Susana C Raimondi

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc Unbalanced chromosome 1 abnormalities leading to partial trisomy 1q in four infants with Down syndrome and acute megakaryocytic leukemia
    Maria Luiza Macedo Silva
    Department of Cytogenetic, The National Center for Bone Marrow Transplantation CEMO INCa, National Cancer Institute INCA, Rio de Janeiro, RJ, Brazil
    Mol Cytogenet 2:7. 2009
  2. ncbi request reprint Fluorescence in situ hybridization: molecular probes for diagnosis of pediatric neoplastic diseases
    S C Raimondi
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer Invest 18:135-47. 2000
  3. ncbi request reprint Near-triploidy and near-tetraploidy in childhood acute lymphoblastic leukemia: association with B-lineage blast cells carrying the ETV6-RUNX1 fusion, T-lineage immunophenotype, and favorable outcome
    Susana C Raimondi
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer Genet Cytogenet 169:50-7. 2006
  4. ncbi request reprint Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a cooperative pediatric oncology group study-POG 8821
    S C Raimondi
    Departments of Pathology and Laboratory Medicine, St Jude Children s Research Hospital, and University of Tennessee, Memphis, TN 38105, USA
    Blood 94:3707-16. 1999
  5. ncbi request reprint Reassessment of the prognostic significance of hypodiploidy in pediatric patients with acute lymphoblastic leukemia
    Susana C Raimondi
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 98:2715-22. 2003
  6. pmc Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia
    Deborah French
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 113:4512-20. 2009
  7. pmc Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial
    Jeffrey E Rubnitz
    Department of Oncology, St Jude Children s Research Hospital and the University of Tennessee Health Science Center, Memphis, TN 38105 2794, USA
    Lancet Oncol 11:543-52. 2010
  8. pmc Treating childhood acute lymphoblastic leukemia without cranial irradiation
    Ching Hon Pui
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    N Engl J Med 360:2730-41. 2009
  9. ncbi request reprint Gene expression profiling of pediatric acute myelogenous leukemia
    Mary E Ross
    Department of Hematology Oncology, Hartwell Center for Bioinformatics and Biotechnology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Blood 104:3679-87. 2004
  10. pmc Comparative analysis of different approaches to measure treatment response in acute myeloid leukemia
    Hiroto Inaba
    Department of Oncology, MS 260, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    J Clin Oncol 30:3625-32. 2012

Detail Information

Publications68

  1. pmc Unbalanced chromosome 1 abnormalities leading to partial trisomy 1q in four infants with Down syndrome and acute megakaryocytic leukemia
    Maria Luiza Macedo Silva
    Department of Cytogenetic, The National Center for Bone Marrow Transplantation CEMO INCa, National Cancer Institute INCA, Rio de Janeiro, RJ, Brazil
    Mol Cytogenet 2:7. 2009
    ..Here four yet unreported infants with such malignancies are reported...
  2. ncbi request reprint Fluorescence in situ hybridization: molecular probes for diagnosis of pediatric neoplastic diseases
    S C Raimondi
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer Invest 18:135-47. 2000
    ..Although FISH has disadvantages when compared with conventional cytogenetics and molecular methods, FISH will continue to be important in analyzing chromosomal abnormalities of tumors in children...
  3. ncbi request reprint Near-triploidy and near-tetraploidy in childhood acute lymphoblastic leukemia: association with B-lineage blast cells carrying the ETV6-RUNX1 fusion, T-lineage immunophenotype, and favorable outcome
    Susana C Raimondi
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer Genet Cytogenet 169:50-7. 2006
    ..16 can be included in the low-risk arm of treatment protocols. We cannot make similar recommendations for patients with T-lineage ALL because of the small number of cases (n = 3) in this study...
  4. ncbi request reprint Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a cooperative pediatric oncology group study-POG 8821
    S C Raimondi
    Departments of Pathology and Laboratory Medicine, St Jude Children s Research Hospital, and University of Tennessee, Memphis, TN 38105, USA
    Blood 94:3707-16. 1999
    ..Limited analysis suggested that patients with inv(16) can be salvaged better following relapse than those with t(8;21). Thus, patients with an inv(16)/t(16;16) may have high survival rates when treated with chemotherapy alone...
