Research Topics
Species | Hiroto InabaSummaryAffiliation: St. Jude Children's Research Hospital Country: USA Publications
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Detail Information
Publications
Herpes simplex virus pneumonia in a patient with ependymomaHiroto Inaba
Divisions of Pediatric Hematology Oncology, Children s Hospital of Michigan, Detroit, Michigan 38105, USA
J Pediatr Hematol Oncol 26:108-11. 2004..HSV must be considered in the differential diagnosis of patients with interstitial pneumonia and T-cell deficiency, especially after craniospinal irradiation...
Comparison of antitumor effects of multitargeted tyrosine kinase inhibitors in acute myelogenous leukemiaShuiying Hu
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale Street, DTRC Room D1034, Mail Stop 314, Memphis, TN 38105, USA
Mol Cancer Ther 7:1110-20. 2008..Our results highlight the pharmacologic features of sorafenib that may provide it an advantage in the treatment of AML...- Clinical and biologic features and treatment outcome of children with newly diagnosed acute myeloid leukemia and hyperleukocytosisHiroto Inaba
Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Cancer 113:522-9. 2008..To the authors' knowledge, no recently published study has evaluated the management and clinical course in this regard, especially in relation to pediatric patients... 
Effect of body mass index on the outcome of children with acute myeloid leukemiaHiroto Inaba
Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee
Cancer 118:5989-96. 2012..The effect of body mass index (BMI) on the treatment outcomes of children with acute myeloid leukemia (AML) is unclear and needs further evaluation...- Comparative analysis of different approaches to measure treatment response in acute myeloid leukemiaHiroto Inaba
Department of Oncology, MS 260, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
J Clin Oncol 30:3625-32. 2012..Response can now be assessed by minimal residual disease (MRD) monitoring with flow cytometry or polymerase chain reaction (PCR). We determined the relation among the results of these approaches and their prognostic value... - Combination of cladribine plus topotecan for recurrent or refractory pediatric acute myeloid leukemiaHiroto Inaba
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Cancer 116:98-105. 2010..The prognosis after recurrence of pediatric acute myeloid leukemia (AML) is poor, and effective salvage regimens are urgently needed... - Glucocorticoid use in acute lymphoblastic leukaemiaHiroto Inaba
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
Lancet Oncol 11:1096-106. 2010..The selection of the type and dose of glucocorticoid should be based on the risk of relapse, treatment phase, and the chemotherapeutic drugs used concomitantly... - Randomized trial of 2 dosages of prophylactic granulocyte-colony-stimulating factor after induction chemotherapy in pediatric acute myeloid leukemiaHiroto Inaba
Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer 117:1313-20. 2011..However, the optimal G-CSF dosage for patients with AML has not been determined. To the authors' knowledge, G-CSF dosages have not been compared in a randomized AML study... - Pulmonary alveolar proteinosis in pediatric leukemiaHiroto Inaba
Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Pediatr Blood Cancer 51:66-70. 2008..Only isolated cases of PAP have been reported, and pediatric experience is limited... - BK virus-induced tubulointerstitial nephritis in a child with acute lymphoblastic leukemiaHiroto Inaba
Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
J Pediatr 151:215-7. 2007..Careful administration of chemotherapy and anti-viral therapy prevented further damage. This diagnosis should be considered in children who experience renal dysfunction during cancer treatment... - Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemiaHiroto Inaba
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Clin Oncol 29:3293-300. 2011..To assess the toxicity, pharmacokinetics, and pharmacodynamics of multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in children with relapsed/refractory leukemia... - Acquisition of Fas resistance by Fas receptor mutation in a childhood B-precursor acute lymphoblastic leukemia cell line, MML-1Hiroto Inaba
Department of Pediatrics, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
Int J Oncol 27:573-9. 2005..Screening for similar Fas mutations in therapy resistant malignancies would lead to a better understanding of tumorigenesis and recurrence... - A case of hemoglobin SC disease with cold agglutinin-induced hemolysisHiroto Inaba
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Am J Hematol 78:37-40. 2005..Careful evaluation of CBCs and peripheral blood smears is required in cases of worsening anemia among sickle cell patients and consideration should be given to cold hemagglutinin disease as an etiology... - Interferon-gamma sensitizes osteosarcoma cells to Fas-induced apoptosis by up-regulating Fas receptors and caspase-8Hiroto Inaba
Division of Pediatric Hematology Oncology, Children s Hospital of Michigan, Detroit, Michigan, USA
Pediatr Blood Cancer 43:729-36. 2004..Because the Fas ligand/Fas receptor (CD95, APO-1) apoptosis pathway is a potential therapeutic target in osteosarcomas, we examined the effect of IFN-gamma on Fas-induced apoptosis in four osteosarcoma cell lines... - Pulmonary dysfunction in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem cell transplantationHiroto Inaba
Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Cancer 116:2020-30. 2010..The number of long-term survivors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is increasing; however, few studies have addressed their long-term pulmonary function... - Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trialJeffrey E Rubnitz
Department of Oncology, St Jude Children s Research Hospital and the University of Tennessee Health Science Center, Memphis, TN 38105 2794, USA
