WILBURN REDDICK

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint Automated segmentation and classification of multispectral magnetic resonance images of brain using artificial neural networks
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    IEEE Trans Med Imaging 16:911-8. 1997
  2. pmc Quantitative morphologic evaluation of magnetic resonance imaging during and after treatment of childhood leukemia
    Wilburn E Reddick
    Division of Translational Imaging Research MS 210, Department of Radiological Sciences, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN, 38105 2794, USA
    Neuroradiology 49:889-904. 2007
  3. pmc Voxel-based analysis of T2 hyperintensities in white matter during treatment of childhood leukemia
    W E Reddick
    Division of Translational Imaging Research, St Jude Children s Research Hospital, Memphis, TN, USA
    AJNR Am J Neuroradiol 30:1947-54. 2009
  4. pmc Smaller white-matter volumes are associated with larger deficits in attention and learning among long-term survivors of acute lymphoblastic leukemia
    Wilburn E Reddick
    Division of Translational Imaging Research, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer 106:941-9. 2006
  5. ncbi request reprint Developmental model relating white matter volume to neurocognitive deficits in pediatric brain tumor survivors
    Wilburn E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 97:2512-9. 2003
  6. pmc Quantitative MRI assessment of leukoencephalopathy
    Wilburn E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Magn Reson Med 47:912-20. 2002
  7. ncbi request reprint Dynamic magnetic resonance imaging of regional contrast access as an additional prognostic factor in pediatric osteosarcoma
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 91:2230-7. 2001
  8. ncbi request reprint Subtle white matter volume differences in children treated for medulloblastoma with conventional or reduced dose craniospinal irradiation
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN, USA
    Magn Reson Imaging 18:787-93. 2000
  9. ncbi request reprint Dynamic MR imaging (DEMRI) of microcirculation in bone sarcoma
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Magn Reson Imaging 10:277-85. 1999
  10. ncbi request reprint A hybrid neural network analysis of subtle brain volume differences in children surviving brain tumors
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, University of Memphis, TN 38105, USA
    Magn Reson Imaging 16:413-21. 1998

