Ibrahim Qaddoumi

..New, effective chemotherapeutic agents are needed for intraocular retinoblastoma...

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..We retrospectively assessed the incidence of ototoxicity and its risk factors in children with retinoblastoma who were treated with carboplatin...

..Pediatric gliomas are rare and heterogeneous tumors. The Surveillance, Epidemiology, and End Results (SEER) database allows a large-scale analysis of the clinical characteristics and prognostic features of these tumors...

..Such progress in pilocytic astrocytoma needs to be consolidated and expanded to other histologic varieties of pediatric low-grade gliomas...

..Use of e-mail in telemedicine can be especially useful to improve the quality of care for children with cancer in developing countries...

..Dysembryoplastic neuroepithelial tumors (DNETs) are benign glioneuronal tumors that occur in children. These tumors are characterized by seizures, lack of neurologic deficits, and a seemingly benign course after resection...

..This study evaluated the outcome of retinoblastoma patients, when employing a telemedicine-based twinning program in Jordan...

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..Contrary to the common belief, our study showed that do not resuscitate should be addressed in Muslim patients with high-risk malignancies. We also found that diffuse pontine glioma warrants further study in developing countries...

..Attempted salvage of eyes with advanced disease is justified, particularly in patients with bilateral disease. We were able to salvage almost half of these eyes. We hope our study provides new insights for counseling patients...

..To determine the impact of chemotherapy or external beam radiotherapy (EBRT) on pediatric anophthalmic sockets...

..Neuroprotective strategies are needed to preserve critical functions...

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..To correlate the clinical and histopathological findings of eyes primarily enucleated for advanced intraocular retinoblastoma...

..Early diagnosis of trilateral retinoblastoma may facilitate the use of less intensive therapeutic approaches and result in excellent outcomes in these patients...

..Malignant rhabdoid tumors (MRTs) are aggressive and often fatal; the Surveillance, Epidemiology, and End Results (SEER) database offers an opportunity to study this rare malignancy...

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..The impact of chemotherapy, focal therapies, radiation and co-existing ocular morbidities on histology of eyes with retinoblastoma enucleated following chemoreduction is not well known...

..This experience suggests that twinning may facilitate the implementation of multidisciplinary neuro-oncology programs in low-income countries. Videoconferencing allows interactive exchanges with a significant learning impact...

..To use functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) to investigate visual system development in children being treated for retinoblastoma...

..We present a de- tailed epidemiological analysis of retinoblastoma in Jordan in an attempt to aid national and regional strategies for improved cancer surveillance and control...

..However, these tumors could also be treated effectively by plaque therapy, which has the potential of preserving the globe and maintaining vision...

..Information about pediatric survivors of brain tumors in developing countries is scant...

..An aggressive surgical approach should be considered with caution in this region. Further studies on different pineal tumors subtypes are needed...

..Internet meetings are a valuable mechanism for enabling participation from under-resourced countries in the development of cooperative studies...

..Carboplatin is the most effective drug in retinoblastoma but systemic clearance is variable in young patients. While most regimens use a flat dose, individualized targeting may provide a more adjusted systemic exposure...

..The prognosis for children with M1 medulloblastoma (positive CSF cytology) has not been well-defined...

..Recommendations are provided for staging and treatment of unilateral and bilateral retinoblastoma and counseling of families for whom compliance is an issue...

..Pathologists with experience in pediatric oncology are in short supply in the developing world. Telepathology is increasingly used for consultations but its overall contribution to diagnostic accuracy is unknown...

..This finding has significant implications given its role in oncogen-induced senescence and possible influence on treatment decisions of subtotally resected tumors...

..To compare clinical features and outcomes of adults and children reported to have rhabdomyosarcoma...

..However, long-term monitoring of hearing with measurements of TEOAEs is warranted, given the risks of delayed hearing loss in some children receiving carboplatin chemotherapy...

..We propose that the role of nursing be strengthened in developing countries to improve the level of care provided to patients and their families...

..It is also unclear whether the desmoplastic noninfantile ganglioglioma has characteristics similar to classical ganglioglioma. This rare case highlights the remarkable versatility of glioneuronal tumors in children...

..Pediatric neuro-oncology is a complex multidisciplinary discipline that is underserved in most of DC and provides a model to test the feasibility of such tool for twinning purposes...