  5. ncbi request reprint Reassessment of the prognostic significance of hypodiploidy in pediatric patients with acute lymphoblastic leukemia
    Susana C Raimondi
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 98:2715-22. 2003
    ..In addition, the authors determined whether subdivision of the hypodiploid category served a prognostic purpose for these patients...
  6. pmc Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia
    Deborah French
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 113:4512-20. 2009
    ..We conclude that acquired genetic variation in leukemia cells has a stronger influence on MTXPG accumulation than inherited genetic variation...
  7. pmc Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial
    Jeffrey E Rubnitz
    Department of Oncology, St Jude Children s Research Hospital and the University of Tennessee Health Science Center, Memphis, TN 38105 2794, USA
    Lancet Oncol 11:543-52. 2010
    ....
  8. pmc Treating childhood acute lymphoblastic leukemia without cranial irradiation
    Ching Hon Pui
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    N Engl J Med 360:2730-41. 2009
    ..Prophylactic cranial irradiation has been a standard treatment in children with acute lymphoblastic leukemia (ALL) who are at high risk for central nervous system (CNS) relapse...
  9. ncbi request reprint Gene expression profiling of pediatric acute myelogenous leukemia
    Mary E Ross
    Department of Hematology Oncology, Hartwell Center for Bioinformatics and Biotechnology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Blood 104:3679-87. 2004
    ..Surprisingly, AMLs containing partial tandem duplications of MLL failed to cluster with MLL chimeric fusion gene cases, suggesting a significant difference in their underlying mechanism of transformation...
  10. pmc Comparative analysis of different approaches to measure treatment response in acute myeloid leukemia
    Hiroto Inaba
    Department of Oncology, MS 260, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    J Clin Oncol 30:3625-32. 2012
    ..Response can now be assessed by minimal residual disease (MRD) monitoring with flow cytometry or polymerase chain reaction (PCR). We determined the relation among the results of these approaches and their prognostic value...
  11. pmc Acute mixed lineage leukemia in children: the experience of St Jude Children's Research Hospital
    Jeffrey E Rubnitz
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 113:5083-9. 2009
    ..We also suggest that hematopoietic stem cell transplantation is often not required for cure of these patients...
  12. ncbi request reprint Clinical significance of residual disease during treatment in childhood acute myeloid leukaemia
    Elaine Coustan-Smith
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Haematol 123:243-52. 2003
    ..022); overt recurrence of AML within the subsequent 6 months was significantly more likely in the former group. The assay described here holds promise for guiding the choice of post-remission treatment options in children with AML...
  13. ncbi request reprint Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital
    Ching Hon Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 104:2690-6. 2004
    ..01% or more at the end of the 6-week remission induction phase. Our results suggest the efficacy of early intensification of intrathecal chemotherapy and provide the basis for studies omitting cranial irradiation altogether...
  14. pmc Reference alignment of SNP microarray signals for copy number analysis of tumors
    Stan Pounds
    Department of Biostatistics, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Bioinformatics 25:315-21. 2009
    ..In our study of acute lymphoblastic leukemia, RSA-RAP gives copy number analysis results that show substantially better concordance with cytogenetics than do two other alignment procedures...
  15. pmc Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia
    Elaine Coustan-Smith
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 10:147-56. 2009
    ..We studied leukaemic cells, collected at diagnosis, to identify cases with ETP features and determine their clinical outcome...
  16. pmc Improved prognosis for older adolescents with acute lymphoblastic leukemia
    Ching Hon Pui
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 29:386-91. 2011
    ..We reviewed the outcome of older adolescents (age 15 to 18 years) treated in four consecutive Total Therapy studies to determine if recent improved treatment extended to this high-risk group...
  17. ncbi request reprint Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements
    C H Pui
    St Jude Chidren s Research Hospital and University of Tennessee, Memphis, 38105, USA
    Leukemia 17:700-6. 2003
    ....
  18. ncbi request reprint Interim comparison of a continuous infusion versus a short daily infusion of cytarabine given in combination with cladribine for pediatric acute myeloid leukemia
    Kristine R Crews
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 20:4217-24. 2002
    ....
  19. ncbi request reprint Results of therapy for acute lymphoblastic leukemia in black and white children
    Ching Hon Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    JAMA 290:2001-7. 2003
    ..Treatment results for acute lymphoblastic leukemia (ALL) clearly have improved over the past decade, but black children have not fared as well as white children in large national trials...
