Thirumala Devi Kanneganti

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc NOD-like receptor (NLR) signaling beyond the inflammasome
    Patrick J Shaw
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Eur J Immunol 40:624-7. 2010
  2. pmc Role of the nlrp3 inflammasome in microbial infection
    Paras K Anand
    Department of Immunology, St Jude Children s Research Hospital Memphis, TN, USA
    Front Microbiol 2:12. 2011
  3. pmc IL-1 family cytokines trigger sterile inflammatory disease
    John R Lukens
    Department of Immunology, St Jude Children s Research Hospital Memphis, TN, USA
    Front Immunol 3:315. 2012
  4. pmc Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection
    Anwari Akhter
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, OH, USA
    PLoS Pathog 5:e1000361. 2009
  5. doi request reprint Immunological complications of obesity
    Thirumala Devi Kanneganti
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 13:707-12. 2012
  6. pmc Central roles of NLRs and inflammasomes in viral infection
    Thirumala Devi Kanneganti
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Rev Immunol 10:688-98. 2010
  7. pmc Critical role for inflammasome-independent IL-1β production in osteomyelitis
    John R Lukens
    Department of Immunology, Small Animal Imaging Core, and Animal Resources Center and the Veterinary Pathology Core, St Jude Children s Research Hospital, Memphis, TN 38105
    Proc Natl Acad Sci U S A 111:1066-71. 2014
  8. pmc The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis
    Frank L van de Veerdonk
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, USA
    Eur J Immunol 41:2260-8. 2011
  9. pmc FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes
    Prajwal Gurung
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105
    J Immunol 192:1835-46. 2014
  10. pmc Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens
    Prajwal Gurung
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 287:34474-83. 2012

Collaborators

Detail Information

Publications71

  1. pmc NOD-like receptor (NLR) signaling beyond the inflammasome
    Patrick J Shaw
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Eur J Immunol 40:624-7. 2010
    ..However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome signaling. Here we highlight the emerging roles of several of these NLR...
  2. pmc Role of the nlrp3 inflammasome in microbial infection
    Paras K Anand
    Department of Immunology, St Jude Children s Research Hospital Memphis, TN, USA
    Front Microbiol 2:12. 2011
    ..In this review, we give an update on the recent literature examining the role of Nlrp3 inflammasome in response to fungal, bacterial, and viral infections...
  3. pmc IL-1 family cytokines trigger sterile inflammatory disease
    John R Lukens
    Department of Immunology, St Jude Children s Research Hospital Memphis, TN, USA
    Front Immunol 3:315. 2012
    ..In this review we highlight the central role that interleukin-1 family cytokines play in sterile inflammatory diseases...
  4. pmc Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection
    Anwari Akhter
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, OH, USA
    PLoS Pathog 5:e1000361. 2009
    ..These results reveal a new mechanism for caspase-7 activation downstream of the Nlrc4 inflammasome and present a novel biological role for caspase-7 in host defense against an intracellular bacterium...
  5. doi request reprint Immunological complications of obesity
    Thirumala Devi Kanneganti
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 13:707-12. 2012
    ..Improved understanding of the immunological processes that regulate obesity may yield new treatments for obesity-associated disorders...
  6. pmc Central roles of NLRs and inflammasomes in viral infection
    Thirumala Devi Kanneganti
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Rev Immunol 10:688-98. 2010
    ..This information will improve our understanding of host defence mechanisms against viruses and provide new avenues for interfering in the pathogenesis of infectious diseases...
  7. pmc Critical role for inflammasome-independent IL-1β production in osteomyelitis
    John R Lukens
    Department of Immunology, Small Animal Imaging Core, and Animal Resources Center and the Veterinary Pathology Core, St Jude Children s Research Hospital, Memphis, TN 38105
    Proc Natl Acad Sci U S A 111:1066-71. 2014
    ..Thus, our findings establish a critical role for inflammasome-independent production of IL-1β in osteolytic bone disease and identify PSTPIP2 as a negative regulator of caspase-1-autonomous IL-1β production. ..
  8. pmc The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis
    Frank L van de Veerdonk
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, USA
    Eur J Immunol 41:2260-8. 2011
    ..These observations identify a critical role for the inflammasome in controlling protective adaptive immune responses during invasive fungal infection...
