PETER MCKINNON

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint The DNA double-strand break response in the nervous system
    Clint W Abner
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332N Lauderdale, Memphis, TN 38105, USA
    DNA Repair (Amst) 3:1141-7. 2004
  2. pmc ATM and ataxia telangiectasia
    Peter J McKinnon
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, Tennessee 38105, USA
    EMBO Rep 5:772-6. 2004
  3. doi request reprint ATM and the molecular pathogenesis of ataxia telangiectasia
    Peter J McKinnon
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Pathol 7:303-21. 2012
  4. pmc DNA repair deficiency and neurological disease
    Peter J McKinnon
    Department of Genetics and Tumour Cell Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nat Rev Neurosci 10:100-12. 2009
  5. pmc Extracellular matrix-associated protein Sc1 is not essential for mouse development
    P J McKinnon
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 20:656-60. 2000
  6. pmc BRCA2 is required for neurogenesis and suppression of medulloblastoma
    Pierre Olivier Frappart
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 26:2732-42. 2007
  7. pmc Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development
    Kenji E Orii
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 103:10017-22. 2006
  8. ncbi request reprint DNA strand break repair and human genetic disease
    Peter J McKinnon
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Genomics Hum Genet 8:37-55. 2007
  9. ncbi request reprint Atm and c-Abl cooperate in the response to genotoxic stress during nervous system development
    Heather L Miller
    Department of Genetics, St Jude Children s Research Hospital, 332N Lauderdale, Memphis, TN 38105, USA
    Brain Res Dev Brain Res 145:31-8. 2003
  10. pmc Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS
    Erin R P Shull
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 23:171-80. 2009

Research Grants

  1. ATM and DNA Damage in the Nervous System
    Peter J McKinnon; Fiscal Year: 2010
  2. ATM AND CELL DEATH IN THE NERVOUS SYSTEM
    PETER MCKINNON; Fiscal Year: 2001
  3. ATM and DNA Damage in the Nervous System
    PETER MCKINNON; Fiscal Year: 2007
  4. ATM AND CELL DEATH IN THE NERVOUS SYSTEM
    PETER MCKINNON; Fiscal Year: 2006
  5. IR-INDUCED APOPTOSIS IN THE DEVELOPING NERVOUS SYSTEM
    PETER MCKINNON; Fiscal Year: 2004

