T E Merchant

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. doi request reprint Children's Oncology Group's 2013 blueprint for research: radiation oncology
    Thomas E Merchant
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pediatr Blood Cancer 60:1037-43. 2013
  2. pmc Evaluation of children with craniopharyngioma using carbon-11 methionine PET prior to proton therapy
    Benjamin S Laser
    Department of Radiation Oncology, University of Maryland, Baltimore, Maryland, USA
    Neuro Oncol 15:506-10. 2013
  3. pmc Clinical controversies: proton therapy for pediatric tumors
    Thomas E Merchant
    Division of Radiation Oncology, Department of Radiologic Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Semin Radiat Oncol 23:97-108. 2013
  4. pmc Disease control after reduced volume conformal and intensity modulated radiation therapy for childhood craniopharyngioma
    Thomas E Merchant
    St Jude Children s Research Hospital, Radiological Sciences, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 85:e187-92. 2013
  5. pmc Valgus and varus deformity after wide-local excision, brachytherapy and external beam irradiation in two children with lower extremity synovial cell sarcoma: case report
    Daniel T Fletcher
    Division of Radiation Oncology, Department of Radiological Sciences, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, Tennessee, USA
    BMC Cancer 4:57. 2004
  6. ncbi request reprint Early neuro-otologic effects of three-dimensional irradiation in children with primary brain tumors
    Thomas E Merchant
    Department ofRadiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 58:1194-207. 2004
  7. doi request reprint Proton beam therapy in pediatric oncology
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Cancer J 15:298-305. 2009
  8. pmc Brain tumors across the age spectrum: biology, therapy, and late effects
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Semin Radiat Oncol 20:58-66. 2010
  9. ncbi request reprint Phase II trial of conformal radiation therapy for pediatric patients with craniopharyngioma and correlation of surgical factors and radiation dosimetry with change in cognitive function
    Thomas E Merchant
    Division of Radiation Oncology, Department of Biostatistics, St Jude Children s Research Hospital, and Semmes Murphey Neurologic and Spine Institute, Memphis, Tennessee 38105 2794, USA
    J Neurosurg 104:94-102. 2006
  10. ncbi request reprint Preirradiation endocrinopathies in pediatric brain tumor patients determined by dynamic tests of endocrine function
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 54:45-50. 2002

Detail Information

Publications115 found, 100 shown here

  1. doi request reprint Children's Oncology Group's 2013 blueprint for research: radiation oncology
    Thomas E Merchant
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pediatr Blood Cancer 60:1037-43. 2013
    ..Radiation oncology is an adult medical specialty; thus, pediatric radiation oncologists are uniquely positioned to work with adult cancer investigators in the reorganized US National Cancer Institute Clinic Trials Network...
  2. pmc Evaluation of children with craniopharyngioma using carbon-11 methionine PET prior to proton therapy
    Benjamin S Laser
    Department of Radiation Oncology, University of Maryland, Baltimore, Maryland, USA
    Neuro Oncol 15:506-10. 2013
    ..Carbon-11 methionine ((11)C MET) has little uptake under normal conditions. We prospectively investigated the uptake of (18)F FDG and (11)C MET PET in patients with craniopharyngioma prior to proton therapy...
  3. pmc Clinical controversies: proton therapy for pediatric tumors
    Thomas E Merchant
    Division of Radiation Oncology, Department of Radiologic Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Semin Radiat Oncol 23:97-108. 2013
    ....
  4. pmc Disease control after reduced volume conformal and intensity modulated radiation therapy for childhood craniopharyngioma
    Thomas E Merchant
    St Jude Children s Research Hospital, Radiological Sciences, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 85:e187-92. 2013
    ..To estimate the rate of disease control after conformal radiation therapy using reduced clinical target volume (CTV) margins and to determine factors that predict for tumor progression...
  5. pmc Valgus and varus deformity after wide-local excision, brachytherapy and external beam irradiation in two children with lower extremity synovial cell sarcoma: case report
    Daniel T Fletcher
    Division of Radiation Oncology, Department of Radiological Sciences, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, Tennessee, USA
    BMC Cancer 4:57. 2004
    ..Wide-local excision combined with radiation therapy is effective in achieving local tumor control with acceptable morbidity and good functional outcomes for most patients...