  9. pmc FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes
    Prajwal Gurung
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105
    J Immunol 192:1835-46. 2014
    ..Thus, our results reveal FADD and caspase-8 as apical mediators of canonical and noncanonical Nlrp3 inflammasome priming and activation. ..
  10. pmc Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens
    Prajwal Gurung
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 287:34474-83. 2012
    ..typhimurium. Thus, TLR4- and TRIF-induced caspase-11 synthesis is critical for noncanonical Nlrp3 inflammasome activation in macrophages infected with enteric pathogens...
  11. pmc The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis
    Md Hasan Zaki
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 20:649-60. 2011
    ..These results reveal a critical role for NLRP12 in maintaining intestinal homeostasis and providing protection against colorectal tumorigenesis...
  12. pmc The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization
    Sirish K Ippagunta
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 12:1010-6. 2011
    ..Thus, ASC shapes adaptive immunity independently of inflammasomes by modulating Dock2-dependent Rac activation and actin polymerization in DCs and lymphocytes...
  13. pmc Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis
    Patrick J Shaw
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38104, USA
    J Immunol 184:4610-4. 2010
    ..We found that CD4(+) T cells deficient in ASC exhibited impaired survival; accordingly, ASC(-/-) mice had fewer myelin oligodendrocyte glycoprotein-specific T cells in the draining lymph nodes and CNS...
  14. pmc Role of inflammasomes in host defense against Citrobacter rodentium infection
    Zhiping Liu
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 287:16955-64. 2012
    ..Thus, production of IL-1β and IL-18 downstream of the Nlrp3 and Nlrc4 inflammasomes plays a critical role in host defense against enteric infections caused by C. rodentium...
  15. pmc IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation
    Mohammad Hasan Zaki
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 185:4912-20. 2010
    ..Thus, IL-18 production downstream of the Nlrp3 inflammasome is critically involved in protection against colorectal tumorigenesis...
  16. pmc Dietary modulation of the microbiome affects autoinflammatory disease
    John R Lukens
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 516:246-9. 2014
    ..Collectively, this work reveals diet-associated changes in the intestinal microbiome as a crucial factor regulating inflammasome- and caspase-8-mediated maturation of IL-1β and osteomyelitis in Pstpip2(cmo) mice...
  17. pmc Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection
    Christopher Lupfer
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 14:480-8. 2013
    ..These results demonstrate a role for NOD2-RIPK2 signaling in protection against virally triggered immunopathology by negatively regulating activation of the NLRP3 inflammasome and production of IL-18 via ULK1-dependent mitophagy...
  18. pmc Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer
    Si Ming Man
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell 162:45-58. 2015
    ..Therapeutic modulation of AIM2 expression and microbiota has the potential to prevent colorectal cancer. ..
  19. pmc NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens
    Paras K Anand
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 488:389-93. 2012
    ..Thus, our results reveal NLRP6 as a negative regulator of inflammatory signalling, and demonstrate a role for this NLR in impeding clearance of both Gram-positive and -negative bacterial pathogens...
  20. pmc TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation
    Paras K Anand
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 286:42981-91. 2011
    ..monocytogenes...
  21. pmc Cutting edge: proteolytic inactivation of poly(ADP-ribose) polymerase 1 by the Nlrp3 and Nlrc4 inflammasomes
    R K Subbarao Malireddi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Immunol 185:3127-30. 2010
    ..Thus, protease-mediated inactivation of PARP1 is a shared feature of apoptotic, necrotic, and pyroptotic cells...
  22. pmc The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    Md Hasan Zaki
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 32:379-91. 2010
    ..Thus, the Nlrp3 inflammasome is critically involved in the maintenance of intestinal homeostasis and protection against colitis...
  23. pmc RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3
    Christopher P Dillon
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell 157:1189-202. 2014
    ..These results clarify the complex roles for RIPK1 in postnatal life and provide insights into the regulation of FADD-caspase-8 and RIPK3-MLKL signaling by RIPK1...
  24. pmc Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection
    Md Hasan Zaki
    Department of Immunology and Animal Resources Center and the Veterinary Pathology Core, St Jude Children s Research Hospital, Memphis, TN 38105
    Proc Natl Acad Sci U S A 111:385-90. 2014
    ..These results underscore a signaling pathway defined by NLRP12-mediated dampening of host immune defenses that could be exploited by S. typhimurium to persist and survive in the host. ..
