R K Mulhern

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint Neurocognitive sequelae of childhood cancers and their treatment
    Raymond K Mulhern
    Division of Behavioral Medicine, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Pediatr Rehabil 7:1-14; discussion 15-6. 2004
  2. ncbi request reprint Risks of young age for selected neurocognitive deficits in medulloblastoma are associated with white matter loss
    R K Mulhern
    Division of Behavioral Medicine and Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 19:472-9. 2001
  3. ncbi request reprint Short-term efficacy of methylphenidate: a randomized, double-blind, placebo-controlled trial among survivors of childhood cancer
    Raymond K Mulhern
    Division of Behavioral Medicine, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 22:4795-803. 2004
  4. ncbi request reprint Late neurocognitive sequelae in survivors of brain tumours in childhood
    Raymond K Mulhern
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Lancet Oncol 5:399-408. 2004
  5. ncbi request reprint Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood
    Raymond K Mulhern
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Int Neuropsychol Soc 10:180-9. 2004
  6. ncbi request reprint Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced-dose craniospinal irradiation: a Pediatric Oncology Group study
    R K Mulhern
    St Jude Children s Research Hospital, Department of Pediatrics, University Tennessee College of Medicine, Memphis, USA
    J Clin Oncol 16:1723-8. 1998
  7. ncbi request reprint Subtle white matter volume differences in children treated for medulloblastoma with conventional or reduced dose craniospinal irradiation
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN, USA
    Magn Reson Imaging 18:787-93. 2000
  8. ncbi request reprint Survival and neurodevelopmental outcome of young children with medulloblastoma at St Jude Children's Research Hospital
    A W Walter
    Departments of Hematology Oncology, Behavioral Medicine, Radiation Oncology, and Biostatistics, St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 17:3720-8. 1999
  9. ncbi request reprint Immediate neurocognitive effects of methylphenidate on learning-impaired survivors of childhood cancer
    S J Thompson
    Division of Neurology, Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Oncol 19:1802-8. 2001
  10. ncbi request reprint Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis
    S L Palmer
    Division of Behavioral Medicine, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
    J Clin Oncol 19:2302-8. 2001

Detail Information

Publications46

  1. ncbi request reprint Neurocognitive sequelae of childhood cancers and their treatment
    Raymond K Mulhern
    Division of Behavioral Medicine, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Pediatr Rehabil 7:1-14; discussion 15-6. 2004
  2. ncbi request reprint Risks of young age for selected neurocognitive deficits in medulloblastoma are associated with white matter loss
    R K Mulhern
    Division of Behavioral Medicine and Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 19:472-9. 2001
    ....
  3. ncbi request reprint Short-term efficacy of methylphenidate: a randomized, double-blind, placebo-controlled trial among survivors of childhood cancer
    Raymond K Mulhern
    Division of Behavioral Medicine, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 22:4795-803. 2004
    ..The present study tests the hypothesis that the psychostimulant methylphenidate (MPH) improves cognitive and social functioning among these patients...
  4. ncbi request reprint Late neurocognitive sequelae in survivors of brain tumours in childhood
    Raymond K Mulhern
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Lancet Oncol 5:399-408. 2004
    ..Further efforts to limit neurocognitive sequelae have included design of clinical trials to test the effectiveness of cognitive, behavioural, and pharmacological interventions...
  5. ncbi request reprint Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood
    Raymond K Mulhern
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Int Neuropsychol Soc 10:180-9. 2004
    ..No gender effects were observed. The results of the present study further support the contention that NAWM is an important substrate for treatment-induced neurocognitive problems among survivors of malignant brain tumors of childhood...
  6. ncbi request reprint Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced-dose craniospinal irradiation: a Pediatric Oncology Group study
    R K Mulhern
    St Jude Children s Research Hospital, Department of Pediatrics, University Tennessee College of Medicine, Memphis, USA
    J Clin Oncol 16:1723-8. 1998
    ..4 gy...
  7. ncbi request reprint Subtle white matter volume differences in children treated for medulloblastoma with conventional or reduced dose craniospinal irradiation
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN, USA
    Magn Reson Imaging 18:787-93. 2000
    ..Serial quantitative MR measures of NAWMV may provide a neuroanatomical substrate for assessing functional impact of CSI on normal brain function following treatment for medulloblastoma...