  20. pmc Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial
    Torben S Mikkelsen
    St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA
    J Clin Oncol 29:1771-8. 2011
    ....
  21. ncbi request reprint ALK-positive anaplastic large cell lymphoma with leukemic peripheral blood involvement is a clinicopathologic entity with an unfavorable prognosis. Report of three cases and review of the literature
    Mihaela Onciu
    Dept of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    Am J Clin Pathol 120:617-25. 2003
    ....
  22. ncbi request reprint A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia
    John T Sandlund
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer Genet Cytogenet 168:69-72. 2006
    ..1) that rearranged BCL6 and placed it adjacent to MYC. We speculate that this genetic lesion occurred as a result of chromosomal instability due to the underlying disease...
  23. ncbi request reprint Classification of pediatric acute lymphoblastic leukemia by gene expression profiling
    Mary E Ross
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Blood 102:2951-9. 2003
    ....
  24. doi request reprint Successful treatment of pediatric plasmacytoid dendritic cell tumors with a contemporary regimen for acute lymphoblastic leukemia
    Karen D Wright
    Department of Oncology, St Jude Children s Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 60:E38-41. 2013
    ..Cases of DCL among pediatric patients have been reported to respond to therapeutic regimens for acute lymphoblastic leukemia, but details regarding the specifics of therapy are lacking...
  25. ncbi request reprint Secondary chromosomal abnormalities predict outcome in pediatric and adult high-stage Burkitt lymphoma
    Mihaela Onciu
    Department of Pathology, St Jude Children s Hospital, Memphis, Tennessee 38105, USA
    Cancer 107:1084-92. 2006
    ..However, to the authors' knowledge, very limited studies have focused on the secondary chromosomal abnormalities in pediatric BL as compared with those of adult BL and on their prognostic impact...
  26. ncbi request reprint Favorable impact of the t(9;11) in childhood acute myeloid leukemia
    Jeffrey E Rubnitz
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 20:2302-9. 2002
    ..To determine the impact of MLL rearrangements on the outcome of children with acute myeloid leukemia (AML)...
  27. pmc Germline genomic variants associated with childhood acute lymphoblastic leukemia
    Lisa R Treviño
    St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 41:1001-5. 2009
    ..86, respectively) and were associated with methotrexate accumulation and gene expression pattern in leukemic lymphoblasts. We conclude that germline variants affect susceptibility to, and characteristics of, specific ALL subtypes...
  28. pmc Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1
    S Jeha
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 23:1406-9. 2009
    ..These data suggest that with contemporary treatment, patients with the t(1;19) and TCF3/PBX1 fusion have a favorable overall outcome but increased risk of CNS relapse...
  29. ncbi request reprint Pilot study to evaluate MYCN expression as a neuroblastoma cell marker to detect minimal residual disease by RT-PCR
    Lars M Wagner
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    J Pediatr Hematol Oncol 28:635-41. 2006
    ..The selective expression of MYCN in tumor cells, and the sensitivity of detection of MYCN by RT-PCR noted in this and other studies, supports further evaluation of MYCN as a NB marker for molecular detection of minimal residual disease...
  30. pmc Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia
    Ina Radtke
    Department of Pathology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 106:12944-9. 2009
    ..These data reflect a remarkably low burden of genomic alterations within pediatric de novo AML, which is in stark contrast to most other human malignancies...
  31. ncbi request reprint Impact of treatment on the outcome of acute myeloid leukemia with inversion 16: a single institution's experience
    B I Razzouk
    Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
    Leukemia 15:1326-30. 2001
    ..They also suggest that dose intensification of etoposide and addition of 2-CDA may also offer an advantage. This study underscores the dependence of the prognostic impact of cytogenetic features on the efficacy of treatment...
  32. ncbi request reprint ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases
    Mihaela Onciu
    Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    Blood 102:2642-4. 2003
    ..Both were positive for NPM-ALK by reverse transcriptase-polymerase chain reaction. Thus, ALK-positive plasmablastic B-cell lymphomas are more heterogeneous at the molecular level than previously recognized...
