Jonathan A McCullers

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc A single amino acid change in the C-terminal domain of the matrix protein M1 of influenza B virus confers mouse adaptation and virulence
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105 2794, USA
    Virology 336:318-26. 2005
  2. pmc Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenza
    Asa Karlström
    Department of Infectious Diseases and the Veterinary Pathology Core, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 199:311-9. 2009
  3. pmc Live, attenuated influenza virus (LAIV) vehicles are strong inducers of immunity toward influenza B virus
    Victor C Huber
    Department of Infectious Disease, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Vaccine 26:5381-8. 2008
  4. pmc The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Scand J Infect Dis 40:11-7. 2008
  5. pmc Immunopathogenic and antibacterial effects of H3N2 influenza A virus PB1-F2 map to amino acid residues 62, 75, 79, and 82
    Irina V Alymova
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 2794, USA
    J Virol 85:12324-33. 2011
  6. pmc Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Infect Dis 202:1287-95. 2010
  7. pmc A multi-valent vaccine approach that elicits broad immunity within an influenza subtype
    Victor C Huber
    Department of Infectious Disease, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Vaccine 27:1192-200. 2009
  8. ncbi request reprint Effect of antiviral treatment on the outcome of secondary bacterial pneumonia after influenza
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 190:519-26. 2004
  9. doi request reprint Immunogenicity and safety of inactivated monovalent 2009 H1N1 influenza A vaccine in immunocompromised children and young adults
    Hana Hakim
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 3678, United States
    Vaccine 30:879-85. 2012
  10. pmc Naturally occurring swine influenza A virus PB1-F2 phenotypes that contribute to superinfection with Gram-positive respiratory pathogens
    Jenni N Weeks-Gorospe
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Virol 86:9035-43. 2012

Collaborators

Detail Information

Publications63

  1. pmc A single amino acid change in the C-terminal domain of the matrix protein M1 of influenza B virus confers mouse adaptation and virulence
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105 2794, USA
    Virology 336:318-26. 2005
    ..This observation suggests a role for the C domain of the M1 protein in growth and virulence in a mammalian host...
  2. pmc Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenza
    Asa Karlström
    Department of Infectious Diseases and the Veterinary Pathology Core, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 199:311-9. 2009
    ..These data suggest that beta-lactam therapy may not be optimal as a first-line treatment for community-acquired pneumonia when it follows influenza...
  3. pmc Live, attenuated influenza virus (LAIV) vehicles are strong inducers of immunity toward influenza B virus
    Victor C Huber
    Department of Infectious Disease, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Vaccine 26:5381-8. 2008
    ..Our results differ from generally accepted influenza A virus vaccine models, and argue that strategies for control of influenza B virus should be considered separately from those for influenza A virus...
  4. pmc The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Scand J Infect Dis 40:11-7. 2008
    ....
  5. pmc Immunopathogenic and antibacterial effects of H3N2 influenza A virus PB1-F2 map to amino acid residues 62, 75, 79, and 82
    Irina V Alymova
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 2794, USA
    J Virol 85:12324-33. 2011
    ....
  6. pmc Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Infect Dis 202:1287-95. 2010
    ..Overall, these data argue that the relationship between respiratory viral infections, acquisition of pneumococci, and development of disease in humans needs further study to be better understood...
  7. pmc A multi-valent vaccine approach that elicits broad immunity within an influenza subtype
    Victor C Huber
    Department of Infectious Disease, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Vaccine 27:1192-200. 2009
    ....
  8. ncbi request reprint Effect of antiviral treatment on the outcome of secondary bacterial pneumonia after influenza
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 190:519-26. 2004
    ....
  9. doi request reprint Immunogenicity and safety of inactivated monovalent 2009 H1N1 influenza A vaccine in immunocompromised children and young adults
    Hana Hakim
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 3678, United States
    Vaccine 30:879-85. 2012
    ..Influenza vaccination is recommended for immunocompromised patients...
  10. pmc Naturally occurring swine influenza A virus PB1-F2 phenotypes that contribute to superinfection with Gram-positive respiratory pathogens
    Jenni N Weeks-Gorospe
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Virol 86:9035-43. 2012
    ..These findings support efforts to increase influenza virus surveillance to consider viral genotypes that could be used to predict increased severity of superinfections with specific Gram-positive respiratory pathogens...