  8. ncbi request reprint Survival and neurodevelopmental outcome of young children with medulloblastoma at St Jude Children's Research Hospital
    A W Walter
    Departments of Hematology Oncology, Behavioral Medicine, Radiation Oncology, and Biostatistics, St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 17:3720-8. 1999
    ..This study sought to assess the relationship, if any, between patient outcome and M stage. Neuropsychologic and endocrine outcomes were also assessed...
  9. ncbi request reprint Immediate neurocognitive effects of methylphenidate on learning-impaired survivors of childhood cancer
    S J Thompson
    Division of Neurology, Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Oncol 19:1802-8. 2001
    ..No significant side effects from MPH were observed. CONCLUSION: MPH resulted in a statistically significant improvement on measures of attention abilities that cannot be explained by placebo or practice effects...
  10. ncbi request reprint Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis
    S L Palmer
    Division of Behavioral Medicine, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
    J Clin Oncol 19:2302-8. 2001
    ....
  11. ncbi request reprint Effect of ionizing radiation on the human brain: white matter and gray matter T1 in pediatric brain tumor patients treated with conformal radiation therapy
    R G Steen
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Int J Radiat Oncol Biol Phys 49:79-91. 2001
    ....
  12. ncbi request reprint CNS germinoma: disease control and long-term functional outcome for 12 children treated with craniospinal irradiation
    T E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 46:1171-6. 2000
    ..To provide evidence that radiation therapy alone in the form of craniospinal irradiation (CSI) and a boost to the primary site of disease provides effective disease control and limited additional morbidity for patients with CNS germinoma...
  13. ncbi request reprint A hybrid neural network analysis of subtle brain volume differences in children surviving brain tumors
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, University of Memphis, TN 38105, USA
    Magn Reson Imaging 16:413-21. 1998
    ..This hybrid neural network analysis of subtle brain volume differences with magnetic resonance may constitute a direct measure of treatment-induced brain damage...
  14. ncbi request reprint Cognitive and academic functioning in survivors of pediatric bone marrow transplantation
    S Phipps
    Division of Behavioral Medicine, Department of Biostatistics, St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 18:1004-11. 2000
    ..To evaluate cognitive and academic functioning in survivors of pediatric bone marrow transplants (BMTs) at 1 and 3 years after a BMT...
  15. ncbi request reprint Subtle neuropsychological deficits in children with sickle cell disease
    A L Wasserman
    Department of Psychiatry and Psychology, St Jude Children s Research Hospital, Memphis, Tennessee
    Am J Pediatr Hematol Oncol 13:14-20. 1991
    ..The possibility that subtle neuropsychological deficits in younger patients with SCD reflect either subclinical strokes or a predisposition for strokes merits further investigation in a large multi-institution study...
  16. ncbi request reprint Radiation dosimetry predicts IQ after conformal radiation therapy in pediatric patients with localized ependymoma
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 63:1546-54. 2005
    ..To assess the effects of radiation dose-volume distribution on the trajectory of IQ development after conformal radiation therapy (CRT) in pediatric patients with ependymoma...
  17. ncbi request reprint Early patterns of verbal memory impairment in children treated for medulloblastoma
    Bonnie J Nagel
    Department of Psychiatry, University of California, San Diego, CA 92161, USA
    Neuropsychology 20:105-12. 2006
    ..Implications of these findings for understanding neurobehavioral sequelae within pediatric medulloblastoma populations and for designing educational and remediation strategies to be used with these children are discussed...
  18. ncbi request reprint Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma
    Raymond K Mulhern
    Division of Behavioral Medicine, Department of Biostatistics, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 23:5511-9. 2005
    ....
  19. ncbi request reprint Cognitive deficits in children with sickle cell disease
    R Grant Steen
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN, USA
    J Child Neurol 20:102-7. 2005
    ..9 points lower than that of controls and decreased as a function of age (probability = .014). The findings suggest that there is diffuse brain injury in patients and that patient deficits increase with age...
  20. pmc Smaller white-matter volumes are associated with larger deficits in attention and learning among long-term survivors of acute lymphoblastic leukemia
    Wilburn E Reddick
    Division of Translational Imaging Research, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer 106:941-9. 2006
    ..The primary objective of this study was to test the hypothesis that survivors of childhood acute lymphoblastic leukemia (ALL) have deficits in neurocognitive performance, and smaller white-matter volumes are associated with these deficits...
