Edwin M Horwitz

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta
    E M Horwitz
    Cell and Gene Therapy Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 97:1227-31. 2001
  2. pmc Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone
    Edwin M Horwitz
    Transplantation and Gene Therapy Program, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 99:8932-7. 2002
  3. ncbi request reprint Stem cell plasticity: a new image of the bone marrow stem cell
    Edwin M Horwitz
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Curr Opin Pediatr 15:32-7. 2003
  4. ncbi request reprint Bone marrow transplantation: it's not just about blood anymore!
    Edwin M Horwitz
    Division of Stem Cell Transplantation and Experimental Hematology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Pediatr Transplant 7:56-8. 2003
  5. ncbi request reprint Stem cell plasticity: the growing potential of cellular therapy
    Edwin M Horwitz
    Department of Hematology Oncology, Divisions of Stem Cell Transplantation and Experimental Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Arch Med Res 34:600-6. 2003
  6. pmc Clinical utility of computed tomography screening of chest, abdomen, and sinuses before hematopoietic stem cell transplantation: the St. Jude experience
    Kimberly A Kasow
    Division of Bone Marrow Transplantation and Cellular Therapy, Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Biol Blood Marrow Transplant 15:490-5. 2009
  7. ncbi request reprint Diagnostic yield of bronchoalveolar lavage is low in allogeneic hematopoietic stem cell recipients receiving immunosuppressive therapy or with acute graft-versus-host disease: the St. Jude experience, 1990-2002
    Kimberly A Kasow
    Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Biol Blood Marrow Transplant 13:831-7. 2007
  8. pmc Transplantable marrow osteoprogenitors engraft in discrete saturable sites in the marrow microenvironment
    Roberta Marino
    Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, TN, USA
    Exp Hematol 36:360-8. 2008
  9. ncbi request reprint Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies
    Xiaohua Chen
    Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Haematol 135:524-32. 2006
  10. ncbi request reprint EBV lymphoproliferative disease of host origin after haploidentical stem cell transplantation
    Kimberly A Kasow
    Department of Hematology Oncology, Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 49:869-72. 2007

