J A McCullers

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptor
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 186:341-50. 2002
  2. ncbi request reprint Levels of total fungus and Aspergillus on a pediatric hematopoietic stem cell transplant unit
    Mary Elizabeth Hensley
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr Oncol Nurs 21:67-78. 2004
  3. pmc The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae
    Irina V Alymova
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Antimicrob Agents Chemother 49:398-405. 2005
  4. ncbi request reprint Increased influenza vaccination of healthcare workers at a pediatric cancer hospital: results of a comprehensive influenza vaccination campaign
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Infect Control Hosp Epidemiol 27:77-9. 2006
  5. pmc Distinct contributions of vaccine-induced immunoglobulin G1 (IgG1) and IgG2a antibodies to protective immunity against influenza
    Victor C Huber
    Deparment of Infectious Disease, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Clin Vaccine Immunol 13:981-90. 2006
  6. pmc PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathology
    Julie L McAuley
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 6:e1001014. 2010
  7. pmc The age distribution of mortality due to influenza: pandemic and peri-pandemic
    Tom Reichert
    Entropy Research Institute, 345 S, Great Road, Lincoln, 01773, Massachusetts, USA
    BMC Med 10:162. 2012
  8. pmc Does Glycosylation as a modifier of Original Antigenic Sin explain the case age distribution and unusual toxicity in pandemic novel H1N1 influenza?
    Tom Reichert
    Entropy Research Institute, 345 S, Great Road, Lincoln, Massachusetts 01773, USA
    BMC Infect Dis 10:5. 2010
  9. ncbi request reprint Evolution, benefits, and shortcomings of vaccine management
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Manag Care Pharm 13:S2-6. 2007
  10. pmc Reassortment and insertion-deletion are strategies for the evolution of influenza B viruses in nature
    J A McCullers
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 73:7343-8. 1999

Research Grants

  1. 2nd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2003
  2. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009
  3. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
  4. Influenza-pneumococcal synergism: role of neuraminidase
    Jonathan McCullers; Fiscal Year: 2004
  5. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2005
  6. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
  7. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2006
  8. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2007

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptor
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 186:341-50. 2002
    ..The model of lethal synergism will be a useful tool for exploring this and other mechanisms underlying viral-bacterial interactions...
  2. ncbi request reprint Levels of total fungus and Aspergillus on a pediatric hematopoietic stem cell transplant unit
    Mary Elizabeth Hensley
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr Oncol Nurs 21:67-78. 2004
    ..t tests and analysis of variance were used to verify the findings...
  3. pmc The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae
    Irina V Alymova
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Antimicrob Agents Chemother 49:398-405. 2005
    ..Prophylaxis of parainfluenza virus infections with antivirals might be an effective strategy for prevention of secondary bacterial complications in humans...
  4. ncbi request reprint Increased influenza vaccination of healthcare workers at a pediatric cancer hospital: results of a comprehensive influenza vaccination campaign
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Infect Control Hosp Epidemiol 27:77-9. 2006
    ..A strategy of weekly feedback to unvaccinated employees was the most important factor in enhancing the rate of vaccination acceptance and was particularly effective among the nursing staff...
  5. pmc Distinct contributions of vaccine-induced immunoglobulin G1 (IgG1) and IgG2a antibodies to protective immunity against influenza
    Victor C Huber
    Deparment of Infectious Disease, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Clin Vaccine Immunol 13:981-90. 2006
    ..This study details separate but important roles for both IgG1 and IgG2a expression in vaccination against influenza and argues for the development of vaccine regimens that stimulate and measure expression of both antibody isotypes...
  6. pmc PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathology
    Julie L McAuley
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 6:e1001014. 2010
    ..These data suggest that the PB1-F2 protein contributes to the virulence of pandemic strains when the PB1 gene segment is recently derived from the avian reservoir...
  7. pmc The age distribution of mortality due to influenza: pandemic and peri-pandemic
    Tom Reichert
    Entropy Research Institute, 345 S, Great Road, Lincoln, 01773, Massachusetts, USA
    BMC Med 10:162. 2012
    ..Pandemic influenza is said to 'shift mortality' to younger age groups; but also to spare a subpopulation of the elderly population. Does one of these effects dominate? Might this have important ramifications?..
  8. pmc Does Glycosylation as a modifier of Original Antigenic Sin explain the case age distribution and unusual toxicity in pandemic novel H1N1 influenza?
    Tom Reichert
    Entropy Research Institute, 345 S, Great Road, Lincoln, Massachusetts 01773, USA
    BMC Infect Dis 10:5. 2010
    ..However, this principle is not sufficient to explain the graded susceptibility between ages 20 and 60, the reduced susceptibility in children below age 10, and the unusual toxicity observed...
