James Ihle

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP)
    Sebastien Gingras
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS ONE 2:e808. 2007
  2. ncbi request reprint Signaling by the cytokine receptor superfamily
    J N Ihle
    Howard Hughes Medical Institute, Department of Biochemistry, Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Ann N Y Acad Sci 865:1-9. 1998
  3. ncbi request reprint The Stat family in cytokine signaling
    J N Ihle
    Department of Biochemistry, Howard Hughes Medical Institute, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Curr Opin Cell Biol 13:211-7. 2001
  4. ncbi request reprint Jak2: normal function and role in hematopoietic disorders
    James N Ihle
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Curr Opin Genet Dev 17:8-14. 2007
  5. ncbi request reprint Evi-1 expression in Xenopus
    Paul E Mead
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Gene Expr Patterns 5:601-8. 2005
  6. pmc Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity
    Megumi Funakoshi-Tago
    Department of Biochemistry, D4013, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA
    Mol Cell Biol 28:1792-801. 2008
  7. pmc Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein
    Nick Carpino
    Department of Biochemistry, St Jude Children s Research Hospital, and University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
    Mol Cell Biol 22:7491-500. 2002
  8. pmc Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2
    Megumi Funakoshi-Tago
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 3810, USA
    EMBO J 25:4763-72. 2006
  9. ncbi request reprint SOCS3 regulates the plasticity of gp130 signaling
    Roland Lang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Immunol 4:546-50. 2003
  10. pmc SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation
    Yutaka Takahashi
    Howard Hughes Medical Institute, Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 22:372-84. 2003

Collaborators

Detail Information

Publications19

  1. pmc Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP)
    Sebastien Gingras
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS ONE 2:e808. 2007
    ..However, combined deficiencies cause partial neonatal lethality suggesting that the genes have redundant functions...
  2. ncbi request reprint Signaling by the cytokine receptor superfamily
    J N Ihle
    Howard Hughes Medical Institute, Department of Biochemistry, Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Ann N Y Acad Sci 865:1-9. 1998
    ..Each Stat family member plays a critical role in the biological functions of specific cytokines as demonstrated by the phenotype of mice lacking one or more of these genes...
  3. ncbi request reprint The Stat family in cytokine signaling
    J N Ihle
    Department of Biochemistry, Howard Hughes Medical Institute, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Curr Opin Cell Biol 13:211-7. 2001
    ....
  4. ncbi request reprint Jak2: normal function and role in hematopoietic disorders
    James N Ihle
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Curr Opin Genet Dev 17:8-14. 2007
    ..Recent studies have implicated de-regulation of Jak2 kinase activity by chromosomal translocations in hematopoietic tumors and mutations within the pseudokinase domain in a spectrum of myeloproliferative diseases...
  5. ncbi request reprint Evi-1 expression in Xenopus
    Paul E Mead
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Gene Expr Patterns 5:601-8. 2005
    ..Expression of Evi-1 is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck...
  6. pmc Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity
    Megumi Funakoshi-Tago
    Department of Biochemistry, D4013, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA
    Mol Cell Biol 28:1792-801. 2008
    ....
  7. pmc Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein
    Nick Carpino
    Department of Biochemistry, St Jude Children s Research Hospital, and University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
    Mol Cell Biol 22:7491-500. 2002
    ..In addition, no impairment in B- and T-cell development and proliferative ability was detected...
  8. pmc Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2
    Megumi Funakoshi-Tago
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 3810, USA
    EMBO J 25:4763-72. 2006
    ..This regulation occurs with the receptors for Epo, thrombopoietin and growth hormone but not with the receptor for interferon-gamma...
  9. ncbi request reprint SOCS3 regulates the plasticity of gp130 signaling
    Roland Lang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Immunol 4:546-50. 2003
    ..Thus, SOCS3 functions to control the quality of the response to IL-6 and prevents the activation of an IFN-induced program of gene expression...
  10. pmc SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation
    Yutaka Takahashi
    Howard Hughes Medical Institute, Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 22:372-84. 2003
    ..Finally, LIFR deficiency rescues the SOCS3-deficient placental defect and embryonic lethality. The results establish SOCS3 as an essential regulator of LIFR signaling in trophoblast differentiation...
  11. ncbi request reprint Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase
    Roland P Piekorz
    Howard Hughes Medical Institute, Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Endocrinol 19:431-40. 2005
    ....
  12. pmc Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function
    Stephane Pelletier
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell Biol 26:8527-38. 2006
    ..Collectively, the results suggest that Jak2 is the sole direct signaling molecule downstream of EpoR required for biological activity...
  13. pmc Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development
    Nick Carpino
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 24:2584-92. 2004
    ..Mice deficient in Jak3 exhibit a SCID phenotype but harbor a residual B220+ splenic lymphocyte population. We demonstrate here that this residual lymphocyte population is lost in mice lacking both the gamma-like chain and Jak3...
  14. ncbi request reprint Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling
    Sebastien Gingras
    Howard Hughes Medical Institute, Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 279:54702-7. 2004
    ..We conclude that previous reports linking SOCS1 to TLR signaling are most likely due to effects on IFN-alpha/beta receptor signaling...
  15. ncbi request reprint A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling
    Martina Gatzka
    Howard Hughes Medical Institute, St Jude Children s Research Hospital, Memphis, TN 38120, USA
    Cytokine 34:143-54. 2006
    ....
  16. pmc The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis
    Roland P Piekorz
    Howard Hughes Medical Institute, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 21:653-64. 2002
    ..The results support the concept that TACC3 is a critical component of the centrosome/mitotic spindle apparatus and its absence triggers p53-mediated apoptosis...
  17. ncbi request reprint Determination of the transphosphorylation sites of Jak2 kinase
    Tadashi Matsuda
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biochem Biophys Res Commun 325:586-94. 2004
    ..Additionally, non-Jak family conserved tyrosines are phosphorylated suggesting that the individual Jaks ability to phosphorylated specific tyrosines may influence signals emitting from activated Jaks...
  18. ncbi request reprint Stat5 tetramer formation is associated with leukemogenesis
    Richard Moriggl
    Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cancer Cell 7:87-99. 2005
    ..In addition, Stat5 tetramers were found to accumulate in excess compared to dimers in various human leukemias. These data suggest that Stat5 tetramers are associated with leukemogenesis...
  19. ncbi request reprint Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5
    Kevin D Bunting
    Hematopoiesis Department, American Red Cross Holland Laboratory, Rockville, MD, USA
    Blood 99:479-87. 2002
    ..These results demonstrate that a significant proportion of the growth factor signals required for multilineage reconstitution potential of HSCs is STAT5 dependent...

