Research Topics
Species | W LeungSummaryAffiliation: St. Jude Children's Research Hospital Country: USA Publications
Research Grants
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Publications
Combination immunotherapy with clinical-scale enriched human gammadelta T cells, hu14.18 antibody, and the immunocytokine Fc-IL7 in disseminated neuroblastomaMario Otto
Department of Hematology-Oncology and Animal Resources Center, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
Clin Cancer Res 11:8486-91. 2005..04). CONCLUSIONS: We have shown a new and promising immunotherapy regimen for neuroblastoma that requires clinical evaluation. Our approach might also serve as a therapeutic model for other malignancies...
KIR-incompatible hematopoietic-cell transplantation for poor prognosis infant acute lymphoblastic leukemiaBrandon Triplett
Blood 107:1238-9. 2006- Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patientsUsman Yusuf
Division of Stem Cell Transplantation, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Transplantation 81:1398-404. 2006..We report our experience with cidofovir (CDV) for treatment of ADV infection in 57 HSCT patients, median age 8 years (range 0.5-26)... - A prospective cohort study of late sequelae of pediatric allogeneic hematopoietic stem cell transplantationWing Leung
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Medicine (Baltimore) 86:215-24. 2007..2%, and male hypogonadism 20.3%. Coexistence of multiple late sequelae was common in HSCT survivors. Our findings provide a basis for more effective patient counseling, optimal surveillance, and early intervention... 
Longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantationHiroto Inaba
Department of Bone Marrow Transplantation and Cellular Therapy, MS 1130, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
J Clin Oncol 30:3991-7. 2012..To measure longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation (HSCT)...- Detectable minimal residual disease before hematopoietic cell transplantation is prognostic but does not preclude cure for children with very-high-risk leukemiaWing Leung
Department of Bone Marrow Transplantation and Cellular Therapy, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105 2794, USA
Blood 120:468-72. 2012..Although MRD before HCT is a strong prognostic factor, its impact has diminished and should not be regarded as a contraindication for HCT... - Immunotherapy in acute leukemiaWing Leung
Division of Bone Marrow Transplantation and Cellular Therapy, Department of Oncology, St Jude Children s Research Hospital, and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38105, USA
Semin Hematol 46:89-99. 2009..This article reviews the latest concepts in antitumor immunology and its application in the treatment of cancer, with particular focus on acute leukemia... - High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemiaWing Leung
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
Blood 118:223-30. 2011..10; P = .01) at the time of transplantation. We concluded that transplantation has improved over time and should be considered for all children with very high-risk leukemia, regardless of matched donor availability... - Determinants of antileukemia effects of allogeneic NK cellsWing Leung
Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
J Immunol 172:644-50. 2004..These findings provide new insights into the determinants of antileukemia effects of allogeneic NK cells and therapeutic strategies... - Phenotype and function of human natural killer cells purified by using a clinical-scale immunomagnetic methodWing Leung
Department of Hematology Oncology, St Jude Children s Research Hospital, Mail Stop 260, 332 N Lauderdale Street, Memphis, TN 38105, USA
Cancer Immunol Immunother 54:389-94. 2005..These results support future clinical investigation of the use of purified NK cells for adoptive immunotherapy in the absence of ATG... - Outcomes of growth hormone replacement therapy in survivors of childhood acute lymphoblastic leukemiaWing Leung
After Completion of Therapy Program and the Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
J Clin Oncol 20:2959-64. 2002..We investigated the adult height of patients who had received GH and estimated their risk of leukemia relapse or development of a second malignancy... - Second malignancy after treatment of childhood non-Hodgkin lymphomaW Leung
St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
Cancer 92:1959-66. 2001.... - Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donorsWing Leung
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Immunol 174:6540-5. 2005..These results caution the use of genotyping alone for donor selection or leukemia-relapse prognostication because some KIRs may be expressed at a very low level... - Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemiaWing Leung
Department of Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 2794, USA
Cancer Epidemiol 34:303-8. 2010..Host immunity and appropriate DNA damage responses are critical inhibitors of carcinogenesis. Therefore, we sought to determine the long-term effects of ALL treatment on immune function and response to DNA damage... - Effect of HLA class I or class II incompatibility in pediatric marrow transplantation from unrelated and related donorsW H Leung