  11. pmc Receptor-binding specificity of the human parainfluenza virus type 1 hemagglutinin-neuraminidase glycoprotein
    Irina V Alymova
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Glycobiology 22:174-80. 2012
    ..Binding to α2-3-linked SAs with a sulfated sialyl-Lewis motif as well as to α2-8-linked SAs was unique for the second binding site. Neither site recognizes α2-6-linked oligosaccharides...
  12. pmc Influenza virus primes mice for pneumonia from Staphylococcus aureus
    Amy R Iverson
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Infect Dis 203:880-8. 2011
    ..The viral cytotoxin PB1-F2 contributed to the negative outcomes. These data suggest that additional study of specific bacterial virulence factors involved in the pathogenesis of inflammation and lung damage during coinfections is needed...
  13. pmc Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia
    Julie L McAuley
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Host Microbe 2:240-9. 2007
    ..These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic...
  14. pmc Molecular signatures of virulence in the PB1-F2 proteins of H5N1 influenza viruses
    Amber M Smith
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Virus Res 178:146-50. 2013
    ..Surveillance efforts should include sequencing of the PB1 gene segment and analysis for these molecular signatures to allow for the potential prioritization of resources during pandemic planning. ..
  15. doi request reprint Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections
    Hazem E Ghoneim
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 191:1250-9. 2013
    ..This novel mechanism will inform development of novel therapeutic approaches to restore lung innate immunity against bacterial superinfections...
  16. doi request reprint Vaccines against pandemic influenza: what can be done before the next pandemic?
    Victor C Huber
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Pediatr Infect Dis J 27:S113-7. 2008
    ..Thus, a prepandemic vaccine strategy that involves the stockpiling of both potential antigens and proven adjuvants may represent the best approach to deal with this looming threat...
  17. pmc Novel strategy to prevent otitis media caused by colonizing Streptococcus pneumoniae
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 3:e28. 2007
  18. pmc PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathology
    Julie L McAuley
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 6:e1001014. 2010
    ..These data suggest that the PB1-F2 protein contributes to the virulence of pandemic strains when the PB1 gene segment is recently derived from the avian reservoir...
  19. pmc Distinct contributions of vaccine-induced immunoglobulin G1 (IgG1) and IgG2a antibodies to protective immunity against influenza
    Victor C Huber
    Deparment of Infectious Disease, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Clin Vaccine Immunol 13:981-90. 2006
    ..This study details separate but important roles for both IgG1 and IgG2a expression in vaccination against influenza and argues for the development of vaccine regimens that stimulate and measure expression of both antibody isotypes...
  20. ncbi request reprint Role of neuraminidase in lethal synergism between influenza virus and Streptococcus pneumoniae
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 187:1000-9. 2003
    ..Selective NA inhibitors may be useful clinically to interrupt this novel mechanism of synergism and to prevent excess mortality from secondary bacterial pneumonia...
  21. pmc Bacterial sinusitis and otitis media following influenza virus infection in ferrets
    Ville T Peltola
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Infect Immun 74:2562-7. 2006
    ..These data may partially explain why bacterial complication rates are higher during seasons when H3N2 viruses predominate. This animal model will be useful for further study of the mechanisms that underlie viral-bacterial synergism...
  22. doi request reprint Safety and immunogenicity of live attenuated and inactivated influenza vaccines in children with cancer
    Silvana Carr
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, USA
    J Infect Dis 204:1475-82. 2011
    ..The safety and immunogenicity of live, attenuated influenza vaccine (LAIV) has not been compared to that of the standard trivalent inactivated vaccine (TIV) in children with cancer...
  23. pmc Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice
    Glendie Marcelin
    Department of Infectious Diseases, Division of Virology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Mail Stop 330, Memphis, TN 38105, USA
    J Virol 85:11208-19. 2011
    ..Therefore, immunopathology likely caused by elevated cellular recruitment is an implicated mechanism of severe pH1N1 infection in pregnant mice...