Research Grants19

  1. Cytokine Regulated Growth Of Hematopoietic Cells
    James Ihle; Fiscal Year: 2007
    ..Both genetic approaches and biochemical approaches are proposed to identify components of this pathway. ..
  2. INTERLEUKIN-3 REGULATED GROWTH HEMATOPOIETIC CELLS
    James Ihle; Fiscal Year: 2002
    ..abstract_text> ..
  3. INTERLEUKIN-3 REGULATED GROWTH OF HEMATOPOIETIC CELLS
    James Ihle; Fiscal Year: 1992
    ..Together these approaches will identify new genes that are involved in the growth regulation of hematopoietic cells and better our understanding of the growth and differentiation of myeloid cells...
  4. Hematopoiesis
    James Ihle; Fiscal Year: 2004
    ..abstract_text> ..
  5. INTERLEUKIN-3 REGULATED GROWTH OF HEMATOPOIETIC CELLS
    James Ihle; Fiscal Year: 1990
    ..Together these approaches will identify new genes that are involved in the growth regulation of hematopoietic cells and better our understanding of the growth and differentiation of myeloid cells...
  6. INTERLEUKIN-3 REGULATED GROWTH HEMATOPOIETIC CELLS
    James Ihle; Fiscal Year: 1999
    ..abstract_text> ..
  7. Cytokine Regulated Growth Of Hematopoietic Cells
    James Ihle; Fiscal Year: 2004
    ..Both genetic approaches and biochemical approaches are proposed to identify components of this pathway. ..
  8. Cytokine Regulated Growth Of Hematopoietic Cells
    James Ihle; Fiscal Year: 2005
    ..Both genetic approaches and biochemical approaches are proposed to identify components of this pathway. ..
  9. Cytokine Regulated Growth Of Hematopoietic Cells
    James Ihle; Fiscal Year: 2006
    ..Both genetic approaches and biochemical approaches are proposed to identify components of this pathway. ..
  10. Cytokine Regulated Growth Of Hematopoietic Cells
    James Ihle; Fiscal Year: 2003
    ..Both genetic approaches and biochemical approaches are proposed to identify components of this pathway. ..
  11. INTERLEUKIN-3 REGULATED GROWTH HEMATOPOIETIC CELLS
    James Ihle; Fiscal Year: 2001
    ..abstract_text> ..
  12. INTERLEUKIN-3 REGULATED GROWTH HEMATOPOIETIC CELLS
    James Ihle; Fiscal Year: 2000
    ..abstract_text> ..
  13. INTERLEUKIN-3 REGULATED GROWTH OF HEMATOPOIETIC CELLS
    James Ihle; Fiscal Year: 1993
    ..Together these approaches will identify new genes that are involved in the growth regulation of hematopoietic cells and better our understanding of the growth and differentiation of myeloid cells...
  14. INTERLEUKIN-3 REGULATED GROWTH OF HEMATOPOIETIC CELLS
    James Ihle; Fiscal Year: 1991
    ..Together these approaches will identify new genes that are involved in the growth regulation of hematopoietic cells and better our understanding of the growth and differentiation of myeloid cells...