  25. pmc Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation
    Gonghua Huang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 13:152-61. 2012
    ..Our results identify p38α signaling as a central pathway for the integration of instructive signals in DCs for T(H)17 differentiation and inflammation...
  26. pmc Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis
    Sirish K Ippagunta
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 285:12454-62. 2010
    ....
  27. pmc The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells
    John R Lukens
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA Center for Brain Immunology and Glia BIG, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Immunity 42:654-64. 2015
    ..These results define an unexpected role for NLRP12 as an intrinsic negative regulator of T-cell-mediated immunity and identify altered NF-κB regulation and IL-4 production as key mediators of NLRP12-associated disease. ..
  28. pmc Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity
    Patrick J Shaw
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38104, USA
    Immunity 34:75-84. 2011
    ..Our results suggest that PGN in the CNS is involved in the pathogenesis of EAE through the activation of infiltrating dendritic cells via NOD1-, NOD2-, and RIP2-mediated pathways...
  29. pmc Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59
    Ali H Ellebedy
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 108:2927-32. 2011
    ..These findings have important implications for the rational design of next-generation adjuvants...
  30. pmc RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3
    John R Lukens
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 498:224-7. 2013
    ....
  31. pmc Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection
    Rajendra Karki
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Host Microbe 17:357-68. 2015
    ..Thus, AIM2 and NLRP3 form a dual cytoplasmic surveillance system that orchestrates responses against A. fumigatus infection...
  32. pmc The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
    Si Ming Man
    1 Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA 2 School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia
    Nat Immunol 16:467-75. 2015
    ..Our results reveal a specific requirement for IRF1 and GBPs in the liberation of DNA for sensing by AIM2 depending on the pathogen encountered by the cell. ..
  33. pmc Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival
    Mohamed Lamkanfi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 113:2742-5. 2009
    ..These results reveal for the first time a nonredundant role for caspase-7 in vivo and identify caspase-7 inhibition as a component of the mechanism by which caspase inhibitors protect from endotoxin-induced mortality...
  34. pmc Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection
    Christopher R Lupfer
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 10:e1004410. 2014
    ..Our findings designate NOD2 and RIP2 as key regulators of cellular ROS homeostasis and demonstrate for the first time that ROS regulates caspase-11 expression and non-canonical NLRP3 inflammasome activation through the JNK pathway. ..
  35. pmc Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation
    Qifan Zhu
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163
    J Immunol 193:4779-82. 2014
    ..Therefore, our results identified an unexpected and important role for STING in mediating protection against colorectal tumorigenesis. ..
  36. pmc The expanding role of NLRs in antiviral immunity
    Christopher Lupfer
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Immunol Rev 255:13-24. 2013
    ..In this review, we discuss current knowledge pertaining to viruses and NLRs as well as areas of potential research, which will help advance the study of NLR biology during virus infection. ..
  37. pmc Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection
    R K Subbarao Malireddi
    Department of Immunology, St Jude Children s Research Hospital Memphis, TN, USA
    Front Cell Infect Microbiol 3:77. 2013
    ..Understanding the specific mechanisms driving type I IFN-mediated cell death and disease could aid in the development of targeted therapies. ..
  38. pmc Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4(+) T cells and γδ T cells
    John R Lukens
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 188:3107-15. 2012
    ..These findings highlight the importance of inflammasome-derived IL-1β and the IL-1R/MyD88 signaling axis in the regulation of GM-CSF production...
  39. pmc The Nlrp3 inflammasome: contributions to intestinal homeostasis
    Md Hasan Zaki
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Trends Immunol 32:171-9. 2011
    ..Here, we review and discuss recent advances of the role of the Nlrp3 inflammasome in colitis and colon tumorigenesis...
  40. pmc Inflammasome activation in obesity-related inflammatory diseases and autoimmunity
    John R Lukens
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Discov Med 12:65-74. 2011
    ....
  41. pmc Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation
    Prajwal Gurung
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, 38105, USA
    Sci Rep 5:14488. 2015
    ..In conclusion, we have uncovered a mechanism by which chronic, but not acute, LPS exposure induces IL-10 to dampen NLRP3 inflammasome activation to avoid overt inflammation...