Collaborators

Detail Information

Publications40

  1. ncbi request reprint The DNA double-strand break response in the nervous system
    Clint W Abner
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332N Lauderdale, Memphis, TN 38105, USA
    DNA Repair (Amst) 3:1141-7. 2004
    ..Thus, appropriate responses to DSBs are critical for the normal development and maintenance of the nervous system...
  2. pmc ATM and ataxia telangiectasia
    Peter J McKinnon
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, Tennessee 38105, USA
    EMBO Rep 5:772-6. 2004
    ..Thus, although it is a rare neurodegenerative disease, understanding the biology of AT will lead to a greater understanding of the fundamental processes that underpin cancer and neurodegeneration...
  3. doi request reprint ATM and the molecular pathogenesis of ataxia telangiectasia
    Peter J McKinnon
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Pathol 7:303-21. 2012
    ..Together with A-T, these syndromes indicate that neurodegeneration can be caused by the failure to appropriately respond to DNA damage. This review focuses on defective DNA-damage signaling as the underlying cause of A-T...
  4. pmc DNA repair deficiency and neurological disease
    Peter J McKinnon
    Department of Genetics and Tumour Cell Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nat Rev Neurosci 10:100-12. 2009
    ..Understanding how DNA repair deficiency affects the nervous system will provide a rational basis for therapies targeted at ameliorating the neurological problems in these syndromes...
  5. pmc Extracellular matrix-associated protein Sc1 is not essential for mouse development
    P J McKinnon
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 20:656-60. 2000
    ..Therefore, the function of Sc1 during development is not critical or, in its absence, is subserved by another protein...
  6. pmc BRCA2 is required for neurogenesis and suppression of medulloblastoma
    Pierre Olivier Frappart
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 26:2732-42. 2007
    ..These data illustrate the importance of Brca2 during nervous system development and underscore the tissue-specific requirements for DNA repair factors...
  7. pmc Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development
    Kenji E Orii
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 103:10017-22. 2006
    ..Thus, these data reveal distinct tissue- and cell-type requirements for each DNA DSB repair pathway during neural development and provide insights for understanding the contributions of DNA DSB responses to disease...
  8. ncbi request reprint DNA strand break repair and human genetic disease
    Peter J McKinnon
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Genomics Hum Genet 8:37-55. 2007
    ..Here we provide an overview of the genetic diseases associated with defects in the repair/response to DNA strand breaks...
  9. ncbi request reprint Atm and c-Abl cooperate in the response to genotoxic stress during nervous system development
    Heather L Miller
    Department of Genetics, St Jude Children s Research Hospital, 332N Lauderdale, Memphis, TN 38105, USA
    Brain Res Dev Brain Res 145:31-8. 2003
    ..Thus, these genetic data link Atm and c-Abl signaling and underscore a significant interrelationship between the two during neural development...
  10. pmc Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS
    Erin R P Shull
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 23:171-80. 2009
    ..Thus, DNA damage signaling in the nervous system is different between ATLD and NBS and likely explains their respective neuropathology...
  11. pmc Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
    Risa Kitagawa
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38018, USA
    Genes Dev 18:1423-38. 2004
    ..These observations suggest that many of the abnormal stress responses seen in cells lacking ATM, NBS1, or BRCA1 result from a failure of ATM migration to sites of DNA breaks and a resultant lack of SMC1 phosphorylation...
  12. pmc A survivor hits the breaks
    Douglas R Green
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell 29:411-2. 2008
    ..In this issue of Molecular Cell, Wang et al. (2008) propose another function for Bcl2: the inhibition of DNA repair by nonhomologous end-joining...
  13. ncbi request reprint Ataxia-telangiectasia and related diseases
    Pierre Olivier Frappart
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Neuromolecular Med 8:495-511. 2006
    ..Collectively, these diseases highlight the critical importance of appropriate responses to DNA-DSBs to maintain homeostasis in the nervous system...
  14. pmc Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency
    Pierre Olivier Frappart
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 106:1880-5. 2009
    ..Thus, our data highlight the preeminence of Ptch1 as a tumor suppressor in cerebellar granule cells and reveal other genomic events central to the genesis of medulloblastoma...
  15. pmc Fanconi anemia and biallelic BRCA2 mutation diagnosed in a young child with an embryonal CNS tumor
    Mariko D Dewire
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 53:1140-2. 2009
    ....
  16. ncbi request reprint Tumour-suppressor function in the nervous system
    Suzanne J Baker
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Nat Rev Cancer 4:184-96. 2004
  17. ncbi request reprint DNA repair deficiency and neurodegeneration
    Sachin Katyal
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell Cycle 6:2360-5. 2007
    ..Therefore, the response to DNA damage in the nervous system occurs in a distinct spatiotemporal manner utilizing different DNA repair pathways to ensure genomic stability and to prevent disease...
  18. ncbi request reprint Patched2 modulates tumorigenesis in patched1 heterozygous mice
    Youngsoo Lee
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 66:6964-71. 2006
    ..Ptch1+/-Ptch2-/- and Ptch1+/-Ptch2+/- animals showed a higher incidence of tumors and a broader spectrum of tumor types compared with Ptch1+/- animals. Therefore, Ptch2 modulates tumorigenesis associated with Ptch1 haploinsufficiency...
  19. pmc The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1
    Youngsoo Lee
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Neurosci 12:973-80. 2009
    ..Collectively, these data detail the in vivo link between DNA single strand break repair and neurogenesis and highlight the diverse consequences of specific types of genotoxic stress in the nervous system...
  20. ncbi request reprint BRCA2 function and the central nervous system
    Pierre Olivier Frappart
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cell Cycle 6:2453-7. 2007
    ..Here, we discuss how this study contributes both to our understanding of BRCA2 functions in vivo, and the tissue-specific requirements for DNA repair and damage-signaling pathways...
  21. pmc The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer
    Michael M Schuendeln
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell Biol 24:6403-9. 2004
    ..Therefore, TACC2 is not required, nonredundantly, for mouse development and normal cell proliferation and is not a tumor suppressor protein...
  22. ncbi request reprint A molecular fingerprint for medulloblastoma
    Youngsoo Lee
    Department of Genetics and Tumor Cell Biology, Saint Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 63:5428-37. 2003