  6. ncbi request reprint Early neuro-otologic effects of three-dimensional irradiation in children with primary brain tumors
    Thomas E Merchant
    Department ofRadiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 58:1194-207. 2004
    ..We modeled hearing threshold levels (HTL) after CRT in children with localized primary brain tumors (ependymoma, low- or high-grade astrocytoma, craniopharyngioma, or CNS germinoma) by using cochlear dose and clinical variables...
  7. doi request reprint Proton beam therapy in pediatric oncology
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Cancer J 15:298-305. 2009
    ..Justification for PBT in pediatric patients should be realized once the costs of treating acute symptoms, growth hormone deficiency, orthopedic deformities, and secondary malignancies are studied and reduced...
  8. pmc Brain tumors across the age spectrum: biology, therapy, and late effects
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Semin Radiat Oncol 20:58-66. 2010
    ....
  9. ncbi request reprint Phase II trial of conformal radiation therapy for pediatric patients with craniopharyngioma and correlation of surgical factors and radiation dosimetry with change in cognitive function
    Thomas E Merchant
    Division of Radiation Oncology, Department of Biostatistics, St Jude Children s Research Hospital, and Semmes Murphey Neurologic and Spine Institute, Memphis, Tennessee 38105 2794, USA
    J Neurosurg 104:94-102. 2006
    ..A Phase II trial of conformal radiation therapy (CRT) for craniopharyngioma was conducted to determine whether the irradiated volume could be safely reduced to decrease effects on cognitive function...
  10. ncbi request reprint Preirradiation endocrinopathies in pediatric brain tumor patients determined by dynamic tests of endocrine function
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 54:45-50. 2002
    ..To prospectively evaluate pediatric patients with localized primary brain tumors for evidence of endocrinopathy before radiotherapy (RT)...
  11. pmc Growth hormone secretion after conformal radiation therapy in pediatric patients with localized brain tumors
    Thomas E Merchant
    St Jude Children s Research Hospital, Memphis, TN 38015 3678, USA
    J Clin Oncol 29:4776-80. 2011
    ..Growth hormone deficiency (GHD) after radiation therapy negatively affects growth and development and quality of life in children with brain tumors...
  12. ncbi request reprint Acute effects of irradiation on cognition: changes in attention on a computerized continuous performance test during radiotherapy in pediatric patients with localized primary brain tumors
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 53:1271-8. 2002
    ..To assess sustained attention, impulsivity, and reaction time during radiotherapy (RT) for pediatric patients with localized primary brain tumors...
  13. ncbi request reprint Current management of childhood ependymoma
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Oncology (Williston Park) 16:629-42, 644; discussion 645-6, 648. 2002
    ..This review presents historical and current practices used to treat ependymoma, and is intended to provide an information framework for caregivers so that they can assist parents in the decision-making process...
  14. ncbi request reprint Differential attenuation of clavicle growth after asymmetric mantle radiotherapy
    Thomas E Merchant
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Int J Radiat Oncol Biol Phys 59:556-61. 2004
    ..To determine the effects of 15 Gy on bone growth as a function of time and age by comparing clavicle length before and after asymmetric mantle irradiation in pediatric patients...
  15. pmc Late effects of conformal radiation therapy for pediatric patients with low-grade glioma: prospective evaluation of cognitive, endocrine, and hearing deficits
    Thomas E Merchant
    Department of Radiological Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105 3678, USA
    J Clin Oncol 27:3691-7. 2009
    ..We conducted a prospective trial to evaluate late effects in pediatric patients with low-grade glioma (LGG) treated with conformal radiation therapy (CRT)...
  16. ncbi request reprint Episcleral plaque brachytherapy for retinoblastoma
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 43:134-9. 2004
    ..The purpose of this study was to report our experience using episcleral plaque brachytherapy (EPBRT) to treat retinoblastoma and to demonstrate its applicability in multimodality treatment...
  17. ncbi request reprint Craniopharyngioma radiotherapy: endocrine and cognitive effects
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38104, USA
    J Pediatr Endocrinol Metab 19:439-46. 2006
    ..Early and accurate evaluation of these functions should be considered for all patients to provide parents and caregivers with the information necessary to plan intervention and mitigate the consequences of tumor and treatment...
  18. pmc Multi-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma
    Thomas E Merchant
    Department of Radiological Sciences, Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 70:782-7. 2008
    ..Conformal RT to less than the entire posterior fossa (PF) after craniospinal irradiation might reduce neurocognitive sequelae and requires evaluation...
