PAUL NEY

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi Role of AP1/NFE2 binding sites in endogenous alpha-globin gene transcription
    Melanie R Loyd
    Department of Biochemistry, Rm 4064, Thomas Tower, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Blood 102:4223-8. 2003
  2. ncbi Gene expression during terminal erythroid differentiation
    Paul A Ney
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Curr Opin Hematol 13:203-8. 2006
  3. pmc Normal and disordered reticulocyte maturation
    Paul A Ney
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Curr Opin Hematol 18:152-7. 2011
  4. ncbi NIX induces mitochondrial autophagy in reticulocytes
    Ji Zhang
    Department of Biochemistry, St Jude Children s Hospital, Memphis, Tennessee USA
    Autophagy 4:354-6. 2008
  5. pmc NIX is required for programmed mitochondrial clearance during reticulocyte maturation
    Rachel L Schweers
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 104:19500-5. 2007
  6. pmc Autophagy-dependent and -independent mechanisms of mitochondrial clearance during reticulocyte maturation
    Ji Zhang
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Autophagy 5:1064-5. 2009
  7. ncbi Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    Blood 105:2571-6. 2005
  8. pmc Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation
    Ji Zhang
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 114:157-64. 2009
  9. pmc Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia
    Ji Zhang
    Department of Biochemistry, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105 2794, USA
    Blood 107:73-8. 2006
  10. ncbi Reticulocyte mitophagy: monitoring mitochondrial clearance in a mammalian model
    Ji Zhang
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN, USA
    Autophagy 6:405-8. 2010

Research Grants

  1. Role of NIX in Erythroid Maturation
    PAUL NEY; Fiscal Year: 2007
  2. Mechanisms of erythroid differentiation
    PAUL NEY; Fiscal Year: 2009
  3. Mechanisms of erythroid differentiation
    PAUL NEY; Fiscal Year: 2007
  4. ROLE OF FV2 IN ERYTHROPOIESIS
    PAUL NEY; Fiscal Year: 2004
  5. NF-E2 BINDING SITES AND GLOBIN GENE REGULATION
    PAUL NEY; Fiscal Year: 2002