Lancet Oncol 11:543-52. 2010.... - Activity of the multikinase inhibitor sorafenib in combination with cytarabine in acute myeloid leukemiaShuiying Hu
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
J Natl Cancer Inst 103:893-905. 2011..We investigated a treatment strategy combining sorafenib, a multikinase inhibitor with limited single-agent activity in AML, and cytarabine, a key component of AML chemotherapy... - Improved prognosis for older adolescents with acute lymphoblastic leukemiaChing Hon Pui
St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Clin Oncol 29:386-91. 2011..We reviewed the outcome of older adolescents (age 15 to 18 years) treated in four consecutive Total Therapy studies to determine if recent improved treatment extended to this high-risk group... - Detectable minimal residual disease before hematopoietic cell transplantation is prognostic but does not preclude cure for children with very-high-risk leukemiaWing Leung
Department of Bone Marrow Transplantation and Cellular Therapy, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105 2794, USA
Blood 120:468-72. 2012..Although MRD before HCT is a strong prognostic factor, its impact has diminished and should not be regarded as a contraindication for HCT... - Treatment outcome in older patients with childhood acute myeloid leukemiaJeffrey E Rubnitz
Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee
Cancer 118:6253-9. 2012..Future trials should focus on improving supportive care while striving to develop more effective antileukemic therapy. Cancer 2012. © 2012 American Cancer Society... - Longitudinal analysis of antibody response to immunization in paediatric survivors after allogeneic haematopoietic stem cell transplantationHiroto Inaba
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
Br J Haematol 156:109-17. 2012..Patients at risk for vaccine failure should have long-term follow-up; those with loss of antibody response or no seroconversion should receive booster immunizations... - NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemiaJeffrey E Rubnitz
Department of Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 2794, USA
J Clin Oncol 28:955-9. 2010..We propose to further investigate the efficacy of KIR-mismatched NK cells in a phase II trial as consolidation therapy to decrease relapse without increasing mortality in children with AML... - Diagnostic challenge in recurrent skin rash after autologous bone marrow transplantationHiroto Inaba
Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
J Pediatr Hematol Oncol 28:525-8. 2006..Establishment of diagnostic criteria and understanding of the pathophysiology of these entities may lead to better management and to improved therapy of refractory cancer... - Longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantationHiroto Inaba
Department of Bone Marrow Transplantation and Cellular Therapy, MS 1130, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678
J Clin Oncol 30:3991-7. 2012..Monitoring and preservation of BMI and lean mass are vital, especially in those with the identified risk factors... - Spinal epidural lipomatosis in children with hematologic malignanciesRachel C Brennan
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Ann Hematol 90:1067-74. 2011..Investigation for SEL in leukemia or lymphoma patients with difficult lumbar punctures is warranted. Placement of an Ommaya reservoir may facilitate safe CNS-directed therapy in severely affected patients... - In vivo suppression of naive CD4 T cell responses by IL-2- and antigen-stimulated T lymphocytes in the absence of APC competitionHiroto Inaba
Department of Oncology and Pathology, St Jude Children s Research Hospital, Memphis, TN, USA
J Immunol 181:3323-35. 2008..They further suggest a novel negative feedback loop limiting the expansion of T cell responses that may be present during vigorous immune responses or after IL-2 immunotherapy... - Parainfluenza virus infections in children with hematologic malignanciesAshok Srinivasan
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
Pediatr Infect Dis J 30:855-9. 2011..However, the epidemiology of PIV infections in children with cancer has not been well studied... - Allogeneic graft-versus-hepatoblastoma effectHiroto Inaba
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
Pediatr Blood Cancer 46:501-5. 2006..Her disease recurred when GVHD resolved. This patient's clinical course provides evidence for the probable existence of allogeneic graft-versus-hepatoblastoma effect... - Ontogeny and sorafenib metabolismEric I Zimmerman
Authors Affiliations Departments of Pharmaceutical Sciences, Information Sciences, and Oncology, St Jude Children s Research Hospital, Memphis, Tennessee
Clin Cancer Res 18:5788-95. 2012..To investigate the role of ontogeny in sorafenib metabolism to the equipotent active metabolite sorafenib N-oxide... - Pulmonary function after whole lung irradiation in pediatric patients with solid malignanciesMegan S Motosue
Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer 118:1450-6. 2012..Although whole lung irradiation is used to treat pulmonary metastases of pediatric solid malignancies, few studies have addressed its long-term pulmonary consequences... - Defective cell cycle induction by IL-2 in naive T-cells antigen stimulated in the presence of refractory T-lymphocytesHiroto Inaba
Department of Hematology and Oncology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
Int Immunol 18:1043-54. 2006..These results have implications for how activation-refractory T cells may influence nascent immune responses... - Recurrent intrathecal methotrexate induced neurotoxicity in an adolescent with acute lymphoblastic leukemia: Serial clinical and radiologic findingsFulvia Brugnoletti
Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Pediatr Blood Cancer 52:293-5. 2009..Resolution of diffusion abnormalities did not preclude further toxicity and a large lesion could cause persisting symptoms... - Childhood acute myeloid leukaemiaJeffrey E Rubnitz
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Br J Haematol 159:259-76. 2012....