Geary W Olsen

Summary

Affiliation: St. Paul
Country: USA

Publications

  1. doi request reprint Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives
    Geary W Olsen
    Medical Department, 3M Company, St Paul, MN 55144, USA
    Reprod Toxicol 27:212-30. 2009
  2. pmc The applicability of biomonitoring data for perfluorooctanesulfonate to the environmental public health continuum
    John L Butenhoff
    3M Company, Medical Department, St Paul, Minnesota 55144, USA
    Environ Health Perspect 114:1776-82. 2006
  3. ncbi request reprint Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers
    Geary W Olsen
    Medical Department, 3M Company, Mail Stop 220 6W 08, St Paul, MN 55144, USA
    Int Arch Occup Environ Health 81:231-46. 2007
  4. doi request reprint Cohort mortality study of roofing granule mine and mill workers. Part II. Epidemiologic analysis, 1945-2004
    Geary W Olsen
    Medical Department, 3M Company, Mail Stop 220 6W 08, St Paul, MN 55144 1000, USA
    J Occup Environ Hyg 9:257-68. 2012
  5. doi request reprint Longitudinal assessment of lipid and hepatic clinical parameters in workers involved with the demolition of perfluoroalkyl manufacturing facilities
    Geary W Olsen
    Medical Department, 3M Company, St Paul, MN 55144, USA
    J Occup Environ Med 54:974-83. 2012
  6. doi request reprint Temporal trends of perfluoroalkyl concentrations in American Red Cross adult blood donors, 2000-2010
    Geary W Olsen
    3M Company, Medical Department, St Paul, Minnesota, United States
    Environ Sci Technol 46:6330-8. 2012
  7. ncbi request reprint Human donor liver and serum concentrations of perfluorooctanesulfonate and other perfluorochemicals
    Geary W Olsen
    3M Medical Department, 220 3W 05, St Paul, Minnesota 55144, USA
    Environ Sci Technol 37:888-91. 2003
  8. ncbi request reprint Decline in perfluorooctanesulfonate and other polyfluoroalkyl chemicals in American Red Cross adult blood donors, 2000-2006
    Geary W Olsen
    3M Company, Medical Department, St Paul, Minnesota, American Red Cross, North Central Region, St Paul, Minnesota, USA
    Environ Sci Technol 42:4989-95. 2008
  9. pmc Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers
    Geary W Olsen
    Medical Department, 3M Company, St Paul, Minnesota 55144, USA
    Environ Health Perspect 115:1298-305. 2007
  10. ncbi request reprint Preliminary evidence of a decline in perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations in American Red Cross blood donors
    Geary W Olsen
    3M Company, Medical Department, St Paul, MN 55144, USA
    Chemosphere 68:105-11. 2007