  24. pmc Kinetics of coinfection with influenza A virus and Streptococcus pneumoniae
    Amber M Smith
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 9:e1003238. 2013
    ..Our model provides a framework to investigate pathogen interaction during coinfections and to uncover dynamical differences based on inoculum size and strain...
  25. pmc N-linked glycosylation attenuates H3N2 influenza viruses
    David J Vigerust
    St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    J Virol 81:8593-600. 2007
    ..The continued exploration of interactions between highly glycosylated viruses and surfactant proteins may lead to an improved understanding of the biology within the lung and strategies for viral control...
  26. pmc Induction of pro- and anti-inflammatory molecules in a mouse model of pneumococcal pneumonia after influenza
    Matthew W Smith
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, USA
    Comp Med 57:82-9. 2007
    ..Mortality correlated with the development of pneumonia and lung inflammation but not with bacteremia. This model has the potential to help us understand the pathogenesis of severe lung infections...
  27. ncbi request reprint Chloroquine is effective against influenza A virus in vitro but not in vivo
    David J Vigerust
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Influenza Other Respi Viruses 1:189-92. 2007
    ..Chloroquine is an inexpensive and widely available 9-aminoquinolone used in the management of malaria. Recently, in vitro assays suggest that chloroquine may have utility in the treatment of several viral infections including influenza...
  28. ncbi request reprint Adjunctive corticosteroid therapy improves lung immunopathology and survival during severe secondary pneumococcal pneumonia in mice
    Hazem E Ghoneim
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee
    J Infect Dis 209:1459-68. 2014
    ..These data support adjunctive clinical use of corticosteroids in severe cases of community-acquired pneumonia. ..
  29. doi request reprint Correlates of vaccine protection from influenza and its complications
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, USA
    Hum Vaccin Immunother 8:34-44. 2012
    ..Assessment of vaccine effectiveness for both viral and bacterial vaccines should include measures of impact on secondary bacterial pneumonia...
  30. pmc Improving therapeutic strategies for secondary bacterial pneumonia following influenza
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Future Microbiol 3:397-404. 2008
    ..In the not-so-distant future, strategies aimed at disarming pathogens without eliminating them may be more effective than our current treatment paradigms...
  31. ncbi request reprint FluBlok, a recombinant influenza vaccine
    Victor C Huber
    St Jude Children s Research Hospital, Department of Infectious Disease, Memphis, TN 38105, USA
    Curr Opin Mol Ther 10:75-85. 2008
    ..Phase III clinical trials to compare FluBlok and a licensed trivalent influenza vaccine for immunogenicity, safety and efficacy in preventing naturally occurring influenza are ongoing...
  32. pmc Toll-like receptor 2 mediates fatal immunopathology in mice during treatment of secondary pneumococcal pneumonia following influenza
    Asa Karlström
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Infect Dis 204:1358-66. 2011
    ..These data suggest that strategies for eliminating bacteria without lysis coupled with immunomodulation of inflammation should be pursued clinically...
  33. pmc No evidence of a link between influenza vaccines and Guillain-Barre syndrome-associated antiganglioside antibodies
    David J Wang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Influenza Other Respir Viruses 6:159-66. 2012
    ..Previously, influenza vaccination was linked with the increased incidence of GBS; however, whether antiganglioside antibodies are subsequently induced remains unresolved...
  34. pmc The effects of influenza A virus PB1-F2 protein on polymerase activity are strain specific and do not impact pathogenesis
    Julie L McAuley
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Virol 84:558-64. 2010
    ..Alternate mechanisms besides alterations to replication are likely responsible for the enhanced virulence in mammalian hosts attributed to PB1-F2 in previous studies...
  35. pmc Recipients of vaccine against the 1976 "swine flu" have enhanced neutralization responses to the 2009 novel H1N1 influenza virus
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Infect Dis 50:1487-92. 2010
    ..Receipt of a vaccine to a related virus significantly enhanced the neutralization capacity of these responses, suggesting homologous vaccination against the 2009 pandemic H1N1 influenza virus would have a similar effect...