  33. ncbi request reprint A complex variant t(8;21) involving chromosome 3 in a child with acute myeloblastic leukemia with eosinophilia (AML M4Eo)
    Susan Mathew
    Department of Pathology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
    Leuk Lymphoma 44:183-7. 2003
    ..Thus, this report illustrates the first description of a complex variant t(8;21) involving chromosome band 3q27 in a child with AML M4Eo...
  34. ncbi request reprint Specific extra chromosomes occur in a modal number dependent pattern in pediatric acute lymphoblastic leukemia
    Nyla A Heerema
    Department of Pathology, The Ohio State University, Columbus, OH 43210, USA
    Genes Chromosomes Cancer 46:684-93. 2007
    ..These results are consistent with different origins of high hyperdiploidy, near-trisomy, and near-tetrasomy...
  35. ncbi request reprint FISH, CGH, and SKY in the diagnosis of childhood acute lymphoblastic leukemia
    Susan Mathew
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN, USA
    Methods Mol Biol 220:213-33. 2003
  36. ncbi request reprint Conventional cytogenetic techniques in the diagnosis of childhood acute lymphoblastic leukemia
    Susana C Raimondi
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN, USA
    Methods Mol Biol 220:73-82. 2003
  37. ncbi request reprint Childhood acute lymphoblastic leukemia with the MLL-ENL fusion and t(11;19)(q23;p13.3) translocation
    J E Rubnitz
    Department of Hematology Oncology, St Jude Children s Research Hospital, The University of Tennessee College of Medicine, Memphis 38105 2794, USA
    J Clin Oncol 17:191-6. 1999
    ..To determine the molecular characteristics, clinical features, and treatment outcomes of children with acute lymphoblastic leukemia (ALL) and the t(11;19)(q23,p13.3) translocation...
  38. ncbi request reprint Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience
    U H Athale
    Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    Blood 97:3727-32. 2001
    ..Allogeneic transplantation during remission offers the best chance of cure; in the absence of remission, transplantation offers no advantage over chemotherapy alone. (Blood. 2001;97:3727-3732)..
  39. ncbi request reprint Trisomy of the long arm of chromosome 1 resulting in a dicentric derivative (6)t(1;6) chromosome in a child with myelodysplastic syndrome following treatment for a primitive neuroectodermal tumor
    S Mathew
    Department of Pathology and Laboratory Medicine, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Leuk Lymphoma 37:213-8. 2000
    ..This report is the first to describe a case of childhood secondary myelodysplastic syndrome associated with a trisomy 1q involving chromosome 6...
  40. pmc Combination of cladribine and cytarabine is effective for childhood acute myeloid leukemia: results of the St Jude AML97 trial
    J E Rubnitz
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Leukemia 23:1410-6. 2009
    ..For all patients, 5-year event-free survival and overall survival estimates were 44.1+/-5.4 and 50.0+/-5.5%. Our results suggest that cladribine in combination with continuous-infusion cytarabine is effective therapy for childhood AML...
  41. ncbi request reprint Concurrent translocations of MLL and CBFA2 (AML1) genes with new partner breakpoints in a child with secondary myelodysplastic syndrome after treatment of acute lymphoblastic leukemia
    S Mathew
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Chromosomes Cancer 28:227-32. 2000
    ..This report is the first to describe new partner breakpoints at 2p23 and 6p22 for MLL and CBFA2 genes, respectively, and concurrent rearrangements of these genes in a patient with secondary MDS...
  42. pmc Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia
    C H Pui
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 24:371-82. 2010
    ..The next main challenge is to further increase cure rates while improving quality of life for all patients...
  43. ncbi request reprint Reappraisal of the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia
    C H Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 16:3768-73. 1998
    ..To reassess the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia (ALL)...
  44. ncbi request reprint Novel cryptic, complex rearrangements involving ETV6-CBFA2 (TEL-AML1) genes identified by fluorescence in situ hybridization in pediatric patients with acute lymphoblastic leukemia
    S Mathew
    Department of Pathology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794
    Genes Chromosomes Cancer 32:188-93. 2001
    ..Our findings also indicate the importance of analyzing metaphase chromosomes in identifying cryptic and complex rearrangements involving ETV6 and CBFA2...
