GUILLERMO C OLIVER

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis
    Alfonso Lavado
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Biol 8:. 2010
  2. pmc Elucidating the molecular characteristics of organogenesis in human embryos
    Xin Geng
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Genome Biol 11:130. 2010
  3. ncbi request reprint Lymphatic vasculature development
    Guillermo Oliver
    Department of Genetics, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, Tennessee 38105, USA
    Nat Rev Immunol 4:35-45. 2004
  4. ncbi request reprint The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature
    Guillermo Oliver
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 16:773-83. 2002
  5. pmc Endothelial cell plasticity: how to become and remain a lymphatic endothelial cell
    Guillermo Oliver
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Development 137:363-72. 2010
  6. ncbi request reprint The lymphatic vasculature: recent progress and paradigms
    Guillermo Oliver
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Cell Dev Biol 21:457-83. 2005
  7. doi request reprint Lymphatic vasculature development: current concepts
    Guillermo Oliver
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital Memphis, TN 38105, USA
    Ann N Y Acad Sci 1131:75-81. 2008
  8. pmc Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature
    R Sathish Srinivasan
    Department of Genetics and Tumor Cell Biology, St Jude Children s Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 21:2422-32. 2007
  9. pmc Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity
    Nicole C Johnson
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 22:3282-91. 2008
  10. pmc An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
    Jeffrey T Wigle
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 21:1505-13. 2002

Research Grants

  1. HOMEOBOX GENE SIX3 IN EYE DEVELOPMENT
    Guillermo Oliver; Fiscal Year: 2001
  2. THE FUNCTIONAL ROLE OF SIX2 IN KIDNEY TUBULOGENESIS
    Guillermo Oliver; Fiscal Year: 2005
  3. Prox1 in Mammalian Lymphangiogenesis
    Guillermo Oliver; Fiscal Year: 2006
  4. THE ROLE OF THE HOMEOBOX SIX3 IN HOLOPROSENCEPHALY/CYCLOPIA
    Guillermo Oliver; Fiscal Year: 2006
  5. THE ROLE OF THE HOMEOBOX SIX3 IN HOLOPROSENCEPHALY/CYCLOPIA
    Guillermo Oliver; Fiscal Year: 2007
  6. Prox1 in Mammalian Lymphangiogenesis
    Guillermo Oliver; Fiscal Year: 2007
  7. Homeobox Gene Six3 in Forebrain and Visual System Development
    Guillermo Oliver; Fiscal Year: 2009
  8. THE ROLE OF THE HOMEOBOX SIX3 IN HOLOPROSENCEPHALY/CYCLOPIA
    Guillermo Oliver; Fiscal Year: 2009
  9. Prox1 in Mammalian Lymphangiogenesis
    Guillermo Oliver; Fiscal Year: 2009
  10. Homeobox Gene Six3 in Forebrain and Visual System Development
    GUILLERMO C OLIVER; Fiscal Year: 2010