  42. pmc Drak2 is not required for tumor surveillance and suppression
    Benjamin A Edwards
    Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, MS 351, Memphis, TN 38105, USA
    Int Immunol 27:161-6. 2015
    ..Importantly, these data also indicate that while Drak2 may induce apoptosis when overexpressed in cell lines, it is not an essential tumor suppressor. ..
  43. pmc NLRP6 in infection and inflammation
    Paras K Anand
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Microbes Infect 15:661-8. 2013
    ..Further, NLRP6 regulates intestinal inflammation by maintaining gut microbiota composition. In this review, we examine the recent studies and emphasize the key functions regulated by NLRP6. ..
  44. pmc Reciprocal regulation of activating and inhibitory Fc{gamma} receptors by TLR7/8 activation: implications for tumor immunotherapy
    Jonathan P Butchar
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
    Clin Cancer Res 16:2065-75. 2010
    ..Here, we wished to test the effect of TLR7/8 activation on monocyte Fcgamma receptor (FcgammaR) function, as they are critical mediators of antibody therapy...
  45. doi request reprint K⁺ drops tilt the NLRP3 inflammasome
    Thirumala Devi Kanneganti
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 38:1085-8. 2013
    ..Its activation must therefore be specifically licensed. In this issue of Immunity, Munoz-Planillo et al. (2013) reveal K⁺ efflux as the sole common denominator of an array of unrelated stimuli engaging this inflammasome...
  46. pmc Cutting edge: SHARPIN is required for optimal NLRP3 inflammasome activation
    Prajwal Gurung
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105
    J Immunol 194:2064-7. 2015
    ..In conclusion, our study identified SHARPIN as a novel regulator of the NLRP3 inflammasome. ..
  47. pmc IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis
    Bofeng Li
    Department of Pathology, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, Tennesse 38105, USA
    Nat Commun 6:6131. 2015
    ..Therefore, lineage-specific effects of IL-10 skew the cytokine dependency of Th17 cell development required for colitis pathogenesis. Coordinated interventions may be needed to fully suppress Th17-mediated immunopathology. ..
  48. pmc The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 30:566-75. 2009
    ..These findings reveal a function of the cryopyrin inflammasome in healing responses. Thus, cryopyrin and caspase-1 are central to both innate immunity and to moderating lung pathology in influenza pneumonia...
  49. pmc Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates
    Gonghua Huang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 35:45-58. 2011
    ....
  50. pmc Inflammasome control of viral infection
    Christopher Lupfer
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, United States
    Curr Opin Virol 12:38-46. 2015
    ..Herein, we highlight recent advances and discuss potential future directions toward understanding the role of inflammasomes during virus infection. ..
  51. pmc AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity
    Si Ming Man
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, USA
    Eur J Immunol 46:269-80. 2016
    ..In this review we provide an overview of the latest research on AIM2 inflammasome and its role in infection, cancer, and autoimmunity. ..
  52. doi request reprint Innate immune recognition of mtDNA--an undercover signal?
    Thirumala Devi Kanneganti
    Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cell Metab 21:793-4. 2015
    ..In Nature, West et al. (2015) demonstrate that mitochondrial stress triggers a type I interferon response and confers viral resistance via release of mtDNA and activation of the cGAS-STING pathway. ..
  53. pmc Mitochondria: diversity in the regulation of the NLRP3 inflammasome
    Prajwal Gurung
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Trends Mol Med 21:193-201. 2015
    ..In addition, we highlight how aberrant regulation of mitochondria-induced inflammasome activation centrally contributes to the inflammatory process that is responsible for obesity and associated metabolic diseases. ..
  54. pmc Nucleotide oligomerization and binding domain 2-dependent dendritic cell activation is necessary for innate immunity and optimal CD8+ T Cell responses to influenza A virus infection
    Christopher Lupfer
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Virol 88:8946-55. 2014
    ..Thus, Nod2(-/-) DCs are unable to efficiently prime CD8(+) T cells. These findings demonstrate that Nod2 is critical for the generation of both innate and adaptive immune responses necessary for controlling IAV infection...
  55. pmc Fungal zymosan and mannan activate the cryopyrin inflammasome
    Mohamed Lamkanfi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 284:20574-81. 2009
    ....