  45. ncbi request reprint Characteristics and outcome of t(8;21)-positive childhood acute myeloid leukemia: a single institution's experience
    J E Rubnitz
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 16:2072-7. 2002
    ..These results suggest that t(8;21)-positive AML represents a heterogeneous disease with variable outcome. The reported favorable outcome for t(8;21)-positive AML in other studies may be due to the use of high-dose cytarabine...
  46. ncbi request reprint Low-dose oral etoposide-based induction regimen for children with acute lymphoblastic leukemia in first bone marrow relapse
    N Hijiya
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Leukemia 18:1581-6. 2004
    ..0+/-9.6% for those with late relapse and 20.0+/-8.0% for those with early relapse. We conclude that low-dose etoposide administered orally has a cytoreductive effect in relapsed ALL...
  47. ncbi request reprint Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes
    Qing Cheng
    Hematological Malignancies Program, Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, Tennessee 38105, USA
    Nat Genet 37:878-82. 2005
    ..Therefore, chromosomal gain can alter the concordance of germline genotype and cancer cell phenotypes, indicating that allele-specific quantitative genotyping may be required to define cancer pharmacogenomics unequivocally...
  48. doi request reprint A novel EWSR1-CREB3L1 fusion transcript in a case of small cell osteosarcoma
    Larisa V Debelenko
    Department of Pathology, Wayne State University, Detroit, MI, USA
    Genes Chromosomes Cancer 50:1054-62. 2011
    ..The 3'-end partner and the inferred structure of EWSR1-CREB3L1, however, are different from those of Ewing sarcoma, suggesting different targets of the new oncogene...
  49. ncbi request reprint Genetic polymorphisms in CYP3A5, CYP3A4 and NQO1 in children who developed therapy-related myeloid malignancies
    Javier G Blanco
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis TN 38105, USA
    Pharmacogenetics 12:605-11. 2002
    ..403), 6.5% vs. 12.5% in blacks (P = 0.508), and 69.6% vs. 75.0% in Hispanics (P= 0.663). Our data do not support an association between common CYP3A4, NQO1 or CYP3A5 polymorphisms and the risk of t-ML in children treated for ALL...
  50. ncbi request reprint Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with outcome
    N A Heerema
    Department of Pathology, The Ohio State University, Columbus, OH 43210, USA
    Leukemia 18:693-702. 2004
    ....
  51. pmc Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia
    J G Blanco
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 98:10338-43. 2001
    ..These data indicate that the malignant clone was not present before therapy, arose early during chemotherapy, and was able to proliferate even during exposure to antileukemic therapy...
  52. doi request reprint Renal cell carcinoma with novel VCL-ALK fusion: new representative of ALK-associated tumor spectrum
    Larisa V Debelenko
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN, USA
    Mod Pathol 24:430-42. 2011
    ..The results should prompt further studies to advance the molecular classification of renal cell carcinoma and help to select patients who would benefit from appropriate targeted therapies...
  53. ncbi request reprint Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling
    Eng Juh Yeoh
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 1:133-43. 2002
    ..Thus, the single platform of expression profiling should enhance the accurate risk stratification of pediatric ALL patients...
  54. ncbi request reprint Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1)
    S M Bodner
    Department of Pathology and Laboratory Medicine, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Gene 229:223-8. 1999
    ..Further study will be needed to determine whether gene-specific mutations implicate hDMP1 as a tumor suppressor in acute leukemias with deletions of the long arm of chromosome 7 or in other types of human malignancy...
  55. ncbi request reprint Multicolor spectral karyotyping identifies novel translocations in childhood acute lymphoblastic leukemia
    S Mathew
    Department of Pathology, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
    Leukemia 15:468-72. 2001
    ..Our study demonstrates the utility of SKY in identifying novel translocations and in refining the identity of chromosomal abnormalities in leukemias...
  56. ncbi request reprint Experience with 2-chlorodeoxyadenosine in previously untreated children with newly diagnosed acute myeloid leukemia and myelodysplastic diseases
    R A Krance
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 19:2804-11. 2001
    ..To develop more effective chemotherapy regimens for childhood acute myelogenous leukemia (AML)...
  57. ncbi request reprint Genome scan implicates adhesion biological pathways in secondary leukemia
    C Hartford
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 21:2128-36. 2007
    ..Independent clinical epidemiologic and in vitro genome-wide approaches converged to identify novel pathways that may contribute to therapy-induced leukemia...