Collaborators

Detail Information

Publications28

  1. pmc Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis
    Alfonso Lavado
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Biol 8:. 2010
    ..Finally, we show that the ectopic expression of Prox1 induces premature differentiation of neural stem cells...
  2. pmc Elucidating the molecular characteristics of organogenesis in human embryos
    Xin Geng
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Genome Biol 11:130. 2010
    ..A transcriptomic analysis of early human organogenesis reveals the molecular signature of these processes and provides a valuable resource for identifying and comparing crucial regulators of mammalian embryogenesis...
  3. ncbi request reprint Lymphatic vasculature development
    Guillermo Oliver
    Department of Genetics, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, Tennessee 38105, USA
    Nat Rev Immunol 4:35-45. 2004
    ....
  4. ncbi request reprint The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature
    Guillermo Oliver
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 16:773-83. 2002
  5. pmc Endothelial cell plasticity: how to become and remain a lymphatic endothelial cell
    Guillermo Oliver
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Development 137:363-72. 2010
    ....
  6. ncbi request reprint The lymphatic vasculature: recent progress and paradigms
    Guillermo Oliver
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Cell Dev Biol 21:457-83. 2005
    ..This knowledge, in turn, should lead to the development of better diagnostic methods and treatments of lymphatic disorders and tumor metastasis...
  7. doi request reprint Lymphatic vasculature development: current concepts
    Guillermo Oliver
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital Memphis, TN 38105, USA
    Ann N Y Acad Sci 1131:75-81. 2008
    ..Understanding these basic mechanisms of lymphatic development will improve our ability to diagnose, prevent, and ideally treat lymphatic disorders...
  8. pmc Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature
    R Sathish Srinivasan
    Department of Genetics and Tumor Cell Biology, St Jude Children s Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 21:2422-32. 2007
    ..We conclude that the mammalian lymphatic system has a solely venous origin...
  9. pmc Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity
    Nicole C Johnson
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 22:3282-91. 2008
    ..Therefore, LECs are one of the few differentiated cell types that require constant expression of a certain gene to maintain their phenotypic identity...
  10. pmc An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
    Jeffrey T Wigle
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 21:1505-13. 2002
    ..On the basis of our findings, we propose that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype...
  11. pmc The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells
    R Sathish Srinivasan
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 24:696-707. 2010
    ..In addition, we show that the direct interaction between nuclear hormone receptors and Prox1 is also necessary for the maintenance of Prox1 expression during early stages of LEC specification and differentiation...
  12. ncbi request reprint Prox1 activity controls pancreas morphogenesis and participates in the production of "secondary transition" pancreatic endocrine cells
    Junfeng Wang
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Dev Biol 286:182-94. 2005
    ..Prox1 thus appears to be an essential component of a genetic program destined to produce the cellular complexity of the mammalian pancreas...
  13. ncbi request reprint Prox1 expression patterns in the developing and adult murine brain
    Alfonso Lavado
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Dev Dyn 236:518-24. 2007
    ..In adulthood, Prox1 expression remains only in the hippocampus and cerebellum. These complex patterns of expression suggest that Prox1 activity is differentially required during brain development and adulthood...
  14. ncbi request reprint Choose your fate: artery, vein or lymphatic vessel?
    Natasha L Harvey
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA
    Curr Opin Genet Dev 14:499-505. 2004
    ..Recent discoveries have impacted our understanding of the embryonic origins of arterial, venous and lymphatic endothelial cells and the signals that mediate their navigation into mature, functional circulatory systems...
