A T Look

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint Oncogenic transcription factors in the human acute leukemias
    A T Look
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA 38163, USA
    Science 278:1059-64. 1997
  2. pmc DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein
    T Inaba
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Mol Cell Biol 14:3403-13. 1994
  3. ncbi request reprint SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein
    T Inukai
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell 4:343-52. 1999
  4. pmc The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1
    J Dang
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell Biol 21:5935-45. 2001
  5. ncbi request reprint Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1)
    S M Bodner
    Department of Pathology and Laboratory Medicine, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Gene 229:223-8. 1999
  6. ncbi request reprint Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
    Z A Khatib
    Department of Experimental Oncology and Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Cancer Res 53:5535-41. 1993
  7. pmc The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF
    T Inukai
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 18:6035-43. 1998
  8. ncbi request reprint cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2)
    M U Kuefer
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, 38101, USA
    Genomics 35:392-6. 1996
  9. pmc cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia
    J K Hitzler
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Am J Pathol 155:53-9. 1999
  10. pmc E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF
    T Yoshihara
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 15:3247-55. 1995

Collaborators

  • T Inaba
  • T Inukai
  • K Goi
  • H Li
  • D A Reardon
  • B G Jones
  • J R Downing
  • C L Willman
  • L C Bowman
  • D P Cerretti
  • D W Drolet
  • J Xiang
  • S C Peiper
  • P Mathew
  • K Ozawa
  • S L Cohn
  • D Malkin
  • M Saito
  • N Nelson
  • F G Behm
  • J K Hitzler
  • S W Morris
  • C W Naeve
  • H Kurosawa
  • J Dang
  • M B Valentine
  • S M Bodner
  • N Yoneda-Kato
  • K M Rakestraw
  • J E Sublett
  • S C Raimondi
  • C J Sherr
  • Z A Khatib
  • S Ikushima
  • M U Kuefer
  • M Valentine
  • M F Roussel
  • N T Lenny
  • S Stifani
  • D N Shapiro
  • M N Kirstein
  • T Yoshihara
  • F W Luthardt
  • V A Valentine
  • N A Jenkins
  • D J Gilbert
  • H D Soares
  • K S Chang
  • J I Morgan
  • T Shinjyo
  • S O'Connel
  • N G Copeland
  • D P Witte
  • - MG Rosenfeld
  • R E Entrekin
  • K W Jolly
  • J M Lahti
  • L H Shapiro
  • S D Nimer
  • J L Cleveland
  • J E Mullersman
  • V Valentine
  • R Kucherlapati
  • K J Cohen
  • A J Carroll
  • D C Williams
  • K Montgomery
  • W M Roberts
  • J Y Kato
  • J Amann
  • G Richmond
  • A E Sinclair
  • D L Saltman
  • V J Kidd
  • T F Brown
  • K G Dittmer
  • J Grenet
  • E C Douglass
  • R A Ashmun
  • H Matsushime
  • C J Kozlosky
  • M P Beckmann
  • L L Deaven
  • J T Foust
  • M Ohtsuka
  • S Seremetis

