Jatinder K Lamba

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants
    Jatinder K Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105, USA
    J Pharmacol Exp Ther 323:935-45. 2007
  2. ncbi request reprint Pharmacogenetics of the constitutive androstane receptor
    Jatinder K Lamba
    St Jude Children s Research Hospital, Department of Pharmaceutical Sciences, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Pharmacogenomics 9:71-83. 2008
  3. ncbi request reprint PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators
    Vishal Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Toxicol Appl Pharmacol 199:251-65. 2004
  4. ncbi request reprint Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans
    Jatinder K Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pharmacogenet Genomics 16:415-27. 2006
  5. ncbi request reprint Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine
    Charis P Zamber
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, and Department of Pharmaceutical Sciences, University of Washington, Seattle, WA, USA
    Pharmacogenetics 13:19-28. 2003
  6. ncbi request reprint Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences
    Jatinder K Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    J Pharmacol Exp Ther 311:811-21. 2004
  7. pmc CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose
    Amarjit S Chaudhry
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pharmacol Exp Ther 332:599-611. 2010
  8. pmc Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation
    Ranjit K Thirumaran
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN, USA
    Biochem Pharmacol 84:104-12. 2012
  9. ncbi request reprint Common allelic variants of cytochrome P4503A4 and their prevalence in different populations
    Jatinder K Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pharmacogenetics 12:121-32. 2002
  10. ncbi request reprint G2677T and C3435T genotype and haplotype are associated with hepatic ABCB1 (MDR1) expression
    Pengfei Song
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA
    J Clin Pharmacol 46:373-9. 2006

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants
    Jatinder K Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105, USA
    J Pharmacol Exp Ther 323:935-45. 2007
    ..These results suggest that genetic variation in DCK influences its activity and expression and may predict the variability observed in intracellular levels of the ara-C active metabolite ara-CTP...
  2. ncbi request reprint Pharmacogenetics of the constitutive androstane receptor
    Jatinder K Lamba
    St Jude Children s Research Hospital, Department of Pharmaceutical Sciences, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Pharmacogenomics 9:71-83. 2008
    ....
  3. ncbi request reprint PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators
    Vishal Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Toxicol Appl Pharmacol 199:251-65. 2004
    ..Moreover, the identification of PXR in many human tissues, such as brain, and activation by tissue specific ligands (such as neurosteroids) suggests additional biological roles for this receptor in these tissues...
  4. ncbi request reprint Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans
    Jatinder K Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pharmacogenet Genomics 16:415-27. 2006
    ..Tumors with increased CYP3A copy number (via amplification or increased chromosome 7q) would be expected to show reduced cytotoxicity to some chemotherapeutic drugs and potentially an increase in the outgrowth of drug resistant tumors...
  5. ncbi request reprint Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine
    Charis P Zamber
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, and Department of Pharmaceutical Sciences, University of Washington, Seattle, WA, USA
    Pharmacogenetics 13:19-28. 2003
    ..Thus, common natural allelic variants of BCRP have been identified, and did not influence interindividual variation in expression of BCRP mRNA in human intestine, but remain to be tested for their effect on BCRP function...
  6. ncbi request reprint Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences
    Jatinder K Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    J Pharmacol Exp Ther 311:811-21. 2004
    ..The expression of CAR in additional human cell types increases the range of tissue specific transcriptional responses regulated by this receptor, suggesting additional biological roles for CAR and CAR-SV proteins in these tissues...
  7. pmc CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose
    Amarjit S Chaudhry
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pharmacol Exp Ther 332:599-611. 2010
    ..These findings may also be relevant to the clinical use of other PXR, CAR, and Nrf2 activators...
  8. pmc Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation
    Ranjit K Thirumaran
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN, USA
    Biochem Pharmacol 84:104-12. 2012
    ..These data suggest VDR polymorphisms are predictors of intestinal CYP3A4, and that CYP3A4 intestinal expression varies seasonally--likely related to annual changes in UV sunlight and vitamin D levels...
  9. ncbi request reprint Common allelic variants of cytochrome P4503A4 and their prevalence in different populations
    Jatinder K Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pharmacogenetics 12:121-32. 2002
    ..None of the 28 CYP3A4 SNPs identified in CYP3A4 phenotyped persons (most individuals being heterozygous for any CYP3A4 variant) was associated with low hepatic CYP3A4 protein expression or low CYP3A4 activity in vivo...
  10. ncbi request reprint G2677T and C3435T genotype and haplotype are associated with hepatic ABCB1 (MDR1) expression
    Pengfei Song
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA
    J Clin Pharmacol 46:373-9. 2006
  11. ncbi request reprint Genetic contribution to variable human CYP3A-mediated metabolism
    Jatinder K Lamba
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Adv Drug Deliv Rev 54:1271-94. 2002
    ....
  12. doi request reprint RRM1 and RRM2 pharmacogenetics: association with phenotypes in HapMap cell lines and acute myeloid leukemia patients
    Xueyuan Cao
    Department of Biostatistics, St Jude Children s Research Hospital, Memphis, TN, USA
    Pharmacogenomics 14:1449-66. 2013
    ..Original submitted 2 April 2013; Revision submitted 8 July 2013. ..
  13. ncbi request reprint The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluation
    Nina Isoherranen
    Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA
    Drug Metab Dispos 36:146-54. 2008
    ..In conclusion, the effect of CYP3A5 on hepatic CYP3A-mediated inhibitory drug-drug interactions is substrate-dependent, and HLM, rather than rCYP3A, are the preferred in vitro system for predicting these interactions in vivo...
  14. ncbi request reprint CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults
    Raymond C Givens
    General Clinical Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA
    J Appl Physiol 95:1297-300. 2003
    ..3 mmHg. We speculate whether a high CYP3A5 expressor allele frequency among African-Americans may contribute to a high prevalence of sodium-sensitive hypertension in this population...