  15. ncbi request reprint Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm
    Zoe Burke
    Department of Genetics, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Mech Dev 118:147-55. 2002
    ..This finding indicates that Prox1 is one of the earliest specific markers of this commonly fated region of the mammalian endoderm...
  16. ncbi request reprint Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
    Natasha L Harvey
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Nat Genet 37:1072-81. 2005
    ..Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease...
  17. ncbi request reprint Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina
    Michael A Dyer
    Department of Developmental Neurobiology, St Jude Children s Research Hospital Memphis, Tennessee 38105, USA
    Nat Genet 34:53-8. 2003
    ..Thus, Prox1 activity is both necessary and sufficient for progenitor-cell proliferation and cell-fate determination in the vertebrate retina...
  18. pmc Current views on the function of the lymphatic vasculature in health and disease
    Yingdi Wang
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 24:2115-26. 2010
    ..In this review, we summarize the functional roles of the lymphatic vasculature in health and disease...
  19. ncbi request reprint Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors
    Changqi C Zhu
    Department of Genetics, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
    Development 129:2835-49. 2002
    ..These specific alterations were not seen when the mutated form of Six3 cDNA was used in similar experimental approaches, indicating that Six3 interaction with Groucho proteins plays an essential role in vertebrate eye development...
  20. pmc Six2 activity is required for the formation of the mammalian pyloric sphincter
    Michelle Self
    Department of Genetics and Tumor Cell Biology, MS 331, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 2794, USA
    Dev Biol 334:409-17. 2009
    ..5, Sox9, and Gremlin) also appear to be required for the formation of this structure in mammals. Thus, we propose that Six2 activity regulates this gene network during the genesis of the pyloric sphincter in the mouse...
  21. pmc Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development
    Xin Geng
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN, USA
    Gene Expr Patterns 7:252-7. 2007
    ..Our results show that Six3OS expression overlaps extensively with that of Six3 and is not altered in Six3-null embryos...
  22. pmc Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly
    Xin Geng
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Dev Cell 15:236-47. 2008
    ..These results identify Six3 as a direct regulator of Shh expression and reveal a crossregulatory loop between Shh and Six3 in the ventral forebrain...
  23. ncbi request reprint Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon
    Alfonso Lavado
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Development 135:441-50. 2008
    ..These results provide insight into the mechanisms that establish anteroposterior identity in the developing mammalian brain...
  24. pmc Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney
    Michelle Self
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    EMBO J 25:5214-28. 2006
    ..We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud...
  25. pmc Six3 activation of Pax6 expression is essential for mammalian lens induction and specification
    Wei Liu
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 25:5383-95. 2006
    ..We conclude that Six3 directly activates Pax6 and probably also Sox2 in the PLE and regulates cell autonomously the earliest stages of mammalian lens induction...
  26. pmc Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
    Yongsu Jeong
    Department of Genetics, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 40:1348-53. 2008
    ..Moreover, Six3 with HPE-causing alterations failed to bind and activate SBE2. These data suggest a direct link between Six3 and Shh regulation during normal forebrain development and in the pathogenesis of HPE...
  27. pmc Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development
    Oleg V Lagutin
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Genes Dev 17:368-79. 2003
    ..Furthermore, these results support the hypothesis that a Wnt signal gradient specifies posterior fates in the anterior neural plate...
  28. pmc Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate
    Wei Liu
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Invest 120:3568-77. 2010
    ....