Collaborators

Detail Information

Publications30

  1. doi request reprint Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives
    Geary W Olsen
    Medical Department, 3M Company, St Paul, MN 55144, USA
    Reprod Toxicol 27:212-30. 2009
    ..Important issues are addressed regarding the methods and data analysis that may limit inferences from this particular study...
  2. pmc The applicability of biomonitoring data for perfluorooctanesulfonate to the environmental public health continuum
    John L Butenhoff
    3M Company, Medical Department, St Paul, Minnesota 55144, USA
    Environ Health Perspect 114:1776-82. 2006
    ....
  3. ncbi request reprint Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers
    Geary W Olsen
    Medical Department, 3M Company, Mail Stop 220 6W 08, St Paul, MN 55144, USA
    Int Arch Occup Environ Health 81:231-46. 2007
    ..The purpose of this assessment was to examine this association in male workers who manufactured or used PFOA at three facilities...
  4. doi request reprint Cohort mortality study of roofing granule mine and mill workers. Part II. Epidemiologic analysis, 1945-2004
    Geary W Olsen
    Medical Department, 3M Company, Mail Stop 220 6W 08, St Paul, MN 55144 1000, USA
    J Occup Environ Hyg 9:257-68. 2012
    ..76, 95% CI 1.01-2.86). This exposure-response trend was suggestive but imprecise. The study results are consistent with other cohorts with similar levels of exposure to respirable crystalline silica...
  5. doi request reprint Longitudinal assessment of lipid and hepatic clinical parameters in workers involved with the demolition of perfluoroalkyl manufacturing facilities
    Geary W Olsen
    Medical Department, 3M Company, St Paul, MN 55144, USA
    J Occup Environ Med 54:974-83. 2012
    ..To examine in a longitudinal occupational assessment whether changes in serum concentrations of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) are associated with changes in non-high-density lipoprotein (HDL) cholesterol...
  6. doi request reprint Temporal trends of perfluoroalkyl concentrations in American Red Cross adult blood donors, 2000-2010
    Geary W Olsen
    3M Company, Medical Department, St Paul, Minnesota, United States
    Environ Sci Technol 46:6330-8. 2012
    ..8 years reported in individuals. This similarity supports the conclusion that the dominant PFOS-related exposures to humans in the United States were greatly mitigated during the phase-out period...
  7. ncbi request reprint Human donor liver and serum concentrations of perfluorooctanesulfonate and other perfluorochemicals
    Geary W Olsen
    3M Medical Department, 220 3W 05, St Paul, Minnesota 55144, USA
    Environ Sci Technol 37:888-91. 2003
    ..This information may be useful in human risk characterization for PFOS. Liver to serum ratios were not estimated for PFOA, PFHxS, and PFOSA as 90% of the human donor liver samples were determined to be less than the LOQ...
  8. ncbi request reprint Decline in perfluorooctanesulfonate and other polyfluoroalkyl chemicals in American Red Cross adult blood donors, 2000-2006
    Geary W Olsen
    3M Company, Medical Department, St Paul, Minnesota, American Red Cross, North Central Region, St Paul, Minnesota, USA
    Environ Sci Technol 42:4989-95. 2008
    ..Direct and indirect exposure sources of PFOA could include historic and ongoing electrochemical cell fluorination (ECF) of PFOA, telomer production of PFOA, fluorotelomer-based precursors, and other fluoropoly-mer production...
  9. pmc Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers
    Geary W Olsen
    Medical Department, 3M Company, St Paul, Minnesota 55144, USA
    Environ Health Perspect 115:1298-305. 2007
    ..The presence of perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate (PFHS), and perfluorooctanoate (PFOA) has been reported in humans and wildlife. Pharmacokinetic differences have been observed in laboratory animals...
  10. ncbi request reprint Preliminary evidence of a decline in perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations in American Red Cross blood donors
    Geary W Olsen
    3M Company, Medical Department, St Paul, MN 55144, USA
    Chemosphere 68:105-11. 2007
    ..0001). The decrease was consistent across donors' age and sex. To confirm these preliminary findings, additional sub-sets of year 2000 samples will be analyzed, and a much larger biomonitoring study of other locations is planned...
  11. doi request reprint Analysis of a homologous series of perfluorocarboxylates from American Red Cross adult blood donors, 2000-2001 and 2006
    Geary W Olsen
    Medical Department, 3M Company, St Paul, Minnesota, United States
    Environ Sci Technol 45:8022-9. 2011
    ..3 vs 0.5. Important observations were the decline in PFBA and increase in PFNA, PFDA, and PFUnA concentrations between 2000-2001 and 2006. The longer chain length perfluorocarboxylates were also highly correlated with each other...
  12. ncbi request reprint Epidemiologic assessment of worker serum perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations and medical surveillance examinations
    Geary W Olsen
    Medical Dept, 3M Company, Mail Stop 220 3W 05, St Paul, MN 55144, USA
    J Occup Environ Med 45:260-70. 2003
    ....
  13. ncbi request reprint Serum concentrations of perfluorooctanesulfonate and other fluorochemicals in an elderly population from Seattle, Washington
    Geary W Olsen
    Medical Department, 3M Company, Mail Stop 220 3W 05, St Paul, MN 55144, USA
    Chemosphere 54:1599-611. 2004
    ..Similar to other reported findings of younger adults, the geometric mean serum PFOS concentration in non-occupational adult populations likely approximates 30-40 ppb with 95% of the population's serum PFOS concentrations below 100 ppb...
  14. pmc Historical comparison of perfluorooctanesulfonate, perfluorooctanoate, and other fluorochemicals in human blood
    Geary W Olsen
    Medical Department, 3M Company, Mail Stop 220 6W 08, St Paul, MN 55144, USA
    Environ Health Perspect 113:539-45. 2005
    ..Comparison with other regional data collected in 2001 did not suggest a continued increase in concentrations since 1989...
  15. ncbi request reprint Analysis of episodes of care in a perfluorooctanesulfonyl fluoride production facility