Research Grants

Detail Information

Publications41

  1. ncbi request reprint Automated segmentation and classification of multispectral magnetic resonance images of brain using artificial neural networks
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    IEEE Trans Med Imaging 16:911-8. 1997
    ..This fully automated technique produces reliable and reproducible MR image segmentation and classification while eliminating intra- and interobserver variability...
  2. pmc Quantitative morphologic evaluation of magnetic resonance imaging during and after treatment of childhood leukemia
    Wilburn E Reddick
    Division of Translational Imaging Research MS 210, Department of Radiological Sciences, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN, 38105 2794, USA
    Neuroradiology 49:889-904. 2007
    ..When evaluating the effect of antileukemia therapy on the developing brain, magnetic resonance (MR) imaging has been the preferred modality because it quantifies morphologic changes objectively and noninvasively...
  3. pmc Voxel-based analysis of T2 hyperintensities in white matter during treatment of childhood leukemia
    W E Reddick
    Division of Translational Imaging Research, St Jude Children s Research Hospital, Memphis, TN, USA
    AJNR Am J Neuroradiol 30:1947-54. 2009
    ..This study uses voxel-based analyses (VBA) of T2-weighted imaging of patients during treatment to identify which WM regions are preferentially damaged...
  4. pmc Smaller white-matter volumes are associated with larger deficits in attention and learning among long-term survivors of acute lymphoblastic leukemia
    Wilburn E Reddick
    Division of Translational Imaging Research, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer 106:941-9. 2006
    ..The primary objective of this study was to test the hypothesis that survivors of childhood acute lymphoblastic leukemia (ALL) have deficits in neurocognitive performance, and smaller white-matter volumes are associated with these deficits...
  5. ncbi request reprint Developmental model relating white matter volume to neurocognitive deficits in pediatric brain tumor survivors
    Wilburn E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 97:2512-9. 2003
    ....
  6. pmc Quantitative MRI assessment of leukoencephalopathy
    Wilburn E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Magn Reson Med 47:912-20. 2002
    ....
  7. ncbi request reprint Dynamic magnetic resonance imaging of regional contrast access as an additional prognostic factor in pediatric osteosarcoma
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 91:2230-7. 2001
    ....
  8. ncbi request reprint Subtle white matter volume differences in children treated for medulloblastoma with conventional or reduced dose craniospinal irradiation
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN, USA
    Magn Reson Imaging 18:787-93. 2000
    ..Serial quantitative MR measures of NAWMV may provide a neuroanatomical substrate for assessing functional impact of CSI on normal brain function following treatment for medulloblastoma...
  9. ncbi request reprint Dynamic MR imaging (DEMRI) of microcirculation in bone sarcoma
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Magn Reson Imaging 10:277-85. 1999
    ....
  10. ncbi request reprint A hybrid neural network analysis of subtle brain volume differences in children surviving brain tumors
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, University of Memphis, TN 38105, USA
    Magn Reson Imaging 16:413-21. 1998
    ..This hybrid neural network analysis of subtle brain volume differences with magnetic resonance may constitute a direct measure of treatment-induced brain damage...
  11. pmc Atypical white matter volume development in children following craniospinal irradiation
    Wilburn E Reddick
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Neuro Oncol 7:12-9. 2005
    ..Therefore, volumetric monitoring of brain development can be used to guide the care of survivors, assess the toxicity of previous and current clinical trials, and aid in the design of therapies that minimize toxicity...
  12. ncbi request reprint Attention and memory functioning among pediatric patients with medulloblastoma
    Cara B Reeves
    Division of Behavioral Medicine, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105 2794, USA
    J Pediatr Psychol 31:272-80. 2006
    ..To test the hypotheses that memory and attention deficits are prevalent in survivors of childhood medulloblastoma (MB) and that these deficits are associated with problems with academic achievement...
  13. ncbi request reprint Understanding the cognitive impact on children who are treated for medulloblastoma
    Shawna L Palmer
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr Psychol 32:1040-9. 2007
    ..Despite these important steps to reduce radiation dose exposure, an overwhelming majority of medulloblastoma survivors continue to experience academic failure and significant learning delays...
  14. ncbi request reprint A digital pediatric brain structure atlas from T1-weighted MR images
    Zuyao Y Shan
    Division of Translational Imaging Research, Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Med Image Comput Comput Assist Interv 9:332-9. 2006
    ..Our brain atlas and structural mesh models (www.stjude.org/brainatlas) can be used to plan treatment, to conduct knowledge and model-driven segmentation, and to analyze the shapes of brain structures in pediatric patients...
  15. ncbi request reprint Acute neurocognitive response to methylphenidate among survivors of childhood cancer: a randomized, double-blind, cross-over trial