Research Grants31

  1. HOMEOBOX GENE SIX3 IN EYE DEVELOPMENT
    Guillermo Oliver; Fiscal Year: 2001
    ..Thus, they will enhance our understanding of eye-related birth defects. ..
  2. THE FUNCTIONAL ROLE OF SIX2 IN KIDNEY TUBULOGENESIS
    Guillermo Oliver; Fiscal Year: 2005
    ....
  3. Prox1 in Mammalian Lymphangiogenesis
    Guillermo Oliver; Fiscal Year: 2006
    ..abstract_text> ..
  4. THE ROLE OF THE HOMEOBOX SIX3 IN HOLOPROSENCEPHALY/CYCLOPIA
    Guillermo Oliver; Fiscal Year: 2006
    ....
  5. THE ROLE OF THE HOMEOBOX SIX3 IN HOLOPROSENCEPHALY/CYCLOPIA
    Guillermo Oliver; Fiscal Year: 2007
    ....
  6. Prox1 in Mammalian Lymphangiogenesis
    Guillermo Oliver; Fiscal Year: 2007
    ....
  7. Homeobox Gene Six3 in Forebrain and Visual System Development
    Guillermo Oliver; Fiscal Year: 2009
    ..To this end, we propose to continue using Six3 as an entry point to better characterize its functional role in the development of different brain structures and retina differentiation and lamination. ..
  8. THE ROLE OF THE HOMEOBOX SIX3 IN HOLOPROSENCEPHALY/CYCLOPIA
    Guillermo Oliver; Fiscal Year: 2009
    ..abstract_text> ..
  9. Prox1 in Mammalian Lymphangiogenesis
    Guillermo Oliver; Fiscal Year: 2009
    ....
  10. Homeobox Gene Six3 in Forebrain and Visual System Development
    GUILLERMO C OLIVER; Fiscal Year: 2010
    ..To this end, we propose to continue using Six3 as an entry point to better characterize its functional role in the development of different brain structures and retina differentiation and lamination. ..
  11. Prox1 in Mammalian Lymphangiogenesis
    GUILLERMO C OLIVER; Fiscal Year: 2010
    ....
  12. HOMEOBOX GENE SIX3 IN EYE DEVELOPMENT
    Guillermo Oliver; Fiscal Year: 2005
    ..abstract_text> ..
  13. Prox1 in Mammalian Lymphangiogenesis
    Guillermo Oliver; Fiscal Year: 2005
    ..abstract_text> ..
  14. HOMEOBOX GENE SIX3 IN EYE DEVELOPMENT
    Guillermo Oliver; Fiscal Year: 2004
    ..abstract_text> ..
  15. PROX 1 DURING MURINE CELLULAR DIFFERENTIATION
    Guillermo Oliver; Fiscal Year: 1999
    ..These experiments will further define the mechanisms and pathways involved in vertebrate cell differentiation, and should help to understand the role of Prox1 during this process. ..
  16. HOMEOBOX GENE SIX3 IN EYE DEVELOPMENT
    Guillermo Oliver; Fiscal Year: 1999
    ..Thus, they will enhance our understanding of eye-related birth defects. ..
  17. PROX 1 DURING MURINE CELLULAR DIFFERENTIATION
    Guillermo Oliver; Fiscal Year: 2000
    ..These experiments will further define the mechanisms and pathways involved in vertebrate cell differentiation, and should help to understand the role of Prox1 during this process. ..
  18. HOMEOBOX GENE SIX3 IN EYE DEVELOPMENT
    Guillermo Oliver; Fiscal Year: 2000
    ..Thus, they will enhance our understanding of eye-related birth defects. ..
  19. PROX 1 DURING MURINE CELLULAR DIFFERENTIATION
    Guillermo Oliver; Fiscal Year: 2001
    ..These experiments will further define the mechanisms and pathways involved in vertebrate cell differentiation, and should help to understand the role of Prox1 during this process. ..
  20. PROX 1 DURING MURINE CELLULAR DIFFERENTIATION
    Guillermo Oliver; Fiscal Year: 2002
    ..These experiments will further define the mechanisms and pathways involved in vertebrate cell differentiation, and should help to understand the role of Prox1 during this process. ..
  21. PROX 1 DURING MURINE CELLULAR DIFFERENTIATION
    Guillermo Oliver; Fiscal Year: 2001
    ..These experiments will further define the mechanisms and pathways involved in vertebrate cell differentiation, and should help to understand the role of Prox1 during this process. ..
  22. HOMEOBOX GENE SIX3 IN EYE DEVELOPMENT
    Guillermo Oliver; Fiscal Year: 2002
    ..abstract_text> ..
  23. Prox1 in Mammalian Lymphangiogenesis
    Guillermo Oliver; Fiscal Year: 2003
    ..abstract_text> ..
  24. HOMEOBOX GENE SIX3 IN EYE DEVELOPMENT
    Guillermo Oliver; Fiscal Year: 2003
    ..abstract_text> ..
  25. PROX 1 DURING MURINE CELLULAR DIFFERENTIATION
    Guillermo Oliver; Fiscal Year: 2003
    ..These experiments will further define the mechanisms and pathways involved in vertebrate cell differentiation, and should help to understand the role of Prox1 during this process. ..
  26. Prox1 in Mammalian Lymphangiogenesis
    Guillermo Oliver; Fiscal Year: 2004
    ..abstract_text> ..
  27. Homeobox Gene Six3 in Forebrain and Visual System Development
    GUILLERMO C OLIVER; Fiscal Year: 2011
    ..To this end, we propose to continue using Six3 as an entry point to better characterize its functional role in the development of different brain structures and retina differentiation and lamination. ..