    Geary W Olsen
    3M Medical Company, Medical Department, St Paul, Minnesota 55144, USA
    J Occup Environ Med 46:837-46. 2004
    ..Non-a priori associations among the fluorochemical plant workers included benign colon polyps, malignant colorectal tumors, and malignant melanoma...
  16. pmc Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors
    Geary W Olsen
    Medical Department, 3M Company, St Paul, Minnesota 55144, USA
    Environ Health Perspect 111:1892-901. 2003
    ..Because serum PFOS concentrations correlate with cumulative human exposure, this information can be useful for risk characterization...
  17. ncbi request reprint An occupational exposure assessment of a perfluorooctanesulfonyl fluoride production site: biomonitoring
    Geary W Olsen
    Medical Department, 3M Co, St Paul, MN 55144, USA
    AIHA J (Fairfax, Va) 64:651-9. 2003
    ..098); perfluorooctanesulfonamide 0.013 (0.009-0.018); and perfluorooctanesulfonamidoacetate 0.022 (0.018-0.029). These geometric means were approximately one order of magnitude higher than those observed for the film plant employees...
  18. ncbi request reprint Characterization of risk for general population exposure to perfluorooctanoate
    John L Butenhoff
    Medical Department, 3M Company, Building 220 2E 02, St Paul, MN 55144, USA
    Regul Toxicol Pharmacol 39:363-80. 2004
    ..These MOE values represent substantial protection of children, adults, and the elderly...
  19. doi request reprint A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans
    Geary W Olsen
    Medical Department, 3M Company, St Paul, MN 55144 1000, USA
    Toxicology 256:65-74. 2009
    ..Thus, compared to PFOS and PFHxS, PFBS has a much lower potential for accumulation in human serum after repeated occupational, non-occupational (e.g., consumer), or environmental exposures...
  20. doi request reprint Comparative pharmacokinetics of perfluorobutyrate in rats, mice, monkeys, and humans and relevance to human exposure via drinking water
    Shu Ching Chang
    Medical Department, 3M Company, St Paul, Minnesota 55144, USA
    Toxicol Sci 104:40-53. 2008
    ..These findings demonstrate that PFBA is eliminated efficiently from serum with a low potential for accumulation from repeated exposure...
  21. ncbi request reprint Comparison of human whole blood, plasma, and serum matrices for the determination of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and other fluorochemicals
    David J Ehresman
    Medical Department, 3M Company, Mail Stop 220 6W 08, St Paul, MN 55144 1000, USA
    Environ Res 103:176-84. 2007
    ..The difference between plasma and serum and whole blood corresponded to volume displacement by red blood cells, suggesting that the fluorochemicals are not found intracellularly or attached to the red blood cells...
  22. doi request reprint Distribution of perfluorooctanesulfonate and perfluorooctanoate into human plasma lipoprotein fractions
    John L Butenhoff
    Medical Department, 3M Company, St Paul, MN 55455, USA
    Toxicol Lett 210:360-5. 2012
    ..These data do not support a strong role for plasma lipoprotein fractions in explaining the inconsistent dose-response associations reported in cross-sectional epidemiological studies...
  23. doi request reprint Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague-Dawley rats
    John L Butenhoff
    3M Company, Medical Department, 3M Center 220 06 W 08, Saint Paul, MN 55144, USA
    Toxicology 298:1-13. 2012
    ..All other tumor types were those seen spontaneously in rats of this stock and age and were not associated with feeding of APFO...
  24. doi request reprint Chronic dietary toxicity and carcinogenicity study with potassium perfluorooctanesulfonate in Sprague Dawley rats
    John L Butenhoff
    Medical Department, 3M Company, Saint Paul, MN 55144, USA
    Toxicology 293:1-15. 2012
    ..Recent mechanistic studies suggest a PPARĪ±/CAR/PXR-mediated mode of action for the liver tumors observed in the present two-year study...
  25. ncbi request reprint Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomolgus monkeys
    Andrew M Seacat
    3M Medical Department, Saint Paul, Minnesota 55133, USA
    Toxicol Sci 68:249-64. 2002
    ..8 +/- 10.8 ppm for females. Comparison of serum PFOS concentrations associated with no adverse effect in this study to those reported in human blood samples (0.028 +/- 0.014 ppm) indicated an adequate margin of safety...
  26. ncbi request reprint Worksite influenza immunization programs. Insight into the implementation and cost-benefit
    Geary W Olsen
    3M Company, St Paul, MN, USA
    AAOHN J 53:105-10. 2005
    ..Efficient large worksite influenza immunization programs are feasible and worthy of employer consideration for economic and employee satisfaction reasons...
  27. ncbi request reprint Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of action
    Melvin E Andersen
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 102:3-14. 2008
    ..This report summarizes the discourse that occurred during the symposium...
  28. ncbi request reprint Pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys--probing the determinants of long plasma half-lives
    Melvin E Andersen
    CIIT Centers for Health Research, Research Triangle Park, NC 27709 2137, United States
    Toxicology 227:156-64. 2006
    ..PFOS has longer half-life and had respective values of 13.6 mg/(h kg), 0.023 mg/L, and 0.025. PFOS appeared to have a higher transport capacity and lower affinity than PFOA. Human kinetics indicates even higher resorption efficiency...
  29. ncbi request reprint The toxicology of perfluorooctanoate
    Gerald L Kennedy
    DuPont, Newark, Delaware, USA
    Crit Rev Toxicol 34:351-84. 2004
    ..Epidemiological investigations and medical surveillance of occupationally exposed workers have not found consistent associations between PFOA exposure and adverse health effects...
  30. ncbi request reprint Bladder cancer in perfluorooctanesulfonyl fluoride manufacturing workers
    Bruce H Alexander
    Division of Environmental Health Sciences, School of Public Health, University of Minnesota, USA
    Ann Epidemiol 17:471-8. 2007
    ..To determine whether bladder cancer is associated with exposure to perfluorooctane sulfonate (PFOS) in an occupational cohort...