Akira Inoue

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. doi request reprint Perturbation of HP1 localization and chromatin binding ability causes defects in sister-chromatid cohesion
    Akira Inoue
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mutat Res 657:48-55. 2008
  2. doi request reprint Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis
    Marcelo Actis
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Bioorg Med Chem 21:1972-7. 2013
  3. pmc Mammalian ChlR1 has a role in heterochromatin organization
    Akira Inoue
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN, USA
    Exp Cell Res 317:2522-35. 2011
  4. pmc Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication
    Chandanamali Punchihewa
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 287:14289-300. 2012
  5. ncbi request reprint Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation
    Akira Inoue
    Department Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell Cycle 6:1646-54. 2007

Collaborators

  • Naoaki Fujii
  • Isao Kuraoka
  • Mark S Lechner
  • Chandanamali Punchihewa
  • Marcelo Actis
  • Benjamin Evison
  • Scott Perry
  • Asami Hishiki
  • Mamoru Sato
  • Yoshihiro Fujikawa
  • Takashi Yagi
  • Youming Shao
  • Michele Connelly
  • Hiroshi Hashimoto
  • Richard Heath
  • Masanobu Kawanishi
  • Patrick Rodrigues

Detail Information

Publications5

  1. doi request reprint Perturbation of HP1 localization and chromatin binding ability causes defects in sister-chromatid cohesion
    Akira Inoue
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mutat Res 657:48-55. 2008
    ..These results indicate that proper HP1 status is required for sister-chromatid cohesion in mammalian cells, and suggest that HP1alpha might be required for chromosome condensation...
  2. doi request reprint Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis
    Marcelo Actis
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Bioorg Med Chem 21:1972-7. 2013
    ..PCNA inhibitors increased γH2AX induction and cell viability reduction mediated by cisplatin. Taken together, these findings suggest that inhibitors of PCNA/PIP-box interaction could chemosensitize cells to cisplatin by inhibiting TLS...
  3. pmc Mammalian ChlR1 has a role in heterochromatin organization
    Akira Inoue
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN, USA
    Exp Cell Res 317:2522-35. 2011
    ..These data suggest that in addition to a role in sister-chromatid cohesion, ChlR1 is also involved in the proper formation of heterochromatin, which in turn contributes to global nuclear organization and pleiotropic effects...
  4. pmc Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication
    Chandanamali Punchihewa
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 287:14289-300. 2012
    ..When cells were treated with a combination of cisplatin and T2AA, a significant increase in phospho(Ser(139))histone H2AX induction and cell growth inhibition was observed...
  5. ncbi request reprint Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation
    Akira Inoue
    Department Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell Cycle 6:1646-54. 2007
    ....