Department of Hematology Oncology, Laboratory Medicine and Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Hum Immunol 62:399-407. 2001..Results of this study suggest that disparity in HLA-A and HLA-B antigens may not be better tolerated than disparity in HLA-DR allele in allogeneic BMT. Further studies are warranted to confirm our results... - Late effects of treatment in survivors of childhood acute myeloid leukemiaW Leung
After Completion of Therapy Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Clin Oncol 18:3273-9. 2000..To investigate the incidence of and risk factors for late sequelae of treatment in patients who survived for more than 10 years after the diagnosis of childhood acute myeloid leukemia (AML)... - Inhibitory KIR-HLA receptor-ligand mismatch in autologous haematopoietic stem cell transplantation for solid tumour and lymphomaW Leung
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
Br J Cancer 97:539-42. 2007..01). The potential applicability of the receptor-ligand mismatch model to autologous HCTs and to patients with lymphoma or solid tumour is clinically significant because of the prevalence of the HCT procedure... - Use of NK cell activity in cure by transplantWing Leung
Department of Bone Marrow Transplantation and Cellular Therapy, St Jude Children s Research Hospital, 26 Danny Thomas Place, Memphis, TN 38105, USA
Br J Haematol 155:14-29. 2011.... - Allogeneic bone marrow transplantation for infants with acute leukemia or myelodysplastic syndromeW Leung
The Department of Hematology-Oncology, St Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105, USA
Bone Marrow Transplant 27:717-22. 2001..Immune function 1 year after transplantation and the incidences and spectra of late sequelae were similar for both groups during a median of 3.5 years (range, 1.5 to 7.2 years) of follow-up... - Second malignancy after treatment of childhood acute myeloid leukemiaW Leung
Department of Hematology-Oncology, St Jude Children's Research Hospital, and University of Tennessee, College of Medicine, Memphis, USA
Leukemia 15:41-5. 2001..Future studies should focus on improving treatments for primary AML while preventing second malignancies... - Allogeneic bone marrow transplantation in children failing prior autologous bone marrow transplantationG A Hale
Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
Bone Marrow Transplant 27:155-62. 2001..Eight patients (two of whom also relapsed) died of RRT. Although RRT and relapse remain significant problems, a significant percentage of pediatric patients failing ABMT may be cured with alloBMT... - Effective donor lymphohematopoietic reconstitution after haploidentical CD34+-selected hematopoietic stem cell transplantation in children with refractory severe aplastic anemiaP Woodard
Division of Stem Cell Transplantation, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
Bone Marrow Transplant 33:411-8. 2004..Further study is required to validate the initial promise of these preliminary observations... - Comparisons of alloreactive potential of clinical hematopoietic graftsW Leung
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 5001, USA
Transplantation 68:628-35. 1999..We sought to compare the immunoreactive potential of human cord blood (CB) versus normal adult bone marrow (BM) versus mobilized blood (peripheral blood stem cells; PBSC) from cancer patients... - Allogeneic bone marrow transplantation for children with histiocytic disorders: use of TBI and omission of etoposide in the conditioning regimenG A Hale
Department of Hematology-Oncology, Memphis, TN 38105-2794, USA
Bone Marrow Transplant 31:981-6. 2003..We conclude that a conditioning regimen containing TBI but not etoposide is effective in allogeneic BMT for children with histiocytic diseases... - Purification of human natural killer cells using a clinical-scale immunomagnetic methodR Iyengar
Hematology-Oncology University of Tennessee Health Science Center Memphis, Memphis, TN, USA
Cytotherapy 5:479-84. 2003..These purified NK cells may be expedient for preclinical and clinical uses... - Encephalopathy in pediatric patients after allogeneic hematopoietic stem cell transplantation is associated with a poor prognosisP Woodard
Division of Stem Cell Transplantation, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
Bone Marrow Transplant 33:1151-7. 2004..However, a standardized approach to accurate and timely diagnosis and treatment is needed to improve outcome in these patients... - Allogeneic graft-versus-hepatoblastoma effectHiroto Inaba
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
Pediatr Blood Cancer 46:501-5. 2006..Her disease recurred when GVHD resolved. This patient's clinical course provides evidence for the probable existence of allogeneic graft-versus-hepatoblastoma effect... - T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantationEric J Lowe
Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN, USA