  58. ncbi request reprint Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia
    T Inaba
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105
    Science 257:531-4. 1992
    ....
  59. ncbi request reprint Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells
    A Manabe
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38101
    Blood 83:758-66. 1994
    ..These results establish direct contact with stroma as a survival requirement of normal B lymphoblasts and show marked heterogeneity in stromal dependency among B-lineage leukemic cells...
  60. ncbi request reprint Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study
    Henrik Hasle
    Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark
    Blood 109:4641-7. 2007
    ..Childhood AML with chromosome 7 aberrations represents a heterogeneous group of disorders with additional cytogenetic aberrations having a major prognostic impact which should be reflected in future risk-group stratification...
  61. ncbi request reprint Two different karyotypes with 1q abnormalities in a patient with Fanconi anemia
    Neide I S S Oliveira
    Laboratório de Citogenética Humana, Departamento de Genetica, Universidade Federal do Parana UFPR, Caixa Postal 19071, CEP 81531 970, Curitiba, Parana, Brazil
    Leuk Res 26:1047-9. 2002
    ..We discuss the cytogenetic clonal fluctuation common in Fanconi anemia, with the Fanconi's anemia (FA) reports available in the literature. Interestingly, we have identified that del(1)(q32) has not been reported before in FA...
  62. ncbi request reprint CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome
    Sureyya Savasan
    Children s Hospital of Michigan, Division of Hematology Oncology, Carman Ann Adams Department of Pediatrics, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Leuk Lymphoma 47:2076-83. 2006
    ..CD36 expression in acute myeloid leukemia cases other than AMKL was not associated with increased in vitro drug sensitivity. CD36 expression in AMKL may be an indicator of megakaryoblast maturation and chemotherapy sensitivity...
  63. ncbi request reprint Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia
    Adolfo A Ferrando
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02142, USA
    Cancer Cell 1:75-87. 2002
    ..Our results illustrate the power of gene expression profiles to elucidate transformation pathways relevant to human leukemia...
  64. pmc Cardiomyopathy in children with Down syndrome treated for acute myeloid leukemia: a report from the Children's Oncology Group Study POG 9421
    MAUREEN M O'BRIEN
    Division of Pediatric Hematology Oncology, Lucile Packard Children s Hospital, Stanford, CA 94304, USA
    J Clin Oncol 26:414-20. 2008
    ..To determine the outcomes, with particular attention to toxicity, of children with Down syndrome (DS) and acute myeloid leukemia (AML) treated on Pediatric Oncology Group (POG) protocol 9421...
  65. doi request reprint Banding and molecular cytogenetic studies detected a CBFB-MYH11 fusion gene that appeared as abnormal chromosomes 1 and 16 in a baby with acute myeloid leukemia FAB M4-Eo
    Maria Luiza Macedo Silva
    National Center for Bone Marrow Transplant, National Cancer Institute, Rio de Janeiro, Brazil
    Cancer Genet Cytogenet 182:56-60. 2008
    ..This rearrangement characterizes a new type of inv(16)(p13.1q22) masked by a chromosome translocation...
  66. pmc Randomized use of cyclosporin A (CsA) to modulate P-glycoprotein in children with AML in remission: Pediatric Oncology Group Study 9421
    David Becton
    University of Arkansas for Medical Sciences, Little Rock, USA
    Blood 107:1315-24. 2006
    ..In this study, intensifying induction with high-dose DAT and the addition of CsA to consolidation chemotherapy did not prolong the durations of remission or improve overall survival for children with AML...
  67. ncbi request reprint Characterization of the MLL partner gene AF15q14 involved in t(11;15)(q23;q14)
    Martin U Kuefer
    Landratsamt Ostallgäu, Abteilung Gesundheitswesen, Marktoberdorf, Germany
    Oncogene 22:1418-24. 2003
    ....
  68. ncbi request reprint 11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop
    Clara D Bloomfield
    Division of Hematology and Oncology and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Genes Chromosomes Cancer 33:362-78. 2002
    ..We conclude that among t-MDS/t-AL patients with balanced aberrations, 11q23 translocations are an independent adverse risk factor. Although BMT is the current therapy of choice, new treatment is required...