Research Grants

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta
    E M Horwitz
    Cell and Gene Therapy Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 97:1227-31. 2001
    ..These results suggest that BMT from HLA-compatible donors may benefit children with severe OI. Further studies are needed to determine the full potential of this strategy...
  2. pmc Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone
    Edwin M Horwitz
    Transplantation and Gene Therapy Program, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 99:8932-7. 2002
    ..Thus, allogeneic mesenchymal cells offer feasible posttransplantation therapy for osteogenesis imperfecta and likely other disorders originating in mesenchymal precursors...
  3. ncbi request reprint Stem cell plasticity: a new image of the bone marrow stem cell
    Edwin M Horwitz
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Curr Opin Pediatr 15:32-7. 2003
    ..Both animal models to carefully address outstanding issues and pilot clinical trials to explore the therapeutic potential will be key elements to advance science for the benefit of patients...
  4. ncbi request reprint Bone marrow transplantation: it's not just about blood anymore!
    Edwin M Horwitz
    Division of Stem Cell Transplantation and Experimental Hematology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Pediatr Transplant 7:56-8. 2003
    ....
  5. ncbi request reprint Stem cell plasticity: the growing potential of cellular therapy
    Edwin M Horwitz
    Department of Hematology Oncology, Divisions of Stem Cell Transplantation and Experimental Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Arch Med Res 34:600-6. 2003
    ....
  6. pmc Clinical utility of computed tomography screening of chest, abdomen, and sinuses before hematopoietic stem cell transplantation: the St. Jude experience
    Kimberly A Kasow
    Division of Bone Marrow Transplantation and Cellular Therapy, Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Biol Blood Marrow Transplant 15:490-5. 2009
    ..The decision to perform chest CT should be made judiciously based on a careful history and physical examination. Sinus imaging, which was frequently abnormal, may be justified in all patients to plan post-HSCT care...
  7. ncbi request reprint Diagnostic yield of bronchoalveolar lavage is low in allogeneic hematopoietic stem cell recipients receiving immunosuppressive therapy or with acute graft-versus-host disease: the St. Jude experience, 1990-2002
    Kimberly A Kasow
    Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Biol Blood Marrow Transplant 13:831-7. 2007
    ....
  8. pmc Transplantable marrow osteoprogenitors engraft in discrete saturable sites in the marrow microenvironment
    Roberta Marino
    Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, TN, USA
    Exp Hematol 36:360-8. 2008
    ..To improve the efficacy of BMT for bone disorders, we sought to gain insight into the cellular mechanism of engraftment of transplantable marrow osteoprogenitors...
  9. ncbi request reprint Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies
    Xiaohua Chen
    Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Haematol 135:524-32. 2006
    ..Rapid T-cell reconstitution, retention of NK-cells in the graft and induction of low grade GvHD may also enhance the potential anti-cancer immune effect...
  10. ncbi request reprint EBV lymphoproliferative disease of host origin after haploidentical stem cell transplantation
    Kimberly A Kasow
    Department of Hematology Oncology, Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 49:869-72. 2007
    ..She subsequently developed disseminated PTLPD involving multiple organ and nodal sites. Her neoplastic lymphoblasts were host-derived and refractory to rituximab treatment due to lack of CD20 expression...
  11. ncbi request reprint Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients
    Usman Yusuf
    Division of Stem Cell Transplantation, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Transplantation 81:1398-404. 2006
    ..We report our experience with cidofovir (CDV) for treatment of ADV infection in 57 HSCT patients, median age 8 years (range 0.5-26)...
  12. pmc Human bone marrow mesenchymal stromal cells express the neural ganglioside GD2: a novel surface marker for the identification of MSCs
    Caridad Martinez
    Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 109:4245-8. 2007
    ..Thus, GD2 appears to be the first reported single surface marker that uniquely distinguishes MSCs from other marrow elements. GD2 may prove valuable to study MSC biology and for the preparation of MSCs for clinical applications...
  13. ncbi request reprint Quantitative bone mineral density assessment in malignant infantile osteopetrosis
    Sue C Kaste
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 48:181-5. 2007
    ..To investigate the use of quantitative computed tomography (QCT) and dual energy absorptiometry (DXA) for assessing bone mineral density (BMD) in the evaluation of children with malignant infantile osteopetrosis (MIOP)...
  14. doi request reprint Airway evaluation and management in 7 children with malignant infantile osteopetrosis before hematopoietic stem cell transplantation
    Kimberly A Kasow
    Division of Bone Marrow Transplantation and Cellular Therapy, St Jude Children s Research Hospital, North Lauderdale, Memphis, TN 38105, USA
    J Pediatr Hematol Oncol 30:225-9. 2008
    ..Using a quantitative approach, we demonstrate that MIOP children have OSA and hypoxemia; thus, these children should have airway evaluations and treatments to potentially reduce the risk of life-threatening pulmonary complications...
  15. ncbi request reprint Hemolytic uremic syndrome after bone marrow transplantation: clinical characteristics and outcome in children
    Gregory A Hale
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Biol Blood Marrow Transplant 11:912-20. 2005
    ..With a multiple regression analysis, the use of antithymocyte globulin (beta = .86; P = .04) and recipient cytomegalovirus seronegativity (beta = .93; P = .035) remained significant risk factors for the development of HUS...
  16. ncbi request reprint T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation
    Eric J Lowe
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Haematol 123:323-6. 2003
    ..In contrast, donor T-cell incompatibility was a risk factor for acute GVHD, chronic GVHD and death. Thus, T-cell alloreactivity dominated that of NK cells in minimally T-cell-depleted grafts...
  17. pmc Hematopoietic cells and osteoblasts are derived from a common marrow progenitor after bone marrow transplantation
    Massimo Dominici
    Division of Experimental Hematology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 101:11761-6. 2004
    ..Its isolation and characterization may suggest novel treatments for genetic bone diseases and bone injuries...
  18. pmc Skeletons in the p53 tumor suppressor closet: genetic evidence that p53 blocks bone differentiation and development
    Gerard P Zambetti
    Department of Biochemistry and 2Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Cell Biol 172:795-7. 2006
    ..These interesting results and their biological and clinical implications are the focus of this comment...
  19. ncbi request reprint Dkk-1-mediated expansion of adult stem cells
    Edwin M Horwitz
    Divisions of Stem Cell Transplantation and Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Trends Biotechnol 22:386-8. 2004
    ..The use of Dkk-1 in cell-processing laboratories might advance cell-expansion technology and greatly increase the clinical uses of MSCs...
  20. ncbi request reprint Etiology and outcome of graft failure in pediatric hematopoietic stem cell transplant recipients
    Paul Woodard
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Pediatr Hematol Oncol 25:955-9. 2003
    ..To determine the incidence, etiology and outcome of graft failure in pediatric allogeneic bone marrow transplant (BMT) recipients...
  21. ncbi request reprint Malignant infantile osteopetrosis and primary pulmonary hypertension: a new combination?
    Kimberly A Kasow
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pediatr Blood Cancer 42:190-4. 2004
    ..We suggest that PPH may be linked to a specific variant of MIOP and recognizing the potential for pulmonary hypertension in children with MIOP may lead to a more rapid diagnosis and life-saving intervention...
  22. ncbi request reprint Report on the workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006
    Jerry C Cheng
    Division of Hematology Oncology, Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories and Mattel Children s Hospital, Jonsson Comprehensive Cancer Center, Los Angeles, California, USA
    Stem Cells 25:1070-88. 2007
  23. pmc Donor cell-derived osteopoiesis originates from a self-renewing stem cell with a limited regenerative contribution after transplantation
    Massimo Dominici
    Department of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, Italy
    Blood 111:4386-91. 2008
    ..The lack of durable donor-derived osteopoiesis may reflect an intrinsic genetic program or exogenous environmental signaling that suppresses the differentiation capacity of the donor stem cells...
  24. ncbi request reprint Reversal of obstructive sleep apnea in osteopetrosis following bone marrow transplantation
    RoseMaryS Stocks
    Department of Otolaryngology, University of Tennessee, Memphis 38105, USA
    Clin Pediatr (Phila) 41:55-7. 2002
  25. ncbi request reprint Chloride channel ClCN7 mutations are responsible for severe recessive, dominant, and intermediate osteopetrosis
    Annalisa Frattini
    Istituto di Tecnologie Biomediche, CNR, Milan, Italy
    J Bone Miner Res 18:1740-7. 2003
    ..The remaining five patients seem to be heterozygous for a ClCN7 mutation, and significant variations were observed in the clinical manifestations of their disease, even within the same family...

Research Grants1

  1. Biology/Transplantation of Multipotent Marrow Stem Cells
    Edwin Horwitz; Fiscal Year: 2007
    ..Collectively, the data generated by this 5-year project will help to clarify several outstanding questions in stem cell biology and the therapeutic relevance of marrow stem cells with apparent multilineage potential. ..