    ..Coordinated deregulation of these same genes also occurred in a large subset of human medulloblastomas. These data identify a group of genes that is central to medulloblastoma tumorigenesis...
  23. pmc DNA strand breaks, neurodegeneration and aging in the brain
    Sachin Katyal
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mech Ageing Dev 129:483-91. 2008
    ..Further, we also consider the utility of mouse models as reagents to understand the connection between DNA strand breaks and aging in the brain...
  24. ncbi request reprint Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo
    Akira Inoue
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 2:279-88. 2002
    ..These results implicate Slug in a novel survival pathway that protects hematopoietic progenitors from apoptosis after DNA damage...
  25. pmc TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo
    Sachin Katyal
    Department Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 26:4720-31. 2007
    ..These data indicate that TDP1 is required for neural homeostasis, and reveal a widespread requisite for TDP1 function in response to acutely elevated levels of Top1-associated DNA strand breaks...
  26. pmc Mouse models of DNA double-strand break repair and neurological disease
    Pierre Olivier Frappart
    Department Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    DNA Repair (Amst) 7:1051-60. 2008
    ..In this regard, the use of mouse models represents an important approach for advancing our understanding of the biology of the DNA damage response in the nervous system...
  27. pmc Detection of apoptosis in the central nervous system
    Youngsoo Lee
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN, USA
    Methods Mol Biol 559:273-82. 2009
    ..In this chapter, we outline standard approaches for the immunohistochemical analysis of apoptosis in the nervous system, with an emphasis on methodology useful for studies involving DNA damage-induced apoptosis...
  28. ncbi request reprint Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma
    Amar Gajjar
    St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Clin Oncol 22:984-93. 2004
    ..To assess the feasibility of performing central molecular analyses of fresh medulloblastomas obtained from multiple institutions and using these data to identify prognostic markers for contemporaneously treated patients...
  29. ncbi request reprint DNA ligase IV suppresses medulloblastoma formation
    Youngsoo Lee
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 62:6395-9. 2002
    ..These data reveal a pronounced susceptibility of the cerebellum to the effects of chronic DNA damage and provide a direct link between genotoxic stress and medulloblastoma formation...
  30. pmc The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation
    Tamar Uziel
    Department of Tumor Cell Biology and Genetics, Memphis, Tennessee 38105, USA
    Genes Dev 19:2656-67. 2005
    ..Methylation of INK4C (CDKN2C) was observed in four of 23 human MBs, and p18(INK4C) protein expression was extinguished in 14 of 73 cases. Hence, p18(INK4C) loss may contribute to MB formation in children...
  31. pmc Murine ovarian development is not affected by inactivation of the bcl-2 family member diva
    Helen R Russell
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 22:6866-70. 2002
    ..Thus, Diva is not critical for the normal development of the ovaries, or in its absence its function is subserved by another protein...
  32. ncbi request reprint Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies
    Ken Sasai
    Department of Developmental Neurobiology, Saint Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 66:4215-22. 2006
    ....
  33. pmc Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis
    Simone Difilippantonio
    Experimental Immunology Branch and 3Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1003-11. 2007
    ..However, the C-terminal region regulates irradiation-induced apoptosis. These studies provide insight into the complex interplay between Nbs1 and ATM in the DNA damage response...
  34. ncbi request reprint Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer
    Kevin Spring
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, 4029, Australia
    Nat Genet 32:185-90. 2002
    ..This finding provides further support for cancer predisposition in human ataxia-telangiectasia carriers...
  35. pmc DNA damage, DNA repair, ageing and age-related disease
    David M Wilson
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Mech Ageing Dev 129:349-52. 2008
  36. ncbi request reprint The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates
    Ivan Ahel
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
    Nature 443:713-6. 2006
    ..These data indicate that neurological disorders associated with APTX mutations may be caused by the gradual accumulation of unrepaired DNA strand breaks resulting from abortive DNA ligation events...
  37. pmc The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development
    Fabienne Desmots
    St Jude Children s Research Hospital, Department of Genetics and Tumor Cell Biology, 332N Lauderdale, Memphis, TN 38105, USA
    Mol Cell Biol 25:10329-37. 2005
    ..These data show that Scythe is critical for viability and normal development, probably via regulation of programmed cell death and cellular proliferation...
  38. ncbi request reprint Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells
    Elke Pogge von Strandmann
    Department of Internal Medicine I, University Hospital of Cologne, Kerpener Str 62, D 50924 Cologne, Germany
    Immunity 27:965-74. 2007
    ..We propose a concept for target cell recognition by NK cells beyond "missing self" and "induced self," mediated through a tumor cell-derived extracellular factor...
  39. ncbi request reprint Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
    John R Jeffers
    St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Cancer Cell 4:321-8. 2003
    ..These findings establish Puma as a principal mediator of cell death in response to diverse apoptotic signals, implicating Puma as a likely tumor suppressor...
  40. pmc Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development
    Oleg V Lagutin
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Genes Dev 17:368-79. 2003
    ..Furthermore, these results support the hypothesis that a Wnt signal gradient specifies posterior fates in the anterior neural plate...

Research Grants17

  1. ATM and DNA Damage in the Nervous System
    Peter J McKinnon; Fiscal Year: 2010
    ..As many cancer therapies induce DNA damage, the results from this proposal may have significant therapeutic implications for understanding the mechanism of action of these drugs, particularly in the treatment of brain tumors. ..
  2. ATM AND CELL DEATH IN THE NERVOUS SYSTEM
    PETER MCKINNON; Fiscal Year: 2001
    ....
  3. ATM and DNA Damage in the Nervous System
    PETER MCKINNON; Fiscal Year: 2007
    ..abstract_text> ..
  4. ATM AND CELL DEATH IN THE NERVOUS SYSTEM
    PETER MCKINNON; Fiscal Year: 2006
    ....
  5. IR-INDUCED APOPTOSIS IN THE DEVELOPING NERVOUS SYSTEM
    PETER MCKINNON; Fiscal Year: 2004
    ..Moreover, as neurodegenerative disease may engage similar apoptotic pathways, the findings from this proposal will be relevant for understanding neuronal death in neurodegenerative disease. ..