  19. ncbi request reprint Ependymoma: new therapeutic approaches including radiation and chemotherapy
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Neurooncol 75:287-99. 2005
    ..Future research in the treatment of this tumor, that afflicts fewer than 200 children in the US each year, will focus on molecular biology, clarifying risk factors for tumor control and late effects, and testing novel agents...
  20. ncbi request reprint Radiation dosimetry predicts IQ after conformal radiation therapy in pediatric patients with localized ependymoma
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 63:1546-54. 2005
    ..To assess the effects of radiation dose-volume distribution on the trajectory of IQ development after conformal radiation therapy (CRT) in pediatric patients with ependymoma...
  21. doi request reprint A retrospective study of surgery and reirradiation for recurrent ependymoma
    Thomas E Merchant
    Department of Radiological Sciences, Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 71:87-97. 2008
    ..To report disease control for patients with recurrent ependymoma (EP) treated with surgery and a second course of radiation therapy (RT(2))...
  22. ncbi request reprint The effects of hydrocephalus on intelligence quotient in children with localized infratentorial ependymoma before and after focal radiation therapy
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Neurosurg 101:159-68. 2004
    ..The goal of this study was to determine the influence of hydrocephalus on intelligence quotient (IQ) in children with infratentorial ependymoma before and after the administration of focal radiation...
  23. doi request reprint Three-dimensional conformal radiation therapy for ependymoma
    Thomas E Merchant
    Department of Radiological Sciences, Mail Stop 220, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Childs Nerv Syst 25:1261-8. 2009
    ..These advances occurred at a time when clinical trial results confirmed that radiotherapy avoidance strategies were unsuccessful...
  24. pmc Factors associated with neurological recovery of brainstem function following postoperative conformal radiation therapy for infratentorial ependymoma
    Thomas E Merchant
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Int J Radiat Oncol Biol Phys 76:496-503. 2010
    ..To identify risk factors associated with incomplete neurological recovery in pediatric patients with infratentorial ependymoma treated with postoperative conformal radiation therapy (CRT)...
  25. ncbi request reprint Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma
    Thomas E Merchant
    Department of Biostatistics, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    J Clin Oncol 22:3156-62. 2004
    ....
  26. ncbi request reprint Craniopharyngioma: the St. Jude Children's Research Hospital experience 1984-2001
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Int J Radiat Oncol Biol Phys 53:533-42. 2002
    ..To review our institution's experience in the treatment of craniopharyngioma and assess the merits of initial therapy with limited surgery and irradiation...
  27. ncbi request reprint Ocular preservation after 36 Gy external beam radiation therapy for retinoblastoma
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr Hematol Oncol 24:246-9. 2002
    ..The purpose of this study was to document the ocular preservation rate after 36 Gy external beam radiation therapy (EBRT) for retinoblastoma...
  28. ncbi request reprint CNS germinoma: disease control and long-term functional outcome for 12 children treated with craniospinal irradiation
    T E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 46:1171-6. 2000
    ..To provide evidence that radiation therapy alone in the form of craniospinal irradiation (CSI) and a boost to the primary site of disease provides effective disease control and limited additional morbidity for patients with CNS germinoma...
  29. ncbi request reprint Esophageal cancer phospholipids correlated with histopathologic findings: a 31P NMR study
    T E Merchant
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA
    NMR Biomed 12:184-8. 1999
    ..These data provide a statistical correlation between histopathologic features and molecules known to play an important role in cellular activities and processes unique to malignant tissues...
  30. ncbi request reprint Effect of low-dose radiation therapy when combined with surgical resection for Ewing sarcoma
    T E Merchant
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Med Pediatr Oncol 33:65-70. 1999
    ..We retrospectively examined the clinical characteristics, treatment, and outcome for 25 patients with Ewing sarcoma treated with limited surgery and low-dose irradiation...
  31. ncbi request reprint Brachytherapy for pediatric soft-tissue sarcoma
    T E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 46:427-32. 2000
    ..To review the use of brachytherapy (BRT) to treat soft-tissue sarcoma (STS) in pediatric patients at St. Jude Children's Research Hospital...
  32. ncbi request reprint Pediatric low-grade and ependymal spinal cord tumors
    T E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pediatr Neurosurg 32:30-6. 2000
    ..Patients with disseminated EP, MPEP, JPA and nonpilocytic astrocytoma may achieve long-term progression-free survival with craniospinal irradiation...
  33. ncbi request reprint Long-term results with radiation therapy for pediatric desmoid tumors
    T E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 47:1267-71. 2000
    ..To retrospectively review the treatment and outcome of pediatric patients with desmoid tumor who received radiation therapy at a single institution...