  36. ncbi request reprint Respiratory viruses predisposing to bacterial infections: role of neuraminidase
    Ville T Peltola
    Department of Infectious Diseases, St Judes Children s Research Hospital, Memphis, TN, USA
    Pediatr Infect Dis J 23:S87-97. 2004
    ..This article focuses on viral and bacterial combinations, particularly synergism between influenza and Streptococcus pneumoniae...
  37. pmc The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae
    Irina V Alymova
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Antimicrob Agents Chemother 49:398-405. 2005
    ..Prophylaxis of parainfluenza virus infections with antivirals might be an effective strategy for prevention of secondary bacterial complications in humans...
  38. ncbi request reprint Increased influenza vaccination of healthcare workers at a pediatric cancer hospital: results of a comprehensive influenza vaccination campaign
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Infect Control Hosp Epidemiol 27:77-9. 2006
    ..A strategy of weekly feedback to unvaccinated employees was the most important factor in enhancing the rate of vaccination acceptance and was particularly effective among the nursing staff...
  39. doi request reprint The co-pathogenesis of influenza viruses with bacteria in the lung
    Jonathan A McCullers
    1 Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee 38103, USA 2 Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Rev Microbiol 12:252-62. 2014
    ..In this Review, advances in our understanding of the underlying mechanisms are discussed, and the key questions that will drive the field forwards are articulated. ..
  40. pmc Insights into the interaction between influenza virus and pneumococcus
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Clin Microbiol Rev 19:571-82. 2006
    ..Identification and exploration of the underlying mechanisms responsible for this synergism will provide targets for prevention and treatment using drugs and vaccines...
  41. doi request reprint Motivating factors for high rates of influenza vaccination among healthcare workers
    Hana Hakim
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, United States
    Vaccine 29:5963-9. 2011
    ..Factors associated with HCW uptake of influenza vaccines have not previously been evaluated in a high compliance rate setting...
  42. pmc Influenza virus neuraminidase contributes to secondary bacterial pneumonia
    Ville T Peltola
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 192:249-57. 2005
    ..These data lend support to our hypothesis that the influenza virus neuraminidase contributes to secondary bacterial pneumonia and subsequent excess mortality...
  43. pmc Glycan shielding of the influenza virus hemagglutinin contributes to immunopathology in mice
    Keith Wanzeck
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Am J Respir Crit Care Med 183:767-73. 2011
    ..Gain of glycans within antigenic sites of the HA during adaptation to the mammalian lung facilitates immune evasion...
  44. doi request reprint Seroprevalence of seasonal and pandemic influenza A viruses in domestic cats
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Arch Virol 156:117-20. 2011
    ..Seroprevalance of seasonal H1N1 (41.9%) and H3N2 (25.6%) viruses was similarly high. These data reflecting past infection of household cats raise the possibility that they may act as a vector of influenza transmission within households...
  45. ncbi request reprint WASP- mice exhibit defective immune responses to influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG
    Samita Andreansky
    Department of Immunology, St Jude Children s Hospital, Memphis, TN 38104, USA
    Exp Hematol 33:443-51. 2005
    ..To quantify the immune response of WASP- mice to three different pathogens: influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis...
  46. pmc Preparing for the next influenza pandemic
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Pediatr Infect Dis J 27:S57-9. 2008
    ..Physicians and hospitals can begin by educating themselves on the problem and developing a pandemic plan for their own practice or organization...
  47. ncbi request reprint Live attenuated influenza vaccine is safe and immunogenic in immunocompromised ferrets
    Victor C Huber
    Department of Infectious Disease, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 193:677-84. 2006
    ..These findings support the potential use of this vaccine in immunocompromised humans...
  48. doi request reprint Therapeutics against influenza
    Elena A Govorkova
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Curr Top Microbiol Immunol 370:273-300. 2013
    ..Therapy for influenza will likely undergo substantial changes in the decades to come, evolving with our knowledge of pathogenesis as new approaches become viable and are validated clinically...
  49. ncbi request reprint Antiviral therapy of influenza
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105 2794, USA
    Expert Opin Investig Drugs 14:305-12. 2005
    ..This review presents the current status of antiviral therapy of, and highlights the challenges presented by, the threat of pandemic influenza...
