordan...

..BAC may present as a solitary pulmonary nodule indistinguishable from a metastatic lesion and should be included in the differential diagnosis of pulmonary nodules in survivors of pediatric cancer...

..CONCLUSIONS: Most adrenocortical carcinomas accumulate and retain FDG and thus can be visualized by PET. However, false-negative findings are possible, especially with very small lesions...

..MPNST of the lung has similar clinical and radiologic characteristics as pleuropulmonary blastoma. We suggest to include MPNST of the lung in the differential diagnosis of intrapulmonary masses in children...

..RESULTS: By clinical examination, retinoblastoma was diagnosed in the right eye. CONCLUSION: Chromosomal abnormalities on the long arm of chromosome 13 predispose to retinoblastoma formation and characteristic facial features...

..The diagnosis of an intra-abdominal malignancy, most commonly a DSRCT, should be considered in the presence of an umbilical mass in a child...

..Our findings lay the groundwork for establishing gene expression profiles that may aid in the diagnosis and prognosis of pediatric ACT, and in the identification of signaling pathways that contribute to this disease...

..The presence of a hepatic abscess should be considered in the differential diagnosis of atypical abdominal pain in patients with SCD...

..These findings support a role for heme oxygenase-1 in the physiologic response to inflammatory stress...

..Therefore, MYC may sensitize tumor cells to DNA damage by suppressing Bcl-X...

..The long-term complications of anemia in children with cancer are unknown. Further investigation of the clinical significance of anemia, including its impact on quality of life, is warranted...

..In addition, our data suggest that the incidence of ACT in this region is about 12-18 times the incidence reported in the United States and Europe...

..2%, respectively, for patients treated during periods I and II (P=0.061). The addition of ifosfamide/etoposide to chemotherapy with cisplatin/teniposide improves survival in these patients, but further studies are still necessary...

..Early diagnosis is necessary to improve the survival of children with retinoblastoma in these countries...

..This approach is feasible in children and allows for tolerance of higher doses of protracted irinotecan...

..The addition of G-CSF to IS shortens the time to neutrophil count recovery, but may not improve overall survival. Because GM-CSF acts differently than G-CSF, its use in combination with IS may be different...

..CONCLUSIONS: Pelvic osteosarcomas often were large and unresectable. A high propensity for metastasis contributed to the poor outcome of patients with pelvic osteosarcoma. New therapeutic approaches are needed...