  34. doi request reprint Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 51:110-7. 2008
    ..To determine whether proton radiotherapy has clinical advantages over photon radiotherapy, we modeled the dose characteristics of both to critical normal tissue volumes using data from patients with four types of childhood brain tumors...
  35. ncbi request reprint Radiation therapy for relapsed CNS germinoma after primary chemotherapy
    T E Merchant
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 16:204-9. 1998
    ....
  36. ncbi request reprint Malignant breast tumor phospholipid profiles using (31)P magnetic resonance
    Thomas E Merchant
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Lett 176:159-67. 2002
    ..31)P MRS phospholipid profile data provide statistical correlations among histologic features and molecules known to play important roles in cellular communication, regulation, and processes unique to malignant tissues...
  37. ncbi request reprint Radiation dose-volume effects on growth hormone secretion
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 52:1264-70. 2002
    ..Conformal radiotherapy (CRT) techniques allow for a more accurate determination of hypothalamic dosimetry. We correlated the dosimetry of the hypothalamus and the peak GH value after CRT in children with localized primary brain tumors...
  38. pmc Phase II trial of conformal radiation therapy for pediatric low-grade glioma
    Thomas E Merchant
    Dept of Radiological Sciences, Mail Stop 220, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105 3678, USA
    J Clin Oncol 27:3598-604. 2009
    ..We conducted a phase II trial of conformal radiation therapy (CRT) to estimate disease control by using a 10-mm clinical target volume (CTV) margin...
  39. ncbi request reprint Preliminary results from a Phase II trail of conformal radiation therapy for pediatric patients with localised low-grade astrocytoma and ependymoma
    Thomas E Merchant
    Department of Radiation Oncology St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 52:325-32. 2002
    ....
  40. ncbi request reprint Influence of tumor grade on time to progression after irradiation for localized ependymoma in children
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 53:52-7. 2002
    ..To investigate the influence of histologic grade on progression-free survival (PFS) after irradiation (RT) for pediatric patients with localized ependymoma...
  41. ncbi request reprint Subtle white matter volume differences in children treated for medulloblastoma with conventional or reduced dose craniospinal irradiation
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN, USA
    Magn Reson Imaging 18:787-93. 2000
    ..Serial quantitative MR measures of NAWMV may provide a neuroanatomical substrate for assessing functional impact of CSI on normal brain function following treatment for medulloblastoma...
  42. ncbi request reprint Effect of ionizing radiation on the human brain: white matter and gray matter T1 in pediatric brain tumor patients treated with conformal radiation therapy
    R G Steen
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Int J Radiat Oncol Biol Phys 49:79-91. 2001
    ....
  43. ncbi request reprint Comparison of lumbar and shunt cerebrospinal fluid specimens for cytologic detection of leptomeningeal disease in pediatric patients with brain tumors
    A Gajjar
    Departments of Hematology Oncology, Radiation Oncology, Pathology and Laboratory Medicine, and Biostatistics and Epidemiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 17:1825-8. 1999
    ....
  44. ncbi request reprint High-grade pediatric spinal cord tumors
    T E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, Tenn 38105
    Pediatr Neurosurg 30:1-5. 1999
    ..It is important to document the extent of disease accurately prior to the initiation of radiation therapy, since a subset of these patients progress rapidly outside of the field of irradiation...
  45. ncbi request reprint Prognostic factors for children and adolescents with surgically resected nonrhabdomyosarcoma soft tissue sarcoma: an analysis of 121 patients treated at St Jude Children's Research Hospital
    S L Spunt
    Departments of Hematology Oncology, Biostatistics and Epidemiology, Surgery, Radiation Oncology, and Pathology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 17:3697-705. 1999
    ....
  46. ncbi request reprint Bithalamic involvement predicts poor outcome among children with thalamic glial tumors
    D A Reardon
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pediatr Neurosurg 29:29-35. 1998
    ....
  47. pmc Radiation associated brainstem injury
    Charles Mayo
    Department of Radiation Oncology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Int J Radiat Oncol Biol Phys 76:S36-41. 2010
    ..Smaller volumes of the brainstem (1-10 mL) may be irradiated to maximum doses of 59 Gy for dose fractions <or=2 Gy; however, the risk appears to increase markedly at doses >64 Gy...