  50. ncbi request reprint Early vancomycin therapy and adverse outcomes in children with pneumococcal meningitis
    Steven C Buckingham
    Department of Pediatrics, University of Tennessee Health Science Center, Le Bonheur Children s Medical Center, Memphis, Tennessee, USA
    Pediatrics 117:1688-94. 2006
    ..The relationship between timing of the first dose of vancomycin relative to other antibiotics and outcome in these children, however, has not been addressed...
  51. doi request reprint Preventing and treating secondary bacterial infections with antiviral agents
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, USA
    Antivir Ther 16:123-35. 2011
    ..By applying these insights to antiviral drug development, the potential exists to improve outcomes by means other than direct inhibition of the virus...
  52. pmc Immunotherapy with a combination of intravenous immune globulin and p4 peptide rescues mice from postinfluenza pneumococcal pneumonia
    Jenni N Weeks
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Antimicrob Agents Chemother 55:2276-81. 2011
    ..Antibody-based therapies, when coupled with immune modulators, such as P4 peptide, may be an effective tool together with antibiotics in our armamentarium against severe pneumonia...
  53. pmc The immune profile associated with acute allergic asthma accelerates clearance of influenza virus
    Amali E Samarasinghe
    1 Department of Infectious Diseases, Memphis, TN, USA 2 St Jude Children s Research Hospital, Memphis, TN, USA 3 Department of Pediatrics, University of Tennessee Health Science Center, Children s Foundation Research Center, Memphis, TN, USA
    Immunol Cell Biol 92:449-59. 2014
    ..These murine models of asthma and influenza comorbidity may improve our understanding of the epidemiology and pathogenesis of viral infections in humans with asthma. ..
  54. ncbi request reprint Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptor
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 186:341-50. 2002
    ..The model of lethal synergism will be a useful tool for exploring this and other mechanisms underlying viral-bacterial interactions...
  55. doi request reprint A practical guide to alcohol-based hand hygiene infrastructure in a resource-poor pediatric hospital
    Miguela A Caniza
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Am J Infect Control 37:851-4. 2009
    ..Alcohol-based HH can compensate for inadequate infrastructure and supplies. We describe the implementation of alcohol-based HH in five high-risk wards of a pediatric hospital in El Salvador...
  56. ncbi request reprint Evolution, benefits, and shortcomings of vaccine management
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Manag Care Pharm 13:S2-6. 2007
    ..However, many targets for immunization remain uncontrolled, and new or improved vaccines are emerging to meet these challenges...
  57. ncbi request reprint Levels of total fungus and Aspergillus on a pediatric hematopoietic stem cell transplant unit
    Mary Elizabeth Hensley
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr Oncol Nurs 21:67-78. 2004
    ..t tests and analysis of variance were used to verify the findings...
  58. pmc Multiple genotypes of influenza B virus circulated between 1979 and 2003
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    J Virol 78:12817-28. 2004
    ....
  59. pmc Are toilet seats a vector for transmission of methicillin-resistant Staphylococcus aureus?
    Mary Anne Giannini
    Infection Control Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Am J Infect Control 37:505-6. 2009
    ..Methicillin-resistant Staphylococcus aureus (MRSA) was recovered from 3.3% of hospital toilets when wipes were not in use. Use of wipes resulted in a 50-fold reduction in mean daily bacterial counts and eliminated MRSA...
  60. ncbi request reprint The clinical need for new antiviral drugs directed against influenza virus
    Jonathan A McCullers
    J Infect Dis 193:751-3. 2006
  61. pmc c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection
    Abiodun D Ogunniyi
    School of Molecular and Biomedical Science, University of Adelaide, South Australia 5005, Australia
    Vaccine 26:4676-85. 2008
    ..We propose that c-di-GMP can be used as an effective broad spectrum immunomodulator and vaccine adjuvant to prevent infectious diseases...
  62. pmc Planning for an influenza pandemic: thinking beyond the virus
    Jonathan A McCullers
    J Infect Dis 198:945-7. 2008
  63. pmc A step closer to meeting the threat of avian influenza
    Stacey Schultz-Cherry
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Med 3:e375. 2006