Research Topics
Genomes and GenesSpecies | Jatinder K LambaSummaryAffiliation: St. Jude Children's Research Hospital Country: USA Publications
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Publications
Pharmacogenetics of the constitutive androstane receptorJatinder K Lamba
St Jude Children s Research Hospital, Department of Pharmaceutical Sciences, 332 North Lauderdale Street, Memphis, TN 38105, USA
Pharmacogenomics 9:71-83. 2008....- Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variantsJatinder K Lamba
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105, USA
J Pharmacol Exp Ther 323:935-45. 2007..These results suggest that genetic variation in DCK influences its activity and expression and may predict the variability observed in intracellular levels of the ara-C active metabolite ara-CTP... - PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activatorsVishal Lamba
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
Toxicol Appl Pharmacol 199:251-65. 2004..Moreover, the identification of PXR in many human tissues, such as brain, and activation by tissue specific ligands (such as neurosteroids) suggests additional biological roles for this receptor in these tissues... - Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestineCharis P Zamber
Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee, and Department of Pharmaceutical Sciences, University of Washington, Seattle, WA, USA
Pharmacogenetics 13:19-28. 2003..Thus, common natural allelic variants of BCRP have been identified, and did not influence interindividual variation in expression of BCRP mRNA in human intestine, but remain to be tested for their effect on BCRP function... - Expression of constitutive androstane receptor splice variants in human tissues and their functional consequencesJatinder K Lamba
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
J Pharmacol Exp Ther 311:811-21. 2004..The expression of CAR in additional human cell types increases the range of tissue specific transcriptional responses regulated by this receptor, suggesting additional biological roles for CAR and CAR-SV proteins in these tissues... - Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humansJatinder K Lamba
Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN 38105, USA
Pharmacogenet Genomics 16:415-27. 2006..Tumors with increased CYP3A copy number (via amplification or increased chromosome 7q) would be expected to show reduced cytotoxicity to some chemotherapeutic drugs and potentially an increase in the outgrowth of drug resistant tumors... 
CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance doseAmarjit S Chaudhry
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Pharmacol Exp Ther 332:599-611. 2010..These findings may also be relevant to the clinical use of other PXR, CAR, and Nrf2 activators...
Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variationRanjit K Thirumaran
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN, USA
Biochem Pharmacol 84:104-12. 2012..These data suggest VDR polymorphisms are predictors of intestinal CYP3A4, and that CYP3A4 intestinal expression varies seasonally--likely related to annual changes in UV sunlight and vitamin D levels...- G2677T and C3435T genotype and haplotype are associated with hepatic ABCB1 (MDR1) expressionPengfei Song
Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA
J Clin Pharmacol 46:373-9. 2006 - Common allelic variants of cytochrome P4503A4 and their prevalence in different populationsJatinder K Lamba
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Pharmacogenetics 12:121-32. 2002..None of the 28 CYP3A4 SNPs identified in CYP3A4 phenotyped persons (most individuals being heterozygous for any CYP3A4 variant) was associated with low hepatic CYP3A4 protein expression or low CYP3A4 activity in vivo... - Genetic contribution to variable human CYP3A-mediated metabolismJatinder K Lamba
St Jude Children s Research Hospital, Memphis, TN 38105, USA
Adv Drug Deliv Rev 54:1271-94. 2002.... - The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluationNina Isoherranen
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA
Drug Metab Dispos 36:146-54. 2008..In conclusion, the effect of CYP3A5 on hepatic CYP3A-mediated inhibitory drug-drug interactions is substrate-dependent, and HLM, rather than rCYP3A, are the preferred in vitro system for predicting these interactions in vivo... - CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adultsRaymond C Givens
General Clinical Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA
J Appl Physiol 95:1297-300. 2003..3 mmHg. We speculate whether a high CYP3A5 expressor allele frequency among African-Americans may contribute to a high prevalence of sodium-sensitive hypertension in this population...