W Leung

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint Combination immunotherapy with clinical-scale enriched human gammadelta T cells, hu14.18 antibody, and the immunocytokine Fc-IL7 in disseminated neuroblastoma
    Mario Otto
    Department of Hematology Oncology and Animal Resources Center, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 11:8486-91. 2005
  2. pmc KIR-incompatible hematopoietic-cell transplantation for poor prognosis infant acute lymphoblastic leukemia
    Brandon Triplett
    Blood 107:1238-9. 2006
  3. ncbi request reprint Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients
    Usman Yusuf
    Division of Stem Cell Transplantation, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Transplantation 81:1398-404. 2006
  4. ncbi request reprint A prospective cohort study of late sequelae of pediatric allogeneic hematopoietic stem cell transplantation
    Wing Leung
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Medicine (Baltimore) 86:215-24. 2007
  5. pmc Longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation
    Hiroto Inaba
    Department of Bone Marrow Transplantation and Cellular Therapy, MS 1130, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    J Clin Oncol 30:3991-7. 2012
  6. pmc Detectable minimal residual disease before hematopoietic cell transplantation is prognostic but does not preclude cure for children with very-high-risk leukemia
    Wing Leung
    Department of Bone Marrow Transplantation and Cellular Therapy, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105 2794, USA
    Blood 120:468-72. 2012
  7. pmc Immunotherapy in acute leukemia
    Wing Leung
    Division of Bone Marrow Transplantation and Cellular Therapy, Department of Oncology, St Jude Children s Research Hospital, and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38105, USA
    Semin Hematol 46:89-99. 2009
  8. pmc High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemia
    Wing Leung
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 118:223-30. 2011
  9. ncbi request reprint Determinants of antileukemia effects of allogeneic NK cells
    Wing Leung
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    J Immunol 172:644-50. 2004
  10. ncbi request reprint Phenotype and function of human natural killer cells purified by using a clinical-scale immunomagnetic method
    Wing Leung
    Department of Hematology Oncology, St Jude Children s Research Hospital, Mail Stop 260, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Cancer Immunol Immunother 54:389-94. 2005

Detail Information

Publications55

  1. ncbi request reprint Combination immunotherapy with clinical-scale enriched human gammadelta T cells, hu14.18 antibody, and the immunocytokine Fc-IL7 in disseminated neuroblastoma
    Mario Otto
    Department of Hematology Oncology and Animal Resources Center, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 11:8486-91. 2005
    ..We tested combinations of clinical-grade, isolated human gammadelta T cells with the humanized anti-GD2 antibody hu14.18 and a novel fusion cytokine, Fc-IL7...
  2. pmc KIR-incompatible hematopoietic-cell transplantation for poor prognosis infant acute lymphoblastic leukemia
    Brandon Triplett
    Blood 107:1238-9. 2006
  3. ncbi request reprint Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients
    Usman Yusuf
    Division of Stem Cell Transplantation, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Transplantation 81:1398-404. 2006
    ..We report our experience with cidofovir (CDV) for treatment of ADV infection in 57 HSCT patients, median age 8 years (range 0.5-26)...
  4. ncbi request reprint A prospective cohort study of late sequelae of pediatric allogeneic hematopoietic stem cell transplantation
    Wing Leung
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Medicine (Baltimore) 86:215-24. 2007
    ..2%, and male hypogonadism 20.3%. Coexistence of multiple late sequelae was common in HSCT survivors. Our findings provide a basis for more effective patient counseling, optimal surveillance, and early intervention...
  5. pmc Longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation
    Hiroto Inaba
    Department of Bone Marrow Transplantation and Cellular Therapy, MS 1130, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    J Clin Oncol 30:3991-7. 2012
    ..To measure longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation (HSCT)...
  6. pmc Detectable minimal residual disease before hematopoietic cell transplantation is prognostic but does not preclude cure for children with very-high-risk leukemia
    Wing Leung
    Department of Bone Marrow Transplantation and Cellular Therapy, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105 2794, USA
    Blood 120:468-72. 2012
    ..Although MRD before HCT is a strong prognostic factor, its impact has diminished and should not be regarded as a contraindication for HCT...