Detail Information

Publications30

  1. ncbi request reprint Oncogenic transcription factors in the human acute leukemias
    A T Look
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA 38163, USA
    Science 278:1059-64. 1997
    ..The insights gained from studies of translocation-generated oncogenes and their protein products should hasten the development of highly specific, and hence less toxic, forms of leukemia therapy...
  2. pmc DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein
    T Inaba
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Mol Cell Biol 14:3403-13. 1994
    ....
  3. ncbi request reprint SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein
    T Inukai
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell 4:343-52. 1999
    ....
  4. pmc The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1
    J Dang
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell Biol 21:5935-45. 2001
    ..Our results identify a highly conserved family of transcriptional corepressors that are activated by E2A-HLF, and they suggest that downregulation of RUNX1 may contribute to E2A-HLF-mediated leukemogenesis...
  5. ncbi request reprint Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1)
    S M Bodner
    Department of Pathology and Laboratory Medicine, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Gene 229:223-8. 1999
    ..Further study will be needed to determine whether gene-specific mutations implicate hDMP1 as a tumor suppressor in acute leukemias with deletions of the long arm of chromosome 7 or in other types of human malignancy...
  6. ncbi request reprint Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
    Z A Khatib
    Department of Experimental Oncology and Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Cancer Res 53:5535-41. 1993
    ....
  7. pmc The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF
    T Inukai
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 18:6035-43. 1998
    ....
  8. ncbi request reprint cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2)
    M U Kuefer
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, 38101, USA
    Genomics 35:392-6. 1996
    ....
  9. pmc cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia
    J K Hitzler
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Am J Pathol 155:53-9. 1999
    ....
  10. pmc E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF
    T Yoshihara
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 15:3247-55. 1995
    ....
  11. ncbi request reprint The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1
    N Yoneda-Kato
    Department of Experimental Oncology, St Jude Children s Research Hospital
    Oncogene 12:265-75. 1996
    ..The nuclear/nucleolar localization of NPM-MLF1 mirrors that of NPM, indicating that NPM trafficking signals direct MLF1 to an inappropriate cellular compartment in myeloid leukemia cells...
  12. ncbi request reprint Two candidate downstream target genes for E2A-HLF
    H Kurosawa
    Department of Experimental Oncology and the Center for Biotechnology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 93:321-32. 1999
    ....
  13. ncbi request reprint Monoclonal antibodies to the human CSF-1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells
    R A Ashmun
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38101
    Blood 73:827-37. 1989
    ....
  14. ncbi request reprint Reassignment of the human CSF1 gene to chromosome 1p13-p21
    S W Morris
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105
    Blood 78:2013-20. 1991
    ..Assignment of the CSF1 gene to chromosome 1 at bands p13-p21 raises the possibility that it may be altered by certain nonrandom chromosomal abnormalities arising in human hematopoietic malignancies and solid tumors...
  15. ncbi request reprint Chromosomal localization and cDNA cloning of the human DBP and TEF genes
    Z A Khatib
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Genomics 23:344-51. 1994
    ..Knowledge of the human chromosome locations of these PAR proteins will facilitate studies to assess their involvement in carcinogenesis and other fundamental biological processes...
  16. ncbi request reprint Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice
    J K Hitzler
    Department of Experimental Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Brain Res 820:1-11. 1999
    ..Together, these data suggest that Hlf plays a role in the function of differentiated neurons in the adult nervous system rather than programmed cell death...
  17. ncbi request reprint Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
    S W Morris
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, TN 38105
    Science 263:1281-4. 1994
    ..Unscheduled expression of the truncated ALK may contribute to malignant transformation in these lymphomas...
  18. pmc Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N
    A T Look
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38101
    J Clin Invest 83:1299-307. 1989
    ....
  19. pmc Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes
    S Ikushima
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 94:2609-14. 1997
    ....
  20. ncbi request reprint Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors
    H Li
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38101, USA
    Genomics 32:253-9. 1996
    ..These results suggest either that haploinsufficiency of the cyclin C protein is sufficient to promote tumorigenesis or that the important tumor suppressor gene is linked to the CCNC locus...
  21. ncbi request reprint Chromosomal localization of the human smoothened gene (SMOH) to 7q32. 3 by fluorescence in situ hybridization and radiation hybrid mapping
    J E Sublett
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genomics 50:112-4. 1998
  22. ncbi request reprint Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma
    D A Reardon
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Chromosomes Cancer 24:230-7. 1999
    ..Recurrent and exclusive losses of 6q or 22q suggest that these regions harbor tumor suppressor genes that may contribute independently to the pathogenesis of childhood ependymoma...
  23. pmc Detection of MYCN gene amplification in neuroblastoma by fluorescence in situ hybridization: a pediatric oncology group study
    P Mathew
    Department of Experimental Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA
    Neoplasia 3:105-9. 2001
    ....
  24. ncbi request reprint Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma
    J M Lahti
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Nat Genet 7:370-5. 1994
    ..We suggest that the PITSLRE locus may harbour one or more tumour suppressor genes affected by chromosome 1p36 modifications in neuroblastoma...
  25. ncbi request reprint Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells
    L H Shapiro
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee
    J Biol Chem 266:11999-2007. 1991
    ..Both aminopeptidase N transcripts encode the same polypeptide, indicating that the physically distinct promoters must have evolved to regulate expression of this cell-surface peptidase by cells of different tissues...
  26. ncbi request reprint Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes
    W M Roberts
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Howard Hughes Medical Institute, Memphis, Tennessee
    Cell 55:655-61. 1988
    ..The as yet unidentified c-fms promoter/enhancer sequences may be confined to the nucleotides separating the two genes or could potentially lie within the PDGF receptor gene itself...
  27. ncbi request reprint Splice-site mutation of the p53 gene in a family with hereditary breast-ovarian cancer
    K W Jolly
    Department of Experimental Oncology and Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Oncogene 9:97-102. 1994
    ..We propose that the term 'p53 familial cancer syndrome' be applied to clusters of tumors in families with documented germline p53 mutations, regardless of the histopathologic findings or pattern of tumor development...
  28. ncbi request reprint Genomic organization, chromosomal localization, and independent expression of human cyclin D genes
    T Inaba
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Genomics 13:565-74. 1992
    ..The complex patterns of expression of individual cyclin D genes and their evolutionary conservation across species suggest that each family member may play a distinct role in cell cycle progression...
  29. ncbi request reprint Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35
    S W Morris
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Genomics 14:685-91. 1992
    ....
  30. ncbi request reprint Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia
    T Inaba
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105
    Science 257:531-4. 1992
    ....