Risa Kitagawa

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi The Cdc20 homolog, FZY-1, and its interacting protein, IFY-1, are required for proper chromosome segregation in Caenorhabditis elegans
    Risa Kitagawa
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Curr Biol 12:2118-23. 2002
  2. pmc Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans
    Maja Tarailo
    Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Genetics 175:1665-79. 2007
  3. pmc Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferation in response to nutrition signals in C. elegans
    Sonoko Watanabe
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 27:1085-96. 2008
  4. pmc The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor
    Monica Morales
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Genes Dev 19:3043-54. 2005
  5. pmc SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans
    Takaharu G Yamamoto
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Cell Biol 183:187-94. 2008
  6. pmc Key players in chromosome segregation in Caenorhabditis elegans
    Risa Kitagawa
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Front Biosci (Landmark Ed) 14:1529-57. 2009
  7. pmc The spindle assembly checkpoint in Caenorhabditis elegans: one who lacks Mad1 becomes mad one
    Risa Kitagawa
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell Cycle 8:338-44. 2009
  8. doi HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans
    Ruishan Wang
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Development 140:2149-59. 2013
  9. pmc Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
    Risa Kitagawa
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38018, USA
    Genes Dev 18:1423-38. 2004
  10. pmc Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
    Simon Bekker-Jensen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Cell Biol 173:195-206. 2006

Collaborators

Detail Information

Publications10

  1. ncbi The Cdc20 homolog, FZY-1, and its interacting protein, IFY-1, are required for proper chromosome segregation in Caenorhabditis elegans
    Risa Kitagawa
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Curr Biol 12:2118-23. 2002
    ..IFY-1 accumulates in one-cell-arrested emb-30/APC4 embryos and interacts with SEP-1, a C. elegans separase, suggesting that IFY-1 functions as a C. elegans securin...
  2. pmc Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans
    Maja Tarailo
    Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Genetics 175:1665-79. 2007
    ..elegans. The such-1/APC5-like mutation, h1960, significantly delays anaphase onset both in germline and in early embryonic cells...
  3. pmc Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferation in response to nutrition signals in C. elegans
    Sonoko Watanabe
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 27:1085-96. 2008
    ....
  4. pmc The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor
    Monica Morales
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Genes Dev 19:3043-54. 2005
    ....
  5. pmc SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans
    Takaharu G Yamamoto
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Cell Biol 183:187-94. 2008
    ..In addition, SPDL-1 coimmunoprecipitates with MDF-1/MAD1 in vivo. These results suggest that SPDL-1 functions in a kinetochore receptor of MDF-1/MAD1 to induce SAC function...
  6. pmc Key players in chromosome segregation in Caenorhabditis elegans
    Risa Kitagawa
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Front Biosci (Landmark Ed) 14:1529-57. 2009
    ..In this review, I will focus on the conservation and diversity of proteins that are required to maintain chromosome transmission fidelity during mitosis and meiosis in C. elegans...
  7. pmc The spindle assembly checkpoint in Caenorhabditis elegans: one who lacks Mad1 becomes mad one
    Risa Kitagawa
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell Cycle 8:338-44. 2009
    ..Studying the function of SAC components in C. elegans provides a new molecular insight into the SAC-regulated cell cycle progression in a context of a multicellular organism...
  8. doi HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans
    Ruishan Wang
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Development 140:2149-59. 2013
    ..Our study reports a novel mechanism, mediated by ETC-1, that co-operates with APC/C to maintain the meiotic arrest required for proper cell cycle timing during reproduction...
  9. pmc Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
    Risa Kitagawa
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38018, USA
    Genes Dev 18:1423-38. 2004
    ..These observations suggest that many of the abnormal stress responses seen in cells lacking ATM, NBS1, or BRCA1 result from a failure of ATM migration to sites of DNA breaks and a resultant lack of SMC1 phosphorylation...
  10. pmc Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
    Simon Bekker-Jensen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Cell Biol 173:195-206. 2006
    ..We propose that subclassification of DSB regulators according to their residence sites provides a useful framework for understanding their involvement in diverse processes of genome surveillance...