  7. pmc Immunotherapy in acute leukemia
    Wing Leung
    Division of Bone Marrow Transplantation and Cellular Therapy, Department of Oncology, St Jude Children s Research Hospital, and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38105, USA
    Semin Hematol 46:89-99. 2009
    ..This article reviews the latest concepts in antitumor immunology and its application in the treatment of cancer, with particular focus on acute leukemia...
  8. pmc High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemia
    Wing Leung
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 118:223-30. 2011
    ..10; P = .01) at the time of transplantation. We concluded that transplantation has improved over time and should be considered for all children with very high-risk leukemia, regardless of matched donor availability...
  9. ncbi request reprint Determinants of antileukemia effects of allogeneic NK cells
    Wing Leung
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    J Immunol 172:644-50. 2004
    ..These findings provide new insights into the determinants of antileukemia effects of allogeneic NK cells and therapeutic strategies...
  10. ncbi request reprint Phenotype and function of human natural killer cells purified by using a clinical-scale immunomagnetic method
    Wing Leung
    Department of Hematology Oncology, St Jude Children s Research Hospital, Mail Stop 260, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Cancer Immunol Immunother 54:389-94. 2005
    ..These results support future clinical investigation of the use of purified NK cells for adoptive immunotherapy in the absence of ATG...
  11. ncbi request reprint Outcomes of growth hormone replacement therapy in survivors of childhood acute lymphoblastic leukemia
    Wing Leung
    After Completion of Therapy Program and the Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 20:2959-64. 2002
    ..We investigated the adult height of patients who had received GH and estimated their risk of leukemia relapse or development of a second malignancy...
  12. ncbi request reprint Second malignancy after treatment of childhood non-Hodgkin lymphoma
    W Leung
    St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Cancer 92:1959-66. 2001
    ....
  13. ncbi request reprint Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors
    Wing Leung
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 174:6540-5. 2005
    ..These results caution the use of genotyping alone for donor selection or leukemia-relapse prognostication because some KIRs may be expressed at a very low level...
  14. ncbi request reprint Effect of HLA class I or class II incompatibility in pediatric marrow transplantation from unrelated and related donors
    W H Leung
    Department of Hematology Oncology, Laboratory Medicine and Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Hum Immunol 62:399-407. 2001
    ..Results of this study suggest that disparity in HLA-A and HLA-B antigens may not be better tolerated than disparity in HLA-DR allele in allogeneic BMT. Further studies are warranted to confirm our results...
  15. pmc Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemia
    Wing Leung
    Department of Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 2794, USA
    Cancer Epidemiol 34:303-8. 2010
    ..Host immunity and appropriate DNA damage responses are critical inhibitors of carcinogenesis. Therefore, we sought to determine the long-term effects of ALL treatment on immune function and response to DNA damage...
  16. ncbi request reprint Late effects of treatment in survivors of childhood acute myeloid leukemia
    W Leung
    After Completion of Therapy Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 18:3273-9. 2000
    ..To investigate the incidence of and risk factors for late sequelae of treatment in patients who survived for more than 10 years after the diagnosis of childhood acute myeloid leukemia (AML)...
  17. pmc Inhibitory KIR-HLA receptor-ligand mismatch in autologous haematopoietic stem cell transplantation for solid tumour and lymphoma
    W Leung
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Cancer 97:539-42. 2007
    ..01). The potential applicability of the receptor-ligand mismatch model to autologous HCTs and to patients with lymphoma or solid tumour is clinically significant because of the prevalence of the HCT procedure...
  18. doi request reprint Use of NK cell activity in cure by transplant
    Wing Leung
    Department of Bone Marrow Transplantation and Cellular Therapy, St Jude Children s Research Hospital, 26 Danny Thomas Place, Memphis, TN 38105, USA
    Br J Haematol 155:14-29. 2011
    ....
  19. ncbi request reprint Allogeneic bone marrow transplantation for infants with acute leukemia or myelodysplastic syndrome
    W Leung
    The Department of Hematology-Oncology, St Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105, USA
    Bone Marrow Transplant 27:717-22. 2001
    ..Immune function 1 year after transplantation and the incidences and spectra of late sequelae were similar for both groups during a median of 3.5 years (range, 1.5 to 7.2 years) of follow-up...