  48. ncbi request reprint A hybrid neural network analysis of subtle brain volume differences in children surviving brain tumors
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, University of Memphis, TN 38105, USA
    Magn Reson Imaging 16:413-21. 1998
    ..This hybrid neural network analysis of subtle brain volume differences with magnetic resonance may constitute a direct measure of treatment-induced brain damage...
  49. ncbi request reprint Comparison of CSF cytology and spinal magnetic resonance imaging in the detection of leptomeningeal disease in pediatric medulloblastoma or primitive neuroectodermal tumor
    M Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 17:3234-7. 1999
    ..To determine the validity of this hypothesis, we compared the rate of detection of LMD between concurrent lumbar CSF cytology and spinal MRI performed at diagnosis in patients with medulloblastoma or PNET...
  50. ncbi request reprint Multiagent chemotherapy as neoadjuvant treatment for multifocal intraocular retinoblastoma
    M W Wilson
    Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
    Ophthalmology 108:2106-14; discussion 2114-5. 2001
    ..CONCLUSIONS: Multiagent chemotherapy alone does not ensure a cure for multifocal intraocular retinoblastoma. Supplemental focal therapy is needed to control disease progression...
  51. ncbi request reprint Myeloablative chemotherapy with autologous bone marrow rescue in young children with recurrent malignant brain tumors
    S Guruangan
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 16:2486-93. 1998
    ....
  52. ncbi request reprint Fractures in pediatric Ewing sarcoma
    L M Wagner
    Department of Hematology/Oncology, University of Tennessee College of Medicine, Memphis, USA
    J Pediatr Hematol Oncol 23:568-71. 2001
    ..CONCLUSIONS: Patients with femoral ESFT are at high-risk for fracture. If fractures occur after the completion of therapy, recurrence or second malignancy should be suspected...
  53. ncbi request reprint Effect on ocular survival of adding early intensive focal treatments to a two-drug chemotherapy regimen in patients with retinoblastoma
    Matthew W Wilson
    Department of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Avenue, Memphis, TN 38163, USA
    Am J Ophthalmol 140:397-406. 2005
    ..To evaluate vincristine and carboplatin with intensive focal treatments in the management of intraocular retinoblastoma...
  54. ncbi request reprint Modeling radiation dosimetry to predict cognitive outcomes in pediatric patients with CNS embryonal tumors including medulloblastoma
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 65:210-21. 2006
    ..Model the effects of radiation dosimetry on IQ among pediatric patients with central nervous system (CNS) tumors...
  55. doi request reprint Radiation-induced astrogliosis and blood-brain barrier damage can be abrogated using anti-TNF treatment
    Christy M Wilson
    School of Biomedical Engineering and Imaging, University of Tennessee Health Science Center, Memphis, TN, USA
    Int J Radiat Oncol Biol Phys 74:934-41. 2009
    ..In this article, we investigate the role of tumor necrosis factor-alpha (TNF) in the initiation of acute damage to the blood-brain barrier (BBB) and brain tissue following radiotherapy (RT) for CNS tumors...
  56. ncbi request reprint Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis
    S L Palmer
    Division of Behavioral Medicine, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
    J Clin Oncol 19:2302-8. 2001
    ....
  57. ncbi request reprint Risk factors for the development of obesity in children surviving brain tumors
    Robert H Lustig
    Departments of Endocrinology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Endocrinol Metab 88:611-6. 2003
    ....
  58. pmc Radiation dose-volume effects in the brain
    Yaacov Richard Lawrence
    Department of Radiation Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 76:S20-7. 2010
    ..Cognitive dysfunction in children is largely seen for whole brain doses of >or=18 Gy. No substantial evidence has shown that RT induces irreversible cognitive decline in adults within 4 years of RT...
  59. ncbi request reprint Attention and memory functioning among pediatric patients with medulloblastoma
    Cara B Reeves
    Division of Behavioral Medicine, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105 2794, USA
    J Pediatr Psychol 31:272-80. 2006
    ..To test the hypotheses that memory and attention deficits are prevalent in survivors of childhood medulloblastoma (MB) and that these deficits are associated with problems with academic achievement...
  60. ncbi request reprint Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma
    Raymond K Mulhern
    Division of Behavioral Medicine, Department of Biostatistics, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 23:5511-9. 2005
    ....
  61. pmc Imaging changes in very young children with brain tumors treated with proton therapy and chemotherapy
    N D Sabin
    Department of Radiological Sciences, St Jude s Children s Research Hospital, Memphis, Tennessee 38105, USA
    AJNR Am J Neuroradiol 34:446-50. 2013
    ..Radiologists should be aware of these findings in children who receive PT after chemotherapy. In this report, we describe the time course of these PT-related imaging findings and correlate them with treatment and clinical outcomes...