  21. ncbi request reprint Factor analysis and validity of the Conners Parent and Teacher Rating Scales in childhood cancer survivors
    Susan C Helton
    Division of Behavioral Medicine, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105 2794, USA
    J Pediatr Psychol 31:200-8. 2006
    ....
  22. pmc A multicenter, randomized clinical trial of a cognitive remediation program for childhood survivors of a pediatric malignancy
    Robert W Butler
    Department of Pediatric Hematology Oncology, Oregon Health and Science University, Portland, OR 97239, USA
    J Consult Clin Psychol 76:367-78. 2008
    ..Long-term clinical significance remains unproven. Further work is needed to improve effect sizes and treatment compliance and to address the needs of other populations with pediatric brain injury...
  23. ncbi request reprint Neural correlates of a clinical continuous performance test
    Robert J Ogg
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Magn Reson Imaging 26:504-12. 2008
    ....
  24. ncbi request reprint Brief report: sluggish cognitive tempo among pediatric survivors of acute lymphoblastic leukemia
    Cara B Reeves
    Division of Clinical Services, Medical University of South Carolina, Charleston, SC 29425 0962, USA
    J Pediatr Psychol 32:1050-4. 2007
    ....
  25. ncbi request reprint Introduction to the special issue: a tribute to the life of Raymond K. Mulhern
    Larry Kun
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr Psychol 32:1025-8. 2007
  26. ncbi request reprint Acute neurocognitive response to methylphenidate among survivors of childhood cancer: a randomized, double-blind, cross-over trial
    Heather M Conklin
    St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Pediatr Psychol 32:1127-39. 2007
    ..To investigate the acute efficacy and adverse side effects of methylphenidate (MPH) among survivors of childhood cancer [acute lymphoblastic leukemia (ALL) or brain tumor (BT)] with learning impairments...
  27. ncbi request reprint Changes in attentional performance of children and young adults with localized primary brain tumors after conformal radiation therapy
    Erin N Kiehna
    Division of Radiation Oncology, Department of Biostatistics, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 24:5283-90. 2006
    ..To prospectively assess the impact of conformal radiation therapy (CRT) and demographic and clinical variables on four measures of attention in pediatric and young adult patients with localized primary brain tumors...
  28. ncbi request reprint Phase II trial of conformal radiation therapy for pediatric patients with craniopharyngioma and correlation of surgical factors and radiation dosimetry with change in cognitive function
    Thomas E Merchant
    Division of Radiation Oncology, Department of Biostatistics, St Jude Children s Research Hospital, and Semmes Murphey Neurologic and Spine Institute, Memphis, Tennessee 38105 2794, USA
    J Neurosurg 104:94-102. 2006
    ..A Phase II trial of conformal radiation therapy (CRT) for craniopharyngioma was conducted to determine whether the irradiated volume could be safely reduced to decrease effects on cognitive function...
  29. ncbi request reprint Modeling radiation dosimetry to predict cognitive outcomes in pediatric patients with CNS embryonal tumors including medulloblastoma
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 65:210-21. 2006
    ..Model the effects of radiation dosimetry on IQ among pediatric patients with central nervous system (CNS) tumors...
  30. ncbi request reprint Attention and memory functioning among pediatric patients with medulloblastoma
    Cara B Reeves
    Division of Behavioral Medicine, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105 2794, USA
    J Pediatr Psychol 31:272-80. 2006
    ..To test the hypotheses that memory and attention deficits are prevalent in survivors of childhood medulloblastoma (MB) and that these deficits are associated with problems with academic achievement...
  31. pmc Atypical white matter volume development in children following craniospinal irradiation
    Wilburn E Reddick
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Neuro Oncol 7:12-9. 2005
    ..Therefore, volumetric monitoring of brain development can be used to guide the care of survivors, assess the toxicity of previous and current clinical trials, and aid in the design of therapies that minimize toxicity...
  32. ncbi request reprint Craniopharyngioma: the St. Jude Children's Research Hospital experience 1984-2001
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Int J Radiat Oncol Biol Phys 53:533-42. 2002
    ..To review our institution's experience in the treatment of craniopharyngioma and assess the merits of initial therapy with limited surgery and irradiation...
