Affiliation: St. Jude Children's Research Hospital
- Human gammadelta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolationMario Otto
Department of Hematology Oncology, Mail stop 321, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
J Immunother 28:73-8. 2005..The cytotoxic properties of the cells were preserved. This method yields sufficient purified gammadelta T cells for use in adoptive immunotherapy as well as laboratory investigations and animal studies...
- Histiocyte-rich xanthomatous pseudotumor mimicking relapse on positron emission tomography imaging in an adolescent with primary mediastinal diffuse large B-cell lymphomaMario Otto
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
J Pediatr Hematol Oncol 34:232-5. 2012..This case is an important reminder of the limitations of positron emission tomography/computed tomography imaging in patients with lymphoma and stresses the importance of histologic confirmation of suspected treatment failure or relapse...
- Combination immunotherapy with clinical-scale enriched human gammadelta T cells, hu14.18 antibody, and the immunocytokine Fc-IL7 in disseminated neuroblastomaMario Otto
Department of Hematology-Oncology and Animal Resources Center, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
Clin Cancer Res 11:8486-91. 2005..04). CONCLUSIONS: We have shown a new and promising immunotherapy regimen for neuroblastoma that requires clinical evaluation. Our approach might also serve as a therapeutic model for other malignancies...
- Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiationMario Otto
Division of Stem Cell Transplantation, Department of Hematology Oncology, St Jude Children s Research Hospital, 332N Lauderdale Street, Memphis, Tennessee 38105 2794, USA
Stem Cells 25:537-42. 2007..Use of different or multiple epitopes, targeting of alternate stem cell markers, or use of cell-depletion strategies might prevent this loss...