  56. pmc The role of inflammasome modulation in virulence
    Christopher R Lupfer
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, USA
    Virulence 3:262-70. 2012
    ..In this review we discuss the pathogen specific modulation of inflammasome activation and the role this plays in virulence and disease pathology...
  57. doi request reprint Converging roles of caspases in inflammasome activation, cell death and innate immunity
    Si Ming Man
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Rev Immunol 16:7-21. 2016
    ..In this Review, we discuss the expanding and interconnected roles of caspases that highlight new aspects of this family of cysteine proteases in innate immunity. ..
  58. doi request reprint Type I Interferon Keeps IL-1β in Check
    Si Ming Man
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Host Microbe 19:272-4. 2016
    ..2016) demonstrate that type I interferons produced during Streptococcus pyogenes infection are required to prevent inflammation-associated tissue damage and host lethality driven by the pro-inflammatory cytokine IL-1β. ..
  59. pmc Gasdermin D: the long-awaited executioner of pyroptosis
    Si Ming Man
    Department of Immunology, St Jude Children s Research Hospital, MS 351, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cell Res 25:1183-4. 2015
    ..Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell. ..
  60. pmc Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins
    Jennifer Martinez
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Cell Biol 17:893-906. 2015
    ..Therefore, we have identified molecules that distinguish LAP from canonical autophagy, thereby elucidating the importance of LAP in response to A. fumigatus infection. ..
  61. pmc NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells
    Steven W Paugh
    1 Hematological Malignancies Program, St Jude Children s Research Hospital, Memphis, Tennessee, USA 2 Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 47:607-14. 2015
    ..The broad impact on the glucocorticoid transcriptional response suggests that this mechanism could also modify glucocorticoid effects in other diseases. ..
  62. pmc Regulation of inflammasome activation
    Si Ming Man
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, USA
    Immunol Rev 265:6-21. 2015
    ..In this review, we provide an overview of the latest development of inflammasome research and discuss how inflammasome activities govern health and disease. ..
  63. pmc Novel roles for caspase-8 in IL-1β and inflammasome regulation
    Prajwal Gurung
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee
    Am J Pathol 185:17-25. 2015
    ..Here, we address recent findings on caspase-8 and its role in modulating IL-1β and inflammation. ..
  64. pmc Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease
    John R Lukens
    Department of Immunology, St Jude Children s Research Hospital, MS 351, 262 Danny Thomas Place, Suite E7004, Memphis, TN, 38105 2794, USA
    Semin Immunopathol 36:595-609. 2014
    ..In particular, we highlight recent studies that describe novel roles for conventional cell death molecules in the regulation of IL-1β production. ..
  65. pmc Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
    Karim C El Kasmi
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38015, USA
    Nat Immunol 9:1399-406. 2008
    ..Specific elimination of Arg1 in macrophages favored host survival during T. gondii infection and decreased lung bacterial load during tuberculosis infection...
  66. pmc Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages
    Dalia H A Abdelaziz
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University Columbus, OH, USA
    Front Microbiol 2:18. 2011
    ..Taken together, our data demonstrate that L. pneumophila infection in murine macrophages is controlled by several mechanisms: Asc-independent activation of caspase-1 and Asc-dependent regulation of NF-κB and caspase-3 activation...
  67. pmc MiR-155 induction by microbes/microbial ligands requires NF-κB-dependent de novo protein synthesis
    Thomas J Cremer
    Molecular, Cellular, and Developmental Biology Program, The Ohio State University Columbus, OH, USA
    Front Cell Infect Microbiol 2:73. 2012
    ..This study provides new insight into the complex regulation of miR-155 during microbial infection...
  68. pmc Inflammasomes and autoimmunity
    Patrick J Shaw
    Department of Immunology, St Jude Children s Research Hospital, MS 351, Suite E7004, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Trends Mol Med 17:57-64. 2011
    ..We summarize the role of inflammasomes in autoimmune disorders, highlight the need for a better understanding of inflammasomes in these conditions and offer suggestions for future research directions...
  69. doi request reprint Fat chance: not much against NKT cells
    John R Lukens
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 37:447-9. 2012
    ..In this issue of Immunity, Lynch et al. (2012) show that invariant natural killer T (iNKT) cells are enriched in adipose tissue and induce anti-inflammatory pathways to confer protection against obesity...