  20. ncbi request reprint Allogeneic bone marrow transplantation in children failing prior autologous bone marrow transplantation
    G A Hale
    Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
    Bone Marrow Transplant 27:155-62. 2001
    ..Eight patients (two of whom also relapsed) died of RRT. Although RRT and relapse remain significant problems, a significant percentage of pediatric patients failing ABMT may be cured with alloBMT...
  21. ncbi request reprint Second malignancy after treatment of childhood acute myeloid leukemia
    W Leung
    Department of Hematology-Oncology, St Jude Children's Research Hospital, and University of Tennessee, College of Medicine, Memphis, USA
    Leukemia 15:41-5. 2001
    ..Future studies should focus on improving treatments for primary AML while preventing second malignancies...
  22. ncbi request reprint Effective donor lymphohematopoietic reconstitution after haploidentical CD34+-selected hematopoietic stem cell transplantation in children with refractory severe aplastic anemia
    P Woodard
    Division of Stem Cell Transplantation, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Bone Marrow Transplant 33:411-8. 2004
    ..Further study is required to validate the initial promise of these preliminary observations...
  23. ncbi request reprint Comparisons of alloreactive potential of clinical hematopoietic grafts
    W Leung
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 5001, USA
    Transplantation 68:628-35. 1999
    ..We sought to compare the immunoreactive potential of human cord blood (CB) versus normal adult bone marrow (BM) versus mobilized blood (peripheral blood stem cells; PBSC) from cancer patients...
  24. ncbi request reprint Allogeneic bone marrow transplantation for children with histiocytic disorders: use of TBI and omission of etoposide in the conditioning regimen
    G A Hale
    Department of Hematology Oncology, Memphis, TN 38105 2794, USA
    Bone Marrow Transplant 31:981-6. 2003
    ..We conclude that a conditioning regimen containing TBI but not etoposide is effective in allogeneic BMT for children with histiocytic diseases...
  25. ncbi request reprint Purification of human natural killer cells using a clinical-scale immunomagnetic method
    R Iyengar
    Hematology Oncology University of Tennessee Health Science Center Memphis, Memphis, TN, USA
    Cytotherapy 5:479-84. 2003
    ..We have therefore sought to develop an automated, efficient, and clinical-scale human NK cell-purification method...
  26. ncbi request reprint Encephalopathy in pediatric patients after allogeneic hematopoietic stem cell transplantation is associated with a poor prognosis
    P Woodard
    Division of Stem Cell Transplantation, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Bone Marrow Transplant 33:1151-7. 2004
    ..However, a standardized approach to accurate and timely diagnosis and treatment is needed to improve outcome in these patients...
  27. ncbi request reprint T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation
    Eric J Lowe
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Haematol 123:323-6. 2003
    ..In contrast, donor T-cell incompatibility was a risk factor for acute GVHD, chronic GVHD and death. Thus, T-cell alloreactivity dominated that of NK cells in minimally T-cell-depleted grafts...
  28. pmc Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine 245
    Rafijul Bari
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 114:5182-90. 2009
    ..Thus, our findings provide novel insights into the molecular determinant of KIR2DL1 and conceivably a fundamental understanding of KIR2DL1 allelic polymorphism in human disease susceptibility, transplant outcome, and donor selection...
  29. ncbi request reprint Allogeneic graft-versus-hepatoblastoma effect
    Hiroto Inaba
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 46:501-5. 2006
    ..Her disease recurred when GVHD resolved. This patient's clinical course provides evidence for the probable existence of allogeneic graft-versus-hepatoblastoma effect...
  30. pmc Tumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: the good news?
    R Handgretinger
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Mail stop 321, 332 N Lauderdale St, Memphis, TN 38105, USA
    Br J Cancer 88:1874-7. 2003
    ..We hypothesise that the presence of a critical number of graft-contaminating neuroblastoma cells can elicit a protective antitumour immune response after autologous transplantation...
  31. ncbi request reprint Human CD34+ cell preparations contain over 100-fold greater NOD/SCID mouse engrafting capacity than do CD34- cell preparations
    Z Gao
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Hematol 29:910-21. 2001
    ..Hematopoiesis derived from actual CD34(-) cells is difficult to distinguish from that due to CD34(+) cells potentially contaminating the preparations...