  9. ncbi request reprint Evolution, benefits, and shortcomings of vaccine management
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Manag Care Pharm 13:S2-6. 2007
    ..However, many targets for immunization remain uncontrolled, and new or improved vaccines are emerging to meet these challenges...
  10. pmc Reassortment and insertion-deletion are strategies for the evolution of influenza B viruses in nature
    J A McCullers
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 73:7343-8. 1999
    ..Reassortment plays a role in the evolution of influenza B viruses and may necessitate a change in the methods used to assess and identify new influenza viruses...
  11. ncbi request reprint Antiviral therapy of influenza
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105 2794, USA
    Expert Opin Investig Drugs 14:305-12. 2005
    ..This review presents the current status of antiviral therapy of, and highlights the challenges presented by, the threat of pandemic influenza...
  12. pmc Recipients of vaccine against the 1976 "swine flu" have enhanced neutralization responses to the 2009 novel H1N1 influenza virus
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Infect Dis 50:1487-92. 2010
    ..Receipt of a vaccine to a related virus significantly enhanced the neutralization capacity of these responses, suggesting homologous vaccination against the 2009 pandemic H1N1 influenza virus would have a similar effect...
  13. pmc Novel strategy to prevent otitis media caused by colonizing Streptococcus pneumoniae
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 3:e28. 2007
  14. pmc Insights into the interaction between influenza virus and pneumococcus
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Clin Microbiol Rev 19:571-82. 2006
    ..Identification and exploration of the underlying mechanisms responsible for this synergism will provide targets for prevention and treatment using drugs and vaccines...
  15. pmc Preparing for the next influenza pandemic
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Pediatr Infect Dis J 27:S57-9. 2008
    ..Physicians and hospitals can begin by educating themselves on the problem and developing a pandemic plan for their own practice or organization...
  16. pmc Improving therapeutic strategies for secondary bacterial pneumonia following influenza
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Future Microbiol 3:397-404. 2008
    ..In the not-so-distant future, strategies aimed at disarming pathogens without eliminating them may be more effective than our current treatment paradigms...
  17. doi request reprint Seroprevalence of seasonal and pandemic influenza A viruses in domestic cats
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Arch Virol 156:117-20. 2011
    ..Seroprevalance of seasonal H1N1 (41.9%) and H3N2 (25.6%) viruses was similarly high. These data reflecting past infection of household cats raise the possibility that they may act as a vector of influenza transmission within households...
  18. doi request reprint Preventing and treating secondary bacterial infections with antiviral agents
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, USA
    Antivir Ther 16:123-35. 2011
    ..By applying these insights to antiviral drug development, the potential exists to improve outcomes by means other than direct inhibition of the virus...
  19. ncbi request reprint Isolation and characterization of vancomycin-tolerant Streptococcus pneumoniae from the cerebrospinal fluid of a patient who developed recrudescent meningitis
    J A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital Division of Infectious Diseases, Center, Memphis, Tennessee, USA
    J Infect Dis 181:369-73. 2000
    ..Because tolerance is a precursor phenotype to resistance and may lead to clinical failure of antibiotic therapy, these observations may have important implications for vancomycin use in infections caused by S. pneumoniae...
  20. ncbi request reprint Candidal meningitis in children with cancer
    J A McCullers
    Departments of Infectious Diseases and Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Clin Infect Dis 31:451-7. 2000
    ..The cases were invariably fatal, supporting aggressive treatment of candidal meningitis in immunocompromised patients and further study of the prevention, diagnosis, and management of C. tropicalis meningitis...
  21. ncbi request reprint Molecular pathogenesis of pneumococcal pneumonia
    J A McCullers
    Department of Infectious Diseases, St Jude Children s, Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Front Biosci 6:D877-89. 2001
    ..In this review we will discuss recent advances in our understanding of the pathogenesis of pneumonia due to S. pneumoniae, highlighting emerging themes common to other organisms such as Haemophilus influenzae and Neisseria meningitidis...
  22. pmc The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Scand J Infect Dis 40:11-7. 2008
    ....
  23. ncbi request reprint Role of neuraminidase in lethal synergism between influenza virus and Streptococcus pneumoniae
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 187:1000-9. 2003
    ..Selective NA inhibitors may be useful clinically to interrupt this novel mechanism of synergism and to prevent excess mortality from secondary bacterial pneumonia...
  24. pmc Multiple genotypes of influenza B virus circulated between 1979 and 2003
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    J Virol 78:12817-28. 2004
    ....
  25. ncbi request reprint Effect of antiviral treatment on the outcome of secondary bacterial pneumonia after influenza
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 190:519-26. 2004
    ....
  26. pmc Immunopathogenic and antibacterial effects of H3N2 influenza A virus PB1-F2 map to amino acid residues 62, 75, 79, and 82
    Irina V Alymova
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 2794, USA
    J Virol 85:12324-33. 2011
    ....