  62. ncbi request reprint Effect of therapeutic ionizing radiation on the human brain
    R G Steen
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Ann Neurol 50:787-95. 2001
    ..If brain T1 is a surrogate for radiation effect, reducing the volume of normal white matter receiving more than 20 Gy could be an important treatment planning goal...
  63. doi request reprint Hearing loss after radiotherapy for pediatric brain tumors: effect of cochlear dose
    Chiaho Hua
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Int J Radiat Oncol Biol Phys 72:892-9. 2008
    ..To determine the effect of cochlear dose on sensorineural hearing loss in pediatric patients with brain tumor treated by using conformal radiation therapy (CRT)...
  64. ncbi request reprint Radiation-induced permeability and leukocyte adhesion in the rat blood-brain barrier: modulation with anti-ICAM-1 antibodies
    Hong Yuan
    Department of Radiation Oncology, Mail Stop 220, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105 2794, USA
    Brain Res 969:59-69. 2003
    ..These findings provide a target to reduce radiation-related permeability and cell adhesion and potentially the side effects of radiation in the CNS...
  65. pmc Predicting behavioral problems in craniopharyngioma survivors after conformal radiation therapy
    Eugenia P Dolson
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Pediatr Blood Cancer 52:860-4. 2009
    ..Survival is often marked by neurologic deficits, panhypopituitarism, diabetes insipidus, cognitive deficiencies, and behavioral and social problems...
  66. ncbi request reprint Intensity-modulated radiation therapy for children with intraocular retinoblastoma: potential sparing of the bony orbit
    M J Krasin
    Department of Radiological Science, Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Clin Oncol (R Coll Radiol) 16:215-22. 2004
    ..We have evaluated the potential for intensity-modulated radiation therapy (IMRT) to reduce dose to surrounding normal tissues in children with retinoblastoma confined to the globe of the eye...
  67. ncbi request reprint Cutaneous and subcutaneous Ewing's sarcoma: an indolent disease
    E Chow
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Int J Radiat Oncol Biol Phys 46:433-8. 2000
    ..A retrospective review of patients with cutaneous or subcutaneous ES was conducted to analyze outcome and patterns of failure...
  68. ncbi request reprint Differences in ICAM-1 and TNF-alpha expression between large single fraction and fractionated irradiation in mouse brain
    M W Gaber
    Department of Radiation Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105 2794, USA
    Int J Radiat Biol 79:359-66. 2003
    ..The expression of the intercellular adhesion molecule (ICAM-1) and tumour necrosis factor-alpha (TNF-alpha) in the mouse brain was compared after single-dose and fractionated whole-brain irradiation...
  69. doi request reprint Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial
    Stephen J Laughton
    Division of Neuro Oncology, Department of Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 26:1112-8. 2008
    ....
  70. ncbi request reprint Risk-adapted, combined-modality therapy with VAMP/COP and response-based, involved-field radiation for unfavorable pediatric Hodgkin's disease
    Melissa M Hudson
    Department of Hematology Oncology, Radiological Sciences and Biostatistics, St Jude Children s Research Hospital and the University of Tennessee College of Medicine, Memphis, TN 38105, USA
    J Clin Oncol 22:4541-50. 2004
    ....
  71. ncbi request reprint Definitive surgery and multiagent systemic therapy for patients with localized Ewing sarcoma family of tumors: local outcome and prognostic factors
    Matthew J Krasin
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 104:367-73. 2005
    ....
  72. ncbi request reprint Survival and functional outcome of children with hypothalamic/chiasmatic tumors
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 97:1084-92. 2003
    ..We evaluated the impact of clinical and neuroimaging parameters and primary therapy on overall (OS) and progression-free (PFS) survival and on neuroendocrine and neurocognitive outcome in children with H and/or C tumors...
  73. ncbi request reprint Treatment of intraocular retinoblastoma with vincristine and carboplatin
    Carlos Rodriguez-Galindo
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    J Clin Oncol 21:2019-25. 2003
    ..To evaluate the efficacy of chemoreduction using vincristine and carboplatin in preventing or delaying external-beam radiotherapy (EBRT) or enucleation in patients with intraocular retinoblastoma...
  74. pmc Retinoblastoma: one world, one vision
    Carlos Rodriguez-Galindo
    Department of Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Pediatrics 122:e763-70. 2008
    ....