  32. ncbi request reprint Diagnostic challenge in recurrent skin rash after autologous bone marrow transplantation
    Hiroto Inaba
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Pediatr Hematol Oncol 28:525-8. 2006
    ..Establishment of diagnostic criteria and understanding of the pathophysiology of these entities may lead to better management and to improved therapy of refractory cancer...
  33. pmc Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial
    Jeffrey E Rubnitz
    Department of Oncology, St Jude Children s Research Hospital and the University of Tennessee Health Science Center, Memphis, TN 38105 2794, USA
    Lancet Oncol 11:543-52. 2010
    ....
  34. doi request reprint Total and active rabbit antithymocyte globulin (rATG;Thymoglobulin) pharmacokinetics in pediatric patients undergoing unrelated donor bone marrow transplantation
    Sandra K Call
    Department of Pharmaceutical Services, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Biol Blood Marrow Transplant 15:274-8. 2009
    ..These conclusions may not apply to patients with nonmalignant disorders...
  35. pmc Clinical utility of computed tomography screening of chest, abdomen, and sinuses before hematopoietic stem cell transplantation: the St. Jude experience
    Kimberly A Kasow
    Division of Bone Marrow Transplantation and Cellular Therapy, Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Biol Blood Marrow Transplant 15:490-5. 2009
    ..The decision to perform chest CT should be made judiciously based on a careful history and physical examination. Sinus imaging, which was frequently abnormal, may be justified in all patients to plan post-HSCT care...
  36. pmc Treating childhood acute lymphoblastic leukemia without cranial irradiation
    Ching Hon Pui
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    N Engl J Med 360:2730-41. 2009
    ..Prophylactic cranial irradiation has been a standard treatment in children with acute lymphoblastic leukemia (ALL) who are at high risk for central nervous system (CNS) relapse...
  37. pmc NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia
    Jeffrey E Rubnitz
    Department of Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 2794, USA
    J Clin Oncol 28:955-9. 2010
    ..We propose to further investigate the efficacy of KIR-mismatched NK cells in a phase II trial as consolidation therapy to decrease relapse without increasing mortality in children with AML...
  38. pmc Pulmonary dysfunction in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem cell transplantation
    Hiroto Inaba
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 116:2020-30. 2010
    ..The number of long-term survivors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is increasing; however, few studies have addressed their long-term pulmonary function...
  39. pmc Improved prognosis for older adolescents with acute lymphoblastic leukemia
    Ching Hon Pui
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 29:386-91. 2011
    ..We reviewed the outcome of older adolescents (age 15 to 18 years) treated in four consecutive Total Therapy studies to determine if recent improved treatment extended to this high-risk group...
  40. pmc Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma
    Alberto Broniscer
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 28:4762-8. 2010
    ....
  41. doi request reprint Iron overload in survivors of childhood leukemia after allogeneic hematopoietic stem cell transplantation
    Thirachit Chotsampancharoen
    Division of Bone Marrow Transplantation and Cellular Therapy, Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Pediatr Transplant 13:348-52. 2009
    ..02). We conclude that iron overload is common after HSCT and is associated with hepatic, cardiac, and endocrine dysfunction...
  42. ncbi request reprint Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia
    Ching Hon Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    N Engl J Med 349:640-9. 2003
    ..We determined the long-term survival and the rates of health insurance coverage, marriage, and employment among patients who had attained at least 10 years of event-free survival...
  43. ncbi request reprint Etiology and outcome of graft failure in pediatric hematopoietic stem cell transplant recipients
    Paul Woodard
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Pediatr Hematol Oncol 25:955-9. 2003
    ..To determine the incidence, etiology and outcome of graft failure in pediatric allogeneic bone marrow transplant (BMT) recipients...
  44. ncbi request reprint Cyclooxygenase-2 inhibition to treat radiation-induced brain necrosis and edema
    Raja B Khan
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr Hematol Oncol 26:253-5. 2004
    ..Cyclooxygenase-2 (COX-2) inhibitor was started, and the child improved clinically and radiologically. The usefulness of COX-2 inhibitors in treating radiation necrosis and edema, as suggested by this report, requires further study...