  33. ncbi request reprint Acute effects of irradiation on cognition: changes in attention on a computerized continuous performance test during radiotherapy in pediatric patients with localized primary brain tumors
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 53:1271-8. 2002
    ..To assess sustained attention, impulsivity, and reaction time during radiotherapy (RT) for pediatric patients with localized primary brain tumors...
  34. ncbi request reprint Decline in corpus callosum volume among pediatric patients with medulloblastoma: longitudinal MR imaging study
    Shawna L Palmer
    Division of Behavioral Medicine, St Jude Children s Research Hospital, TN 38105 2794, USA
    AJNR Am J Neuroradiol 23:1088-94. 2002
    ....
  35. ncbi request reprint Cognitive impairment in children with hemoglobin SS sickle cell disease: relationship to MR imaging findings and hematocrit
    R Grant Steen
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    AJNR Am J Neuroradiol 24:382-9. 2003
    ..We test a hypothesis that cognitive impairment in children with hemoglobin SS sickle cell disease is associated with low hematocrit and MR imaging abnormalities...
  36. ncbi request reprint Developmental model relating white matter volume to neurocognitive deficits in pediatric brain tumor survivors
    Wilburn E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 97:2512-9. 2003
    ....
  37. ncbi request reprint Neurocognitive late effects in pediatric cancer
    Raymond K Mulhern
    St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Curr Probl Cancer 27:177-97. 2003
  38. ncbi request reprint Atonic seizures in survivors of childhood cancer
    Raja B Khan
    Division of Neurology and Neuro Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Child Neurol 18:397-400. 2003
    ..Recognition and appropriate treatment of atonic seizures in cancer survivors could improve seizure control, neurologic development, and quality of life...
  39. ncbi request reprint Predicting intellectual outcome among children treated with 35-40 Gy craniospinal irradiation for medulloblastoma
    Shawna L Palmer
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Neuropsychology 17:548-55. 2003
    ..A steeper decline was found for those with higher baseline performance. Clinicians may use the proposed predictive model to identify those patients who are at risk of significant intellectual decline...
  40. ncbi request reprint Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma
    Thomas E Merchant
    Department of Biostatistics, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    J Clin Oncol 22:3156-62. 2004
    ....
  41. ncbi request reprint Abnormal hippocampal development in children with medulloblastoma treated with risk-adapted irradiation
    Bonnie J Nagel
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN, USA
    AJNR Am J Neuroradiol 25:1575-82. 2004
    ..Therefore, we hypothesized that longitudinal hippocampal volume measurements are abnormal in patients with medulloblastoma and thereby provide a possible substrate for explaining memory dysfunction...
  42. ncbi request reprint White matter lesions detected by magnetic resonance imaging after radiotherapy and high-dose chemotherapy in children with medulloblastoma or primitive neuroectodermal tumor
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 22:4551-60. 2004
    ....
  43. ncbi request reprint BOLD responses to visual stimulation in survivors of childhood cancer
    Ping Zou
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Neuroimage 24:61-9. 2005
    ..However, fMRI studies in this population must take into account effects of quantitative differences in their BOLD responses as compared to healthy subjects...
  44. ncbi request reprint Neurocognitive interventions for children and adolescents surviving cancer
    Robert W Butler
    Oregon Health Science University, Portland, Oregon, 97239, USA
    J Pediatr Psychol 30:65-78. 2005
    ..As cure rates have improved over the past three decades, increasing efforts have been directed toward reducing treatment-related late effects...
  45. ncbi request reprint Using problem-solving skills training to reduce negative affectivity in mothers of children with newly diagnosed cancer: report of a multisite randomized trial
    Olle Jane Z Sahler
    Golisano Children s Hospital at Strong, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Consult Clin Psychol 73:272-83. 2005
    ..In general, efficacy for Spanish-speaking mothers exceeded that for English-speaking mothers. Findings also suggest young, single mothers profit most from PSST...
  46. ncbi request reprint Problem-solving skills training for mothers of children with newly diagnosed cancer: a randomized trial
    Olle Jane Z Sahler
    Division of Hematology Oncology, Strong Children s Hospital University of Rochester Medical Center, New York 14642, USA
    J Dev Behav Pediatr 23:77-86. 2002
    ..The implications of these findings for refinement of the PSST intervention and for extension to other groups of children with serious illnesses are discussed...