    Heather M Conklin
    St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Pediatr Psychol 32:1127-39. 2007
    ..To investigate the acute efficacy and adverse side effects of methylphenidate (MPH) among survivors of childhood cancer [acute lymphoblastic leukemia (ALL) or brain tumor (BT)] with learning impairments...
  16. pmc Childhood central nervous system leukemia: historical perspectives, current therapy, and acute neurological sequelae
    Fred H Laningham
    Division of Diagnostic Imaging MS 210, Department of Radiological Sciences, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN, 38105 2794, USA
    Neuroradiology 49:873-88. 2007
    ....
  17. pmc Predicting methylphenidate response in long-term survivors of childhood cancer: a randomized, double-blind, placebo-controlled, crossover trial
    Heather M Conklin
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr Psychol 35:144-55. 2010
    ..To investigate the methylphenidate (MPH) response rate among childhood survivors of acute lymphoblastic leukemia (ALL) and brain tumors (BTs) and to identify predictors of positive MPH response...
  18. doi request reprint DCE-MRI pixel-by-pixel quantitative curve pattern analysis and its application to osteosarcoma
    Jun Yu Guo
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    J Magn Reson Imaging 30:177-84. 2009
    ....
  19. pmc Dynamic contrast-enhanced magnetic resonance imaging parameters independent of baseline T10 values
    Jun Yu Guo
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Magn Reson Imaging 27:1208-15. 2009
    ..The estimation of parameters themselves (K(trans), v(e) and IAUC) is highly dependent on the T(10) value...
  20. pmc Retrospective evaluation of PET-MRI registration algorithms
    Zuyao Y Shan
    Division of Translational Imaging Research, Department of Radiological Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    J Digit Imaging 24:485-93. 2011
    ..71 for both). We also observed that the GM concordances of linear and affine registration were higher than those of the rigid and nonlinear registration among the methods evaluated...
  21. pmc Regional white matter anisotropy and reading ability in patients treated for pediatric embryonal tumors
    Shawna L Palmer
    St Jude Children s Research Hospital, Memphis, TN, USA
    Brain Imaging Behav 4:132-40. 2010
    ..The integrity of the white matter in these regions may affect communication among visual, auditory, and language cortical areas that are engaged during reading...
  22. pmc Attention and working memory abilities in children treated for acute lymphoblastic leukemia
    Jason Ashford
    Department of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 116:4638-45. 2010
    ....
  23. pmc Long-term efficacy of methylphenidate in enhancing attention regulation, social skills, and academic abilities of childhood cancer survivors
    Heather M Conklin
    Department of Psychology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 28:4465-72. 2010
    ..Methylphenidate (MPH) ameliorates attention problems experienced by some cancer survivors in the short term, but its long-term efficacy is unproven...
  24. ncbi request reprint The cause and clinical significance of central tumor photopenia on thallium scintigraphy of pediatric osteosarcoma of the extremity
    M Beth McCarville
    Department of Radiological Sciences, Division of Diagnostic Imaging, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2974, USA
    AJR Am J Roentgenol 188:572-8. 2007
    ....
  25. ncbi request reprint Quantitative morphologic evaluation of white matter in survivors of childhood medulloblastoma
    Zuyao Y Shan
    Division of Translational Imaging Research, Department of Radiological Sciences MS212, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Magn Reson Imaging 24:1015-22. 2006
    ..We conclude that fractal geometry can be used to monitor the morphologic effects of neurotoxicity in brain tumor survivors...
  26. ncbi request reprint Short-term efficacy of methylphenidate: a randomized, double-blind, placebo-controlled trial among survivors of childhood cancer
    Raymond K Mulhern
    Division of Behavioral Medicine, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 22:4795-803. 2004
    ..The present study tests the hypothesis that the psychostimulant methylphenidate (MPH) improves cognitive and social functioning among these patients...
  27. pmc Improving the segmentation of therapy-induced leukoencephalopathy in children with acute lymphoblastic leukemia using a priori information and a gradient magnitude threshold
    John O Glass
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Magn Reson Med 52:1336-41. 2004
    ..603, 0.699, P = 0.024). More accurate and reliable quantification reduces the amount of variance in MR measures and facilitates clinical trials to determine the clinical significance of leukoencephalopathy in this vulnerable population...
  28. ncbi request reprint Late neurocognitive sequelae in survivors of brain tumours in childhood
    Raymond K Mulhern
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Lancet Oncol 5:399-408. 2004
    ..Further efforts to limit neurocognitive sequelae have included design of clinical trials to test the effectiveness of cognitive, behavioural, and pharmacological interventions...
  29. ncbi request reprint A knowledge-guided active contour method of segmentation of cerebella on MR images of pediatric patients with medulloblastoma
    Zu Y Shan