  75. pmc Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Mail Stop 260, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Clin Cancer Res 15:701-7. 2009
    ....
  76. pmc Dosimetric impact of intrafractional patient motion in pediatric brain tumor patients
    Chris Beltran
    Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN, USA
    Med Dosim 35:43-8. 2010
    ..Because the motion did not affect the dose to the CTV, the 3-mm PTV margin used is sufficient to account for intrafractional motion, given the patient is properly localized at the start of treatment...
  77. pmc Evolution of neurological impairment in pediatric infratentorial ependymoma patients
    E Brannon Morris
    Division of Neurology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Neurooncol 94:391-8. 2009
    ..Because of this tumor typically arises within the 4th ventricle and can invade the brainstem, patients are at risk for significant neurological impairment...
  78. ncbi request reprint Definitive irradiation in multidisciplinary management of localized Ewing sarcoma family of tumors in pediatric patients: outcome and prognostic factors
    Matthew J Krasin
    Department of Radiological Sciences, Division of Radiation Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
    Int J Radiat Oncol Biol Phys 60:830-8. 2004
    ..To assess the effect of radiation dose on local tumor control of the Ewing sarcoma family of tumors in 79 patients with localized disease treated at a single institution...
  79. pmc Locoregional tumor progression after radiation therapy influences overall survival in pediatric patients with neuroblastoma
    Atmaram S Pai Panandiker
    Division of Radiation Oncology, Department of Radiological Sciences, St Jude Children s Research Hospital, MS220, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Int J Radiat Oncol Biol Phys 76:1161-5. 2010
    ..We conducted a retrospective review to identify factors that might predict for locoregional tumor control and its impact on overall survival...
  80. ncbi request reprint Intratumoral hemorrhage among children with newly diagnosed, diffuse brainstem glioma
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer 106:1364-71. 2006
    ..In the current study, the authors assessed the characteristics and estimated the cumulative incidence of IH among children with BSG...
  81. doi request reprint Dosimetric effect of setup motion and target volume margin reduction in pediatric ependymoma
    Chris Beltran
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38120, USA
    Radiother Oncol 96:216-22. 2010
    ....
  82. pmc Region-specific radiotherapy and neuropsychological outcomes in adult survivors of childhood CNS malignancies
    Gregory T Armstrong
    Department of Epidemiology and Cancer Control, St Jude Children s Research Hospital, 262 Danny Thomas Place, MS 735, Memphis, TN 38105 3678, USA
    Neuro Oncol 12:1173-86. 2010
    ..Survivors with a history of radiation exposure to temporal brain regions are at increased risk for impairment in memory and social functioning...
  83. ncbi request reprint Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 7:813-20. 2006
    ..We aimed to investigate the effectiveness of risk-adapted radiotherapy followed by a shortened period of dose-intense chemotherapy in children with medulloblastoma...
  84. pmc Survival and long-term health and cognitive outcomes after low-grade glioma
    Gregory T Armstrong
    Department of Epidemiology and Cancer Control, St Jude Children s Research Hospital, 262 Danny Thomas Place, Mail Stop 735, Memphis, TN 38105, USA
    Neuro Oncol 13:223-34. 2011
    ..Survivors of childhood LGG experience substantial long-term adverse effects that continue to increase well beyond the 5-year survival time point...
  85. ncbi request reprint A model for quantitative changes in the magnetic resonance parameters of muscle in children after therapeutic irradiation
    Matthew J Krasin
    Division of Radiation Oncology, Department of Radiological Sciences, St Jude Children s Research Hospital, and Department of Pediatrics, University of Tennessee School of Medicine, Memphis, TN 38105 2794, USA
    Magn Reson Imaging 24:1319-24. 2006
    ....
  86. ncbi request reprint Survival and late mortality in long-term survivors of pediatric CNS tumors
    E Brannon Morris
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:1532-8. 2007
    ..To describe the pattern of survival and late mortality among contemporary long-term survivors of pediatric CNS tumor...
  87. ncbi request reprint Daily image-guided localization for neuroblastoma
    Chris Beltran
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN, USA
    J Appl Clin Med Phys 11:3388. 2010
    ..The internal margin needs further investigation before PTV reduction can be made. Ultrasound localization was highly variable and not correlated to CBCT shifts...
  88. ncbi request reprint High-grade astrocytoma in very young children
    Robert P Sanders
    Division of Neuro Oncology, Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 49:888-93. 2007
    ..High-grade astrocytomas are rare in young children, but have been reported to have a better prognosis than similar tumors in older patients...