  27. pmc Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenza
    Asa Karlström
    Department of Infectious Diseases and the Veterinary Pathology Core, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 199:311-9. 2009
    ..These data suggest that beta-lactam therapy may not be optimal as a first-line treatment for community-acquired pneumonia when it follows influenza...
  28. pmc Live, attenuated influenza virus (LAIV) vehicles are strong inducers of immunity toward influenza B virus
    Victor C Huber
    Department of Infectious Disease, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Vaccine 26:5381-8. 2008
    ..Our results differ from generally accepted influenza A virus vaccine models, and argue that strategies for control of influenza B virus should be considered separately from those for influenza A virus...
  29. ncbi request reprint Bacillus cereus bacteremia and meningitis in immunocompromised children
    A H Gaur
    Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
    Clin Infect Dis 32:1456-62. 2001
    ..cereus toxins...
  30. ncbi request reprint Respiratory viruses predisposing to bacterial infections: role of neuraminidase
    Ville T Peltola
    Department of Infectious Diseases, St Judes Children s Research Hospital, Memphis, TN, USA
    Pediatr Infect Dis J 23:S87-97. 2004
    ..This article focuses on viral and bacterial combinations, particularly synergism between influenza and Streptococcus pneumoniae...
  31. pmc A multi-valent vaccine approach that elicits broad immunity within an influenza subtype
    Victor C Huber
    Department of Infectious Disease, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Vaccine 27:1192-200. 2009
    ....
  32. ncbi request reprint Pneumococcal meningitis in children: relationship of antibiotic resistance to clinical characteristics and outcomes
    S C Buckingham
    Department of Pediatrics, University of Tennessee Health Science Center, Le Bonheur Children s Medical Center, Memphis, TN, USA
    Pediatr Infect Dis J 20:837-43. 2001
    ..Previous studies have been limited by inclusion of relatively few patients infected with nonsusceptible pneumococci and inconsistent use of empiric vancomycin...
  33. pmc Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Infect Dis 202:1287-95. 2010
    ..Overall, these data argue that the relationship between respiratory viral infections, acquisition of pneumococci, and development of disease in humans needs further study to be better understood...
  34. doi request reprint A practical guide to alcohol-based hand hygiene infrastructure in a resource-poor pediatric hospital
    Miguela A Caniza
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Am J Infect Control 37:851-4. 2009
    ..Alcohol-based HH can compensate for inadequate infrastructure and supplies. We describe the implementation of alcohol-based HH in five high-risk wards of a pediatric hospital in El Salvador...
  35. doi request reprint Vaccines against pandemic influenza: what can be done before the next pandemic?
    Victor C Huber
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Pediatr Infect Dis J 27:S113-7. 2008
    ..Thus, a prepandemic vaccine strategy that involves the stockpiling of both potential antigens and proven adjuvants may represent the best approach to deal with this looming threat...
  36. pmc A single amino acid change in the C-terminal domain of the matrix protein M1 of influenza B virus confers mouse adaptation and virulence
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105 2794, USA
    Virology 336:318-26. 2005
    ..This observation suggests a role for the C domain of the M1 protein in growth and virulence in a mammalian host...
  37. ncbi request reprint Live attenuated influenza vaccine is safe and immunogenic in immunocompromised ferrets
    Victor C Huber
    Department of Infectious Disease, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 193:677-84. 2006
    ..These findings support the potential use of this vaccine in immunocompromised humans...
  38. pmc Bacterial sinusitis and otitis media following influenza virus infection in ferrets
    Ville T Peltola
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Infect Immun 74:2562-7. 2006
    ..These data may partially explain why bacterial complication rates are higher during seasons when H3N2 viruses predominate. This animal model will be useful for further study of the mechanisms that underlie viral-bacterial synergism...
  39. pmc Glycan shielding of the influenza virus hemagglutinin contributes to immunopathology in mice
    Keith Wanzeck
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Am J Respir Crit Care Med 183:767-73. 2011
    ..Gain of glycans within antigenic sites of the HA during adaptation to the mammalian lung facilitates immune evasion...
  40. pmc Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia
    Julie L McAuley
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Host Microbe 2:240-9. 2007
    ..These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic...
  41. ncbi request reprint Chloroquine is effective against influenza A virus in vitro but not in vivo
    David J Vigerust
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Influenza Other Respi Viruses 1:189-92. 2007
    ..Chloroquine is an inexpensive and widely available 9-aminoquinolone used in the management of malaria. Recently, in vitro assays suggest that chloroquine may have utility in the treatment of several viral infections including influenza...
  42. ncbi request reprint WASP- mice exhibit defective immune responses to influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG
    Samita Andreansky
    Department of Immunology, St Jude Children s Hospital, Memphis, TN 38104, USA
    Exp Hematol 33:443-51. 2005
    ..To quantify the immune response of WASP- mice to three different pathogens: influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis...