  45. ncbi request reprint Human gammadelta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolation
    Mario Otto
    Department of Hematology Oncology, Mail stop 321, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    J Immunother 28:73-8. 2005
    ..The cytotoxic properties of the cells were preserved. This method yields sufficient purified gammadelta T cells for use in adoptive immunotherapy as well as laboratory investigations and animal studies...
  46. ncbi request reprint Outcome of hematopoietic stem cell transplantation for pediatric patients with therapy-related acute myeloid leukemia or myelodysplastic syndrome
    Paul Woodard
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 47:931-5. 2006
    ..Therapy-related myelodysplastic syndrome (t-MDS) and acute myeloid leukemia (t-AML) carry a poor prognosis. We analyzed the results of allogeneic HSCT in 38 children to determine which factors, if any, affected outcome...
  47. ncbi request reprint Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients
    Xiaohua Chen
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis TN 38105 2794, USA
    Blood 105:886-93. 2005
    ..Therefore, pretransplantation measurement of sjTREC may provide an important tool for predicting thymus-dependent T-cell reconstitution after transplantation...
  48. ncbi request reprint EBV lymphoproliferative disease of host origin after haploidentical stem cell transplantation
    Kimberly A Kasow
    Department of Hematology Oncology, Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 49:869-72. 2007
    ..She subsequently developed disseminated PTLPD involving multiple organ and nodal sites. Her neoplastic lymphoblasts were host-derived and refractory to rituximab treatment due to lack of CD20 expression...
  49. ncbi request reprint Diagnostic yield of bronchoalveolar lavage is low in allogeneic hematopoietic stem cell recipients receiving immunosuppressive therapy or with acute graft-versus-host disease: the St. Jude experience, 1990-2002
    Kimberly A Kasow
    Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Biol Blood Marrow Transplant 13:831-7. 2007
    ....
  50. ncbi request reprint Prophylaxis of Pneumocystis carinii pneumonia with atovaquone in children with leukemia
    Renee M Madden
    Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 109:1654-8. 2007
    ..Therefore, a retrospective analysis was conducted to determine the incidence of PCP in pediatric patients who received prophylactic atovaquone during treatment for acute leukemia...
  51. ncbi request reprint Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiation
    Mario Otto
    Division of Stem Cell Transplantation, Department of Hematology Oncology, St Jude Children s Research Hospital, 332N Lauderdale Street, Memphis, Tennessee 38105 2794, USA
    Stem Cells 25:537-42. 2007
    ..Use of different or multiple epitopes, targeting of alternate stem cell markers, or use of cell-depletion strategies might prevent this loss...
  52. doi request reprint Frequent mutations in SH2D1A (XLP) in males presenting with high-grade mature B-cell neoplasms
    J T Sandlund
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 60:E85-7. 2013
    ..Prospective screening for XLP in males with B-cell lymphoma at the time of initial diagnosis should be considered...
  53. ncbi request reprint Possible allogeneic graft-versus-tumor effect in childhood melanoma
    Kimberly A Kasow
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr Hematol Oncol 25:982-6. 2003
    ..She died of progressive disease 21 months after diagnosis and 17 months after transplantation. Her clinical course suggested the possible existence of an allogeneic graft-versus-melanoma response that prolonged her survival...
  54. pmc ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy
    D Bhojwani
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 26:265-70. 2012
    ....
  55. ncbi request reprint Long-term complete remission and immune tolerance after intensive chemotherapy for lymphoproliferative disorders complicating liver transplant
    W Leung
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Transplantation 67:1487-9. 1999
    ..B cell lymphoproliferative disorders (LPD) and liver rejection are major lethal complications after hepatic transplantation. Reduction in immunosuppression is the treatment for the former, but is a risk factor for the latter...

Research Grants4

  1. Antileukemic effort of NK cells in HCT for pediatric AML
    Wing Leung; Fiscal Year: 2007
    ..Our goal is to optimize the pairing of unrelated donors and recipients of HCT, thereby improving survival of pediatric patients with AML who typically have a poor prognosis. ..
  2. Antileukemic effort of NK cells in HCT for pediatric AML
    Wing Leung; Fiscal Year: 2010
    ..Our goal is to optimize the pairing of unrelated donors and recipients of HCT, thereby improving survival of pediatric patients with AML who typically have a poor prognosis. ..