  89. pmc Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma
    Alberto Broniscer
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 28:4762-8. 2010
    ....
  90. ncbi request reprint Temozolomide after radiotherapy for newly diagnosed high-grade glioma and unfavorable low-grade glioma in children
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    J Neurooncol 76:313-9. 2006
    ..Although the heterogeneity of prognostic factors in our patients made assessment of treatment outcome more difficult, the addition of 6 cycles of temozolomide after radiotherapy did not seem to alter the poor outcome of these patients...
  91. ncbi request reprint CSF cytology has limited value in the evaluation of patients with ependymoma who have MRI evidence of metastasis
    Igor M Poltinnikov
    Kimmel Cancer Center of Jefferson Medical College, Thomas Jefferson University Hospital, Department of Radiation Oncology, Philadelphia, PA, USA
    Pediatr Blood Cancer 47:169-73. 2006
    ..To investigate the usefulness of cerebrospinal fluid (CSF) cytology in pediatric patients with ependymoma who relapsed after focal irradiation...
  92. ncbi request reprint Brief report: Evaluation of an interactive intervention designed to reduce pediatric distress during radiation therapy procedures
    James L Klosky
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr Psychol 29:621-6. 2004
    ....
  93. ncbi request reprint Survival after recurrence of Ewing tumors: the St Jude Children's Research Hospital experience, 1979-1999
    Carlos Rodriguez-Galindo
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 94:561-9. 2002
    ..Despite improved therapies, 30-40% of patients with Ewing tumors (ET) experience recurrence and have a poor prognosis. The authors analyzed factors prognostic of survival in patients with recurrent ET...
  94. ncbi request reprint Clinical features and outcome of initially unresected nonmetastatic pediatric nonrhabdomyosarcoma soft tissue sarcoma
    Sheri L Spunt
    Department of Hematology Oncology, St Jude Children s Research Hospital, University of Tennessee College of Medicine, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    J Clin Oncol 20:3225-35. 2002
    ..To describe the clinical features, response to therapy, and outcome of pediatric patients with initially unresected nonmetastatic nonrhabdomyosarcoma soft tissue sarcoma (NRSTS)...
  95. ncbi request reprint Estimating differences in volumetric flat bone growth in pediatric patients by radiation treatment method
    Chiaho Hua
    Division of Radiation Oncology, Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Int J Radiat Oncol Biol Phys 67:552-8. 2007
    ..To estimate potential differences in volumetric bone growth in children with sarcoma treated with intensity-modulated (IMRT) and conformal (CRT) radiation therapy using an empiric dose-effect model...
  96. pmc Preliminary results from a prospective study using limited margin radiotherapy in pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft-tissue sarcoma
    Matthew J Krasin
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 76:874-8. 2010
    ..To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS)...
  97. ncbi request reprint An intravital microscopy study of radiation-induced changes in permeability and leukocyte-endothelial cell interactions in the microvessels of the rat pia mater and cremaster muscle
    M Waleed Gaber
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Brain Res Brain Res Protoc 13:1-10. 2004
    ..Our results demonstrate that this method is sensitive to changes in these properties of the BBB...
  98. ncbi request reprint Predicting pediatric distress during radiation therapy procedures: the role of medical, psychosocial, and demographic factors
    James L Klosky
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatrics 119:e1159-66. 2007
    ..The purpose of this work was to identify demographic, medical, and psychosocial variables that predict radiation therapy-related distress among pediatric patients with cancer...
  99. ncbi request reprint Noninvasive evaluation of late anthracycline cardiac toxicity in childhood cancer survivors
    Melissa M Hudson
    Department of Hematology Oncology, Division of Behavioral Medicine, St Jude Children s Research Hospital, The University of Tennessee, College of Medicine, Memphis, TN 38105, USA
    J Clin Oncol 25:3635-43. 2007
    ..The purpose of this study was to delineate the relationship between clinical factors and abnormalities of noninvasive cardiac testing (NICT)...
  100. ncbi request reprint Neuroimaging-detected late transient treatment-induced lesions in pediatric patients with brain tumors
    Kathleen J Helton
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennesee 38105 2794, USA
    J Neurosurg 102:179-86. 2005
    ..Although late-delayed reactions are thought to be permanent, in this study the authors sought to characterize transient brain lesions (TBLs) in the late-delayed period that completely resolved without imaging or neurological sequelae...