W T Hughes

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi Effects of aerosolized synthetic surfactant, atovaquone, and the combination of these on murine Pneumocystis carinii pneumonia
    W T Hughes
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Infect Dis 177:1046-56. 1998
  2. ncbi Phase I safety and pharmacokinetics study of micronized atovaquone in human immunodeficiency virus-infected infants and children. Pediatric AIDS Clinical Trials Group
    W Hughes
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Antimicrob Agents Chemother 42:1315-8. 1998
  3. ncbi Single-dose pharmacokinetics and safety of the oral antiviral compound adefovir dipivoxil in children infected with human immunodeficiency virus type 1. The Pediatrics AIDS Clinical Trials Group
    W T Hughes
    St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Antimicrob Agents Chemother 44:1041-6. 2000
  4. ncbi Comparison of atovaquone and azithromycin with trimethoprim-sulfamethoxazole for the prevention of serious bacterial infections in children with HIV infection
    Walter T Hughes
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Clin Infect Dis 40:136-45. 2005
  5. ncbi 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer
    Walter T Hughes
    St. Jude Children's Research Hospital, Memphis, TN, 38105, USA
    Clin Infect Dis 34:730-51. 2002
  6. ncbi Synergistic anti-Pneumocystis carinii effects of erythromycin and sulfisoxazole
    W T Hughes
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee
    J Acquir Immune Defic Syndr 4:532-7. 1991
  7. ncbi Aspergillosis in children with cancer: A 34-year experience
    S Abbasi
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Clin Infect Dis 29:1210-9. 1999
  8. ncbi Oral cefixime is similar to continued intravenous antibiotics in the empirical treatment of febrile neutropenic children with cancer
    J L Shenep
    Department of Infectious Diseases, St Jude Children s Research Hospital, University of Tennessee Health Sciences Center, Memphis, TN 38105, USA
    Clin Infect Dis 32:36-43. 2001
  9. ncbi Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia
    W T Hughes
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Antimicrob Agents Chemother 40:962-5. 1996
  10. ncbi The effect of atovaquone on etoposide pharmacokinetics in children with acute lymphoblastic leukemia
    M E van de Poll
    Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    Cancer Chemother Pharmacol 47:467-72. 2001

Detail Information

Publications15

  1. ncbi Effects of aerosolized synthetic surfactant, atovaquone, and the combination of these on murine Pneumocystis carinii pneumonia
    W T Hughes
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Infect Dis 177:1046-56. 1998
    ..Aerosolized synthetic surfactant alone significantly increased survival of rats with PCP and, when combined with atovaquone, increased plasma and lung concentrations of the drug and eradication of the organism...
  2. ncbi Phase I safety and pharmacokinetics study of micronized atovaquone in human immunodeficiency virus-infected infants and children. Pediatric AIDS Clinical Trials Group
    W Hughes
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Antimicrob Agents Chemother 42:1315-8. 1998
    ..A single daily dose of 30 mg/kg provides bioavailability considered adequate for therapy of P. carinii pneumonia, but infants between 3 and 24 months of age may require a dosage of 45 mg/kg/day...
  3. ncbi Single-dose pharmacokinetics and safety of the oral antiviral compound adefovir dipivoxil in children infected with human immunodeficiency virus type 1. The Pediatrics AIDS Clinical Trials Group
    W T Hughes
    St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Antimicrob Agents Chemother 44:1041-6. 2000
    ..07) among the subjects in the older and younger age groups. No significant adverse events were encountered. These data provide the basis for a multidose phase II study of adefovir dipivoxil in HIV-infected infants and children...
  4. ncbi Comparison of atovaquone and azithromycin with trimethoprim-sulfamethoxazole for the prevention of serious bacterial infections in children with HIV infection
    Walter T Hughes
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Clin Infect Dis 40:136-45. 2005
    ....
  5. ncbi 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer
    Walter T Hughes
    St. Jude Children's Research Hospital, Memphis, TN, 38105, USA
    Clin Infect Dis 34:730-51. 2002
  6. ncbi Synergistic anti-Pneumocystis carinii effects of erythromycin and sulfisoxazole
    W T Hughes
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee
    J Acquir Immune Defic Syndr 4:532-7. 1991
    ....
  7. ncbi Aspergillosis in children with cancer: A 34-year experience
    S Abbasi
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Clin Infect Dis 29:1210-9. 1999
    ..0014). Aspergillosis continues to be associated with poor outcome. Development of improved medical and adjuvant therapies, including surgery, is warranted...
  8. ncbi Oral cefixime is similar to continued intravenous antibiotics in the empirical treatment of febrile neutropenic children with cancer
    J L Shenep
    Department of Infectious Diseases, St Jude Children s Research Hospital, University of Tennessee Health Sciences Center, Memphis, TN 38105, USA
    Clin Infect Dis 32:36-43. 2001
    ..0). Results support the safety of oral cefixime therapy for low-risk febrile neutropenic children, a therapeutic approach that would facilitate earlier outpatient management and decrease the costs of treatment...
  9. ncbi Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia
    W T Hughes
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Antimicrob Agents Chemother 40:962-5. 1996
    ..These studies suggest that a sulfonamide, such as sulfamethoxazole, might provide effective prophylaxis for P. carinii pneumonitis without trimethoprim...
  10. ncbi The effect of atovaquone on etoposide pharmacokinetics in children with acute lymphoblastic leukemia
    M E van de Poll
    Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    Cancer Chemother Pharmacol 47:467-72. 2001
    ....
  11. ncbi Prophylaxis of Pneumocystis carinii pneumonia with atovaquone in children with leukemia
    Renee M Madden
    Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 109:1654-8. 2007
    ..Therefore, a retrospective analysis was conducted to determine the incidence of PCP in pediatric patients who received prophylactic atovaquone during treatment for acute leukemia...
  12. ncbi Pneumocystis carinii vs. Pneumocystis jiroveci: another misnomer (response to Stringer et al.)
    Walter T Hughes
    Emerg Infect Dis 9:276-7; author reply 277-9. 2003
  13. ncbi Bloodstream infections in cancer patients
    Walter T Hughes
    Eur J Cancer 41:1370-1. 2005
  14. ncbi Pneumocystis carinii versus Pneumocystis jirovecii (jiroveci) Frenkel
    Walter T Hughes
    Clin Infect Dis 42:1211-2; author reply 1212-4. 2006
  15. ncbi Transmission of Pneumocystis species among renal transplant recipients
    Walter T Hughes
    Clin Infect Dis 44:1150-1. 2007