    Division of Translational Imaging Research, Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Magn Reson Imaging 21:1-11. 2005
    ..To develop an automated method for identification of the cerebella on magnetic resonance (MR) images of patients with medulloblastoma...
  30. ncbi request reprint Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood
    Raymond K Mulhern
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Int Neuropsychol Soc 10:180-9. 2004
    ..No gender effects were observed. The results of the present study further support the contention that NAWM is an important substrate for treatment-induced neurocognitive problems among survivors of malignant brain tumors of childhood...
  31. ncbi request reprint Prediction of total cerebral tissue volumes in normal appearing brain from sub-sampled segmentation volumes
    John O Glass
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Magn Reson Imaging 21:977-82. 2003
    ..This study demonstrated that investigators can choose the amount of cerebrum sampled to optimize the acquisition and processing time against the degree of accuracy needed in the total cerebral volume estimates...
  32. ncbi request reprint A model for quantitative changes in the magnetic resonance parameters of muscle in children after therapeutic irradiation
    Matthew J Krasin
    Division of Radiation Oncology, Department of Radiological Sciences, St Jude Children s Research Hospital, and Department of Pediatrics, University of Tennessee School of Medicine, Memphis, TN 38105 2794, USA
    Magn Reson Imaging 24:1319-24. 2006
    ....
  33. pmc Computer-aided detection of therapy-induced leukoencephalopathy in pediatric acute lymphoblastic leukemia patients treated with intravenous high-dose methotrexate
    John O Glass
    Division of Translational Imaging Research, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Magn Reson Imaging 24:785-91. 2006
    ....
  34. ncbi request reprint Predicting intellectual outcome among children treated with 35-40 Gy craniospinal irradiation for medulloblastoma
    Shawna L Palmer
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Neuropsychology 17:548-55. 2003
    ..A steeper decline was found for those with higher baseline performance. Clinicians may use the proposed predictive model to identify those patients who are at risk of significant intellectual decline...
  35. ncbi request reprint A knowledge-guided active model method of cortical structure segmentation on pediatric MR images
    Zuyao Y Shan
    Division of Translational Imaging Research, Department of Radiological Sciences, St Jude Children s Research Hospital, and Department of Biomedical Engineering, The University of Memphis, Tennessee 381005, USA
    J Magn Reson Imaging 24:779-89. 2006
    ..To develop an automated method for quantification of cortical structures on pediatric MR images...
  36. ncbi request reprint Abnormal hippocampal development in children with medulloblastoma treated with risk-adapted irradiation
    Bonnie J Nagel
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN, USA
    AJNR Am J Neuroradiol 25:1575-82. 2004
    ..Therefore, we hypothesized that longitudinal hippocampal volume measurements are abnormal in patients with medulloblastoma and thereby provide a possible substrate for explaining memory dysfunction...
  37. pmc A quantitative MR imaging assessment of leukoencephalopathy in children treated for acute lymphoblastic leukemia without irradiation
    Wilburn E Reddick
    Division of Translational Imaging Research, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    AJNR Am J Neuroradiol 26:2371-7. 2005
    ..The purpose of this study was to use objective quantitative MR imaging to prospectively assess the temporal evolution of LE extent and intensity...
  38. pmc Prevalence of leukoencephalopathy in children treated for acute lymphoblastic leukemia with high-dose methotrexate
    Wilburn E Reddick
    Division of Translational Imaging Research, Department of Radiological Sciences, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    AJNR Am J Neuroradiol 26:1263-9. 2005
    ..The purpose of this study was to use objective quantitative MR imaging to prospectively assess potential risk factors on the temporal evolution of LE in patients treated for ALL...
  39. pmc A novel, fast entropy-minimization algorithm for bias field correction in MR images
    Qing Ji
    Division of Translational Imaging Research, Department of Radiological Sciences MS 210, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Magn Reson Imaging 25:259-64. 2007
    ..Results showed that this algorithm could correct different types of MR images from different types of coils acquired at different field strengths very efficiently and with decreased computational load...
  40. ncbi request reprint Brain volume in pediatric patients with sickle cell disease: evidence of volumetric growth delay?
    R Grant Steen
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN, USA
    AJNR Am J Neuroradiol 26:455-62. 2005
    ..This study was designed to test a hypothesis that children with SCD have a disease-related delay in brain volumetric growth compared with healthy children...
  41. ncbi request reprint Decline in corpus callosum volume among pediatric patients with medulloblastoma: longitudinal MR imaging study
    Shawna L Palmer
    Division of Behavioral Medicine, St Jude Children s Research Hospital, TN 38105 2794, USA
    AJNR Am J Neuroradiol 23:1088-94. 2002
    ....

Research Grants5

  1. Quantitative MR measure of MTX neurotoxicity in children
    WILBURN REDDICK; Fiscal Year: 2006
    ....