Br J Haematol 123:323-6. 2003..In contrast, donor T-cell incompatibility was a risk factor for acute GVHD, chronic GVHD and death. Thus, T-cell alloreactivity dominated that of NK cells in minimally T-cell-depleted grafts... - Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine 245Rafijul Bari
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
Blood 114:5182-90. 2009..Thus, our findings provide novel insights into the molecular determinant of KIR2DL1 and conceivably a fundamental understanding of KIR2DL1 allelic polymorphism in human disease susceptibility, transplant outcome, and donor selection... - Human CD34+ cell preparations contain over 100-fold greater NOD/SCID mouse engrafting capacity than do CD34- cell preparationsZ Gao
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Exp Hematol 29:910-21. 2001..Hematopoiesis derived from actual CD34(-) cells is difficult to distinguish from that due to CD34(+) cells potentially contaminating the preparations... - Tumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: the good news?R Handgretinger
Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Mail stop 321, 332 N Lauderdale St, Memphis, TN 38105, USA
Br J Cancer 88:1874-7. 2003..We hypothesise that the presence of a critical number of graft-contaminating neuroblastoma cells can elicit a protective antitumour immune response after autologous transplantation... - Diagnostic challenge in recurrent skin rash after autologous bone marrow transplantationHiroto Inaba
Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
J Pediatr Hematol Oncol 28:525-8. 2006..Establishment of diagnostic criteria and understanding of the pathophysiology of these entities may lead to better management and to improved therapy of refractory cancer... - NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemiaJeffrey E Rubnitz
Department of Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 2794, USA
J Clin Oncol 28:955-9. 2010..We propose to further investigate the efficacy of KIR-mismatched NK cells in a phase II trial as consolidation therapy to decrease relapse without increasing mortality in children with AML... - Pulmonary dysfunction in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem cell transplantationHiroto Inaba
Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Cancer 116:2020-30. 2010..The number of long-term survivors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is increasing; however, few studies have addressed their long-term pulmonary function... - Improved prognosis for older adolescents with acute lymphoblastic leukemiaChing Hon Pui
St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Clin Oncol 29:386-91. 2011..We reviewed the outcome of older adolescents (age 15 to 18 years) treated in four consecutive Total Therapy studies to determine if recent improved treatment extended to this high-risk group... - Clinical utility of computed tomography screening of chest, abdomen, and sinuses before hematopoietic stem cell transplantation: the St. Jude experienceKimberly A Kasow
Division of Bone Marrow Transplantation and Cellular Therapy, Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Biol Blood Marrow Transplant 15:490-5. 2009..The decision to perform chest CT should be made judiciously based on a careful history and physical examination. Sinus imaging, which was frequently abnormal, may be justified in all patients to plan post-HSCT care... - Total and active rabbit antithymocyte globulin (rATG;Thymoglobulin) pharmacokinetics in pediatric patients undergoing unrelated donor bone marrow transplantationSandra K Call
Department of Pharmaceutical Services, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
Biol Blood Marrow Transplant 15:274-8. 2009..These conclusions may not apply to patients with nonmalignant disorders... - Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine gliomaAlberto Broniscer
St Jude Children s Research Hospital, Memphis, TN, USA
J Clin Oncol 28:4762-8. 2010.... - Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trialJeffrey E Rubnitz
Department of Oncology, St Jude Children s Research Hospital and the University of Tennessee Health Science Center, Memphis, TN 38105 2794, USA
Lancet Oncol 11:543-52. 2010.... - Treating childhood acute lymphoblastic leukemia without cranial irradiationChing Hon Pui
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
N Engl J Med 360:2730-41. 2009..Prophylactic cranial irradiation has been a standard treatment in children with acute lymphoblastic leukemia (ALL) who are at high risk for central nervous system (CNS) relapse... - Iron overload in survivors of childhood leukemia after allogeneic hematopoietic stem cell transplantationThirachit Chotsampancharoen
Division of Bone Marrow Transplantation and Cellular Therapy, Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
Pediatr Transplant 13:348-52. 2009..02). We conclude that iron overload is common after HSCT and is associated with hepatic, cardiac, and endocrine dysfunction... - Etiology and outcome of graft failure in pediatric hematopoietic stem cell transplant recipientsPaul Woodard
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