  43. pmc N-linked glycosylation attenuates H3N2 influenza viruses
    David J Vigerust
    St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    J Virol 81:8593-600. 2007
    ..The continued exploration of interactions between highly glycosylated viruses and surfactant proteins may lead to an improved understanding of the biology within the lung and strategies for viral control...
  44. pmc Induction of pro- and anti-inflammatory molecules in a mouse model of pneumococcal pneumonia after influenza
    Matthew W Smith
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, USA
    Comp Med 57:82-9. 2007
    ..Mortality correlated with the development of pneumonia and lung inflammation but not with bacteremia. This model has the potential to help us understand the pathogenesis of severe lung infections...
  45. ncbi request reprint FluBlok, a recombinant influenza vaccine
    Victor C Huber
    St Jude Children s Research Hospital, Department of Infectious Disease, Memphis, TN 38105, USA
    Curr Opin Mol Ther 10:75-85. 2008
    ..Phase III clinical trials to compare FluBlok and a licensed trivalent influenza vaccine for immunogenicity, safety and efficacy in preventing naturally occurring influenza are ongoing...
  46. pmc Influenza virus neuraminidase contributes to secondary bacterial pneumonia
    Ville T Peltola
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 192:249-57. 2005
    ..These data lend support to our hypothesis that the influenza virus neuraminidase contributes to secondary bacterial pneumonia and subsequent excess mortality...
  47. doi request reprint Do specific virus-bacteria pairings drive clinical outcomes of pneumonia?
    J A McCullers
    Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, TN 38103, USA
    Clin Microbiol Infect 19:113-8. 2013
    ..This would have implications for surveillance, vaccine development, and the conduct of clinical trials for the prevention or treatment of pneumonia...
  48. ncbi request reprint Association between tea ingestion and invasive Bacillus cereus infection among children with cancer
    C M El Saleeby
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Infect Dis 39:1536-9. 2004
    ..cereus bacteremia. Policies designed to interrupt transmission of this pathogen to susceptible patients should be considered...
  49. pmc Are toilet seats a vector for transmission of methicillin-resistant Staphylococcus aureus?
    Mary Anne Giannini
    Infection Control Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Am J Infect Control 37:505-6. 2009
    ..Methicillin-resistant Staphylococcus aureus (MRSA) was recovered from 3.3% of hospital toilets when wipes were not in use. Use of wipes resulted in a 50-fold reduction in mean daily bacterial counts and eliminated MRSA...
  50. pmc The effects of influenza A virus PB1-F2 protein on polymerase activity are strain specific and do not impact pathogenesis
    Julie L McAuley
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Virol 84:558-64. 2010
    ..Alternate mechanisms besides alterations to replication are likely responsible for the enhanced virulence in mammalian hosts attributed to PB1-F2 in previous studies...
  51. ncbi request reprint Early vancomycin therapy and adverse outcomes in children with pneumococcal meningitis
    Steven C Buckingham
    Department of Pediatrics, University of Tennessee Health Science Center, Le Bonheur Children s Medical Center, Memphis, Tennessee, USA
    Pediatrics 117:1688-94. 2006
    ..The relationship between timing of the first dose of vancomycin relative to other antibiotics and outcome in these children, however, has not been addressed...
  52. pmc Immunotherapy with a combination of intravenous immune globulin and p4 peptide rescues mice from postinfluenza pneumococcal pneumonia
    Jenni N Weeks
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Antimicrob Agents Chemother 55:2276-81. 2011
    ..Antibody-based therapies, when coupled with immune modulators, such as P4 peptide, may be an effective tool together with antibiotics in our armamentarium against severe pneumonia...
  53. pmc c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection
    Abiodun D Ogunniyi
    School of Molecular and Biomedical Science, University of Adelaide, South Australia 5005, Australia
    Vaccine 26:4676-85. 2008
    ..We propose that c-di-GMP can be used as an effective broad spectrum immunomodulator and vaccine adjuvant to prevent infectious diseases...
  54. ncbi request reprint The clinical need for new antiviral drugs directed against influenza virus
    Jonathan A McCullers
    J Infect Dis 193:751-3. 2006
  55. pmc A step closer to meeting the threat of avian influenza
    Stacey Schultz-Cherry
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Med 3:e375. 2006
  56. pmc Planning for an influenza pandemic: thinking beyond the virus
    Jonathan A McCullers
    J Infect Dis 198:945-7. 2008

Research Grants9

  1. 2nd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2003
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  2. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009
    ....
  3. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
    ....
  4. Influenza-pneumococcal synergism: role of neuraminidase
    Jonathan McCullers; Fiscal Year: 2004
    ....
  5. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2005
    ....
  6. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  7. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2006
    ....
  8. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2007
    ....