Collaborators

Detail Information

Publications14

  1. ncbi Role of AP1/NFE2 binding sites in endogenous alpha-globin gene transcription
    Melanie R Loyd
    Department of Biochemistry, Rm 4064, Thomas Tower, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Blood 102:4223-8. 2003
    ..Thus, we have demonstrated that AP1/NFE2 binding sites in the murine alpha-globin PRE contribute to long-range alpha-globin gene activation. The proteins that mediate this effect remain to be determined...
  2. ncbi Gene expression during terminal erythroid differentiation
    Paul A Ney
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Curr Opin Hematol 13:203-8. 2006
    ..Expression profiling is a powerful technique to sample cell state. This review shows how expression profiling is being applied to the study of erythroid differentiation...
  3. pmc Normal and disordered reticulocyte maturation
    Paul A Ney
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Curr Opin Hematol 18:152-7. 2011
    ..This review covers recent advances in our understanding of these processes in reticulocytes and the role of these processes in erythroid development...
  4. ncbi NIX induces mitochondrial autophagy in reticulocytes
    Ji Zhang
    Department of Biochemistry, St Jude Children s Hospital, Memphis, Tennessee USA
    Autophagy 4:354-6. 2008
    ..Rather, NIX is required for the selective incorporation of mitochondria into autophagosomes. Elucidation of the mechanism of this effect will improve our understanding of the role of autophagy in the maintenance of cellular homeostasis...
  5. pmc NIX is required for programmed mitochondrial clearance during reticulocyte maturation
    Rachel L Schweers
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 104:19500-5. 2007
    ..These results yield insight into the mechanism of mitochondrial clearance in higher eukaryotes. Furthermore, they show a BAX- and BAK-independent role for a BCL2-related protein in development...
  6. pmc Autophagy-dependent and -independent mechanisms of mitochondrial clearance during reticulocyte maturation
    Ji Zhang
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Autophagy 5:1064-5. 2009
    ..We propose that there are two mechanisms of mitochondrial clearance: one that is triggered by mitochondrial depolarization, and a second NIX-dependent mechanism, which is not. The NIX-dependent mechanism remains to be elucidated...
  7. ncbi Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels
    Sheng Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    Blood 105:2571-6. 2005
    ..Taken together, our results demonstrate that ABCG2 plays a role in regulating PPIX levels during erythroid differentiation and suggest a potential role for ABCG2 as a genetic determinant in erythropoietic protoporphyria...
  8. pmc Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation
    Ji Zhang
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 114:157-64. 2009
    ..This suggests that mitochondrial depolarization is a consequence rather than a cause of autophagosome formation in reticulocytes...
  9. pmc Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia
    Ji Zhang
    Department of Biochemistry, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105 2794, USA
    Blood 107:73-8. 2006
    ..These results suggest that Friend virus activates both sf-STK and the EPOR to cause deregulated erythroid proliferation and differentiation...
  10. ncbi Reticulocyte mitophagy: monitoring mitochondrial clearance in a mammalian model
    Ji Zhang
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN, USA
    Autophagy 6:405-8. 2010
    ..This process depends on the mitochondrial protein NIX, is partially dependent on autophagy, and is independent of mitochondrial depolarization. Here we describe the use of reticulocytes to study mitochondrial clearance...
  11. doi Mitophagy in mammalian cells: the reticulocyte model
    Ji Zhang
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Methods Enzymol 452:227-45. 2009
    ..Here we describe several methods for monitoring mitochondrial clearance and autophagy in reticulocytes, and show that in reticulocytes these processes require genes involved in both nonselective and selective autophagy...
  12. pmc Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation
    Mondira Kundu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Blood 112:1493-502. 2008
    ..Together, these data suggest that the ATG1 homologue, Ulk1, is a component of the selective autophagy machinery that leads to the elimination of organelles in erythroid cells rather that an essential mechanistic component of autophagy...
  13. ncbi Short-form Ron receptor is required for normal IFN-gamma production in concanavalin A-induced acute liver injury
    Cynthia C Wetzel
    Department of Pediatrics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Am J Physiol Gastrointest Liver Physiol 292:G253-61. 2007
    ..Taken together, these results suggest for the first time that SF-Ron impacts the progression of inflammatory immune responses in vivo and further support a role for the Ron receptor and its various forms in liver pathophysiology...
  14. pmc GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein
    Clemens R Scherzer
    Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:10907-12. 2008
    ..This critical link between GATA factors and SNCA may enable therapies designed to lower alpha-synuclein production...

Research Grants14

  1. Role of NIX in Erythroid Maturation
    PAUL NEY; Fiscal Year: 2007
    ..We propose to explore that possibility in experiments with Nix mice and other BCL2-related mouse strains. ..
  2. Mechanisms of erythroid differentiation
    PAUL NEY; Fiscal Year: 2009
    ..Irs2 activates some of the same signaling pathways as the distal Epor. So, we will determine whether Irs2 is functionally redundant with the distal Epor in normal erythroid cells. ..
  3. Mechanisms of erythroid differentiation
    PAUL NEY; Fiscal Year: 2007
    ..Irs2 activates some of the same signaling pathways as the distal Epor. So, we will determine whether Irs2 is functionally redundant with the distal Epor in normal erythroid cells. ..
  4. ROLE OF FV2 IN ERYTHROPOIESIS
    PAUL NEY; Fiscal Year: 2004
    ..These studies should improve our understanding of normal hematopoiesis and leukemic transformation. ..
  5. NF-E2 BINDING SITES AND GLOBIN GENE REGULATION
    PAUL NEY; Fiscal Year: 2002
    ..To identify molecules that interact with these motifs, we propose yeast one/two-hybrid screens. Results from these experiments should yield important insights into the regulation of globin gene expression. ..