J Pediatr Hematol Oncol 25:955-9. 2003..To determine the incidence, etiology and outcome of graft failure in pediatric allogeneic bone marrow transplant (BMT) recipients... - Cyclooxygenase-2 inhibition to treat radiation-induced brain necrosis and edemaRaja B Khan
Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
J Pediatr Hematol Oncol 26:253-5. 2004..Cyclooxygenase-2 (COX-2) inhibitor was started, and the child improved clinically and radiologically. The usefulness of COX-2 inhibitors in treating radiation necrosis and edema, as suggested by this report, requires further study... - Human gammadelta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolationMario Otto
Department of Hematology Oncology, Mail stop 321, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
J Immunother 28:73-8. 2005..The cytotoxic properties of the cells were preserved. This method yields sufficient purified gammadelta T cells for use in adoptive immunotherapy as well as laboratory investigations and animal studies... - Outcome of hematopoietic stem cell transplantation for pediatric patients with therapy-related acute myeloid leukemia or myelodysplastic syndromePaul Woodard
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Pediatr Blood Cancer 47:931-5. 2006..Therapy-related myelodysplastic syndrome (t-MDS) and acute myeloid leukemia (t-AML) carry a poor prognosis. We analyzed the results of allogeneic HSCT in 38 children to determine which factors, if any, affected outcome... - Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patientsXiaohua Chen
Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis TN 38105 2794, USA
Blood 105:886-93. 2005..Therefore, pretransplantation measurement of sjTREC may provide an important tool for predicting thymus-dependent T-cell reconstitution after transplantation... - EBV lymphoproliferative disease of host origin after haploidentical stem cell transplantationKimberly A Kasow
Department of Hematology Oncology, Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Pediatr Blood Cancer 49:869-72. 2007..She subsequently developed disseminated PTLPD involving multiple organ and nodal sites. Her neoplastic lymphoblasts were host-derived and refractory to rituximab treatment due to lack of CD20 expression... - Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiationMario Otto
Division of Stem Cell Transplantation, Department of Hematology Oncology, St Jude Children s Research Hospital, 332N Lauderdale Street, Memphis, Tennessee 38105 2794, USA
Stem Cells 25:537-42. 2007..Use of different or multiple epitopes, targeting of alternate stem cell markers, or use of cell-depletion strategies might prevent this loss... - Prophylaxis of Pneumocystis carinii pneumonia with atovaquone in children with leukemiaRenee M Madden
Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer 109:1654-8. 2007..Therefore, a retrospective analysis was conducted to determine the incidence of PCP in pediatric patients who received prophylactic atovaquone during treatment for acute leukemia... - Diagnostic yield of bronchoalveolar lavage is low in allogeneic hematopoietic stem cell recipients receiving immunosuppressive therapy or with acute graft-versus-host disease: the St. Jude experience, 1990-2002Kimberly A Kasow
Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Biol Blood Marrow Transplant 13:831-7. 2007.... - Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemiaChing Hon Pui
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
N Engl J Med 349:640-9. 2003..We determined the long-term survival and the rates of health insurance coverage, marriage, and employment among patients who had attained at least 10 years of event-free survival... - Possible allogeneic graft-versus-tumor effect in childhood melanomaKimberly A Kasow
Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
J Pediatr Hematol Oncol 25:982-6. 2003..She died of progressive disease 21 months after diagnosis and 17 months after transplantation. Her clinical course suggested the possible existence of an allogeneic graft-versus-melanoma response that prolonged her survival... - ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapyD Bhojwani
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Leukemia 26:265-70. 2012.... - Long-term complete remission and immune tolerance after intensive chemotherapy for lymphoproliferative disorders complicating liver transplantW Leung
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Transplantation 67:1487-9. 1999..B cell lymphoproliferative disorders (LPD) and liver rejection are major lethal complications after hepatic transplantation. Reduction in immunosuppression is the treatment for the former, but is a risk factor for the latter...
Research Grants
- Antileukemic effort of NK cells in HCT for pediatric AMLWing Leung; Fiscal Year: 2007..Our goal is to optimize the pairing of unrelated donors and recipients of HCT, thereby improving survival of pediatric patients with AML who typically have a poor prognosis. ..
- Antileukemic effort of NK cells in HCT for pediatric AMLWing Leung; Fiscal Year: 2010..Our goal is to optimize the pairing of unrelated donors and recipients of HCT, thereby improving survival of pediatric patients with AML who typically have a poor prognosis. ..